Category: 104-03-0

Mengheres, Gabriel published the artcileThe synthesis and anti-inflammatory evaluation of 1,2,3-triazole linked isoflavone benzodiazepine hybrids, Recommanded Product: 4-Nitrophenylacetic acid, the publication is ARKIVOC (Gainesville, FL, United States) (2020), 306-321, database is CAplus.

Copper catalyzed azide-alkyne cycloaddition was used for the first time to access a small series of eight novel 1,2,3-triazole linked isoflavone benzodiazepine hybrids I [R¹ = H, C(O)Me; R² = Me; R³ = H; R²R³ = (CH₂)₃] and II [R⁴ = H, C(O)Me; R⁵ = Me; R⁶ = H; R⁵R⁶ = (CH₂)₃]. As part of this work, a previously unreported alkyne substituted pyrrolo[1,4]benzodiazepine was synthesized using a Sonogashira coupling reaction. Two previously unreported azide substituted isoflavones were also synthesized using TMS-azide as a key reagent. The eight new 1,2,3-triazole linked products, and several precursors, were evaluated as potential anti-inflammatory compounds This revealed that two of the triazole linked isoflavone benzodiazepine hybrids together with one of the azido-isoflavone precursors showed useful NO inhibitory activity when compared to natural isoflavones.

ARKIVOC (Gainesville, FL, United States) published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Recommanded Product: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ishihara, Kazuaki published the artcileEnantio- and Site-Selective ¦Á-Fluorination of N-Acyl 3,5-Dimethylpyrazoles Catalyzed by Chiral ¦Ð-Cu^II Complexes, Formula: C8H7NO4, the publication is Angewandte Chemie, International Edition (2020), 59(40), 17641-17647, database is CAplus and MEDLINE.

Catalytic enantioselective ¦Á-fluorination reactions of carbonyl compounds are among the most powerful and efficient synthetic methods for constructing optically active ¦Á-fluorinated carbonyl compounds Nevertheless, ¦Á-fluorination of ¦Á-nonbranched carboxylic acid derivatives is still a big challenge because of relatively high pK_a values of their ¦Á-hydrogen atoms and difficulty of subsequent synthetic transformation without epimerization. Herein we show that chiral copper(II) complexes of 3-(2-naphthyl)-L-alanine-derived amides are highly effective catalysts for the enantio- and site-selective ¦Á-fluorination of N-(¦Á-arylacetyl) and N-(¦Á-alkylacetyl) 3,5-dimethylpyrazoles [e.g., I ¡ú II (99%, 91% ee)]. The substrate scope of the transformation is very broad (25 examples including a quaternary ¦Á-fluorinated ¦Á-amino acid derivative). ¦Á. ¦Á-Fluorinated products were converted into the corresponding esters, secondary amides, tertiary amides, ketones, and alcs. with almost no epimerization in high yield.

Angewandte Chemie, International Edition published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Formula: C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sokolov, Anatolii I. published the artcileConvenient and Versatile Synthetic Protocol for Arylidene-1H-imidazol-5(4H)-ones, Related Products of catalysis-chemistry, the publication is ChemistrySelect (2020), 5(23), 7000-7003, database is CAplus.

A new protocol for synthesis of the arylidene-1H-imidazol-5(4H)-ones based on O-alkylation of amidoacetates using triethyloxonium tetrafluoroborate leading to carboximidates was proposed. These imidates have long been used in the synthesis of imidazolones by [2+3] cycloaddition reaction with Schiff bases. However, diversity of carboximidates prepared by the common techniques was limited. The protocol proposed here eliminated these limitations. Using this technique, a number of derivatives of the green fluorescent protein (GFP) and as FP chromophores were synthesized, and influence of the C₂ residue on their optical properties was studied.

ChemistrySelect published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C6H6N2O, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Narobe, Rok published the artcileDecarboxylative Ritter-Type Amination by Cooperative Iodine (I/III)-Boron Lewis Acid Catalysis, Quality Control of 104-03-0, the publication is ACS Catalysis (2022), 12(1), 809-817, database is CAplus.

Recent years have witnessed important progress in synthetic strategies exploiting the reactivity of carbocations via photochem. or electrochem. methods. Yet, most of the developed methods are limited in their scope to certain stabilized positions in mols. Herein, Author report a metal-free system based on the iodine (I/III) catalytic manifold, which gives access to carbenium ion intermediates also on electronically disfavored benzylic positions. The unusually high reactivity of the system stems from a complexation of iodine (III) intermediates with BF₃. The synthetic utility of decarboxylative Ritter-type amination protocol has been demonstrated by the functionalization of benzylic as well as aliphatic carboxylic acids, including late-stage modification of different pharmaceutical mols. Notably, the amination of ketoprofen was performed on a gram scale. Detailed mechanistic investigations by kinetic anal. and control experiments suggest two mechanistic pathways.

ACS Catalysis published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Quality Control of 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ispizua-Rodriguez, Xanath published the artcileDirect Synthesis of Tri-/Difluoromethyl Ketones from Carboxylic Acids by Cross-Coupling with Acyloxyphosphonium Ions, COA of Formula: C8H7NO4, the publication is Chemistry – A European Journal (2021), 27(64), 15908-15913, database is CAplus and MEDLINE.

A simple and straightforward approach to the synthesis of trifluoromethyl and difluoromethyl ketones RC(O)CF₃ [R = naphth-2-yl, benzyl, (Z)-cycloundecen-2-yl, etc.] and RC(O)CF₂H from widely available carboxylic acids RC(O)OH is disclosed. The transformation utilizes an acyloxyphosphonium ion as the active electrophile, conveniently generated in situ from the carboxylic acid substrate by using commodity chems. The utility of the reaction system is exemplified by its chemoselectivity, with tolerance to a variety of important functional groups. The late-stage functionalization of carboxylic acid active pharmaceutical ingredients and pharmaceutically relevant compounds is also discussed.

Chemistry – A European Journal published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, COA of Formula: C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Datta, Sanchita published the artcileSynthesis, anticancer activity, SAR and binding mode of interaction studies of substituted pentanoic acids: part II, Name: 4-Nitrophenylacetic acid, the publication is Future Medicinal Chemistry (2022), 14(1), 17-34, database is CAplus and MEDLINE.

Here, 13 new compounds were synthesized and characterized. Along with these new compounds, 16 previously reported phenyl/naphthylacetyl pentanoic acid derivatives were biol. evaluated. Compounds I and II showed good cytotoxicity against leukemia cell line Jurkat E6.1. The mechanisms of cytotoxicity of these compounds were confirmed by DNA deformation assay and reactive oxygen species assay. MMP-2 and HDAC8 expression assays suggested the dual inhibiting property of these two compounds These findings were supported by results of mol. docking studies. In silico pharmacokinetic properties showed compounds I and II have high gastrointestinal absorption. This study highlights the action of phenyl/naphthylacetyl pentanoic acid derivatives as anticancer agents.

Future Medicinal Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Name: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kumar, Naresh published the artcileAnti-oxidation properties of 2-substituted furan derivatives: A mechanistic study, HPLC of Formula: 104-03-0, the publication is Journal of Luminescence (2021), 117725, database is CAplus.

2-(P-Ph substituted styryl)-furans were synthesized and studied the excited state and anti oxidation properties using absorption, fluorescence, d. functional theory and DPPH radical scavenging assay. 2-(P-hydroxy Ph styryl)-furan (6) exhibits good antioxidant properties with IC₅₀ ? 40¦ÌM as compared to the amine, chloro, cyano methoxy and nitro substituted styryl compounds (1-5, 7-8) (IC₅₀ > 150¦ÌM). It is shown that furans 1-3 with strong electron withdrawing nitro, cyano and chloro substituent do not show antioxidant properties. The O-H bond dissociation energy (BDE) of p-hydroxy substituted furan compound is comparable to the BDE of vitamin E. The antioxidant activity of furan compound is further reduced with increasing the dipolar nature of the mol. From the thermodn. parameters and antioxidant properties, it is shown that there is a correlation of antioxidant properties with the ground state dipole moment, X-H bond dissociation energy (X: O; N) and proton affinity (PA). In presence of the furan compound, the quenching of DPPH radical is occurred predominantly through hydrogen atom transfer mechanism.

Journal of Luminescence published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Dong published the artcileCu-Catalyzed Dual C-O Bonds Cleavage of Cyclic Ethers with Carboxylic Acids, NaI, and TMSCF₃ to Give Iodoalkyl Ester, Application In Synthesis of 104-03-0, the publication is Organic Letters (2022), 24(15), 2826-2831, database is CAplus and MEDLINE.

Herein, by dual C-O bonds cleavage of cyclic ethers with Cu-catalysis led to the development of a selective three-component coupling of com. available chems., carboxylic acids, ethers, and halogens to synthesize iodoalkyl esters RC(O)OR¹ [R = Ph, 2-furyl, 4-BrC₆H₄, etc.; R¹ = (CH₂)₄-I, n-decyl, (CH₂)₅-I, etc.] in the presence of TMSCF₃ was reported. This allowed for the concise synthesis of highly functionalized iodoalkyl esters directly. And the synthetic insect pheromones were also disclosed.

Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Application In Synthesis of 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Smith, Samuel M. published the artcileScope, Limitations and Mechanistic Analysis of the HyperBTM-Catalyzed Acylative Kinetic Resolution of Tertiary Heterocyclic Alcohols, SDS of cas: 104-03-0, the publication is European Journal of Organic Chemistry (2022), 2022(1), e202101111, database is CAplus.

The full scope and limitations of the catalytic acylative kinetic resolution of a range of tertiary heterocyclic alcs. (78 examples, s up to >200) is reported under operationally-simple conditions, using low loadings of a com. available Lewis basic isothiourea catalyst, HyperBTM (generally 1 mol %). The protocol is highly effective for the kinetic resolution of 3-substituted 3-hydroxyoxindole and ¦Á-substituted ¦Á-hydroxylactam derivatives bearing up to three potential recognition motifs at the stereogenic tertiary carbinol center. The full power of this methodol. has been showcased through the synthesis of highly enantioenriched biol.-active target compounds in both enantiomeric forms. To provide further insight into the reaction mechanism, a detailed kinetic anal. of this Lewis base-catalyzed acylation of tertiary alcs. is reported using the variable time normalization anal. (VTNA) method.

European Journal of Organic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C15H23BO2, SDS of cas: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hornum, Mick published the artcileSubstituted 9-Diethylaminobenzo[a]phenoxazin-5-ones (Nile Red Analogues): Synthesis and Photophysical Properties, Related Products of catalysis-chemistry, the publication is Journal of Organic Chemistry (2021), 86(2), 1471-1488, database is CAplus and MEDLINE.

Nile Red is a benzo[a]phenoxazone dye containing a diethylamino substituent at the 9-position. In recent years, it has become a popular histol. stain for cellular membranes and lipid droplets due to its unrivaled fluorescent properties in lipophilic environments. This makes it an attractive lead for chem. decoration to tweak its attributes and optimize it for more specialized microscopy techniques, e.g., fluorescence lifetime imaging or two-photon excited fluorescence microscopy, to which Nile Red has never been optimized. Herein, we present synthesis approaches to a series of monosubstituted Nile Red derivatives (9-diethylbenzo[a]phenoxazin-5-ones) starting from 1-naphthols or 1,3-naphthalenediols. The solvatochromic responsiveness of these fluorophores is reported with focus on how the substituents affect the absorption and emission spectra, luminosity, fluorescence lifetimes, and two-photon absorptivity. Several of the analogs emerge as strong candidates for reporting the polarity of their local environment. Specifically, the one- and two-photon excited fluorescence of Nile Red turns out to be very responsive to substitution, and the spectroscopic features can be finely tuned by judiciously introducing substituents of distinct electronic character at specific positions. This new toolkit of 9-diethylbenzo[a]phenoxazine-5-ones constitutes a step toward the next generation of optical mol. probes for advancing the understanding of lipid structures and cellular processes.

Journal of Organic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia