Category: 104-03-0

Mohammadifarani, Ahmad published the artcileSynthesis and cytotoxicity evaluation of N-(5-mercapto-4H-1,2,4-triazol3-yl)-2-phenylacetamide derivatives as apoptosis inducers with potential anticancer effects, Related Products of catalysis-chemistry, the publication is Journal of Reports in Pharmaceutical Sciences (2020), 9(1), 128-135, database is CAplus.

Discovery of new anticancer drugs is one of the urgent issues in the medicinal chem. researches. Incidence of severe side effects and acquired resistance to the current medications are the logical reasons for the development of novel antineoplastic agents. Herein, a new series of 4H-1,2,4-triazole derivatives was synthesized and subsequently their cytotoxicity was assessed using dimethylthiazol diphenyltetrazolium bromide assay. Furthermore, activity of caspase 3, mitochondrial membrane potential (MMP), and generation of reactive oxygen species (ROS) were investigated. All synthesized derivatives (3a-3o) were tested against Hela (cervical cancer), A549 (lung carcinoma), and U87 (glioblastoma), and the obtained data were compared with doxorubicin. Among the chlorinated derivatives, compound 3c with para positioning of the chlorine on the Ph residue possessed higher cytotoxicity (IC50 = s3.2 ¡À 0.6 ¦ÌM) than compounds 3a and 3b, which positioned chlorine at ortho and meta position, resp. Chlorine as electron-withdrawing moiety caused enhancement in cytotoxicity. Fortunately, most of the tested compounds showed remarkable cytotoxic activity toward applied cells, especially Hela. Activation of caspase 3, MMP reduction, and ROS generation were also observed for the studied compounds

Journal of Reports in Pharmaceutical Sciences published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Trisovic, N. published the artcileMesomorphism of novel stilbene-based bent-core liquid crystals, Product Details of C8H7NO4, the publication is Liquid Crystals (2021), 48(7), 1054-1064, database is CAplus.

A series of asym. bent-core liquid crystals I (X = COO; Y = H, Cl), bearing the stilbene moiety in the side wing, was synthesized and characterised. Structural modifications of the non-stilbene wing resulted in formation of various mesophases. Compounds I (X = COO; Y = H) and I (X = COO; Y = Cl) with an ester linking group between the Ph rings in this wing have an enantiotropic non-polar smectic-type mesophase, while compound I (Y = H), incorporating the biphenyl moiety, has a ferroelec. SmC_aP_F phase. The mols. of I (Y = H) undergo photoisomerisation in solution under UV irradiation, while the mesophases are unstable and UV irradiation leads to irreversible changes. The mesophases of I (X = COO; Y = H) and I (X = COO; Y = Cl) do not show any electro-optical switching and polarisation current. Applying low frequency AC voltage on a planarly aligned film of compound I (Y = H), smectic domains grow, while the birefringence and an image flickering increase. The observed features of these compounds identify stilbene as an attractive moiety in the design of advanced materials based on bent-core mols.

Liquid Crystals published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C10H7IN2, Product Details of C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ren, Zili published the artcileConstruction of oxime ester derivatives of osthole from Cnidium monnieri, and evaluation of their agricultural activities and control efficiency, SDS of cas: 104-03-0, the publication is Pest Management Science (2020), 76(11), 3560-3567, database is CAplus and MEDLINE.

In order to discover natural-product-based pesticidal candidates, a series of coumarin-like derivatives containing oxime ester fragments at the C-8 position were prepared by structural modification of osthole, a natural plant product isolated from Cnidium monnieri. Their pesticidal activities were evaluated against two typically fruit trees/crop-threatening agricultural pests, Mythimna separata Walker and Tetranychus cinnabarinus Boisduval. Osthole was regioselectively oxidized by selenium dioxide to give the E-isomer, (2¡äE)-3¡ä-formaldehydylosthole (2). Four key steric structures of 2, (2¡äE, 4¡äE)-(o-chloropyrid-3-ylcarbonyl)oximinylosthole (4o), (2¡äE, 4¡äE)-(styrylcarbonyl)oximinylosthole (4t), and (2¡äE, 4¡äE)-(acetyl)oximinylosthole (4w) were undoubtedly confirmed by X-ray crystallog. Against T. cinnabarinus, it is noteworthy that (2¡äE, 4¡äE)-(p-chlorophenylcarbonyl)oximinylosthole (4c) exhibited over three-fold more potent acaricidal activity of the precursor osthole, with especially good control efficiency observed in the glasshouse. Against M. separata, compounds 4c and (2¡äE, 4¡äE)-(p-nitrophenylcarbonyl)oximinylosthole (4f) showed the most pronounced growth inhibitory activity. The relationships between their structures and agricultural activities also were studied. These results demonstrate that compound 4c could be further structurally modified as pesticidal agents. It will lay the foundation for future application of osthole derivatives as pesticides.

Pest Management Science published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, SDS of cas: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yang, Kai published the artcileSimple inorganic base promoted C-N and C-C formation: synthesis of benzo[4,5]imidazo[1,2-a]pyridines as functional AIEgens used for detecting picric acid, Related Products of catalysis-chemistry, the publication is Organic & Biomolecular Chemistry (2021), 19(37), 8133-8139, database is CAplus and MEDLINE.

Metal-free catalyzed intermol. tandem Michael addition/cyclization was developed for the synthesis of benzo[4,5]imidazo[1,2-a]pyridines I [R = H, Me, Ph, etc.; R¹ = H, 7-Me, 7,8-Cl₂, etc.] from ¦Á-bromocinnamaldehyde and 2-substituted benzimidazoles. The reaction promoted by a simple inorganic base displayed moderate to good yields and good functional group tolerance. The optical properties of some typical products I were investigated. Due to the presence of the benzene ring at the C1-position of compounds I which restricted intramol. motion, as a new type of aggregation-induced emission (AIE) luminogen (AIEgen), they showed very good solid-state fluorescence with quantum yields up to 88.80%. Importantly, the AIE performance of compound I [R = Me; R¹ = H] could be useful to detect the nitroarom. explosive picric acid (PA) with a detection limit and quenching constant of 42.5 nM and 7.27 x 10⁴ M^-M, resp.

Organic & Biomolecular Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C4H11NO, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ding, Ge published the artcileStrengthened near-IR two-photon absorption induced emission of ESIPT chromophores by molecular aggregation, SDS of cas: 104-03-0, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2021), 127476, database is CAplus.

In this study, a range of new free open-chain conjugated organic chromophores including salicylidene methylamine part were synthesized and characterized. The steady state and transient state absorption and emission properties of the target dyes in DMF were investigated. The results showed that the target dyes processed the excited state intramol. proton transfer (ESIPT) in DMF under one-photon excitation. Furthermore, the ESIPT was more competitive under the exposure of pulsed pumping near-IR femtosecond laser in DMF. The further survey showed that the target dyes yielded gradually the regular mol. aggregates in the mixed DMF/H2O (the water volume fractions, 60-80%) with evolving time. In particular, the target mol. aggregates exhibited the strong enol emission but the quenched keto emission under one-photon exposure and near-IR two-photon irradiation, resp. In addition, the near-IR two-photon absorption (TPA) induced enol emission of the target dyes showed an enhancement in the aggregation state. This study demonstrates that it is feasible to strengthen TPA induced emission of enol phototautomers of some ESIPT compounds by the mol. aggregation under the irradiation of near-IR femtosecond laser.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, SDS of cas: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ma, He published the artcileNew Cy5 photosensitizers for cancer phototherapy: A low singlet-triplet gap provides high quantum yield of singlet oxygen, SDS of cas: 104-03-0, the publication is Chemical Science (2021), 12(41), 13809-13816, database is CAplus and MEDLINE.

In the current work, a new strategy to enhance the singlet-triplet intersystem crossing (ISC) and high phototherapy efficiency was developed, based on the mol. design of a thio-pentamethine cyanine dye I [X = H, 4-MeOC₆H₄, 4-O₂NC₆H₄, CHO, Q] (TCy5) as a photosensitizer. The introduction of an electron-withdrawing group at the meso-position of I could dramatically reduce the singlet-triplet energy gap (¦ÄEst) value (from 0.63 eV to as low as 0.14 eV), speed up the ISC process (¦ÓISC = 1.7 ps), prolong the lifetime of the triplet state (¦ÓT = 319¦Ìs) and improve singlet oxygen (¹O₂) quantum yield to as high as 99%, a value much higher than those of most reported triplet PSs. Further in vitro and in vivo experiments showed that I [X = CHO], with its efficient ¹O₂ generation and good biocompatibility, causes an intense tumor ablation in mice. This provided a new strategy for designing ideal photosensitizers for cancer phototherapy.

Chemical Science published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, SDS of cas: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shen, Zhenpeng published the artcileIron-Promoted Decarboxylation of Arylacetic Acids for the Synthesis of Aromatic Nitriles with Sodium Nitrite as the Nitrogen Source, Quality Control of 104-03-0, the publication is Synlett (2020), 31(18), 1805-1808, database is CAplus.

A new and effective method was developed for the synthesis of aromatic nitriles ArCN (Ar = 4-chlorophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) (I) from arylacetic acids ArCH₂C(O)OH (II) by using NaNO₂ as the nitrogen source and Fe(OTf)₃ as the promoter at 50¡ãC. A series of arylacetic acids II underwent this transformation to give the targeted products I in yields of 51-90%. Because of the mild conditions, the reaction is compatible with a broad range of functional groups, including ester, carboxy, hydroxy, acetamido, halo, nitro, cyano, methoxy, and even highly reactive formyl groups.

Synlett published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C18H21BO4, Quality Control of 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lv, Cong published the artcileFrom amides to urea derivatives or carbamates with chemospecific C-C bond cleavage at room temperature, Name: 4-Nitrophenylacetic acid, the publication is Organic Chemistry Frontiers (2022), 9(5), 1354-1363, database is CAplus.

Herein, a significant advancement in this area and present a general method for copper-catalyzed chemospecific C-C bond cleavage of amides to synthesize urea derivatives and carbamates at room temperature was reported. A catalytic process via a resonant six-membered N,O-chelated copper cycle and superoxide radical was proposed according to mechanistic and control experiments The combination of chelation assistance and radical oxygenation strategies opened a door for C-C bond cleavage of common substrates which possess multiple reactive sites and was envision that this broadly applicable method will be of great interest in organic synthesis, the pharmaceutical industry and the agrochem. industry.

Organic Chemistry Frontiers published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Name: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lei, Jie published the artcileExpeditious access of chromone analogues via a Michael addition-driven multicomponent reaction, COA of Formula: C8H7NO4, the publication is Organic Chemistry Frontiers (2020), 7(8), 987-992, database is CAplus.

A Michael addition-driven four-component reaction (4-CR) was developed for derivatizing chromones by strategically suppressing competing 4-CR Ugi reaction without a catalyst. A series of structurally diverse 4-oxochroman-2-carboxamides was synthesized with this one-pot protocol. In addition, the new reaction was expanded for the synthesis of a series of tetrazole substituted chromones by replacing carboxylic acid with trimethylsilyl azide (TMSN₃). The imine functional group and the corresponding aldehyde hydrolyzed from the imine were utilized for further structural diversification.

Organic Chemistry Frontiers published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, COA of Formula: C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Ming-jun published the artcileStructure-activity relationship studies on Pd176252 derivatives leading to discovery of novel GRP receptor antagonist with potent anticancer activity, Recommanded Product: 4-Nitrophenylacetic acid, the publication is Medicinal Chemistry Research (2021), 30(11), 2069-2089, database is CAplus.

Abstract: Gastrin-releasing peptide (GRP)/gastrin-releasing peptide receptor (GRPR) have various physiol. effects, and many studies report that GRPR is a potential anticancer target. Pd176252 is a typical small-mol. GRPR antagonist that exhibits anti-proliferation activity against most cancers. In this study, 31 novel Pd176252 analogs were designed, synthesized, and evaluated for anti-proliferation activity against human prostate cancer (PC3), mouse pancreatic cancer (Pan02), human gastric cancer (HGC-27), and hepatocellular carcinoma (HepG2) cell lines. Of all the compounds evaluated, 5a and 6e showed better anti-proliferation activity compared to Pd176252 against PC3 (half-maximal inhibitory concentration [IC50] = 4.97 and 9.88 ¦ÌM, resp.), Pan02 (IC50 = 4.36 and 2.50 ¦ÌM, resp.), and HGC-27 (IC50 = 4.36 and 2.50 ¦ÌM, resp.), cell lines. Moreover, combining 5a or 6e with a histone deacetylase (HDAC) inhibitor further improved the in vitro anti-proliferation activity. Further research showed that 5a caused HGC-27 cell apoptosis by downregulating Bcl-2 and upregulating Bax. In addition, a mol. docking anal. showed that compounds 5a and 6e could bind to GRPR. In conclusion, compounds 5a and 6e are novel GRPR antagonists with potent anticancer activity. [graphic not available: see fulltext]

Medicinal Chemistry Research published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C20H28B2O4S2, Recommanded Product: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia