Category: 104-03-0

Li, Yong published the artcileMicrowave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction, Category: catalysis-chemistry, the publication is Beilstein Journal of Organic Chemistry (2020), 663-669, database is CAplus and MEDLINE.

A facile microwave-assisted method for the synthesis of tetramic acid derivatives I (R¹ = Ph, Bn, 4-MeOC₆H₄, etc.; R² = 3-F, 4-NO₂, 3,4-(OMe)₂, etc.; R³ = Ph, Bn, c-hexyl, 2,6-(Me)₂C₆H₃) has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogs in good yields. With com. available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogs, which cannot be easily accessed by the classic synthetic methods.

Beilstein Journal of Organic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Xiaofan published the artcileAsymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogues Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight, Recommanded Product: 4-Nitrophenylacetic acid, the publication is Journal of Organic Chemistry (2020), 85(8), 5598-5614, database is CAplus and MEDLINE.

(S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline [(S)-1-(4-methoxybenzyl)-OHIQ, (S)-1a] is a key synthetic intermediate in the industrial production of dextromethorphan, one of the most widely used over-the-counter antitussives. We report here that a new cyclohexylamine oxidase discovered by genome mining, named CHAO_CCH12-C2, was able to completely deracemize 100 mM 1a under Turner’s deracemization conditions to afford (S)-1a in 80% isolated yield and 99% ee at a semipreparative scale (0.4 mmol). When this biocatalytic reaction was scaled up to a gram scale (5.8 mmol), without reaction optimization (S)-1a was still isolated in 67% yield and 96% ee. The relatively higher k_cat determined for CHAO_CCH12-C2 was rationalized as one major factor rendering this enzyme capable of oxidizing 1a effectively at elevated substrate concentrations Protein sequence alignment, anal. of our co-crystal structure of CHAO_CCH12-C2 complexed with the product 1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydroisoquinoline [1-(4-methoxybenzyl)-HHIQ, 2a], and the structure-guided mutagenesis study together indicated L295 is one of the critical residues for this efficient enzymic oxidation process and supported the presence of two cavities as well as a catalytically important “aromatic cage” formed by F342, Y433, and FAD. The synthetic applicability of CHAO_CCH12-C2 was further underscored by the stereoselective synthesis of various enantioenriched 1-benzyl-OHIQ derivatives of potential pharmaceutical importance at a semipreparative scale.

Journal of Organic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C5H12BrO3P, Recommanded Product: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xia, Yujia published the artcileNH₄I-promoted oxidative formation of benzothiazoles and thiazoles from arylacetic acids and phenylalanines with elemental sulfur, Name: 4-Nitrophenylacetic acid, the publication is Organic & Biomolecular Chemistry (2021), 19(23), 5108-5113, database is CAplus and MEDLINE.

A NH₄I/K₃PO₄-based catalytic system had been established to enable oxidative formation of thiazole compounds I [R¹ = H, MeO; R² = H, MeO, t-Bu; R³ = H, MeO; R¹R² = HC=CHCH=CH, HC=CHCH=N, HC=CHC(Br)=CH, HC=CHC(4-methoxyphenyl)=CH; R²R³ = OCH₂O; Ar = Ph, 3-pyridyl, 2-naphthyl, etc.], II [Ar = Ph, 4-MeC₆H₄, 2,4-di-ClC₆H₃, etc.] from arylacetic acids and phenylalanines with elemental sulfur. While the three-component reaction of anilines or ¦Â-naphthylamines with arylacetic acids and elemental sulfur afforded benzo[2,1-d]thiazoles I [R¹ = H, MeO; R² = H, MeO, t-Bu; R³ = H, MeO; R²R³ = OCH₂O; Ar = Ph] and naphtho[2,1-d]thiazoles, I [R¹R² = HC=CHCH=CH, HC=CHCH=N, HC=CHC(Br)=CH, HC=CHC(4-methoxyphenyl)=CH; Ar = Ph, 3-pyridyl, 2-naphthyl, etc.] the annulation of phenylalanines with elemental sulfur produces 2-benzyl II [Ar = Ph] and 2-benzoylthiazoles. This work well complements previous three-component annulations of benzothiazoles from other coupling partners.

Organic & Biomolecular Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C10H9ClN2O, Name: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Destro, Gianluca published the artcileTransition-Metal-Free Carbon Isotope Exchange of Phenyl Acetic Acids, Safety of 4-Nitrophenylacetic acid, the publication is Angewandte Chemie, International Edition (2020), 59(32), 13490-13495, database is CAplus and MEDLINE.

A transition-metal-free carbon isotope exchange procedure on Ph acetic acids is described. Utilizing the universal precursor CO₂, this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [¹⁴C] and [¹³C]. A proof of concept with [¹¹C] was also obtained with low molar activity valuable for distribution studies.

Angewandte Chemie, International Edition published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Safety of 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abdallah, Mira published the artcileCoumarin Derivatives as Photoinitiators in Photo-Oxidation and Photo-Reduction Processes and a Kinetic Model for Simulations of the Associated Polymerization Profiles, Safety of 4-Nitrophenylacetic acid, the publication is ACS Applied Polymer Materials (2020), 2(7), 2769-2780, database is CAplus.

In this work, the design of an original series of coumarin derivatives (CoumC1-CoumC13) is presented. Chem. structures of these coumarins were selected by mol. modeling to ensure both excellent light absorption properties and high potential photoreactivity (high excited-state energy). As a striking result of this in silico design, eight of the 13 proposed coumarins were never presented and were specifically proposed for this work, indicating the interest in their structures. New multicomponent photoinitiating systems (PISs) based on these coumarins are proposed for the free radical polymerization (FRP) of (meth)acrylates and examined upon visible light irradiation using a light-emitting diode (LED) as a safe and economical irradiation source. The proposed systems are based on coumarins that act as remarkable photoinitiators/photosensitizers (PIs/PSs) combined with N-phenylglycine (NPG) and/or iodonium salt (Iod) as co-initiators to generate the reactive species (radicals) that will initiate the photopolymerization reaction. Investigations of the chem. mechanisms suggested by the different interactions that take place as well as the photophys. and photochem. properties of coumarins are provided. It is possible to obtain high polymerization rates (R_p), excellent photoinitiating abilities, and great reactive function conversions (FC) with these structures based on the coumarin core. Coumarins show high efficiency for the FRP of (meth)acrylates by reaction with iodonium salt (a photo-oxidation process) or with amine (a photo-reduction process). These compounds were used in three-dimensional (3D) printing resins but also for the preparation of photocomposites. In this latter case, excellent depth of cure was noted as remarkable behavior. To rationalize the exptl. results, a kinetic model for a three-component system has been established to analyze the role of oxygen in the monomer conversions and the conversion enhancement observed while using an amine as a co-initiator.

ACS Applied Polymer Materials published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Safety of 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiao, Mengzhao published the artcileFast immobilization of human carbonic anhydrase II on Ni-based metal-organic framework nanorods with high catalytic performance, COA of Formula: C8H7NO4, the publication is Catalysts (2020), 10(4), 401, database is CAplus.

Carbonic anhydrase (CA) has received considerable attention for its ability to capture carbon dioxide efficiently. This study reports a simple strategy for immobilizing recombinant carbonic anhydrase II from human (hCA II) on Ni-based MOFs (Ni-BTC) nanorods, which was readily achieved in a one-pot immobilization of His-tagged hCA II (His-hCA II). Consequently, His-hCA II from cell lysate could obtain an activity recovery of 99% under optimal conditions. After storing for 10 days, the immobilized His-hCA II maintained 40% activity while the free enzyme lost 91% activity. Furthermore, during the hydrolysis of p-nitrophenyl acetic acid, immobilized His-hCA II exhibited excellent reusability and still retained more than 65% of the original activity after eight cycles. In addition, we also found that Ni-BTC had no fixation effect on proteins without histidine-tag. These results show that the Ni-BTC MOFs have a great potential with high efficiency for and specific binding of immobilized enzymes.

Catalysts published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, COA of Formula: C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gallo, Rafael D. C. published the artcileA Selective C-C Bond Cleavage Strategy Promoted by Visible Light, Computed Properties of 104-03-0, the publication is Organic Letters (2021), 23(22), 8916-8920, database is CAplus and MEDLINE.

A new visible-light-promoted reaction between aryldiazoacetates ArC(=N₂)COOR¹ (Ar = Ph, 4-chlorophenyl, 3,5-dimethoxypheny, etc.; R¹ = Me, Bn, i-Pr, allyl) and 1,3-diketones R²C(O)CH₂C(O)R³ (R² = Me, 4-chlorophenyl, cyclopropyl, etc.; R³ = Me, Ph, 2-methoxyphenyl, etc.) allows good yields and selectivities for C-C bond insertions, leading to the corresponding 1,4-dicarbonyl compounds R²C(O)C(COOR¹)(Ar)CH₂C(O)R³ . This transformation is straightforward and highly practical. It tolerates air and moisture and does not require the use of any metals. Mechanistic investigations support the involvement of a key cyclopropanol intermediate derived from an intramol. rearrangement.

Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Computed Properties of 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Hui published the artcileDirect amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp₂Cl₂, Safety of 4-Nitrophenylacetic acid, the publication is Applied Organometallic Chemistry (2020), 34(5), e5568, database is CAplus.

A mild and efficient direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp₂Cl₂ was described. Arylacetic acid derivatives reacted with different amines to afford the corresponding amides in good to excellent yield except of aniline. Aryl formic acids failed to react with aniline but smoothly reacted with aliphatic amines and benzylamine in moderate to good yield, fatty acids reacting with benzyl and aliphatic amines give amides in good to excellent yield. Chiral amino acids derivatives were transformed into amides without racemization in moderate yield. The possible mechanism of direct amidation catalyzed by TiCp₂Cl₂ was discussed. This catalytic method was very suitable for the amidation of low sterically hindered arylacetic acid, fatty acids with different low sterically hindered amines except aniline, as well as the amidation of aryl formic acid with benzyl and aliphatic amines.

Applied Organometallic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C17H16O2, Safety of 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gak Simic, Kristina published the artcileOn the photophysical properties of a liquid crystal dimer based on 4-nitrostilbene: A combined experimental and theoretical study, Recommanded Product: 4-Nitrophenylacetic acid, the publication is Journal of Molecular Liquids (2021), 116969, database is CAplus.

A new liquid crystal dimer, 1,12-bis(4-(2-(4-nitrophenyl)ethenyl)phenoxy)dodecane, was synthesized and structurally characterized. The compound exhibited enantiotropic nematic phase. The spectroscopic properties were analyzed by UV-Vis and fluorescence techniques. Theor. calculations were used to predict the UV-Vis spectral properties of three isomers and propose a mechanism of conversion between them. The obtained results present a solid basis for the future studies on the stilbene-based liquid crystal dimers, thus affording guidelines for development of a structure-property relationship of these compounds

Journal of Molecular Liquids published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Recommanded Product: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rana, Priyanka published the artcileSynthesis and Study of Some 17a-aza-D-homo Steroids as 5¦Á-Reductase Inhibitors, Related Products of catalysis-chemistry, the publication is Current Drug Discovery Technologies, database is CAplus and MEDLINE.

Tremendous advances have been made in the development of new pharmacotherapuetic agents and less invasive techniques to help men with lower urinary tract symptoms. The use of 5¦Á-reductase inhibitor (5-ARI) is restricted to the patients with large prostate volumes, whose symptoms are refractory to antiandrogens or ¦Á-adrenergic blockers. Out of the various synthesized 5-reductase inhibitors with different substituents on the steroidal nucleus, esters have been found to exhibit high anti-androgenic activity. In our attempt to find new, safer and potent 5-ARI and our continued interest in azasteorids, esters of 17a-Aza-D-homo-5-androsten-3¦Â-ol with synergistic effect were synthesized and characterized using different anal. techniques. The compounds were evaluated for their 5¦Á-reductase inhibitory activity in-vivo by their effect on serum androgen level by ELISA assay procedure. The interaction with receptors was studied using an advanced docking program to predict the correlation of the synthesized compounds with actual biol. activity. The target compounds (6-12) showed increased anti-androgenic activity as compared to finasteride and control, which imply that the target compounds are effective in inhibiting 5¦Á-reductase. Particularly, compound 6 showed the highest inhibitory activity and greater affinity for the 5- AR receptor with the highest dock score. The results of these studies when compared with Finasteride showed increased solubility and dissolution of target compound 6. Compound 6 showed immense potential with improved efficacy and better bioavailability, thus makes it a suitable candidate for further studies and optimal formulation.

Current Drug Discovery Technologies published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia