Category: 104-03-0

Wakuluk-Machado, Anne-Marie published the artcilePd(OH)₂/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide, Related Products of catalysis-chemistry, the publication is Organic Process Research & Development (2020), 24(5), 713-723, database is CAplus.

A simple, efficient, cheap, and broadly applicable system for the carboxylation of benzylic bromides with carbon monoxide and water is reported. Upon simple reaction with only 2.5 wt % of Pearlman’s catalyst and 10 mol % of tetrabutylammonium bromide in THF at 110¡ãC for 4 h, a range of benzylic bromides can be smoothly converted to the corresponding arylacetic acids in good to excellent yields after simple extraction and acid-base wash. The reaction was found to be broadly applicable, scalable, and could be successfully extended to the use of ex situ-generated carbon monoxide and applied to the synthesis of the nonsteroidal anti-inflammatory drug diclofenac.

Organic Process Research & Development published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H5F3N4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zubar, Viktoriia published the artcileChemoselective Hydrogenation of Nitroarenes Using an Air-Stable Base-Metal Catalyst, Quality Control of 104-03-0, the publication is Organic Letters (2021), 23(7), 2742-2747, database is CAplus and MEDLINE.

The reduction of nitroarenes to anilines as well as azobenzenes to hydrazobenzenes using a single base-metal catalyst is reported. The hydrogenation reactions are performed with an air-and moisture-stable manganese catalyst and proceed under relatively mild reaction conditions. The transformation tolerates a broad range of functional groups, affording aniline derivatives and hydrazobenzenes in high yields. Mechanistic studies suggest that the reaction proceeds via a bifunctional activation involving metal-ligand cooperative catalysis.

Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C7H5Cl2NO, Quality Control of 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Roque, Ana Carolina Abbud Hanna published the artcileConformational analysis for infrared spectroscopy and theoretical calculations of some 2-bromo-2-propyl 2-aryl-acetates, ibuprofen and naproxen analogs, Safety of 4-Nitrophenylacetic acid, the publication is Journal of Molecular Structure (2021), 130027, database is CAplus.

Conformational anal. of new para-substituted 2-bromo-2-Pr 2-aryl-acetates (Y = H, OMe, Cl, and NO₂) (R1), ibuprofen (R2), and naproxen (R3) analogs using IR (IR) spectroscopy and theor. calculations was performed to determine the preferential conformers of these compounds in solvents with increasing polarity (CCl₄, CH₃Cl, and CH₃CN). The aryl-bromo-esters were synthesized via the esterification of 2-bromo-2-methylpropan-1-ol and the corresponding carboxylic acids, with good yields (?36-70%). The IR spectra showed that these compounds presented only one conformation, and the exptl. data were supported by the theor. results obtained by d. functional theory (DFT) calculations using the 6311+G (2df, 2p) basis set. The calculations revealed that all the studied compounds presented two stable geometric conformations, which agrees with the data obtained exptl. in CCl₄. Theses conformers are stabilized by intramol. hydrogen bonds. However, the orbital interaction calculations using the natural bond orbital (NBO) method showed that the ¦Ç_O¡ú¦Ò*_C-C,¦Ç_O¡ú¦Ò*_C-O, ¦Ç_O¡ú¦Ò*_C-O and ¦Ç_O¡ú¦Ð*_C-O hyper-conjugations are the main interactions that stabilize the conformations. The compounds preferentially adopt the anti-conformation because the steric effect between the gauche bromo and oxygen atoms overrides the hyper-conjugative interactions, in addition to the stabilizing ¦Ò_C-H¡ú ¦Ò*_C-Br interactions in the conformers.

Journal of Molecular Structure published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Safety of 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ozalp, Lalehan published the artcileInvestigation of HMG-CoA reductase inhibitory and antioxidant effects of various hydroxycoumarin derivatives, HPLC of Formula: 104-03-0, the publication is Archiv der Pharmazie (Weinheim, Germany) (2020), 353(10), 1900378, database is CAplus and MEDLINE.

Cardiovascular diseases are one of the primary causes of deaths worldwide, and the development of atherosclerosis is closely related to hypercholesterolemia. As the reduction of the low-d. lipoprotein cholesterol level is critical for treating these diseases, the inhibition of 3-hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase, which is essentially responsible for cholesterol biosynthesis, stands out as a key solution to lower plasma cholesterol levels. In this study, we synthesized several dihydroxycoumarins and investigated their antioxidant and in vitro HMG-CoA reductase inhibitory effects. Furthermore, we carried out in silico studies and examined the quantum-chem. properties of the coumarin derivatives We also performed mol. docking experiments and analyzed the binding strength of each coumarin derivative Our results revealed that compound IV(I) displayed the highest HMG-CoA reductase inhibitory activity (IC₅₀ = 42.0 ¦ÌM) in vitro. Cupric-reducing antioxidant capacity and ferric-reducing antioxidant power assays demonstrated that coumarin derivatives exhibit potent antioxidant activities. Addnl., a close relationship was found between the LUMO energy levels and the antioxidant activities.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chauhan, Laxmi K. published the artcileHydroxytriazenes incorporating sulphonamide derivatives: evaluation of antidiabetic, antioxidant, anti-inflammatory activities, and computational study, Product Details of C8H7NO4, the publication is Molecular Diversity, database is CAplus and MEDLINE.

The existent investigation deals with synthesis, characterization, computational anal., and biol. activities of some hydroxytriazene derivatives containing sulfonamide moiety. The compounds were screened for antidiabetic, antioxidant, and anti-inflammatory activities. The antidiabetic activity was assessed using ¦Á-glucosidase and ¦Á-amylase inhibition assays with IC₅₀ values ranging from 32.0 to 759.13 ¦Ìg/mL and 157.77 to 340.47 ¦Ìg/mL while standard drug acarbose showed IC₅₀ values 12.21 and 69.74 ¦Ìg/mL, resp. The antioxidant activity was evaluated using DPPH and ABTS radical scavenging assays with IC₅₀ value ranging from 54.01 to 912.66 ¦Ìg/mL and 33.22 to 128.11 ¦Ìg/mL, and standard drug ascorbic acid showed IC₅₀ values 29.12 ¦Ìg/mL and 69.13 ¦Ìg/mL, resp. Anti-inflammatory activity was investigated using the carrageenan-induced paw edema method, where percentage inhibition was up to 93.0 and 98.57 for 2 h and 4 h, resp., and all the compounds were found to exhibit excellent anti-inflammatory activity. Moreover, prediction of activity spectra for substance and mol. docking were also performed. The PASS prediction hypothesized the potential of the compounds for anti-inflammatory activity, and docking results suggested the best binding pose for compounds 1b and 2b with the least energy value from which compounds can be considered as potent COX-2 inhibitors. Furthermore, possible interactions between hydroxytriazene analogs and the targets of antioxidant NADPH oxidase and antidiabetic human maltase-glucoamylase enzyme have been identified. The HOMO and LUMO anal. revealed charge transfer within the compounds These findings suggested that the synthesized compounds can be potential agents for the treatment of diabetes and inflammation.

Molecular Diversity published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Product Details of C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sbaraglini, Maria L. published the artcileLipase catalyzed synthesis of alkyl phenylacetates with anticonvulsant activity, Recommanded Product: 4-Nitrophenylacetic acid, the publication is Latin American Journal of Pharmacy (2020), 39(7), 1350-1356, database is CAplus.

Despite the wide spectra of available antiepileptic drugs, one third of the patients still suffer from drug-resistant epilepsy, justifying the ongoing search of novel therapies. The anticonvulsant activity of Pr 4-hydroxybenzoate was previously identified through in silico screening. Here, Candida antarctica B (CAL B) lipase was employed as biocatalyst for the enzymic synthesis of a series of alkyl phenylacetates I (R = H, 4-OH, 4-MeO, 4-NH₂, 4-NO₂; R¹ = Et, Pr) which, based on their mol. similarity to propylparaben, were tested in two acute mice models of seizure (maximal electroshock seizure and s.c. pentylenetetrazol tests). Mol. docking was later applied to explain the observed activities. All the synthesized compounds displayed some degree of protective activity in the maximal electroshock seizure model, whereas none of them showed protection against pentylenetetrazol-induced convulsions. Et 4-methoxyphenylacetate and Pr phenylacetate showed the most promising in vivo results. In consistence with the observed anticonvulsant effects, Pr phenylacetate obtained the best predicted binding energy among the synthesized alkyl phenylacetates.

Latin American Journal of Pharmacy published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Recommanded Product: 4-Nitrophenylacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chi, Fuyun published the artcileJAK3 inhibitors based on thieno[3,2-d]pyrimidine scaffold: design, synthesis and bioactivity evaluation for the treatment of B-cell lymphoma, COA of Formula: C8H7NO4, the publication is Bioorganic Chemistry (2020), 103542, database is CAplus and MEDLINE.

JAK3 is predominantly expressed in hematopoietic cells and has been a promising therapeutic target for the treatment of B-cell lymphoma. In this study, a new class of thieno[3,2-d]pyrimidines harboring acrylamide pharmacophore were synthesized as potent covalent JAK3 inhibitors (IC₅₀ < 10 nM). Among them, 9a and 9 g displayed the strongest inhibitory potency against JAK3 kinase activity, with IC₅₀ values of 1.9 nM and 1.8 nM, resp. Furthermore, compared with the reference agents, Spebrutinib and Ibrutinib, 9a not only demonstrated enhanced antiproliferative activity against B lymphoma cells, but also showed very weak proliferative inhibition against normal peripheral blood mononuclear cells (PBMCs) at a concentration of 20¦ÌM. Anal. of the mechanism revealed that 9a could induce the obvious apoptosis in B lymphoma cells and prevent JAK3-STAT3 cascade as well as BTK pathway. Taken together, 9a may be served as a potential new JAK3 inhibitor for the treatment of B-cell lymphoma.

Bioorganic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, COA of Formula: C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ruan, Mengyao published the artcileElectrochemical two-electron oxygen reduction reaction (ORR) induced aerobic oxidation of ¦Á-diazoesters, Synthetic Route of 104-03-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(13), 2168-2171, database is CAplus and MEDLINE.

The recent progress in the oxidation of ¦Á-diazoesters R¹C(=N₂)C(O)OR² (R¹ = Ph, 2-naphthyl, benzo[d][1,3]dioxol-5-yl, etc.; R² = Me, cyclohexyl, (tetrahydrofuran-2-yl)methyl, etc.) to ¦Á-ketoesters R¹C(O)C(O)OR² by in situ generated hydrogen peroxide via a two-electron oxygen reduction approach was described. A diverse collection of valuable ¦Á-ketoester products was obtained with moderate to high yields under an exogenous-oxidant-free and metal catalyst-free electrochem. conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Synthetic Route of 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Yinrong published the artcileCopper-Mediated Decarboxylative Sulfonylation of Arylacetic Acids with Sodium Sulfinates, COA of Formula: C8H7NO4, the publication is Organic Letters (2020), 22(18), 7164-7168, database is CAplus and MEDLINE.

Herein, we present a copper-mediated decarboxylative sulfonylation of arylacetic acids with sodium sulfinates that provides viable access to sulfone compounds This protocol features readily available feedstocks, simple operations, high regioselectivities, and moderate to good yields. The newly obtained products could be converted to other useful compounds Importantly, the products and their derivatives exhibited potent antitumor activities in vitro, which were tested by MTT assay.

Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C13H10N2S, COA of Formula: C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lopez Cisneros, Carmen Lucia published the artcileStudy of a Selected Series of 3- and 4-Arylcoumarins as Antifungal Agents against Dermatophytic Fungi: T. rubrum and T. mentagrophytes, Formula: C8H7NO4, the publication is ChemistrySelect (2021), 6(37), 9981-9989, database is CAplus.

The main etiol. agents in dermatophytosis of human skin and nails are Trichophyton, in particular Trichophyton rubrum (T. rubrum) and Trichophyton mentagrophytes (T. mentagrophytes). A new series of twenty-three 3- and 4-arylcoumarins was synthesized and the antifungal activities against clin. isolates of T. rubrum and T. mentagrophytes were evaluated. Sixteen out of twenty-three mols. exhibited antifungal activity against one or both fungi strains. In some cases, the activity against T. rubrum has been comparable to fluconazole, one of the standards, being 8-methoxy-3-(4¡ä-nitrophenyl)coumarin (16) the best compound within this series (min. inhibitory concentration, MIC=6.25 ¦¬g/mL). The preliminary structure-activity relationship study showed that the antifungal activity depends on the position and nature of the substitution patterns. The cytotoxicity of eleven compounds on D-384 (astrocytoma), A-549 (lung cancer) and RKO (colorectal cancer) cell lines was also performed. With the aim of deeply understand the potential of these mols. as hits to develop new drugs, the theor. absorption, distribution, metabolism and excretion (ADME) properties of the active compounds were calculated

ChemistrySelect published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Formula: C8H7NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia