Category: 10510-54-0

Rand, Matthew D. published the artcilePermeabilization of Drosophila embryos for introduction of small molecules, Product Details of C18H15N3O3, the publication is Insect Biochemistry and Molecular Biology (2010), 40(11), 792-804, database is CAplus and MEDLINE.

Pharmacol. manipulations in the Drosophila embryo have been hindered by the impermeability of the eggshell. The ultimate barrier to delivery of small mol. solutes to the embryo is the waxy layer that lies beneath the external chorion layers and encases the underlying vitelline membrane of the eggshell. Conventional protocols call for heptane or octane to permeabilize the dechorionated eggshell however, these solvents are toxic and can result in low viability. Furthermore, heptane and octane require transition of the embryo between aqueous and organic phase solvents making it challenging to avoid desiccation. Here we describe an embryo permeabilization solvent (EPS) composed of D-limonene and plant-derived surfactants that is water miscible and highly effective in rendering the dechorionated eggshell permeable. EPS permeabilization enables embryo uptake of several different dyes of various mol. mass up to 995 Da. We find that the embryo undergoes an age-dependent decrease in the ability to be permeabilized in the first six to eight hours after egg laying. This apparent developmental change in the vitelline membrane contributes to the heterogeneity in permeabilization seen even among closely staged embryos. However, using fluorescent properties of Rhodamine B dye and various conditions of EPS treatment we demonstrate the ability to obtain optimally permeabilized viable embryos. We also demonstrate the ability to assess teratogenic activity of several compounds applied to embryos in vitro, using both early and late developmental endpoints. Application of the method to transgenic strains carrying GFP-reporter genes results in a robust readout of pharmacol. alteration of embryogenesis. The straightforward and rapid nature of the manipulations needed to prepare batches of permeabilized embryos has the potential of establishing the Drosophila embryo as an alternative model in toxicol. and for small mol. screening in a high-throughput format.

Insect Biochemistry and Molecular Biology published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Product Details of C18H15N3O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Evoy, Erin published the artcileUnified Description of Diffusion Coefficients from Small to Large Molecules in Organic-Water Mixtures, Safety of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Journal of Physical Chemistry A (2020), 124(11), 2301-2308, database is CAplus and MEDLINE.

Diffusion coefficients in mixtures of organic mols. and water are needed for many applications, ranging from the environmental modeling of pollutant transport, air quality, and climate, to improving the stability of foods, biomols., and pharmaceutical agents for longer use and storage. The Stokes-Einstein relation has been successful for predicting diffusion coefficients of large mols. in organic-water mixtures from viscosity, yet it routinely underpredicts, by orders of magnitude, the diffusion coefficients of small mols. in organic-water mixtures Herein, a unified description of diffusion coefficients of large and small mols. in organic-water mixtures, based on the fractional Stokes-Einstein relation, is presented. A fractional Stokes-Einstein relation is able to describe 98% of the observed diffusion coefficients from small to large mols., roughly within the uncertainties of the measurements. The data set used in the anal. includes a wide range of radii of diffusing mols., viscosities, and intermol. interactions. As a case study, we show that the degradation of polycyclic aromatic hydrocarbons (PAHs) by O₃ within organic-water particles in the planetary boundary layer is relatively short (?1 day) when the viscosity of the particle is ?10² Pa s. We also show that the degradation times predicted using the Stokes-Einstein relation and the fractional Stokes-Einstein relation can differ by up to a factor of 10 in this region of the atm.

Journal of Physical Chemistry A published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Safety of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Banik, Soma published the artcileModified aggregation pattern of cresyl violet acetate adsorbed on nano clay mineral layers in Langmuir Blodgett film, Formula: C18H15N3O3, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2018), 570-580, database is CAplus.

Present work investigated the modified aggregation behavior of a cationic oxazine dye, Cresyl violet acetate (CVA) in presence of Laponite nano clay mineral layers in aqueousclay mineral dispersion as well as in ultra thin organo-clay hybrid Langmuir Blodgett (LB) films. The presence of non-fluorescent H-dimeric sites in aqueoussolutionof CVA even at very low concentrationdiminishes its fluorescence intensity and CVA ceases to emit any fluorescence in solid state and in the ultrathin films due to the abundance of H-dimeric sites. Incorporation of clay in aqueoussolutiondrastically modified the absorption spectrum of CVA. Organo-clay hybrid film of CVA, fabricated at higher clay concentration, showed intense J-aggregated band due to the formation of J-aggregated species. UV-vis absorption and fluorescence spectroscopy as well as in-situ Brewster angle microscopic (BAM) studies were employed in this investigation.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Formula: C18H15N3O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Marling, J. B. published the artcileLasing characteristics of seventeen visible-wavelength dyes using a coaxial-flashlamp-pumped laser, Product Details of C18H15N3O3, the publication is Applied Optics (1974), 13(10), 2317-20, database is CAplus and MEDLINE.

The performance and tuning characteristic of organic dye lasers were measured using com. available coaxial flashlamps as the pumping source. Tuning by a diffraction grating permitted continuous coverage of the 4200-7500-? region at up to 0.6% tuned output energy efficiency. Preliminary results with a 600-J Marx-Bank coaxial laser at 4500 ? show 1% efficiency and single-pass unsaturated gain >20 at 4500 ?.

Applied Optics published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Product Details of C18H15N3O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Penney, Dp published the artcileStain and dye stability over a 30-year period: a comparison of certified dye powders by the Biological Stain Commission, Application In Synthesis of 10510-54-0, the publication is Biotechnic & Histochemistry (2009), 84(1), 11-15, database is CAplus and MEDLINE.

The Biol. Stain Commission (BSC) Assay Laboratory has received numerous inquiries during the past several years regarding the long-term stability of stain and dye powders, particularly since packaging requirements call for expiration dates on reagents. We have conducted a study to examine the long-term stability of selected dye powders. We used the standard procedures of the BSC for testing biol. stains for certification to give an indication of the long-term chem. stability as well as staining performance of the dye powders. An earlier study by Emmel and Stotz examined the stability of various dye powders after a five-year storage period. The present study is a follow-up project covering the same dyes after storage for 30 years. The dye samples chosen for the study are the same samples used in the five-year storage period study and give comparative results for all three time periods. The results of this study affirm the generally held speculation that dye powders are stable for many years and thus have a substantial shelf-life.

Biotechnic & Histochemistry published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Application In Synthesis of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Woods, Caleb M. published the artcileAllosteric Activation of Cytochrome P450 3A4 by ¦Á-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis, Application of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Biochemistry (2011), 50(46), 10041-10051, database is CAplus and MEDLINE.

Cytochrome P 450 3A4 (CYP3A4) is the dominant xenobiotic metabolizing CYP. Despite great interest in CYP enzymol., two in vitro aspects of CYP3A4 catalysis are still not well understood, namely, sequential metabolism and allosteric activation. We have therefore investigated such a system in which both phenomena are present. Here we report that the sequential metabolism of Nile Red (NR) is accelerated by the heterotropic allosteric effector ¦Á-naphthoflavone (ANF). ANF increases the rates of formation for NR metabolites M1 and M2 and also perturbs the metabolite ratio in favor of M2. Thus, ANF has as an allosteric effect on a kinetic branch point. Co-incubating deuterium-labeled NR and unlabeled M1, we show that ANF increases k_cat/k_off ?1.8-fold in favor of the k_cat of M2 production Steady-state metabolic experiments are analyzed using a kinetic model in which the enzyme and substrates are not in rapid equilibrium, and this distinction allows for the estimation of rates of catalysis for the formation of both the primary (M1) and secondary (M2) products, as well as the partitioning of enzyme between these states. These results are compared with those of earlier spectroscopic investigations of NR and ANF cooperativity, and a mechanism of ANF heteroactivation is presented that involves effects on substrate off rate and coupling efficiency.

Biochemistry published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C4H6BrFO2, Application of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Stokes, E. D. published the artcileHigh efficiency dye laser tunable from the UV to the IR, Application of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Optics Communications (1972), 5(4), 267-70, database is CAplus.

A dye laser was developed as a source of tunable radiation at 3500-7300 ?. A variety of dyes and dye mixtures were used to cover this range. Output powers ¡Ü30 kW were obtained with line widths <1.8 ?. A Fabry-Perot etalon reduced the output line width of 0.1 ? and the peak output power by a factor of 3. Second harmonic powers in excess of 2 kW were generated from the output of this laser. The efficient 2nd harmonic generation extended the lower wavelength limit to 2442 A. A N laser was used as pumping source.

Optics Communications published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C8H7NO4, Application of 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rabinovitch, Michel published the artcileDestruction of Leishmania mexicana amazonensis amastigotes within macrophages in culture by phenazine methosulfate and other electron carriers, Synthetic Route of 10510-54-0, the publication is Journal of Experimental Medicine (1982), 155(2), 415-31, database is CAplus and MEDLINE.

Exposure of macrophages infected with L. mexicana?amazonensis to phenazine?methosulfate (PMS) [299-11-6] resulted in rapid damage and disappearance of the intracellular amastigotes without obvious ill effects to the host cells. The reduction of the percent infection was related to the concentration of PMS and to the duration of the pulse. Most Leishmania disappeared within 2 h of a 2-h pulse with 10 ¦ÌM of the drug. In contrast, pretreatment of the macrophages with PMS followed by removal of the drug before infection did not result in disappearance of the parasites. The pH of the PMS medium markedly influenced the disappearance of Leishmania: maximum effect was observed at pH 8.0, while the effect was negligible at pH 6.3. The pH effect may be related to pseudobase formation by the PMS cation. Dose-response curves for PMS were similar for resident, elicited, or activated macrophages. Observations by time-lapse cinemicrog. documented the explosion-like fragmentation of the amastigotes within 1-2 h of exposure of infected macrophages to the drug. Parasite-derived granules and vacuoles were seen to scatter within the parasitophorous vacuoles. This early damage to the parasites was confirmed by transmission electron microscopic observations. Infected macrophages incubated with PMS displayed detectable vacuolar fluorescence, indicating that PMS or a metabolite of PMS had access to the vacuoles. A series of other electron carriers, including phenylmethanes, phenazines, oxazines, a xanthene, and a naphthoquinone, given continuously for 18 h, also induced the disappearance of the Leishmania. The most potent was crystal?violet??[548-62-9], active at 70 nM. The presence of apolar substituents enhanced activity and this is probably related to increased permeation of the dyes. Finally, PMS, as well as other electron carriers examined, also reduced the growth of Leishmania promastigotes in culture. The results are compatible with a direct effect of the drugs on the intracellular amastigotes, involving only a permissive participation of the macrophages. The diverse agents may destroy the amastigotes by redox-cycling generation of active O metabolites at or near the parasites. Alternatively, the effect of the drugs could be mediated by toxic free radical reduction species of the drugs or by interference with electron flow or with the intermediary metabolism of Leishmania.

Journal of Experimental Medicine published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Synthetic Route of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, C. Y. published the artcileGiant Raman scattering and luminescence by molecules adsorbed on silver and gold metal island films, SDS of cas: 10510-54-0, the publication is Surface Science (1980), 101(1-3), 363-6, database is CAplus.

In order to elucidate the role played by the submicroscopic surface roughness in the enhancement of Raman scattering (RS) by mols. adsorbed on a Ag electrode, the RS was studied for mols. such as isonicotinic acid and benzoic acid adsorbed on ?50-? island films of Ag and Au. When a Ag island film is used as an overlayer on mols. that are chemisorbed on an oxide substrate, such as glass, a strongly enhanced RS is observed for isonicotinic acid, which is comparable in intensity and also similar in character to that observed for pyridine adsorbed on an electrochem. processed Ag electrode. However, no RS is observed when the Ag island film is used as the overlayer on PhCO₂H. When a Ag island film is used as a substrate for the adsorption of the mols. from solution (via chemisorption of the carboxylate group to the oxide or sulfide layer that forms when the Ag island film is exposed to air) a strong RS is observed for PhCO₂H acid as well as for isonicotinic acid. Chemisorption may play an important role in the enhancement process.

Surface Science published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, SDS of cas: 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ballesteros-Gomez, Ana published the artcileMultifunctional vesicular coacervates as engineered supramolecular solvents for wastewater treatment, Computed Properties of 10510-54-0, the publication is Chemosphere (2019), 569-576, database is CAplus and MEDLINE.

In this study, multifunctional supramol. solvents (SUPRASs) able to simultaneously extract ionic, polar and hydrophobic organic compounds from wastewater have been developed. SUPRASs were synthesized in aqueous solutions containing mixtures of carboxylic acids and carboxylates that underwent spontaneous self-assembly and coacervation under the addition of tetraalkylammonium ions. These SUPRAS consisted of coacervate droplets made up of large unilamellar vesicular aggregates bridged by tetraalkylammonium ions. Both, the high kinetic stability of vesicles and their strong interaction with tetraalkylammonium ions through different bonds working cooperatively, made supramol. nanostructures in the SUPRAS chem. stable, which minimized the presence of solvent residues in the treated water. The suitability of the synthesized SUPRASs to behave as multifunctional extractants in water treatment was investigated by their application to the removal of anionic, cationic and ionizable dyes and PAHs. All the variables affecting the extraction process were optimized (i.e. chain length of the tetraalkylammonium ion, fractional SUPRAS phase volume, pH, ionic strength, pollutant concentration and stirring time/rate). All the pollutants selected were efficiently removed at room temperature and a fractional SUPRAS phase volume of 0.01. Applicability of the SUPRAS-based treatment to the efficient removal of dyes in textile effluents and benzo(a)pyrene in tap water was proved.

Chemosphere published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Computed Properties of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia