Category: 119-80-2

Santos, Joao Cesar N. published the artcileThimerosal changes protein conformation and increase the rate of fibrillation in physiological conditions: Spectroscopic studies using bovine serum albumin (BSA), SDS of cas: 119-80-2, the publication is International Journal of Biological Macromolecules (2018), 1032-1040, database is CAplus and MEDLINE.

The interaction between bovine serum albumin (BSA) and thimerosal (TM), an organomercury compound widely employed as a preservative in vaccines, was investigated simulating physiol. conditions and using different spectroscopic techniques. The results, employing mol. fluorescence showed the interaction occurs by static quenching through electrostatic forces (¦ÄH < 0 and ¦ÄS > 0), spontaneously (¦ÄG = -4.40 kJ mol^-1) and with a binding constant of 3.24 ¡Á 10³ M^-1. Three-dimensional fluorescence studies indicated that TM causes structural changes in the polypeptide chain of the BSA, confirmed by CD that showed an increase in a-helix (from 43.9 to 47.8%) content after interaction process. Through synchronized fluorescence and employing bilirubin as a protein site marker, it was confirmed the preferential interaction of TM in the subdomain IB of BSA. The interaction mechanism proposed in this work is based on the reaction of TM with BSA through of free Cys34 residue, forming the adduct BSA-HgEt with the thiosalicylic acid release, which possibly interacts electrostatically with pos. side chain amino acids of the modified protein. Finally, it was proven that both TM and EtHgCl accelerate the protein fibrillation kinetics in 42 and 122%, resp., indicating the toxicity of these compounds in biol. systems.

International Journal of Biological Macromolecules published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, SDS of cas: 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Yong published the artcileThree piperazine compounds as corrosion inhibitors for copper in 0.5 M sulfuric acid medium, SDS of cas: 119-80-2, the publication is Journal of the Taiwan Institute of Chemical Engineers (2021), 231-243, database is CAplus.

Searching for and developing green corrosion-resisting drugs plays an significant role in protecting Cu during its pickling treatment. The toxicities and inhibitive performances are closely correlated with their mol. formulas. Therefore, Amoxapine, Loxapine and Clozapine, all of which belong to piperazines, were assessed as inhibitive agents to protect Cu from corrosion in 0.5 M H2SO4 via electrochem. measurements, surface morphologies and theor. calculations According to the electrochem. results, the anti-corrosion efficiencies of AP, LP and CP reached their maximum at 5 mM, namely 94.0, 95.2 and 96.6, resp. They were all proved to be cathodic-type corrosion inhibitors. The morphol. anal. implied the shaping of protective films on Cu surfaces. Moreover, the absorption of AP, LP and CP on Cu surfaces deferred to the Langmuir isotherm model, confirming the anal. of Fourier transform IR spectroscopy (FT-IR) and XPS. Theor. calculations revealed their adsorption models and anti-corrosive mechanisms. Both experiment and calculation manifested favorable corrosion-proof properties of the three researched drugs. Further anal. also proved the enhanced inhibitive effect of Me that connected with benzene ring owing to its conjugative effect. Furthermore, N atom possessed higher electronegativity and accordingly stronger electron-donating ability compared to O atom. The corrosion-resisting efficiency of Clozapine was 96.6%, being higher than that of Loxapine which was 95.2%.

Journal of the Taiwan Institute of Chemical Engineers published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, SDS of cas: 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Menon, Swetha S. published the artcileCopper- Based Metal-Organic Frameworks as Peroxidase Mimics Leading to Sensitive H₂O₂ and Glucose Detection, Application of 2,2′-Dithiodibenzoic acid, the publication is ChemistrySelect (2018), 3(28), 8319-8324, database is CAplus.

A copper based metal organic framework (MOF) synthesized under solvo-thermal conditions was found to exhibit intrinsic peroxidase-like activity and was established both spectrophotometrically and electrochem. It was found that the catalytic behavior had been consistent with Michaelis-Menten kinetics with a Km value of 0.08 mM with H₂O₂, relatively lower than that of Horseradish peroxidase enzyme (HRP) ie; 3.7 mM. The suitability of Cu-MOF for sensing H₂O₂ was investigated by electrochem. means. In the case of electrochem. studies, the Cu-MOF modified GCE (glassy carbon electrode) showed a very high sensitivity of 263¦ÌA mmol^-1 cm^-2 with a detection limit up to 35 mM for H₂O₂. The peroxidase mimics can be combined with the enzymic oxidation of glucose for sensing glucose. The detection of H₂O₂ and glucose using Cu-MOF was found to be highly selective towards the common interfering species.

ChemistrySelect published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Application of 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Calisir, Umit published the artcileSynthesis, characterizations of aryl-substituted dithiodibenzothioate derivatives, and investigating their anti-Alzheimer¡äs properties, Application of 2,2′-Dithiodibenzoic acid, the publication is Journal of Biomolecular Structure and Dynamics, database is CAplus and MEDLINE.

The main objective of the present study was to synthesize potential inhibitor/activators of AChE and hCA I-II enzymes, which was thought to be directly related to Alzheimer¡äs disease. Dithiodibenzothioate compounds were synthesized by thioesterification. HOMO-LUMO calculations and electronic properties of all synthesized compounds were comprehensively illuminated with a semi-empirical MO (SEMO) package for organic and inorganic systems using Austin Model 1 (AM1)-Hamiltonian as implemented in the VAMP module of Materials Studio. In addition, the inhibition effects of these compounds for AChE and hCA I-II in vitro conditions were investigated. It was revealed that compounds I [R = 2-Me, 3-Me, 4-Me, 2-MeO, 3-MeO, 4-MeO] inhibited the AChE under in vitro conditions. Compound I [R = 2-Me] activated the enzyme hCA I while compounds I [R = 3-Me, 4-Me, 2-MeO] inhibited it. Compounds I [R = 3-MeO, 4-MeO], on the other hand, did not exhibit a regular inhibition profile. Similarly, compound I [R = 2-Me] activated the hCA II enzyme whereas compounds I [R = 3-Me, 4-Me, 2-MeO, 3-MeO] inhibited it. CompoundI [R = 4-MeO] did not have a consistent inhibition profile for hCA II. Docking studies were performed with the compounds against AChE and hCA I-II receptors using induced-fit docking method. Mol. Dynamics (MD) simulations for best effective three protein-ligand couple were conducted to explore the binding affinity of the considered compounds in semi-real in-silico conditions. Along with the MD results, compound I [R = 2-Me]-based protein complexes were found more stable than compound I [R = 3-MeO].

Journal of Biomolecular Structure and Dynamics published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Application of 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wen, Wuqiang published the artcileStructure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis, Category: catalysis-chemistry, the publication is Journal of Medicinal Chemistry (2022), 65(3), 2656-2674, database is CAplus and MEDLINE.

Fructose-1,6-bisphosphate aldolase (FBA) represents an attractive new antifungal target. Here, we employed a structure-based optimization strategy to discover a novel covalent binding site (C292 site) and the first-in-class covalent allosteric inhibitors of FBA from Candida albicans (CaFBA). Site-directed mutagenesis, liquid chromatog.-mass spectrometry, and the crystallog. structures of APO-CaFBA, CaFBA-G3P, and C157S-I revealed that S268 is an essential pharmacophore for the catalytic activity of CaFBA, and L288 is an allosteric regulation switch for CaFBA. Furthermore, most of the CaFBA covalent inhibitors exhibited good inhibitory activity against azole-resistant C. albicans, and compound II can inhibit the growth of azole-resistant strains 103 with the MIC₈₀ of 1¦Ìg/mL. Collectively, this work identifies a new covalent allosteric site of CaFBA and discovers the first generation of covalent inhibitors for fungal FBA with potent inhibitory activity against resistant fungi, establishing a structural foundation and providing a promising strategy for the design of potent antifungal drugs.

Journal of Medicinal Chemistry published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C20H28B2O4S2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Krishnamurti, Vinayak published the artcileAqueous Base Promoted O-Difluoromethylation of Carboxylic Acids with TMSCF₂Br: Bench-Top Access to Difluoromethyl Esters, Quality Control of 119-80-2, the publication is Organic Letters (2019), 21(23), 9377-9380, database is CAplus and MEDLINE.

A method for the O-difluoromethylation of carboxylic acids using com. available TMSCF₂Br is disclosed. The devised bench-top reaction system is air-stable and offers mild reaction conditions while using readily available reagents and solvents. The method is applicable to both aliphatic and aromatic carboxylic acids while demonstrating compatibility with a range of commonly encountered functional groups. The difluoromethyl esters of FDA approved drugs and pharmaceutically relevant mols. are also presented, demonstrating the potential for late-stage functionalization.

Organic Letters published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Quality Control of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia