Category: 1798-04-5

Naik, Ravi published the artcileMethyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism, COA of Formula: C12H16O3, the publication is Journal of Medicinal Chemistry (2017), 60(20), 8631-8646, database is CAplus and MEDLINE.

Previously, the authors reported a hypoxia-inducible factor (HIF)-1 inhibitor LW6 containing an (aryloxyacetylamino)benzoic acid moiety inhibits malate dehydrogenase 2 (MDH2) using a chem. biol. approach. Structure-activity relationship studies on a series of (aryloxyacetylamino)benzoic acids identified selective MDH1, MDH2, and dual inhibitors, which were used to study the relationship between MDH enzyme activity and HIF-1 inhibition. The authors hypothesized that dual inhibition of MDH1 and MDH2 might be a powerful approach to target cancer metabolism and selected methyl-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)-benzoate (16c)as the most potent dual inhibitor. Kinetic studies revealed that compound 16c competitively inhibited MDH1 and MDH2. Compound 16c inhibited mitochondrial respiration and hypoxia-induced HIF-1α accumulation. In xenograft assays using HCT116 cells, compound 16c demonstrated significant in vivo antitumor efficacy. This finding provides concrete evidence that inhibition of both MDH1 and MDH2 may provide a valuable platform for developing novel therapeutics that target cancer metabolism and tumor growth.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sekar, K. G. published the artcileKinetics of oxidation of phenoxyacetic acids by nicotinium dichromate, Synthetic Route of 1798-04-5, the publication is Oxidation Communications (2011), 34(2), 314-319, database is CAplus.

The kinetics of oxidation of phenoxyacetic acid and several para- and meta-substituted phenoxyacetic acids by nicotinium dichromate (NDC) in the presence of perchloric acid was studied in 60% (volume/volume) aqueous acetic acid. The reaction shows unit order dependence each with respect to oxidant and substrate. The order with respect to hydrogen ion concentration is two. The rate of oxidation increases with increase in the percentage of acetic acid and increase in ionic strength has negligible effect on the rate. The reaction does not induce the polymerization of acrylonitrile. The addition of Mn²⁺ ion had a noticeable catalytic effect on the reaction rate. In general, electron-releasing substituents accelerate the rate while electron attracting substituents retard the rate and the rate data obey the Hammett relation.

Oxidation Communications published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C15H21BO2, Synthetic Route of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia