Category: 1798-04-5

He, Xingrui published the artcileFinding new elicitors that induce resistance in rice to the white-backed planthopper Sogatella furcifera, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(23), 5601-5603, database is CAplus and MEDLINE.

Herein we report a new way to identify chem. elicitors that induce resistance in rice to herbivores. Using this method, by quantifying the induction of chems. for GUS activity in a specific screening system that we established previously, 5 candidate elicitors were selected from the 29 designed and synthesized phenoxyalkanoic acid derivatives Bioassays confirmed that these candidate elicitors could induce plant defense and then repel feeding of white-backed planthopper Sogatella furcifera.

Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Le Vaillant, Franck published the artcileRoom temperature decarboxylative cyanation of carboxylic acids using photoredox catalysis and cyanobenziodoxolones: a divergent mechanism compared to alkynylation, Synthetic Route of 1798-04-5, the publication is Chemical Science (2017), 8(3), 1790-1800, database is CAplus and MEDLINE.

The one-step conversion of aliphatic carboxylic acids to the corresponding nitriles was accomplished via the merger of visible light mediated photoredox and s (CBX) reagents. The reaction proceeded in high yields with natural and non-natural ¦Á-amino and ¦Á-oxy acids, affording a broad scope of nitriles with excellent tolerance of the substituents in the ¦Á position. The direct cyanation of dipeptides and drug precursors was also achieved. The mechanism of the decarboxylative cyanation was investigated both computationally and exptl. and compared with the previously developed alkynylation reaction. Alkynylation was found to favor direct radical addition, whereas further oxidation by CBX to a carbocation and cyanide addition appeared more favorable for cyanation. A concerted mechanism was proposed for the reaction of radicals with EBX reagents, in contrast to the usually assumed addition elimination process.

Chemical Science published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Synthetic Route of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Satchell, D. P. N. published the artcileQuantitative aspects of Lewis acidity. I. A spectroscopic study of the equilibrium in solution between stannic halides and aromatic amines, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of the Chemical Society (1964), 4134-42, database is CAplus.

Stannic chloride, bromide, and iodide, and substituted anilines (B) interact reversibly, in dilute solution in o-dichlorobenzene, to form 1B:1SnHal₄ adducts. From concentrated solutions, solids are precipitated These are normally brightly colored, and for the primary anilines studied have a 2B:1SnHal₄ stoichiometry. For secondary and tertiary anilines the stoichiometry found was 1:1. Steric factors probably prevent octahedral structures involving 2 bulkily substituted N atoms. Equilibrium constants were measured for the interactions in solution and, in all, 23 bases were studied, mostly with stannic chloride. The general order of increasing basicity toward a given stannic halide is very similar to that exhibited toward Broensted acids, though relative basicities are by no means exactly the same. The order of acid strength is SnCl₄ > SnBr₄ > SnI₄ and toward a given base the resp. equilibrium constants are roughly in the ratios 20,000:20:1. From a spectroscopic and structural viewpoint, the adducts fall into 2 types: “anilinium” type species involving spectral behavior similar to that attendant on anilinium-ion formation, and charge-transfer species which exhibit new, long-wavelength absorption. The former adducts result from strong acid-strong base pairs, while progressive weakening of either partner favors charge-transfer interaction. Solvent effects on the charge-transfer absorption and the related equilibrium constants were studied. A number of new pK_a values for aqueous solution are also reported.

Journal of the Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Zheng published the artcileDesign, synthesis and structure-activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes, Category: catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry (2015), 23(20), 6666-6672, database is CAplus and MEDLINE.

The free fatty acid receptor 1 (FFA1) has attracted extensive attention as a novel antidiabetic target in the last decade. Several FFA1 agonists reported in the literature have been suffered from relatively high mol. weight and lipophilicity. We have previously reported the FFA1 agonist 1. Based on the common amide structural characteristic of SAR1 and NIH screened compound, we here describe the continued structure-activity exploration to decrease the mol. weight and lipophilicity of the compound 1 series by converting various amide linkers. All of these efforts lead to the discovery of the preferable lead compound 18, a compound with considerable agonistic activity, high LE and LLE values, lower lipophilicity than previously reported agonists, and appreciable efficacy on glucose tolerance in both normal and type 2 diabetic mice.

Bioorganic & Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jing, Xiaobi published the artcileSynthesis and characterization of 2-phenyl-6-hydrazinyl-3-pyridazinone derivatives, Application In Synthesis of 1798-04-5, the publication is Youji Huaxue (2010), 30(6), 904-907, database is CAplus.

A method for the preparation of 2-phenyl-6-hydrazine-3-pyridazinone derivatives was designed and the synthesis of the target compounds was achieved involving a rearrangement reaction of acetyl hydrazine derivatives in the presence of sodium hydroxide in ethanol and formation of hydrazone compounds and the product structures (i.e., pyridazine hydrazine derivatives) were confirmed by IR, ¹H-NMR, ¹³C-NMR. The rearrangment reaction of 2-[(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl)oxy]acetic acid hydrazide thus gave 6-hydrazinyl-2-phenyl-3(2H)-pyridazinone.

Youji Huaxue published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Application In Synthesis of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

de Kruijff, Goswinus H. M. published the artcileElectrochemical Synthesis of Aryl Methoxymethyl Ethers, Application In Synthesis of 1798-04-5, the publication is ChemElectroChem (2019), 6(16), 4180-4183, database is CAplus.

Methoxymethyl protected phenols/thiophenols ArXCH₂OCH₃ [X = O, S; Ar = Ph, 4-ClC₆H₄, 2,6-di-ClC₆H₃, etc.] were synthesized by safe, reagent- and reagent waste-free anodic decarboxylation protocol. High current efficiencies and good functional group tolerance made this methodol. a useful tool for the preparation of these valuable and protected phenol building blocks.

ChemElectroChem published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Application In Synthesis of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chu, Wenyi published the artcileSynthesis and herbicidal activity of N-(4,6-dimethoxy-2-pyrimidinyl)-2-(aryloxy)acetamide, HPLC of Formula: 1798-04-5, the publication is Huaxue Shijie (2005), 46(12), 741-744, database is CAplus.

Seven (phenoxy)acetamide derivatives were prepared on the basis of (oxy)acetamide herbicides. They were synthesized by the reaction of 2-amino-4,6-dimethoxypyrimidine with (aryloxy)acetic acids prepared from phenol derivatives Their chem. structures and purity were confirmed by IR, ¹H NMR spectra, elemental anal., and HPLC. The result of the biol. tests showed that two of them had strong herbicidal activity. The compounds thus prepared were evaluated against Setaria viridis (green bristlegrass), Digitaria sanguinalis (large crabgrass), Echinochloa crus-galli (barnyard grass), Zinnia elegans, Abutilon theophrasti (Indian mallow).

Huaxue Shijie published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Randall, William C. published the artcileQuantitative structure-activity relationships involving the inhibition of glycolic acid oxidase by derivatives of glycolic and glyoxylic acids, Related Products of catalysis-chemistry, the publication is Journal of Medicinal Chemistry (1979), 22(6), 608-13, database is CAplus and MEDLINE.

Seventy substituted glycolic, oxyacetic, and glyoxylic acids [RCH(OH)CO₂H, RCOCO₂H, and ROCH₂CO₂H where R = alkyl, substituted alkyl, Ph, aryl, or substituted aryl] including 6 new glycolic and glyoxylic acids were investigated as inhibitors of glycolate oxidase [9028-71-1], an enzyme involved in the metabolic production of oxalate. Such inhibitors are important in the treatment of genetic hyperoxalurias, diseases in which the overproduction of oxalate leads to systemic deposits of CaC₂O₄. Regression anal. and quant. structure-activity relations were used. The best overall correlation with inhibition was with the Hansch parameter ¦Ð.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bowman, Robert S. published the artcileSteric and resonance effects in the tert-butyl and isobutylphenols, Computed Properties of 1798-04-5, the publication is Journal of the American Chemical Society (1957), 87-92, database is CAplus.

C₆H₆ treated with Me₂C:CH₂ (I) in the presence of H₂O.BF₃ gave Me₃CPh (II), b₇₄₁ 168.8¡ã, n_D²⁰ 1.4880. PhOH treated with I at 70¡ã in the presence of 5% by weight H₂SO₄ yielded p-Me₃CC₆H₄OH (III), b₂₀ 130.0¡ã, m. 100¡ã; p-Me₃CC₆H₄OCH₂CO₂H, m. 96.5¡ã. PhOH treated with I at 40-5¡ã in the presence of 0.1% H₂SO₄ gave mainly o-Me₃CC₆H₄OH (IV), b₂₀ 113.0¡ã. PhOH in Et₂O treated at 10¡ã in the presence of dilute H₂SO₄ with I gave mainly Me₃COPh (V), b₂₀ 80.0¡ã, n_D²⁰ 1.4869. p-O₂NC₆H₄CMe₃ hydrogenated under ambient conditions over Pd-C yielded 90% p-Me₃CC₆H₄NH₂, iso-PrBz treated at 0¡ã with fuming HNO₃ in AcOH gave 60-70% m-O₂NC₆H₄COCHMe₂ (VI), m. 37¡ã, which oxidized gave p-O₂NC₆H₄CO₂H, m. 141¡ã. VI in glacial AcOH hydrogenated under ambient conditions over Pd-C (from 8 g. 10% PdCl₂ and 20 g. Norit A), the mixture basified with NaOH and extracted with C₆H₆, and the resulting amino compound diazotized and hydrolyzed in HCl gave 19% m-Me₂CHCOC₆H₄OH (semi-carbazone, m. 188¡ã with darkening), which reduced by the method of Huang-Minlon (C.A. 41, 1649a) gave m-Me₂CHCH₂C₆H₄OH (VII), b₂₀ 129.5¡ã; m-Me₂CHCH₂C₆H₄OCH₂CO₂H, m. 90.5¡ã. By conventional methods were prepared the following compounds: m-Me₃C₆H₄OH (VIII), b₂₀ 129.5¡ã, m. 43.0 (m-Me₃CC₆H₄OCH₂CO₂H, m. 116.5¡ã); o-iso-BuC₆H₄OH (IX), b₂₀ 116.5¡ã [o-iso-BuC₆H₄OCH₂CO₂H (X), m. 96.5¡ã]; p-isomer (XI) of IX, b₂₀ 131.0¡ã, m. 48.0¡ã (p-isomer of X, m. 109.5¡ã); iso-BuOPh (XII), b₂₀ 93.0¡ã, n_D²⁰ 1.4929; iso-BuPh (XIII), b₂₀ 67.5¡ã, n_D²⁰ 1.4854. The various Bu compounds were thermally decomposed at initial pressures of 150-400 mm. at 420.0 ¡À0.1¡ã in a specially designed, completely Pyrex glass system and the pressure changes measured. On the basis of the thermal decomposition the compounds can be arranged in the following order of decreasing stability: VIII > II> III > XIII > VII> XI > IV > IX > XII > V. The 1st order rate of the thermal decomposition of IV was determined at 4 temperatures (temperature and k ¡Á 10⁴ given): 383.0¡ã, 11.72 ¡À 0.44; 392.6¡ã, 21.12 ¡À 0.60; 403.2¡ã, 44.39 ¡À 0.59; 413.3¡ã 89.75 ¡À 0.85; activation energy 58.4 kcal./mole. The content of the gaseous hydrocarbons formed in the thermal decomposition of the Bu compounds was determined (compound pyrolyzed, mole-% CH₄, C₃H₈, C₃H₆, iso-C₄H₁₀, iso-C₄H₈, and H given): IV, 20, 3, 56, -, 16, 1; IX, 24, 3, 66, -, 2, 2; VIII, 66, 12, 6, 2, 4, 7; VII, 69, 6, 14, -, 2,5; III, 58, 9, 4, 17, 8, 2; XI, 57, 28, 8, -, 2, 2; II, 41, 10, 6, 8,19 (and 3 C₂H₆), 8; V, 1, 1, -, 4, 93, -; XII, 9, 26, 7, 3, 22 (and 24% CO and 7% C₂H₆), -.

Journal of the American Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Palaniappan, An. published the artcileKinetics and mechanism of oxidation of some meta- and para- substituted phenoxyacetic acids by N-chloropiperazine-2,5-dione in non-aqueous medium, SDS of cas: 1798-04-5, the publication is Asian Journal of Chemistry (2002), 14(2), 607-613, database is CAplus.

The kinetics of oxidation of a number of meta- and para- substituted phenoxyacetic acids by N-chloropiperazine-2,5-dione (NCPD) were studied in methanol medium. The reaction shows unit order dependence with respect to oxidant and the order with respect to substrate varies depending on the nature of the substituent present in the ring. The rate is showing an inverse order of dependence with respect to [TsOH]. The rate increases with decrease in the percentage of methanol. Increase in ionic strength has no effect on the reaction rate. From the kinetic data obtained the activation parameters were computed and a suitable mechanism was proposed in accordance with multiparameter correlation anal.

Asian Journal of Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia