Category: 1798-04-5

Yu, Zhiyi published the artcileDesign, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid derivatives, Application In Synthesis of 1798-04-5, the publication is European Journal of Medicinal Chemistry (2009), 44(11), 4726-4733, database is CAplus and MEDLINE.

A series of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (norfloxacin) derivatives I (R = 2-furanyl, 3-pyridinyl, 2-ClC₆H₄OCH₂, etc.) were prepared according to the principle of combining bioactive substructures, and tested for activity against five plant pathogenic bacteria and three fungi in vitro. The preliminary bioassays indicated that almost all the synthesized target compounds retained the antibacterial activities of norfloxacin and had some antifungal activities as seen with carboxamide compounds The activities of compounds I (R = 2-furanyl, Ph) against Xanthomonas oryzae were better than norfloxacin and all tested compounds had better antibacterial activities as compared to the agricultural streptomycin sulfate (a com. bactericide) against X. oryzae, Xanthomonas axonopodis and Erwinia aroideae. Addnl., compounds I [R = (E)-2-(5-methylfuran-2-yl)ethenyl, (E)-4-MeOC₆H₄CH:CH] displayed good antifungal activities against Rhizoctonia solani and their inhibition of growth reached 83% and 94% resp. at the concentration of 200 mg/L.

European Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C10H18O, Application In Synthesis of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nagasaki, Takeshi published the artcileSynthesis and solvent extraction studies of novel calixarene-based uranophiles bearing hydroxamic groups, SDS of cas: 1798-04-5, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1991), 1063-6, database is CAplus.

Calix[n]arene-based uranophiles [I; n = 4 (II), 6 (III)] bearing hydroxamic groups on the lower rim have been synthesized and the extractability (Ex%) and the selectivity towards uranyl ion (UO₂²⁺) estimated in a two-phase (water-chloroform) solvent extraction system. Ex% for II and III increases from pH 2 and saturation is reached at around pH 5 where 100% extractability occurs. Since the pK_a values for hydroxamic acids are 8-9, the apparent pK_a shift caused by the UO₂²⁺-complexation amounts to 6-7 pK units. Extraction of UO₂²⁺ from aqueous carbonate solution established that III in the organic phase can compete efficiently with CO₃^2- ions in the aqueous phase for UO₂²⁺ whereas in II and a calix[6]arene-based uranophile bearing six carboxy groups, UO₂²⁺ is reextracted to the aqueous phase. The difference indicates that III which has the hexacoordination geometry preorganized for the binding of UO₂²⁺, is superior to II as a uranophile. The selectivity of III is superior to the uranophile bearing six carboxy groups. The Ex% values for III are scarcely affected by the addition of competing metal cations (except Fe³⁺). These results shows that III serves as an excellent UO₂²⁺-selective extraction reagent.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nagasaki, Takeshi published the artcileSolvent extraction of transition metal cations by calixarene-based cyclic ligands, Computed Properties of 1798-04-5, the publication is Bulletin of the Chemical Society of Japan (1992), 65(2), 471-5, database is CAplus.

Calix[n]arenes (n =4 and 6) bearing carboxyl group (1_n), hydroxamate groups (2_n), and dimethylamino groups (3_n) on the lower rim and their monomeric analogs (1₁, 2₁, and 3₁) were synthesized to estimate selective extraction of transition metal cations from the aqueous phase to the organic (chloroform) phase. 1₄ And 1₆ showed the selectivity toward Fe³⁺, Cu²⁺, Zn²⁺, and Pd²⁺. In particular, 1₆ showed the unusually high extractability toward Fe³⁺. 2₄ And 2₆ showed the selectivity toward Fe³⁺, Cu²⁺, and Pd²⁺, but only Fe³⁺ was extracted to a significant extent at pH 2.2, the order of the extractability being 2₆ > 2₄ > 2₁. 3₄ And 3₆ showed the selectivity toward Pd²⁺ and Pt⁴⁺. The detailed examination of the extraction mechanism established that the ion-pair extraction mechanism is operative in Pt⁴⁺ (i.e., extracted as [PtCl₆]^2-) whereas both the ion-pair extraction mechanism and the chelate-complex extraction mechanism are operative in Pd²⁺ i.e., extracted as [PdCl₄]^2- in the ion-pair extraction mechanism). The results indicate that the ligand groups circularly arranged on the lower rim of the calixarene cavity form novel binding sites for transition metal cations.

Bulletin of the Chemical Society of Japan published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pieber, Bartholomaeus published the artcileContinuous heterogeneous photocatalysis in serial micro-batch reactors, SDS of cas: 1798-04-5, the publication is Angewandte Chemie, International Edition (2018), 57(31), 9976-9979, database is CAplus and MEDLINE.

Solid reagents, leaching catalysts, and heterogeneous photocatalysts are commonly employed in batch processes but are ill-suited for continuous-flow chem. Heterogeneous catalysts for thermal reactions are typically used in packed-bed reactors, which cannot be penetrated by light and thus are not suitable for photocatalytic reactions involving solids. We demonstrate that serial micro-batch reactors (SMBRs) allow for the continuous utilization of solid materials together with liquids and gases in flow. This technol. was utilized to develop selective and efficient fluorination reactions using a modified graphitic carbon nitride heterogeneous catalyst instead of costly homogeneous metal polypyridyl complexes. The merger of this inexpensive, recyclable catalyst and the SMBR approach enables sustainable and scalable photocatalysis.

Angewandte Chemie, International Edition published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Egetenmeyer, Simone published the artcileA 5′-cap for DNA probes binding RNA target strands, Computed Properties of 1798-04-5, the publication is Chemistry – A European Journal (2011), 17(42), 11813-11827, S11813/1-S11813/37, database is CAplus and MEDLINE.

Detecting short RNA strands with high fidelity at any of the bases of their sequence, including the termini, can be challenging, since fraying, wobbling, and refolding all compete with canonical base pairing. We performed a search for 5′-substituents of oligodeoxynucleotides that increase base pairing fidelity at the terminus of duplexes with RNA target strands. From a total of over 70 caps, differing in stacking moiety and linker, a phosphodiester-linked sequence of the residues of L-prolinol, glycine, and oxolinic acid, dubbed ogOA, was identified as a 5′-cap that stabilizes any of the four canonical base pairs, with ¦¤T_m values of up to +13.1 ¡ãC for an octamer. At the same time, the cap increases discrimination against any of the 12 possible terminal mismatches, including mismatches that are more stable than their perfectly matched counterparts in the control duplex, such as A:A. A probe with the cap also showed increased selectivity in the detection of two closely related microRNAs, let7c and let7a, with a ¦¤T_m value of 9.2 ¡ãC. Melting curves also yielded thermodn. data that shed light on the uniformity of mol. recognition in the sequence space of DNA:DNA and DNA:RNA duplexes. Hybridization probes with fidelity-enhancing caps should find applications in the individual and parallel detection of biol. active RNA species.

Chemistry – A European Journal published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Joseph, Roymon published the artcileLower Rim 1,3-Di{bis(2-picolyl)}amide Derivative of Calix[4]arene (L) as Ratiometric Primary Sensor toward Ag⁺ and the Complex of Ag⁺ as Secondary Sensor toward Cys: Experimental, Computational, and Microscopy Studies and INHIBIT Logic Gate Properties of L, Category: catalysis-chemistry, the publication is Journal of Organic Chemistry (2009), 74(21), 8181-8190, database is CAplus and MEDLINE.

A structurally characterized lower rim 1,3-di{bis(2-picolyl)}amide derivative of calix[4]arene (L) exhibits high selectivity toward Ag⁺ by forming a 1:1 complex, among nine other biol. important metal ions, viz., Na⁺, K⁺, Mg²⁺, Ca²⁺, Mn²⁺, Fe²⁺, Co²⁺, Ni²⁺, and Zn²⁺, as studied by fluorescence, absorption, and ¹H NMR spectroscopy. The 1:1 complex formed between L and Ag⁺ was further proven from ESI mass spectrometry and has an association constant, K_a, of 11117 ¡À 190 M^-1 based on fluorescence data. L acts as a primary ratiometric sensor toward Ag⁺ by switch-on fluorescence and exhibits a lowest detectable concentration of 450 ppb. DFT computational studies carried out in mimicking the formation of a 1:1 complex between L and Ag⁺ resulted in a tetrahedral complex wherein the nitrogens of all four pyridyl moieties present on both arms are being coordinated. Whereas these pyridyls are located farther apart in the crystal structure, appropriate dihedral changes are induced in the arms in the presence of silver ion to form a coordination complex. Even the nanostructural features obtained in TEM clearly differentiates L from its Ag⁺ complex. The in situ prepared silver complex of L detects Cys ratiometrically among the naturally occurring amino acids to a lowest concentration of 514 ppb by releasing L from the complex followed by formation of the cysteine complex of Ag⁺. These were demonstrated from emission, absorption, ¹H NMR, and ESI mass spectra. The INH logic gate also was generated by choosing Ag⁺ and Cys as input and by monitoring the output signal at 445 nm that originates from the excimer emission of L in the presence of Ag⁺. Thus L is a potential primary sensor toward Ag⁺ and is a secondary sensor toward Cys.

Journal of Organic Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Joseph, Roymon published the artcileExperimental and Computational Studies of Selective Recognition of Hg²⁺ by Amide Linked Lower Rim 1,3-Dibenzimidazole Derivative of Calix[4]arene: Species Characterization in Solution and that in the Isolated Complex, Including the Delineation of the Nanostructures, Category: catalysis-chemistry, the publication is Journal of Organic Chemistry (2008), 73(15), 5745-5758, database is CAplus and MEDLINE.

Amide linked lower rim 1,3-dibenzimidazole derivative of calix[4]arene, L has been shown to be sensitive and selective to Hg²⁺ in aqueous acetonitrile solution based on fluorescence spectroscopy, and the stoichiometry of the complexed species has been found to be 1:1. The selectivity of L toward Hg²⁺ has been shown among 11 M²⁺ ions, viz., Mn²⁺, Fe²⁺, Co²⁺, Ni²⁺, Cu²⁺, Zn²⁺, Cd²⁺, Hg²⁺, Pb²⁺, Ca²⁺, and Mg²⁺ studied, including those of the mercury group and none of these ions impede the recognition of Hg²⁺ by L. Role of the solvent on the recognition of Hg²⁺ has been demonstrated. The role of calix[4]arene platform and the benzimidazole moieties in the recognition of Hg²⁺ by L has been delineated upon performing such studies with five different mols. of relevance as reference mol. systems. The binding cores formed by the receptor L and the reference compounds have been established based on the single crystal XRD structures, and the preferential metal ion binding cores have been discussed. The binding of Hg²⁺ with L has been further established based on ¹H and ¹³C NMR, ESI MS, absorption, and fluorescence lifetime measurements. Some of these techniques have been used to establish the stoichiometry of the species formed. The complex species formed between L and Hg²⁺ have been isolated and characterized and found to be 1:1 species even in the isolated complex. Whereas transmission electron microscopy (TEM), at. force microscopy (AFM), and SEM provided the nanostructural behavior of L, the TEM and SEM demonstrated that the mercury complex has different characteristics when compared to L. The TEM, SEM, and powder XRD studies revealed that whereas L is crystalline, that of the mercury complex is not, perhaps a reason for not being able to obtain single crystals of the complex. Binding characteristics of Hg²⁺ toward L have been established based on the DFT computational calculations

Journal of Organic Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Acharya, Amitabha published the artcile1,3-diamido-calix[4]arene conjugates of amino acids: recognition of -COOH side chain present in amino acids, peptides, and proteins by experimental and computational studies, Computed Properties of 1798-04-5, the publication is Journal of Organic Chemistry (2011), 76(1), 127-137, database is CAplus and MEDLINE.

Lower rim 1,3-diamido conjugates of calix[4]arene have been synthesized and characterized, and the structures of some of these have been established by single crystal XRD. The amido-calix conjugates possessing a terminal -COOH moiety have been shown to exhibit recognition toward guest mols. possessing -COOH moiety, viz., Asp, Glu, and reduced and oxidized glutathione (GSH, GSSG), by switch-on fluorescence in aqueous acetonitrile and methanol solutions when compared to the control mols. via forming a 1:1 complex. The complex formed has been shown by mass spectrometry, and the structural features of the complexes were derived on the basis of DFT computations. The association constants observed for the recognition of Asp/Glu by Phe-calix conjugate, viz., 532/676 M^-1, are higher than that reported for the recognition of Val, Leu, Phe, His, and Trp (16-63 M^-1) by a water-soluble calixarene (Arena, G., et al. Tetrahedron Lett. 1999, 40, 1597). For this recognition, there should be a free -COOH moiety from the guest mol. AFM, SEM, and DLS data exhibited spherical particles with a hundred-fold reduction in the size of the complexes when compared to the particles of the precursors. These spherical particles have been computationally modeled to possess hexameric species reminiscent of the hexameric micellar structures shown for a Ag⁺ complex of a calix[6]arene reported in the literature (Houmadi, S., et al. Langmuir 2007, 23, 4849). Both AFM and TEM studies demonstrated the formation of nanospheres in the case of GSH-capped Ag nanoparticles in interaction with the amido-calix conjugate that possesses terminal -COOH moiety. The AFM studies demonstrated in this paper have been very well applied to albumin proteins to differentiate the aggregational behavior and nanostructural features exhibited by the complexes of proteins from those of the uncomplexed ones. To the authors’ knowledge, this is the first report wherein a amido-calix[4]arene conjugate and its amino acid/peptide/protein complexes have been differentiated on the basis of spectroscopy and microscopy studies followed by species modeling by computations.

Journal of Organic Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kelly, Donovan P. published the artcilePhotochemical rearrangement of aromatic ethers, COA of Formula: C12H16O3, the publication is Australian Journal of Chemistry (1969), 22(5), 977-91, database is CAplus.

The irradiation of various types of aromatic ethers with uv light yields o- and p-substituted phenols, resulting from C-O bond fission followed by recombination of the 2 fragments. Also formed in these photolyses was the parent phenol, produced presumably by abstraction of H from the solvent by the aryloxy fragment. The ethers investigated were aryloxyacetic acids, allyl aryl ethers, benzyl phenyl ether, and diphenyl ether. Mixture experiments have shown that for both the aryloxyacetic acids and allyl aryl ethers the rearrangement is intramol. and most probably proceeds by formation of a radical-pair enclosed in a solvent cage.

Australian Journal of Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Webb, Eric W. published the artcileNucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of the American Chemical Society (2020), 142(20), 9493-9500, database is CAplus and MEDLINE.

A redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters e.g., I using an Ir photocatalyst under visible light irradiation was reported. The method provides access to a broad range of aliphatic fluorides, including primary, secondary, and tertiary benzylic fluorides as well as unactivated tertiary fluorides, that are typically inaccessible by nucleophilic fluorination due to competing elimination. In addition, the decarboxylative fluorination conditions are readily adapted to radiofluorination with [18F]KF. The reactions proceed by two electron transfers between the Ir catalyst and redox-active ester substrate to afford a carbocation intermediate that undergoes subsequent trapping by fluoride. Examples of trapping with O- and C-centered nucleophiles and deoxyfluorination via N-hydroxyphthalimidoyl oxalates are also presented, suggesting that this approach may offer a general blueprint for affecting redox-neutral SN1 substitutions under mild conditions.

Journal of the American Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C20H21ClN4O4, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia