Category: 1798-04-5

Zhang, Hanyun published the artcileSynthesis of diamides containing of 2-aryloxyacetyl and meta-trifluoromethylphenyl moieties and their herbicidal activity, Quality Control of 1798-04-5, the publication is Yingyong Huaxue (2016), 33(6), 668-676, database is CAplus.

Based on the combination of different active groups with different herbicidal modes of action, a series of diamide compounds containing 2-(aryloxy)acetyl and meta-trifluoromethylphenyl moieties were designed and synthesized via the four-component Ugi reaction. Their structures were characterized by IR, ¹H NMR, EI-MS, and elemental analyses. The glass house bioassay (in vivo) shows that some of compounds 3 exhibit moderate to good herbicidal activities against B. campestris, A. retroflexus, E. crusgalli, and D. sanguinalis at a dose of 1.5 kg/ha. For example, compound 3r displays 100% inhibition against both of A. retroflexus and D. sanguinalis in the pre-emergence treatment, it also exhibits 100% inhibition against D. sanguinalis in the post-emergence treatment. In addition, the preliminary structure-activity relationships are also discussed.

Yingyong Huaxue published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C15H24S, Quality Control of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Blodgett, Jordan published the artcileThe 4-tert-butylphenyl group as a simple tag for solution phase synthesis, Formula: C12H16O3, the publication is Tetrahedron Letters (2004), 45(35), 6649-6652, database is CAplus.

A solution phase synthesis strategy was investigated using 4-tert-butylphenyl group as the tag and a beta-cyclodextrin column as the affinity chromatog. support for the isolation of compounds containing the tag. It was found that compounds containing the tag have significantly longer retention times on the beta-cyclodextrin column than those compounds that do not have such a tag. The tag is chem. inert and can be introduced onto and removed from target compounds readily. This solution phase synthesis method was applied to the synthesis of some simple amino acid derivatives

Tetrahedron Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Dong published the artcileCopper-Catalyzed Regioselective Olefination and Trifluoromethylation of Carboxylic Acids To Give (Z)-Trifluoromethyl Enol Esters, HPLC of Formula: 1798-04-5, the publication is Organic Letters (2022), 24(28), 5197-5202, database is CAplus and MEDLINE.

A method to produce (Z)-trifluoromethyl enol esters via the olefination and trifluoromethylation of carboxylic acids with TMSCF₃ was reported. This synthetic method used inexpensive and easy-to-handle TMSCF₃. It employed a com. available CuCl catalyst to transform a broad range of carboxylic acids into versatile (Z)-trifluoromethyl enol esters with good regio- and stereoselectivity. This protocol allowed the concise synthesis of highly functionalized (Z)-trifluoromethyl enol esters directly from carboxylic acids.

Organic Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Hao published the artcileSynthesis and herbicidal activity of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives, HPLC of Formula: 1798-04-5, the publication is Youji Huaxue (2015), 35(1), 159-166, database is CAplus.

In order to find new herbicidal leading compounds, a series of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives were designed and synthesized via the strategy of linking active sub-structures which are chlorophthalim and phenoxy carboxylic ester. The target compounds were synthesized from starting material 2-chloro-4-fluoro-5-nitrophenol in four steps, and their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. The preliminary bioassay results indicated that most compounds exhibited excellent herbicidal activities at 1,500 g/ha in both pre- and post-emergence treatments against Abutilon theophrasti and Amaranthus retroflexus. On the basis of advanced screening tests, compound 6d exhibited 100% inhibitory effect against Abutilon theophrasti and Amaranthus retroflexus at 750 g/ha, compounds 7a and 7i were much more effective against Abutilon theophrasti than com. acifluorfen with 80%-86% inhibitory activity at 22.5 g/ha.

Youji Huaxue published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C10H2F12NiO4, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zoh, Dyung Duk published the artcileCooperation of ¦Â-cyclodextrin with macrocyclic metal centers in the action of artificial metalloesterases built on poly(ethylenimine), Computed Properties of 1798-04-5, the publication is Bioorganic Chemistry (1994), 22(3), 242-52, database is CAplus.

¦Â-Cyclodextrin (CD) was attached to poly(ethylenimine) (PEI), and then macrocyclic metal centers were constructed on the polymer by condensation with glyoxal or butanedione in the presence of metal (Zn^II, Ni^II, or Co^II) templates. The resulting polymers were treated with acetic anhydride to block primary or secondary amines. Hydrolysis of 2 nitrophenyl esters containing t-butylphenyl residues in the acyl moieties was catalyzed by the PEI derivatives containing both CD cavities and macrocyclic metal centers. Anal. of the kinetic data indicated that the CD cavities and the metal centers provided binding sites and catalytic sites, resp., for the ester substrates, mimicking metalloesterases. Although the content of the metal center was much smaller for the Zn^II-containing artificial enzyme compared with the Ni^II and Co^II analogs, catalytic efficiency was greater for the Zn^II derivative Kinetic data indicate high reactivity of the metal center in the productive complex formed between the catalyst and the substrate, when the unproductive binding by the CD cavities is considered.

Bioorganic Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C5H10N2OS, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gortner, Willis A. published the artcileRelation of chemical structure to plant growth-regulator activity in the pineapple plant. V. Post-harvest delay of senescence of pineapple fruit, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Botanical Gazette (Chicago) (1969), 130(2), 87-97, database is CAplus.

The effects of 369 compounds, including 94 phenoxyacetic acids, 43 other phenoxy acids, 23 phenylacetic acids, 15 hydrocinnamic acids, 9 benzoic acids, 7 salicylic acids, 48 naphthalene derivatives, 22 indole acids, 5 hydrazine derivatives, and 8 cinnamic acids, for postharvest delay of senescence of pineapple fruit (Ananas comosus) were determined Seventy-six of the compounds were active, and 27 were highly active in delaying senescence. In the phenoxyacetic acid series, high activity was obtained from some halogen-substituted acids but not generally from Me-substituted acids. In the phenoxy-¦Á-propionic acid series, high activity was not observed for a number of halogen- and Me-substituted acids. None of the substituted phenoxy acids other than HOAc and ¦Á- propionic showed even moderate activity. An appreciable number of Cl-substituted phenylacetic acids and several benzoic acids showed activity. None of the phenylalkylcarboxylic acids other than HOAc showed even moderate activity. None of the salicylic acid, phthalic acids, or phthalamic acids showed any activity. All hydrazine derivatives were inactive.

Botanical Gazette (Chicago) published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Faivre-duPaigre, Roger published the artcileMorphological modifications produced in Italian ryegrass by 2,4-dichlorophenoxyacetic acid (2,4-D), 2-methyl-4-chlorophenoxyacetic acid (MCPA), and 2-methyl-4-chlorophenoxybutyric acid (MCPB), Product Details of C12H16O3, the publication is Compt. rend. (1961), 3107-9, database is CAplus.

Application of 1, 2, 5, or 10 kg./hectare of 2,4-D, MCPA, or MCPB to Lolium italicum after tillering produces anomalous growth of stems and heads. Stems show aberrant tillering at the base of the plants and at internodes, and curvature of nodes and internodes. Rachises may be bi- or trifurcated, elongated or shortened, or have spiral or sinuate conformations. Spikelets may vary in point of attachment, may be pedicellate, compound, or sterile. A single plant may show any or all of these modifications.

Compt. rend. published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Product Details of C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, Kyeong published the artcile(Aryloxyacetylamino)benzoic Acid Analogues: A New Class of Hypoxia-Inducible Factor-1 Inhibitors, Formula: C12H16O3, the publication is Journal of Medicinal Chemistry (2007), 50(7), 1675-1684, database is CAplus and MEDLINE.

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1¦Á protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sheiman, B. M. published the artcileSynthesis of alkylphenols from borates by the Friedel-Crafts reaction, Related Products of catalysis-chemistry, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1960), 876-80, database is CAplus.

Two preparations of alkylphenols from sym. boric esters [trialkyl borates and triphenyl borate(I)] in the presence of AlCl₃, and through a preliminary preparation of mixed boric esters were given. The yields reached 70-98% and the alkylphenols obtained did not contain nonphenolic compounds A mixture of 23 g. tributyl borate, 18.8 g. PhOH, and 0.2 g. PhONa was heated to 200-30¡ã (maintaining the temperature of BuOH below 120-30¡ã) to yield 14.8 g. BuOH [i.e., the theoretical amount, assuming the formation of (PhO)₂BOBu (II)], n²⁰_D 1.4000. To a mixture of 1 g. II in 200 ml. pyridine was added, portionwise, with cooling, 52 g. freshly sublimed AlCl₃. The mixture heated 15-20 min. to 80¡ã and 15 min. at 80-5¡ã, poured into a mixture of ice and HCl, and extracted with Et₂O, and the phenols extracted with 10% NaOH and treated as usual gave 80% mixture of o- and p-butylphenol, b_5.5 92-106¡ã, further fractionated to yield 11.6% o-sec-butylphenol, b_6.5 92.5¡ã, n²⁰_D 1.5228, d₂₀ 0.9876, MR_D 46.42 (o-sec-butylphenoxyacetic acid m. 109.5-110¡ã; the toluide m. 69.5-70.5¡ã) and 81.2% p-sec-butylphenol, b_6.5 105.5¡ã, m. 57-7.5¡ã (petr. ether), n²⁰_D 1.5200, d₂₀ 0.9787, MR_D 46.59 (the toluidide of p-sec-butylphenoxyacetic acid m. 90-1¡ã). In an analogous manner, 58 g. I and 18.8 g. triisopropyl borate dissolved in 150 ml. ligroine and 52 g. AlCl₃ yielded a fraction b₁₀ 99-120¡ã, further fractionated to yield o-isopropylphenol, b_2.5 67-7.5¡ã, n²⁰_D 1.5282, d₂₀ 1.0127, MR_D 41.43. Propyl diphenyl borate was obtained by the simultaneous esterification of 18 g. PrOH and 56.4 g. phenol with 18.6 g. boric acid in 80 ml. toluene in a Dean-Stark apparatus; after distillation of PhCH₃ and the unreacted phenol in vacuo (water-jet pump), 150 ml. ligroine and 52 g. AlCl₃ were added, and the mixture treated as above to yield 73% propylphenol isomers, b₁₀ 103-4¡ã, n²⁰_D 1.5253, d₂₀ 0.9972, MR_D 41.88; the phenoxyacetic acid m. 63-5¡ã; phenylurethan m. 77-85¡ã. A mixture of 76.7 g. triisobutyl borate, 193.4 g. I dissolved in 450 ml. ligroine, and 133.5 g. AlCl₃ was heated 2 hrs. at 35-60¡ã and about 1 hr. at 85-90¡ã, and treated as usual to yield 70% p-tert-butylpbenol, b₅ 99-9.5¡ã, m. 98.5-99¡ã (petr. ether); (the phenoxyacetic acid m. 85.5-86¡ã) and 2 high-boiling fractions of polyalkyl phenols b₅ 120-30¡ã (10.3 g.), and b₅ 150-65¡ã (4 g.). I (58 g.) and 30.8 g. tricyclohexyl borate 100 ml. ligroine heated 30 min. at 90¡ã with 40 g. AlCl₃ yielded 42.2% p-cyclohexylphenol b₁₁ 1.50-3¡ã, m. 127.5-8¡ã (benzene); benzoate derivative m. 114-14.5¡ã (alc.). The nonphenolic part yielded 10.8 g. of a fraction, b₆ 101-3¡ã, n²⁰_D 1.5283, d₂₀ 0.9586, and 6.2 g. of a fraction b₆ 178-80¡ã, n²⁰_D 1.5432. 27 references.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C8H5F3O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Singh, Pashupati Prasad published the artcileQuantitative structure activity relationship of inhibitors of glycolic acid oxidase, Application of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Medicinal Chemistry: An Indian Journal (2006), 2(1), 1-15, database is CAplus.

In order to avoid trial and error method in selecting a suitable drug, QSAR methods have provided a rational basis to the design of enzyme inhibitors. 90 Derivatives of enzyme inhibitors, whose inhibitory potencies in term of PI₅₀ are reported, have been used as study material for QSAR study. These derivatives are divided into five groups: (1) substituted glycolic acids, (2) substituted oxyacetic acids, (3) substituted glyoxylic acids, (4) substituted-3-hydroxy-1H pyrrole-2,5-diones derivatives, (5) 4-heterocyclic substituted 3-hydroxy-1H-pyrrole-2,5-diones derivatives The QSAR study and MLR anal. have been collectively made, because the potency is reported in one unit and the target enzyme glycolic acid oxidase (GAO) is common to all. The study has been made with the help of seven descriptors in different combinations: (1) Heat of formation (¦¤H_f), (2) HOMO energy (3) LUMO energy, (4) Absolute hardness (¦Ç) (5) Mol. weight (MW), (6) Electronegativity (¦Ö) (7) Total energy (TE). This is perhaps for the first time when inhibitory potency has been related with quantum mech. parameters, without any significance to structure of compounds The values of descriptors have been obtained with the help of PC MODEL software using the semiempirical PM3 Hamiltonian. 32 Multi linear regression models using different combinations of descriptors have been developed using the project leader program associated with CAChe software. The predicted activity is close to the observed activity and the correlation coefficient is above 0.80. The best QSAR models are obtained by MLR anal. using the combinations, (i) heat of formation, mol. weight and electronegativity, (ii) mol. wight, total energy and electronegativity.

Medicinal Chemistry: An Indian Journal published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C22H21N3O3S, Application of 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia