Category: 1798-04-5

Al-Awadi, Nouria A. published the artcileKinetics and mechanism of thermal gas-phase elimination of 2-aryloxyacetic acid, Synthetic Route of 1798-04-5, the publication is International Journal of Chemical Kinetics (2001), 33(10), 612-616, database is CAplus.

Rates of thermal gas-phase elimination of eleven 2-aryloxyacetic acid have been measured over a 45¡ãC temperature range for each compound Hammett correlation of the present kinetic data with the literature ¦Ò⁰ values of the given substituents gave a reaction ¦Ñ constant of 0.69 at 600 K; this is more than that for the gas-phase elimination parameter of 2-aryloxypropanoic acid (¦Ñ = 0.26) and consistent with a transition state with some charge separation, suggesting a partial formation of carbocation. The implications of this observation for the thermal gas-phase elimination of ¦Á-aryloxycarboxylic acids are considered.

International Journal of Chemical Kinetics published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Synthetic Route of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Csiba, I. published the artcileSolubilization properties of some water-soluble aryl alkyl ether derivatives. I. Preparation and solubilization properties of aryloxyacetic acids, SDS of cas: 1798-04-5, the publication is Cesko-Slovenska Farmacie (1968), 17(1), 28-33, database is CAplus and MEDLINE.

Aryloxyacetic acids of the general formula I were prepared by heating a mixture of the appropriate Na phenolate (II) and ClCH2CO2H on a boiling water bath, and extracting the reaction mixture with Et2O and saturated NaHCO3 solution In cases when II was not soluble, EtOH was added to the reaction mixture I prepared were (R1, R2, R3, R4, R5, % yield, and m.p. given): H, Me, H, H, H, 71.9, 101¡ã; H, H, Me, H, H, 72.3, 125¡ã; Et, H, H, H, H, 51.5, 138-40¡ã; NO2, H, H, H, H, 25, 152¡ã; H, H, NO2, H, H, (Ia), 50.1, 182¡ã; H, H, Cl, H, H, 61.5, 158-9¡ã; H, H, tert-Bu, H, H, (IIb), 54.2, 86¡ã; H, H, tert-C8H17, H, H (IIc), 48.3, 106-8¡ã; Ph, H, H, H, H, 28.8, 98-100¡ã; OMe, H, H, H, H, 68.3, 128¡ã; H, OMe, H, H, H, 54.5, 114-15¡ã; H, H, OMe, H, H, 35, 110-12¡ã; EtCO, H, H, H, H, 22.2, 127-9¡ã; H, H, EtCO, H, H, 61.5, 125-7¡ã; Me, Me, H, H, H, 60, 160; Me, H, Me, H, H, 48.6, 140¡ã; Me, H, H, Me, H, 34.5, 118¡ã; Cl, H, Cl, H, H, 56, 138-9¡ã; Me, H, H, iso-Pr, H, 53.8, 149¡ã; iso-Pr, H, H, Me, H, 62.4, 148¡ã; OMe, H, H, CHO, H, 57.5, 175-7¡ã; H, OMe, H, OMe, H, 32.6, 143-4¡ã; Me, H, Me, H, H, 76, 117¡ã; Cl, H, Cl, H, Cl, 49.3, 153-4¡ã; H, Me, Cl, Me, H, 54, 148-5¡ã. Ia (40 g.) and 394.86 g. FeSO4¡¤7H2O in 310 ml. 25% NH4OH was refluxed, and the mixture acidified with AcOH to give 66% I (R1 = R2 = R4 = R5 = H, R3 = NH2), m. 220-2¡ã. Na, K, or Li salts of I were prepared by treating an alc. solution of the appropriate I with alc. metallic hydroxide or alcoholate. Solubility of caffeine and (or) 8-methylcaffeine in solutions of I alkali salts was determined I with substituents having +I and +M effects had higher dissolution power than unsubstituted PhOCH2CO2H (III). IIb, and IIc, resp. acted as surfactants but their dissolution power was lower than that of III.

Cesko-Slovenska Farmacie published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Park, Seol Rin published the artcile2-Methylacrylamide as a bioisoster of thiourea group for 1,3-dibenzylthioureido TRPV1 receptor antagonists, HPLC of Formula: 1798-04-5, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(11), 2080-2083, database is CAplus and MEDLINE.

In order to replace thiourea group with the more drug-like moiety for 1,3-dibenzylthioureas having TRPV1 antagonist activity, we introduced a set of functional groups between the two aromatic rings based on bioisosteric replacement. The synthesized bioisosteres of 1,3-dibenzylthioureas were tested for their antagonist activities on TRPV1 by ⁴⁵Ca²⁺-influx assay using neonatal rat cultured spinal sensory neurons. Among the tested 14 kinds of bioisosters, 2-methylacrylamide group was the best candidate to replace thiourea group. Compound 7c, 2-methylacrylamide analog of ATC-120, showed as potent as ATC-120 in its antagonist activity. In addition, 2-methylacrylamide analog 7e having vinyl moiety showed the most potent activity with 0.022¦ÌM of IC₅₀ value, indicating that thiourea group of 1,3-dibenzylthioureas could be replaced to 2-methylacrylamide without loss of their potencies.

Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abraham, D. J. published the artcileDesign, synthesis, and testing of potential antisickling agents. 4. Structure-activity relationships of benzyloxy and phenoxy acids, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of Medicinal Chemistry (1984), 27(8), 967-78, database is CAplus and MEDLINE.

The title compounds I (R¹ = O, S, CH₂O, CH₂S, or CH₂OCH₂; R² = H, Br, Cl, F, Me, or MeO; R³ = H, Cl, F, Me, or MeO; R⁴ = H, Br, Cl, Me, NH₂, etc.; R⁵ = H, Cl, F, Me, or MeO; R⁶ = H, Br, Cl, F, or Me; R⁷ and R⁸ = H or Me) and miscellaneous compounds were prepared and evaluated in vitro for antigelling activity. 2-[(p-Bromophenoxy)ethyl]malonic?acid (II) [90296-21-2] was the most active compound A hypothesis about a mechanism to explain their effects on the O equilibrium properties of Hb is given. Structure-activity relations are discussed.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ozcan, Sevil published the artcileOxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of Medicinal Chemistry (2013), 56(10), 3783-3805, database is CAplus and MEDLINE.

Screening of the 50 000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide I (PI-1833) which inhibited chymotrypsin-like (CT-L) activity (IC₅₀ = 0.60 ¦ÌM) with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). LC-MS/MS and dialysis show that I is a noncovalent and rapidly reversible CT-L inhibitor. Focused library synthesis provided II (PI-1840) with CT-L activity (IC₅₀ = 27 nM). Detailed SAR studies indicate that the amide moiety and the two Ph rings are sensitive toward modifications. Hydrophobic residues, such as Pr or Bu in the para position (not ortho or meta) of the A-ring and a m-pyridyl group as B-ring, significantly improve activity. Compound II (IC₅₀ = 0.37 ¦ÌM) is more potent than I (IC₅₀ = 3.5 ¦ÌM) at inhibiting CT-L activity in intact MDA-MB-468 human breast cancer cells and inhibiting their survival. The activity of II warrants further preclin. investigation of this class as noncovalent proteasome inhibitors.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gurumurthy, R. published the artcileRuthenium(III)-catalyzed oxidation of phenoxyacetic acids by aqueous phenyliodoso acetate, Formula: C12H16O3, the publication is Oxidation Communications (1993), 16(3-4), 351-7, database is CAplus.

The kinetics of oxidation of phenoxyacetic acid and its derivatives (19 compounds) by phenyliodoso acetate has been studied in 60% (volume/volume) aqueous acetic acid. The reaction is first order with respect to both phenoxyacetic acid and phenyliodoso acetate and is catalyzed by hydrogen ions. Catalysis by Ru(III) is observed A Hammett ¦Ñ value of -2.62 at 35¡ã indicates an electron-deficient transition state. The oxidation rates of ortho-substituted compounds have been analyzed by applying Taft’s steric energy parameters. A suitable mechanism has been proposed.

Oxidation Communications published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Elango, K. P. published the artcileKinetics and mechanism of oxidation of phenoxyacetic acids by periodate complex of Cu(III), Formula: C12H16O3, the publication is Oxidation Communications (1996), 19(1), 44-9, database is CAplus.

The kinetics of oxidation of phenoxyacetic acid by copper(III)-periodate complex have been studied in aqueous alk. medium. The reaction is first order with respect to phenoxyacetic acid and copper(III). The rate dependence on [NaOH] is unity. The rates of oxidation of a number of para- and meta-substituted phenoxyacetic acids were correlated with Hammett substituent constants On the basis of the kinetic studies, a mechanism has been proposed.

Oxidation Communications published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sen, A. B. published the artcileSearch for organic fungicides: chemical constitution and fungicidal activity, Related Products of catalysis-chemistry, the publication is Journal of the Science of Food and Agriculture (1952), 526-31, database is CAplus.

The results are presented of studies on the fungicidal action of a number of compounds (cf. C.A. 46, 7271e) on Aspergillus niger, employing the agar growth method. Most of the compounds were highly toxic to the fungus. The introduction of an addnl. Br atom imparted fair toxicity to substituted bromoamides, in contrast to the lack of toxicity of the corresponding unhalogenated amides. The dibromoamides did not, however, have exceptionally strong fungicidal activity, having only slightly more activity than the monobromoamides. The esters of cresotinic acid were fairly effective, as expected since esters of p-HOC₆H₄CO₂H are toxic and alkyl substitution increases toxicity. The ethers of cresotinic acid esters were considerably more active than the hydroxy esters. With the higher ether-esters of cresotinic acids, a decrease in fungicidal activity occurred in compounds containing more than 12 C atoms, the hexyl ether of o-cresotinic acid butyl ester having least activity. Generally, with ether-esters of cresotinic acid the o-derivatives were less effective than the m- and p-derivatives; exceptions were noted. Substituted phenoxy fatty acids acted as fungicides at relatively low dilutions, some possessing fairly high toxicity. All of these compounds inhibited growth at a concentration of 1:10,000, maximum inhibition being exerted by p-tert-butylphenoxyacetic acid, while at 1:1,000,000 dilution, all of the compounds stimulated growth; intermediate effects were also observed. Hg derivatives of phenoxy fatty acids, especially Hg derivatives of aryloxyacetic acids, were extremely toxic to the fungus. The toxicity of most of the compounds fell rapidly as the concentration was lowered.

Journal of the Science of Food and Agriculture published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C19H14O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sen, A. B. published the artcileOrganic fungicides. IV. Preparation of some aryloxy-fatty acids and their mercury derivatives, COA of Formula: C12H16O3, the publication is Journal of the Indian Chemical Society (1951), 469-70, database is CAplus.

The aryloxy aliphatic acids were prepared by heating the appropriate phenol (1 mol.), the halogenated fatty acid (1 mol.) and NaOH (2 mols.) at 100¡ã for 3-6 h., and either crystallized from 10% MeOH or petr. ether or distilled in vacuo. The following acids are reported: 4-EtC₆H₄OCH₂CO₂h (I) m. 91¡ã; 3-EtC₆H₄OCH₂CO₂H (II), m. 73¡ã; 4-Me₃CC₆H₄OCH₂CO₂H (III), m. 80¡ã; 4-Me₂(Et)CC₆H₄OCH₂CO₂H (IV), m. 50¡ã; 4-EtC₆H₄OCH₂CH₂CO₂H (V), m. 50¡ã; 3-EtC₆H₄OCH₂CH₂CO₂H (VI), m. 51¡ã, b₁₂ 188¡ã; 4-Me₃CC₆H₄OCH₂CH₂CO₂H (VII), m. 51-2¡ã; 4-Me₂(Et)CC₆H₄OCH₂CH₂CO₂H (VIII), b₃ 210¡ã; 4-Me₃CC₆H₄O(CH₂)₃CO₂H (IX), 84, b₂₀ 210¡ã; 4-Me₂(Et)CC₆H₄O(CH₂)₃CO₂H (X), m. 54¡ã, b₁₈ 198¡ã. Equimol. amounts Hg(OAc)₂ in H₂O and the aryloxy aliphatic acids in dilute AcOH, or HgO in 50% AcOH and the aryloxy aliphatic acid in 50% alc. were heated 1-6 h. on a steam bath until a sandy powder separated ((RCO₂)₂Hg compound corresponding to the above acids and m.p.): I, 224¡ã (with decomposition); II, 198¡ã (with decomposition); III, 192¡ã; IV, 160¡ã; V, 227¡ã; VI, 234¡ã (with decomposition); VII, 248¡ã (with decomposition); VIII, 228¡ã; IX, 238¡ã (with decomposition); and X, 240¡ã (with decomposition).

Journal of the Indian Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C3H8N2S, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hargreaves, John S. published the artcileThe degradation of dG phosphoramidites in solution, Category: catalysis-chemistry, the publication is Nucleosides, Nucleotides & Nucleic Acids (2015), 34(10), 691-707, database is CAplus and MEDLINE.

The reaction of 2′-deoxynucleoside phosphoramidites with water is an important degradation reaction that limits the lifetimes of reagents used for chem. deoxyoligonucleotide synthesis. The hydrolysis of nucleoside phosphoramidites in solution has therefore been investigated. The degree of degradation depends not only on the presence of water but also on the specific nucleoside, 2′-deoxyguanosine (dG) being especially susceptible. Addnl., the nature of the group protecting the exocyclic amine on the nucleoside base strongly influences the rate of hydrolysis. For dG, the degradation is 2nd-order in phosphoramidite concentration, indicating autocatalysis of the hydrolysis reaction. Comparison of the degradation rates of dG phosphoramidites with different protecting groups as well as with phosphoramidites containing bases that are structurally similar to dG afforded clues to the nature of how dG catalyzes its own destruction and indicated a direct correlation between ease of protecting group removal and the propensity to undergo autocatalytic degradation

Nucleosides, Nucleotides & Nucleic Acids published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia