Category: 1798-04-5

Claes, Pieter published the artcilePalladium(II)-Catalyzed Synthesis of 2H,3’H-Spiro[benzofuran-3,2′-naphthoquinones], Quality Control of 1798-04-5, the publication is Journal of Organic Chemistry (2013), 78(17), 8330-8339, database is CAplus and MEDLINE.

2H,3’H-Spiro[benzofuran-3,2′-naphthoquinones], constituting a new spiroheterocyclic skeleton, were synthesized starting from 2-aryloxymethyl-1,4-naphthoquinones by means of a palladium(II)-catalyzed reaction, which is a new spirocyclic transformation. Under optimal conditions, i.e. 10 mol % of palladium(II) acetate, 15 mol % of 3,5-dichloropyridine, and 5 mol % of trifluoroacetic acid in acetic acid at 110 ¡ãC, various 2H,3’H-spiro[benzofuran-3,2′-naphthoquinones] were synthesized in yields strongly dependent on the substitution pattern of the aryloxy group. Unsubstituted or ortho-substituted 2-aryloxymethyl-1,4-quinones were found to rearrange toward the corresponding 2-(4-hydroxyaryl)-1,4-quinones upon treatment with trifluoroacetic acid.

Journal of Organic Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Quality Control of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fujita, Toshio published the artcileA new substituent constant, ¦Ð, derived from partition coefficients, HPLC of Formula: 1798-04-5, the publication is Journal of the American Chemical Society (1964), 86(23), 5175-80, database is CAplus.

The partition coefficients between 1-octanol and water were determined for 203 mono- and disubstituted benzenes. From these values a substituent constant, ¦Ð, was calculated for 67 functional groups. The constant ¦Ð is defined as: ¦Ð = log Px – log P_H, where Px is the partition coefficient of a derivative and P_H is that of the parent compound ¦Ð was derived for many of the functions from 8 different systems: benzene, PhNO₂, PhNH₂, PhOH, benzyl alc., BzOH, phenylacetic acid, and phenoxyacetic acid. Although ¦Ð varies continuously for a given function depending on its electronic environment, the range over which it varies is not great. In certain of the systems, ¦Ð values are related by a simple linear expression.

Journal of the American Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, HPLC of Formula: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Palotash, L. published the artcileProduction and properties of several aryloxycarboxylic acids, Application of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Nauch.-Tekh. Konf., Moskov. Neftekhim. i Gaz. Prom. Inst., 11-ya[Odinnadtsataya]i 12-ya[Dvenadtsataya] (1958), 205-14, database is CAplus.

In the search for dicarboxylic acids (like terephthalic acid) to use in the production of synthetic fibers, o-C₆H₄(CO₂H)OCH₂CO₂H was prepared Salicylic acid (10 g.) was treated with 35 g. 33.3% NaOH. After addition of 25 g. ClCH₂CO₂H (50% solution), the mixture was heated 2 hrs. on a water bath, cooled, neutralized with dilute HCl (1:1), extracted with Et₂O, and the product precipitated with soda. Acidification of the Na salt yielded 60% white needles, m. 151¡ã (H₂O). Me₂C(C₆H₄OCH₂CO₂H-4)₂, m. 165¡ã, was also prepared

Nauch.-Tekh. Konf., Moskov. Neftekhim. i Gaz. Prom. Inst., 11-ya[Odinnadtsataya]i 12-ya[Dvenadtsataya] published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Application of 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cheeseright, Timothy J. published the artcileNovel Lead Structures for p38 MAP Kinase via FieldScreen Virtual Screening, SDS of cas: 1798-04-5, the publication is Journal of Medicinal Chemistry (2009), 52(14), 4200-4209, database is CAplus and MEDLINE.

The p38 MAP kinase has received considerable interest in the pharmaceutical industry and remains a valid and interesting target for the treatment of inflammation. To discover novel p38 inhibitors, the ligand-based virtual screening technique, FieldScreen, was applied to 1.2 million com. available compounds Fifty-eight diverse compounds were selected for biol. anal., using mol. field similarity to known inhibitors, while explicitly removing any structure that shared a scaffold with previously reported p38 inhibitors. Of these, 11 (19%) showed ¡Ý20% inhibition of p38 at 10 ¦ÌM. Analogs of two distinct chem. series were prepared, resulting in a potential lead compound with pIC₅₀ of 6.4. Modeling of SAR using FieldAlign, a ligand alignment protocol, was used to rationalize the SAR of the series of thiadiazole based inhibitors.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rosenwald, R. H. published the artcileAlkyl phenols as antioxidants, COA of Formula: C12H16O3, the publication is Industrial and Engineering Chemistry (1950), 162-5, database is CAplus.

A number of Me- and Bu-substituted phenols were tested as stabilizers for cracked gasoline, and the effects on stabilizing potency of number of substituents and their size, position, and configuration were studied. Potency of a phenol as stabilizer was found to increase with increased number of substituents, but size of substituent had little effect. Substituting in the ortho position was most effective, and the tert-Bu group gave best results. The best stabilizer studied was 2,4-dimethyl-6-tert-butylphenol. Phys. properties reported for new compounds are: 2-methyl-6-sec-butylphenol b_2.5 81.5-2¡ã, 229-31¡ã, n_D²⁰ 1.5197; 2,4-dimethyl-6-sec-butylphenol b_2.5 91-2.5¡ã, n_D²⁰ 1.5189; 2-tert-butyl-4-butylphenol b. 270-2¡ã, n_D²⁰ 1.5089; 2-tert-butyl-4-isobutylphenol b. 259-60¡ã, b_2.5 105-106¡ã, n_D²⁰ 1.5070; 2-tert-butyl-sec-butylphenol b. 255-6¡ã, n_D²⁰ 1.5078.

Industrial and Engineering Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saito, Kaori published the artcileCalix[4]arenes bearing four redox-active ¦Ð-conjugated pendant groups for a dimensionally oriented redox system, Quality Control of 1798-04-5, the publication is Bulletin of the Chemical Society of Japan (2002), 75(8), 1845-1846, database is CAplus.

A p-tert-butylcalix[4]arene I [R = CH₂CONH(p-C₆H₄NH)₃Ac], bearing four redox-active phenylenediamine pendant groups on the lower rim, was synthesized and characterized spectroscopically and electrochem. The interconversion of the oxidation states of the pendant groups was demonstrated both chem. and electrochem.

Bulletin of the Chemical Society of Japan published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Quality Control of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Takahashi, Eiki published the artcileDiscovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(11), 3154-3156, database is CAplus and MEDLINE.

We aimed to discover a novel type of transient receptor potential vanilloid 1 (TRPV1) antagonist because such antagonists are possible drug candidates for treating various disorders. We modified the structure of hit compound I (human TRPV1 IC₅₀ = 411 nM) and converted its pyrrolidino group to a (hydroxyethyl)methylamino group, which substantially improved inhibitory activity (II; human TRPV1 IC₅₀ = 33 nM). In addition, II ameliorated bladder overactivity in rats in vivo.

Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C14H31NO2, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hill, Carl M. published the artcileThe synthesis, properties, and catalytic hydrogenation of several aryloxy substituted ketene monomers and dimers, Product Details of C12H16O3, the publication is Journal of the American Chemical Society (1953), 1084-6, database is CAplus.

p-Me₃CC₆H₄ONa treated with EtCHBrCO₂Et in MeOH gave p-Me₃CC₆H₄OCHEtCO₂Et which was hydrolyzed to the corresponding acid (I), 63%, m. 87-8.5¡ã (from petr. ether-C₆H₆) (all m.ps. reported are corrected). Similarly were obtained: p-Me₃CC₆H₄CHBuCO₂H, 69%, m. 89-90¡ã, and p-Me₃CC₆H₄CHAmCO₂H, 63%, m. 72-3¡ã. The ¦Á-aryloxy acids were converted with SOCl₂ to the corresponding acyl chlorides, p-Me₃CC₆H₄OCHRCOCl (II) (R, b.p./mm., % yield, n²⁰_D, and d₂₀ given): H (III), 130-2¡ã/5, 90, 1.5162, 1.1128, from p-tert-BuC₆H₄OCH₂CO₂H, m. 88-9¡ã; Me (IV), 143-5¡ã/26, 60, 1.5092, 1.0775, from p-Me₃CC₆H₄OCHMeCO₂H, m. 86-7¡ã; Et, 131-2¡ã/3, 94, 1.5055, 1.0651; Bu, 143-4¡ã/3, 95, 1.5018, 1.0641; and Am, 149-50¡ã/6, 97, 1.5003, 0.9984. To 0.5 g. II in 100 cc. dry Et₂O was added dry NH₃ and the crude precipitate filtered off and recrystallized from MeOH to give the amides p-Me₃CC₆H₄OCHRCONH₂ (R, m.p., and % yield given): H, 131-2¡ã, 86; Me, 116-17¡ã, 91; Et, 97-9¡ã, 87; Bu, 145-6¡ã, 71; and Am, 86-7¡ã, 76. III in 20 cc. dry C₆H₆ warmed with an equivalent amount PhNH₂ on the water bath gave p-Me₃CC₆H₄OCH₂CONHPh, m. 91-2¡ã. Similarly was prepared p-Me₃CC₆H₄OCHMeCONHPh, m. 83-4¡ã. The dehydrochlorination of III as previously described (cf. C.A. 45, 10128i) gave 37% p-tert-butylphenoxyketene dimer (V), m. 85-6¡ã, b₅ 180-3¡ã. IV gave similarly 55% p-tert-butylphenoxymethylketene dimer (VI), m. 78-9¡ã, b₆ 147-50¡ã. By the same procedure were prepared the following p-tert-butylphenoxyalkylketene monomers (alkyl, b.p./mm., % yield, n²⁰_D, and d₂₀ given): Et (VII), 175-6¡ã/12, 66, 1.5178, 1.0132; Bu (VIII), 169-71¡ã/10, 54, 1.5044, 1.0157; and Am (IX), 132-3¡ã/5, 73, 1.5056, 0.9771. Weighed samples of the ketenes (5-15 g.) in 25 cc. petr. ether were hydrogenated 4-6 hrs. over 2-4 g. Raney Ni at 1500-3500 lb./sq. in. pressure, the mixture filtered, the solvent distilled off, the residue distilled, and the glycol fraction washed with small portions 15% aqueous Na₂CO₃ and H₂O, dried with MgSO₄, and redistilled, giving 2 fractions, p-Me₃CC₆H₄OH, m. 94-5¡ã (from petr. ether-C₆H₆), and glycols corresponding to the ketene dimer. In the case of V, the p-Me₃C₆H₄ was not split off and the only product was 2,4-bis(p-tert-butylphenoxy)-1,3-butanediol dimer, m. 88-9¡ã ; bis(3,5-dinitrobenzoate), m. 140-1¡ã. VI gave by hydrogenation 50% CHMe.CH(OH).CHMe.CHOH, b₂₀ 83-4¡ã n²⁰_D 1.5328, d₂₀ 1.0570; bis(3,5-dinitrobenzoate), 40%, m. 126-7¡ã. The other ketenes were converted similarly to the corresponding CHR.CH(OH).CHR.CHOH (X) [R, % yield, b.p./mm., n²⁰_D, d₂₀, and, in parentheses, the % yield and m.p. of the bis(3,5-dinitrobenzoate), given]: Et, 65, 75-7¡ã/10, 1.4458, 0.9165 (37, 165-6¡ã); Bu, 40, 125-6¡ã/3, 1.4343, 0.9108 (35, 162-3¡ã); and Am, 35, 125-7¡ã/5, 1.4388, 0.8957 (50, 163-4¡ã). The 2 isomeric forms of the previously prepared (2,4-Cl₂C₆H₃OCR:C:O)₂ (XI), where R is Et, Pr, and Bu, gave by the same procedure the following pairs of isomeric X [R, % yield, b.p./mm., n²⁰_D (except where otherwise stated), d₂₀ values and in parentheses, the % yield and m.p. of the bis(p-nitrobenzoate) given]: Et, 55, 60-3¡ã/3, n²¹_D 1.5228, 1.0018 (48, 118-19¡ã), and 40% 2,4-Cl₂C₆H₃OH (XII), m. 42-3¡ã (3,5-dinitrobenzoate, m. 142-3¡ã), from liquid XI with R = Et; Et, 20, 59-61¡ã/3, 1.5362, 1.0784, MR_D 41.64 (54, 85-6¡ã), and 35% XII from solid XI with R = Et; Pr, 20, m. 21-3¡ã, 63-5¡ã/3, n²⁵_D 1.5362, 1.0757 (56, 88-90¡ã), and 65% XII from liquid XI with R = Pr; Pr, 67, 102-4¡ã/3, 1.5261, 1.0612, MR_D 49.76 (68, 114-15¡ã), and 28% XII from solid XI with R = Pr; Bu, 27, 62¡ã/4, 1.5183, 1.0688, MR_D) 56.73 (45, 115-16¡ã), and 45% XII from liquid XI with R = Bu; and Bu, 56, 65-8¡ã/2, 1.5299, 1.0378, MR_D 59.53 (61, 119-20¡ã), and 38% XII from solid XI with R = Bu.

Journal of the American Chemical Society published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Product Details of C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Berger, Michael published the artcileMetal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Chemical Science (2020), 11(23), 6053-6057, database is CAplus and MEDLINE.

Electrochem. decarboxylation of aryloxyacetic acids followed by fluorination provided easy access to fluoromethyl aryl ethers. This electrochem. fluorodecarboxylation offers a sustainable approach with elec. current as traceless oxidant. Using Et₃N¡¤5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis afforded various fluoromethoxyarenes in yields up to 85%.

Chemical Science published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Recommanded Product: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hamdy, Rania published the artcileDesign, synthesis and evaluation of new bioactive oxadiazole derivatives as anticancer agents targeting Bcl-2, Product Details of C12H16O3, the publication is International Journal of Molecular Sciences (2020), 21(23), 8980, database is CAplus and MEDLINE.

A series of 2-(1H-indol-3-yl)-5-substituted-1,3,4-oxadiazoles I [R = benzyl, 4-methylphenoxymethyl, 4-nitrophenyl, etc.] were designed, synthesized and tested in-vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents based on previously reported compounds Synthesis of the target 1,3,4-oxadiazoles I were readily accomplished through a cyclization reaction of indole carboxylic acid hydrazide with substituted carboxylic acid derivatives RC(O)OH in the presence of phosphorus oxychloride. New compounds I showed a range of IC₅₀ values concentrated in the low micromolar range selectively in Bcl-2 pos. human cancer cell lines. The most potent candidate I [R = 4-trifluorophenyl] showed selective IC₅₀ values of 0.52-0.88¦ÌM against Bcl-2 expressing cell lines with no inhibitory effects in the Bcl-2 neg. cell line. Moreover, I [R = 4-trifluorophenyl] showed binding that was two-fold more potent than the pos. control gossypol in the Bcl-2 ELISA binding affinity assay. Mol. modeling studies helped to further rationalize anti-apoptotic Bcl-2 binding and identified compound I [R = 4-trifluorophenyl] as a candidate with drug-like properties for further investigation as a selective Bcl-2 inhibitory anticancer agent.

International Journal of Molecular Sciences published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Product Details of C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia