Category: 1798-04-5

Karunakaran, K. published the artcileKinetics of oxidation of phenoxyacetic acids by pyridinium hydrobromide perbromide, Computed Properties of 1798-04-5, the publication is Journal of Physical Organic Chemistry (1996), 9(2), 105-10, database is CAplus.

The oxidation of several monosubstituted phenoxyacetic acids by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid. The reaction is first order with respect to PHPB. Michaelis-Menten-type kinetics are observed with respect to phenoxyacetic acids. The oxidation of [2,2-²H₂]phenoxyacetic acid exhibits a substantial kinetic isotopic effect. The effect of solvent composition indicates that the transition state is more polar than the reactants. The formation constants of the intermediate phenoxyacetic acid-PHPB complexes and the rates of their decomposition were determined at different temperatures The rates of oxidation of para- and meta-substituted phenoxyacetic acids were correlated with Hammett’s substituent constants The ¦Ñ value is -2¡¤59 at 35¡ã. The rates of oxidation of ortho-substituted compounds are correlated with Charton’s triparametric equation. A mechanism involving transfer of a hydride ion from the substrate to the oxidant is proposed.

Journal of Physical Organic Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Karunakaran, K. published the artcileKinetics and mechanism of ruthenium(III) catalyzed oxidation of phenoxyacetic acids by lead tetraacetate, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Oxidation Communications (1994), 17(3-4), 274-81, database is CAplus.

The kinetics of oxidation of a number of ortho-, meta- and para-substituted phenoxyacetic acids by lead tetraacetate to yield ortho and para isomers of acetoxyphenols, has been studied. The reaction is first order each with respect to phenoxyacetic acid, lead tetraacetate, and Ru(III) and is catalyzed by hydrogen ions. The observed solvent effect suggests that the transition state is more polarized than the reactants in a S_N2 type reaction. A fairly large Hammett value (-2.29 at 35¡ãC) indicates an electron deficient transition state. The oxidation rates of ortho-substituted compounds have been analyzed in the light of the application of Taft’s steric energy parameters. A mechanism involving the existence of Ru(V) as an intermediate complex with phenoxyacetic acid, in the rate-determining step, has been proposed.

Oxidation Communications published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Safety of 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Csiba, I. published the artcileOrganic ammonium salts. XV. Preparation and antimicrobial activity of alkylammonium salts of 2-(N,N-dimethylamino)-esters of benzoic, phenylacetic and phenoxyacetic acids, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Cesko-Slovenska Farmacie (1986), 35(2), 61-7, database is CAplus.

The preparation of 22 new organic ammonium unsubstituted salts and p–tert-Bu substituted benzoyl-, phenylacetyl-, and phenoxyacetyloxyethylalkyldimethylammonium bromides and alkyldimethyl-p–tert-butylbenzylammonium bromides is reported, where the linear alkyl chain (R) has 8-16 C atoms. Besides the preparation of the above-mentioned compounds, soft analogs of hard antimicrobially active benzalkonium salts were investigated for the influence of structural changes on the antimicrobial activity, expressed as the min. inhibitory concentration (MIC). The test strains included Staphylococcus?aureus, Escherichia?coli and Candida?albicans. A change in the length of the alkyl chain influenced the activity against E. coli only, the course of the dependence MIC = f(R) was nonlinear, and maximum effectiveness was achieved in decyl and dodecyl derivatives This structural change did not principally influence the activity against S. aureus and C. albicans. The presence of the p–tert-Bu group in the mol. enhanced the activity against S. aureus and C. albicans, the introduction of the ester group into the mol. decreased the activity against E. coli. Interruption of the conjugation of the aromate by the CH₂ and the O-CH₂ bridge decreased the activity against E. coli; the effectiveness against S. aureus and C. albicans was not markedly changed. In comparison with the hard analog Ajatin (benzyldodecyldimethylammonium bromide) the compounds under study were more effective and comparable to Septonex (N-[1-(ethoxycarbonyl)pentadecyl]trimethylammonium bromide) in all 3 microorganisms tested. The proposed products of hydrolytic degradation of the compounds with an ester group show a low (dodecyl-2-hydroxyethyldimethylammonium bromide) or negligible (the pertinent substituted and unsubstituted acids) antimicrobial activity and from this point of view the studied ammonium salts with an ester group in the mol. can be classed into the category of soft antimicrobially effective compounds

Cesko-Slovenska Farmacie published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Le Vaillant, Franck published the artcileRoom-Temperature Decarboxylative Alkynylation of Carboxylic Acids Using Photoredox Catalysis and EBX Reagents, Computed Properties of 1798-04-5, the publication is Angewandte Chemie, International Edition (2015), 54(38), 11200-11204, database is CAplus and MEDLINE.

The direct synthesis of alkynes from readily available carboxylic acids at room temperature under visible-light irradn was reported. The combination of an iridium photocatalyst with (alkynyl)benziodoxolone reagents allowed the decarboxylative alkynylation of carboxylic acids in good yields under mild conditions. The method was applied to silyl-, aryl-, and alkyl- substituted alkynes. It was particularly successful in the case of ¦Á-amino and ¦Á-oxo acids derived from biomass.

Angewandte Chemie, International Edition published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bochenska, Maria published the artcileSulfonamides as ionophores for ion-selective electrodes. I, Application In Synthesis of 1798-04-5, the publication is Journal of Inclusion Phenomena (1987), 5(6), 689-94, database is CAplus.

o-R¹RNCOC₆H₄SO₂NRR¹, o-(R¹RNSO₂)₂C₆H₄, 2,4-R¹RNSO₂(Me₃C)C₆H₃OCH₂CONR²R³ [R = R¹ = Et, Bu, CH₂CHMe₂, CH₂Ph; R = Et, R¹ = Ph; NRR¹ = morpholino, piperidino, NH(CH₂)₁₃Me; R² = R³ = Bu, CH₂CHMe₂), and X[CON(CHMe₂)₂]₂ (X = o-C₆H₄, o-C₆H₄OCH₂, 1,2-cyclohexanediyl) were prepared for use as ion-selective ligands in liquid membrane electrodes. Most of the ligands preferentially chelated K.

Journal of Inclusion Phenomena published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Application In Synthesis of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Joseph, Roymon published the artcileBenzothiazole appended lower rim 1,3-di-amido-derivative of calix[4]arene: Synthesis, structure, receptor properties towards Cu²⁺, iodide recognition and computational modeling, Computed Properties of 1798-04-5, the publication is Inorganica Chimica Acta (2010), 363(12), 2833-2839, database is CAplus.

A new mol. fluorescent sensor (L) for Cu²⁺ was synthesized by derivatizing the lower rim of calix[4]arene with benzothiazole moiety, through amide linkage to result in 1,3-di-derivative The receptor mol., L exhibited fluorescence quenching towards Cu²⁺ among eleven divalent ions, viz., Mn²⁺, Fe²⁺, Co²⁺, Ni²⁺, Cu²⁺, Zn²⁺, Cd²⁺, Hg²⁺, Ca²⁺, Mg²⁺ and Pb²⁺, studied. The 1:1 stoichiometry of the complex formed between L and Cu²⁺ was demonstrated by electronic absorption and ESI-MS. The role of calix[4]arene for the selective sensing of Cu²⁺ was established by comparing the data with that obtained for an appropriate control mol. The min. concentration at which L can detect Cu²⁺ is 403 ppb. The computations carried out at DFT level provided the coordination and structural features of the Cu²⁺ complex of L as species of recognition. The Cu²⁺ complex thus formed recognizes iodide by bringing change in the color, among the 14 anions studied.

Inorganica Chimica Acta published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Computed Properties of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Guo, Jing published the artcileNovel Shikonin Derivatives Targeting Tubulin as Anticancer Agents, Application of 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Chemical Biology & Drug Design (2014), 84(5), 603-615, database is CAplus and MEDLINE.

In this study, the authors report the identification of a new shikonin-phenoxyacetic acid derivative, as an inhibitor of tubulin. A series of compounds were prepared; among them, compound 16 [(R) -1 – (5, 8- dihydroxy-1, 4- dioxo-1, 4- dihydronaphthalen-2-yl)-4-methylpent-3-enyl 2- (4- phenoxyphenyl) acetate] potently inhibited the function of microtubules, inducing cell growth inhibition, apoptosis of cancer cell lines in a concentration and time-dependent manner. Mol. docking involving compound 16 at the vinblastine binding site of tubulin indicated that a phenoxy moiety interacted with tubulin via hydrogen bonding with asparaginate (Asn) and tyrosine (Tyr). Anal. of microtubules with confocal microscopy demonstrated that compound 16 altered the microtubule architecture and exhibited a significant reduction in microtubule d. Cell cycle assay further proved that HepG2 cells were blocked in G2/M phase. The authors’ study provides a new, promising compound for the development of tubulin inhibitors by proposing a new target for the anticancer activity of shikonin.

Chemical Biology & Drug Design published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Application of 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Leung, Joe C. T. published the artcilePhoto-fluorodecarboxylation of 2-Aryloxy and 2-Aryl Carboxylic Acids, Category: catalysis-chemistry, the publication is Angewandte Chemie, International Edition (2012), 51(43), 10804-10807, database is CAplus and MEDLINE.

Transition-metal-free photo-fluorodecarboxylation of 2-aryloxy- and 2-arylacetic acids was accomplished via use of Selectfluor. E.g.., irradiation of an aqueous alk. solution of 4-FC₆H₄OCH₂CO₂H at 300 nm for 1 h in presence of Selectfluor gave up to 94% of the monofluoromethyl ether 4-FC₆H₄OCH₂F. Also prepared were difluoromethyl ethers.

Angewandte Chemie, International Edition published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Qing-Wei published the artcileFluorodecarboxylation for the synthesis of trifluoromethyl aryl ethers, COA of Formula: C12H16O3, the publication is Angewandte Chemie, International Edition (2016), 55(33), 9758-9762, database is CAplus and MEDLINE.

The synthesis of mono-, di-, and trifluoromethyl aryl ethers by fluorodecarboxylation of the corresponding carboxylic acids is reported. AgF₂ induces decarboxylation of aryloxydifluoroacetic acids, and AgF, either generated in situ or added sep., serves as a source of fluorine to generate the fluorodecarboxylation products. The addition of 2,6-difluoropyridine increased the reactivity of AgF₂, thereby increasing the range of functional groups and electronic properties of the aryl groups that are tolerated. The reaction conditions used for the formation of trifluoromethyl aryl ethers also served to form difluoromethyl and monofluoromethyl aryl ethers.

Angewandte Chemie, International Edition published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16N2O2, COA of Formula: C12H16O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Weintraub, Robert L. published the artcileRelation between molecular structure and physiological activity of plant-growth regulators. II. Formative activity of phenoxyacetic acids, Application In Synthesis of 1798-04-5, the publication is Journal of Agricultural and Food Chemistry (1954), 996-9, database is CAplus.

cf. C.A. 46, 5773g; 47, 6593a. The formative activities of approx. 145 ring-substituted phenoxyacetic acids have been measured by the bean-leaf repression technique. The presence of a halogen atom at position 4 appears to be a requisite for high activity. The order of effectiveness of the halogens is Cl > F > Br > I. Further enhancement of activity may ensue through introduction of an addnl. halogen or Me substituent at position 2.

Journal of Agricultural and Food Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C9H10O4, Application In Synthesis of 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia