Category: 1860-58-8

Moragas, Toni published the artcileNickel-Catalyzed Carboxylation of Benzylic C-N Bonds with CO₂, Quality Control of 1860-58-8, the publication is Angewandte Chemie, International Edition (2016), 55(16), 5053-5057, database is CAplus and MEDLINE.

A user-friendly Ni-catalyzed reductive carboxylation of benzylic C-N bonds with CO₂ is described. This procedure outperforms state-of-the-art techniques for the carboxylation of benzyl electrophiles by avoiding commonly observed parasitic pathways, such as homodimerization or ¦Â-hydride elimination, thus leading to new knowledge in cross-electrophile reactions.

Angewandte Chemie, International Edition published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Quality Control of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chrysanthopoulos, Panagiotis K. published the artcileIdentification of a New Zinc Binding Chemotype by Fragment Screening, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Journal of Medicinal Chemistry (2017), 60(17), 7333-7349, database is CAplus and MEDLINE.

The discovery of a new zinc binding chemotype from screening a nonbiased fragment library is reported. Using the orthogonal fragment screening methods of native state mass spectrometry and surface plasmon resonance a 3-unsubstituted 2,4-oxazolidinedione fragment was found to have low micromolar binding affinity to the zinc metalloenzyme carbonic anhydrase II (CA II). This affinity approached that of fragment sized primary benzenesulfonamides, the classical zinc binding group found in most CA II inhibitors. Protein X-ray crystallog. established that 3-unsubstituted 2,4-oxazolidinediones bound to CA II via an interaction of the acidic ring nitrogen with the CA II active site zinc, as well as two hydrogen bonds between the oxazolidinedione ring oxygen and the CA II protein backbone. Furthermore, 3-unsubstituted 2,4-oxazolidinediones appear to be a viable starting point for the development of an alternative class of CA inhibitor, wherein the medicinal chem. pedigree of primary sulfonamides has dominated for several decades.

Journal of Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Febles, Martin published the artcileSynthesis and biological evaluation of crown ether acyl derivatives, Safety of 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(22), 5591-5593, database is CAplus and MEDLINE.

A set of crown Et acyl derivatives based on 18-crown-6 moiety was synthesized and evaluated for biol. activity. In vitro antiproliferative profiling demonstrated significant activities against HBL-100, HeLa, SW1573 and WiDr human cell lines. The most active compound exhibited GI₅₀ values in the range of 3.7-5.6 ¦ÌM. Antimicrobial evaluation showed that three polyaromatic compounds were active against Staphylococcus aureus (MIC₉₀ values from 8.3 ¦ÌM to 50 ¦ÌM), whereas a (decyloxy)benzene substitution exhibited moderate activity against Candida albicans (MIC₉₀ values 36 ¦ÌM). According to SAR evaluation, the size of the crown ether and the acyl side chain had a significant effect on the bioactivity. Aromatic moieties close to the acyl group led to improved bioactivity as exemplified by some of the tested compounds These results provide further evidence on the potential of crown Et structure as a scaffold for developing new biol. probes and lead candidates for drug development.

Bioorganic & Medicinal Chemistry Letters published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Safety of 2-(3-(Benzyloxy)phenyl)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Miyakoshi, Hitoshi published the artcile1,2,3-Triazole-Containing Uracil Derivatives with Excellent Pharmacokinetics as a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Journal of Medicinal Chemistry (2012), 55(14), 6427-6437, database is CAplus and MEDLINE.

Deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as a 5-fluorouracil-based combination chemotherapy. The design and synthesis of a novel class of human dUTPase inhibitors, 1,2,3-triazole-containing uracil derivatives, is described. Compound I, which possesses 1,5-disubstituted 1,2,3-triazole moiety that mimics the amide bond of tert-amide-containing inhibitor II locked in a cis conformation showed potent inhibitory activity, and its structure-activity relationship studies led us to the discovery of highly potent inhibitors III and IV (IC₅₀ = ?0.029 ¦ÌM). These derivatives dramatically enhanced the growth inhibition activity of 5-fluoro-2′-deoxyuridine against HeLa S3 cells in vitro (EC₅₀ = ?0.05 ¦ÌM). In addition, compound IV exhibited a markedly improved pharmacokinetic profile as a result of the introduction of a benzylic hydroxy group and significantly enhanced the antitumor activity of 5-fluorouracil against human breast cancer MX-1 xenograft model in mice. These data indicate that IV is a promising candidate for combination cancer chemotherapies with TS inhibitors.

Journal of Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiao, Ke-Jin published the artcileNickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids, Quality Control of 1860-58-8, the publication is Organic Chemistry Frontiers (2021), 8(23), 6603-6608, database is CAplus.

A highly regioselective Ni-catalyzed electrochem. (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides was developed. This strategy allowed the direct acylation of benzylic C(sp³)-H bonds in good yields from com. available alkyl carboxylic acids, thus provided an alternative strategy for the synthesis of dialkyl ketones. Various functional groups were tolerated under mild reaction conditions.

Organic Chemistry Frontiers published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Quality Control of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ren, Jie published the artcileDesign, synthesis, and biological evaluation of oxazolidone derivatives as highly potent N-acylethanolamine acid amidase (NAAA) inhibitors, Formula: C15H14O3, the publication is RSC Advances (2017), 7(21), 12455-12463, database is CAplus.

N-Acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme that catalyzes the hydrolysis of endogenous fatty acid ethanolamides (FAEs), such as N-palmitoylethanolamide (PEA). PEA exhibits anti-inflammatory and analgesic activities by engaging peroxisome proliferator-activated receptor ¦Á (PPAR-¦Á). Preventing PEA degradation by inhibition of NAAA has been proposed as a novel strategy for the treatment of inflammation and pain. In the present study, we reported the discovery of the oxazolidone derivative as a novel scaffold for NAAA inhibitors, and studied the structure-activity relationship (SAR) by modification of the side chain and terminal lipophilic substituents. The results showed that the link chain length of C5, straight and saturated linkages were the preferred shape patterns for NAAA inhibition. Several nanomolar NAAA inhibitors were described, including 2f, 3h, 3i and 3j with IC₅₀ values of 270 nM, 150 nM, 100 nM and 190 nM, resp. Enzymic degradation studies suggested that 2f inhibited NAAA in a selective, noncompetitive and reversible pattern. Moreover, 2f showed high anti-inflammatory and analgesic activities after systemic and oral administration.

RSC Advances published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Formula: C15H14O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pearson, Anthony J. published the artcileSome Studies on the Uses of 2-Bromoethyl and 2-Iodoethyl Ester Blocking Groups in Peptide Synthesis: Samarium Diiodide-Mediated Deprotection, Computed Properties of 1860-58-8, the publication is Journal of Organic Chemistry (1994), 59(8), 2257-60, database is CAplus.

Deprotection of 2-bromoethyl esters during peptide synthesis is often problematic, owing to competing formation of 2-hydroxyethyl esters. A simple and reproducible method is described for the removal of the 2-bromoethyl group via conversion to the corresponding 2-iodoethyl ester, followed by deprotection of the latter by treatment with samarium diiodide under anhydrous oxygen-free conditions. No racemization was observed for phenylglycine derivatives during the protection/halide exchange/deprotection sequence. Application of this methodol. to a number of peptides as well as simple carboxylate derivatives is described.

Journal of Organic Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Computed Properties of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, Jeewoo published the artcile2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands, SDS of cas: 1860-58-8, the publication is Bioorganic & Medicinal Chemistry (2006), 14(6), 2022-2031, database is CAplus and MEDLINE.

A series of 2-benzyl and 2-phenyl-3-hydroxypropyl pivalates designed to incorporate the principal pharmacophores of phorbol esters have been synthesized and tested as PKC-¦Á ligands. Among the analogs, I exhibited the most potent binding affinity with a K_i = 0.7 ¦ÌM. The synthesized analogs were subjected to mol. modeling anal. based on two alternative models of the phorbol pharmacophore and a docking study of I was carried out.

Bioorganic & Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, SDS of cas: 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Amaravathi, M. published the artcileOxidation of 1-benzyl-3,4-dihydroisoquinolines using active manganese dioxide, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1983), 22B(12), 1246-7, database is CAplus.

Oxidation of benzyldihydroisoquinolines I [R, R¹, R² = H, H, H; MeO, PhCH₂O, H; H, MeO, H; H, H, NO₂ (II), H, H, Cl] by active MnO₂ gave benzoyldihydroisoquinolines III in yields >80%, except in the case of II which gave the oxidation product in 46% yield.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Recommanded Product: 2-(3-(Benzyloxy)phenyl)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ando, Ryoichi published the artcile3-(Arylacetylamino)-N-methylbenzamides: A Novel Class of Selective Anti-Helicobacter pylori Agents, SDS of cas: 1860-58-8, the publication is Journal of Medicinal Chemistry (2001), 44(25), 4468-4474, database is CAplus and MEDLINE.

After chem. modification preceded by the random screening of a chem. library, a novel class of selective anti-Helicobacter pylori agents was generated. Consequently, the 3-(arylacetylamino)-N-methylbenzamides, which were quite easy to prepare, showed potent inhibitory activity against Helicobacter pylori but exhibited no inhibitory activity against other sorts of bacteria and fungi, e.g., Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Bacteroides fragilis, and Candida albicans. These compounds showed potent anti-H. pylori activity under acidic conditions, whereas amoxicillin and clarithromycin decreased activity. The 3-(3-arylpropionylamino)-N-methylbenzamides, 3-(aryloxyacetylamino)-N-methylbenzamides, and (3-methylcarbamoylphenyl)carbamic acid 1-arylmethyl esters also exhibited potent anti-H. pylori activity. Finally, 2-C₁₀H₇CH₂CONHC₆H₄CONHMe-3 (BAS-118) was selected as a candidate compound for further evaluation.

Journal of Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, SDS of cas: 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia