Category: 312-40-3

Tacke, Reinhold published the artcileSyntheses and Pharmacological Properties of the Histaminic H₁ Antagonists Sila-terfenadine-A, Sila-terfenadine-B, Disila-terfenadine, and Sila-fexofenadine: A Study on C/Si Bioisosterism, Formula: C12H10F2Si, the publication is Organometallics (2004), 23(21), 4915-4923, database is CAplus.

Sila-substitution (C/Si exchange) of one or both of the two quaternary carbon atoms of the histaminic H₁ antagonist terfenadine (1a) leads to sila-terfenadine-A (1b; R₃COH ¡ú R₃SiOH), sila-terfenadine-B (1c; R₄C ¡ú R₄Si), or disila-terfenadine (1d; R₃COH ¡ú R₃SiOH, R₄C ¡ú R₄Si). Sila-substitution of the quaternary carbon atom of the histaminic H₁ antagonist fexofenadine (2a) affords sila-fexofenadine (2b; R₃COH ¡ú R₃SiOH). The silicon compounds were synthesized in multistep syntheses, and the identities of these compounds and their precursors were established by elemental analyses and multinuclear NMR studies. Some of the precursors were addnl. characterized by single-crystal x-ray diffraction. The pharmacol. profiles of silicon compounds were assessed across a range of histaminic receptor binding assays (radioligand binding studies at histamine central H₁, peripheral H₁, H₂, and H₃ receptors). The silicon compounds, within exptl. error, exhibited an affinity and selectivity profile similar to their corresponding carbon analogs.

Organometallics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C3H6F3N, Formula: C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhun’, V. I. published the artcileReaction of Germanium Tetrachloride with Chloro(phenyl)silanes in the Presence of Aluminum Chloride, Recommanded Product: Difluorodiphenylsilane, the publication is Russian Journal of General Chemistry (2005), 75(6), 867-869, database is CAplus.

The effect of the quantity of AlCl₃ on the direction and depth of reaction of GeCl₄ with chloro(phenyl)silanes Ph_nSiCl_4-n (n = 1-3) was studied to show that radical exchange between Ge and Si is initiated only if the mixture contains ¡Ý2.5-5% of AlCl₃. With trichloro(phenyl)silane, the radical exchange is initiated at 5% of AlCl₃ and results in exclusive formation of trichloro(phenyl)germane. The reactions of GeCl₄ with dichlorodiphenylsilane and chlorotriphenylsilane in the presence = 2.5-7.5% of AlCl₃ give dichlorodiphenylgermane as the major product, and at AlCl₃ concentrations of >10% the major product becomes trichloro(phenyl)germane.

Russian Journal of General Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C23H20BN, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lafferty, Walter J. published the artcileFar-infrared spectra of solid methyl halides, Recommanded Product: Difluorodiphenylsilane, the publication is Journal of Chemical Physics (1962), 83-6, database is CAplus.

The infrared spectra of solid MeCl, MeBr, MeI, CD₃Cl, CD₃Br, and CD₃I were measured at 130-30 cm.^-1 at 78¡ãK. Two sharp bands were found in the chloride and the bromide, and 3 in the iodide. These absorptions arise from lattice vibrational modes. The isotopic shifts exclude libration about the symmetry axis as a possible assignment for any of the bands; however, definite assignments to B-axis librations or translational modes cannot be made with confidence.

Journal of Chemical Physics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Satge, Jacques published the artcileInsertion reaction of germanium fluoride (GeF2) into a variety of ¦Ò type bonds, Application In Synthesis of 312-40-3, the publication is Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques (1974), 278(21), 1309-12, database is CAplus.

The in-sertion of F2Ge into RX gave RGeXF2 (R = Et, MeOCH2; X = Cl, Br, iodo). Phenylchlorosilanes, Ph3SiCl, Ph2SiCl2, and Ph-SiCl3 inserted F2Ge to give Ph3SiGeF2Cl, Ph2Si(GeF2Cl)2, andPhSi(GeF2Cl)3, resp. A 95:5% mixture of the diastereomers of 2-chloro-5-methyl-2-phenyl-l-oxa-2-germacyclopentane inserted di-fluorogermylene stereospecifically to give a 95:5% mixture of the diastereomers of oxadigermacyclohexane I. Butadiene added methoxyfluorogermylene to give 1-fluoro-1-methoxy-2,3-di-methylgermacyclopent-3-ene (II).

Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Application In Synthesis of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hencsei, Pal published the artcileMolecular structure of phenylhalosilanes. I, Synthetic Route of 312-40-3, the publication is Periodica Polytechnica, Chemical Engineering (1972), 16(2), 101-12, database is CAplus.

Phenylhalosilanes were prepared and their spectra (NMR, uv, ir) determined and related to their mol. structure. Phenylbromosilanes were prepared by reacting MeCOBr with PhnSi(OEt)4-n. The uv spectra showed a bathochromic shift in the order: F, Cl, Br, in compound series of identical types. The ir spectra was used to determine frequencies corresponding to the most important vibrations and from the NMR spectra, the chem. shifts of H in the Me and Ph groups were identified. Compounds of the following type were investigated; PhSiX3, Ph2SiX2, Ph2SiMeX2 (X = F, Br, Cl).

Periodica Polytechnica, Chemical Engineering published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Synthetic Route of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hunter, B. K. published the artcileChemical shifts for compounds of the Group IV elements silicon and tin, COA of Formula: C12H10F2Si, the publication is Canadian Journal of Chemistry (1968), 46(8), 1399-414, database is CAplus.

Chem. shifts for 29Si in seven series of mols. of the type XnSiY4-n have been measured where Y is an alkyl group and X varies widely in electronegativity. A considerable amount of proton and F chem. shift data has been obtained for the same compounds and in one series (CH3)nSiCl4-n the 13C chem. shifts in the Me groups have been measured. The gross features of the 29Si chem. shifts are understood by considering the series (Alkyl)3SiX with the electronegativity of X widely varied. The hybridization at Si is approx. conserved in these series and the theoretically anticipated linear dependence on electronegativity of X is demonstrated. The ligands X = O, N, and F are exceptional and these 29Si chem. shifts have a high field shift. This addnl. shielding has been associated with (p ¡ú d)¦Ð bonding. The approx. nature of present chem. shift theories is not likely to provide a measure of the order of (p ¡ú d)¦Ð bonding. The 29Si chem. shifts in the series XnSiY4-n are discussed and also indicate a net shielding effect with (p ¡ú d)¦Ð bonding. A comparison is always made with corresponding 13C chem. shifts. A long-range proton-proton coupling in mols. Me3SnX and Me2SnX2, H-C-Si-C-H is observed only when X = O, (N?), F. 119Sn chem. shifts in a series of alkyltin compounds have been measured. The same dependence on the electronegativity of X in the series (alkyl)3SnX is noted, but the variation of X is much more limited. Some shielding due to (p ¡ú d)¦Ð bonding in the series (Butyl)nSnCl4-n is suggested. The Sn chem. shift has been measured as a function of concentration and solvent for simple methyltin bromides and chlorides. In donor solvents, it has been possible to obtain equilibrium constants for complex formation from Sn dilution chem. shifts. The nature of the bonding in complexes suggested previously is consistent with the variations in the coupling constant |JSn-C-H| with concentration The distinction between ionization and complex formation with the solvent for (CH3)2SnCl2 can be made on the basis of the concentration dependence of |JSn-C-H|. The spin-lattice relaxation time T1 for 13C and 29Si in natural abundance in several pure degassed compounds has been measured. These are not in the case of 13C (as has been suggested) of the order several min., but are always <50 sec. and in one case as low as 3-4 sec. Both 29Si and 13C T1 values follow what might be expected on the basis of a dipole-dipole mechanism from the closest protons. The short value of 35 sec. in CS2 is probably a result of spin-rotation interaction in the liquid state. 46 references.

Canadian Journal of Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, COA of Formula: C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Veszpremi, Tamas published the artcileInvestigation of the molecular structure of phenylhalosilanes, Safety of Difluorodiphenylsilane, the publication is Kemiai Kozlemenyek (1976), 46(3-4), 418-24, database is CAplus.

Del Re, PPP and IPPP, MO calculations for the UV spectra and dipole moments of 8 PhSiRR1X (R = R1 = X = F, Cl; R = R1 = Ph, X = F, Cl; R = X = F, Cl, R1 = Me, Ph) agreed with exptl. data. The spectra are similar to that of C6H6, with a bathochromic shift. A deformation of the F-Si-F bond angle in PhSiF3 is postulated on the basis of the difference between calculated and exptl. dipole moments.

Kemiai Kozlemenyek published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C14H10O4, Safety of Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hermann, Uwe published the artcileReaction pathways towards novel open chain and cyclic stannasilanes, Recommanded Product: Difluorodiphenylsilane, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2001), 145-150, database is CAplus.

Cyclic stannasilaalkanes were formed by rearrangement reactions of open chain and branched Si-Sn derivatives For example, ^tBu₂Sn(H)(SiMe₂)₄Sn(H)^tBu₂ reacted with LDA resulting in 2,2,3,3,4,4,5,5-octamethyl-1,1-ditert-butyl-2,3,4,5-tetrasilastannacyclopentane. First attempts for producing three membered Si-Sn rings via lithio or potassio substituted stannanes are reported.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Klingebiel, Uwe published the artcileFluorosilyl-substituted N,N- and N,O-bis(trimethylsilyl)hydroxylamines, Recommanded Product: Difluorodiphenylsilane, the publication is Journal of Organometallic Chemistry (1979), 179(4), 391-6, database is CAplus.

Fluoro- and aminofluorosilanes react with the Li salt on N,O-bis(trimethylsilyl)hydroxylamine with LiF elimination and substitution. Alkyl- and aminofluorosilanes give O-fluorosilyl-N,N-bis(trimethylsilyl)hydroxylamines, arylfluorosilanes give N-fluorosilyl-N,O-bis(trimethylsilyl)hydroxylamines. By the further reaction of O-difluorosilyl-N,N-bis(trimethylsilyl)hydroxylamine with the lithiated hydroxylamine, O,O‘-fluoromethylsilyldi[N,N-bis(trimethylsilyl)hydroxyalmine] is formed. On heating N-difluorophenylsilyl-N,O-bis(trimethylsilyl)hydroxylamine, di[fluorophenylsilyl(methyl)amino]pentamethylsiloxane is formed by Me group migration.

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sieburth, Scott McN. published the artcileSilanediols: a new class of potent protease inhibitors, Synthetic Route of 312-40-3, the publication is Angewandte Chemie, International Edition (1998), 37(6), 812-814, database is CAplus and MEDLINE.

The preparation and ACE inhibitor activity of the silanediol-based dipeptide analogs PhC(O)NHCHⁱBuSi(OH)₂CH₂CHRC(O)R¹ (R¹ = (S)-2-carboxy-1-pyrrolidinyl; R = H, Me) are reported.

Angewandte Chemie, International Edition published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C11H21BF4N2O2, Synthetic Route of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia