Category: 312-40-3

Mutahi, Mwangi Wa published the artcileSilicon-Based Metalloprotease Inhibitors: Synthesis and Evaluation of Silanol and Silanediol Peptide Analogues as Inhibitors of Angiotensin-Converting Enzyme, Recommanded Product: Difluorodiphenylsilane, the publication is Journal of the American Chemical Society (2002), 124(25), 7363-7375, database is CAplus and MEDLINE.

Silanols are best known as unstable precursors of siloxane (silicone) polymers, substances generally considered stable and inert, but have the potential to mimic a hydrated carbonyl and inhibit protease enzymes. While previous testing of simple silanediol and silanetriol compounds as inhibitors of hydrolase enzymes found them ineffective, this study reports the synthesis of peptidomimetics containing a central methylsilanol, -Si(Me)(OH)-, or silanediol, -Si(OH)₂-, group and their assessment as effective transition state analog inhibitors of metalloprotease angiotensin-converting enzyme (ACE). Central to the synthesis strategy, phenylsilanes were employed as acid-hydrolyzable precursors of the silanol group. The N-benzoyl Leu-[SiMeOH]-Gly benzyl amides, PhCONHCH(iso-Bu)Si(Me)(OH)CH₂CH₂CONHBn, proved to be stable and readily characterized. In contrast, the Leu-[Si(OH)₂]-Gly, PhCONHCH(iso-Bu)Si(OH)₂CH₂CH₂CONHBn, structure was difficult to characterize, possibly because of self-association Capping the silanediol with chlorotrimethylsilane gave a well-defined trisiloxane, demonstrating that the silanediol was monomeric. The Leu-[Si]-Gly structures were converted to Leu-[Si]-Ala analogs by enolate alkylation. Coupling of the silanol precursors with L-proline tert-Bu ester, followed by treatment with TFA, gave N-benzoyl Leu-[Si]-Gly-Pro I (R = H; R¹ = Me, OH) and N-benzoyl Leu-[Si]-Ala-Pro I (R = Me; R¹ = Me, OH) tripeptide analogs. Silanediol peptides I (R = H, Me; R¹ = OH) inhibited ACE with IC₅₀ values ¡Ü 14 nM. Methylsilanol peptides I (R = H, Me; R¹ = Me), in contrast, were poor inhibitors, with IC₅₀ values > 3000 nM. These data, including comparisons with inhibition data from peptide carbon analogs II and III, are consistent with binding of the silanediols by chelation of the ACE active site zinc, whereas the methylsilanols ligate poorly.

Journal of the American Chemical Society published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Harvey, Mack C. published the artcileSilicon-phenyl asymmetrical stretching vibration, Synthetic Route of 312-40-3, the publication is Applied Spectroscopy (1962), 12-14, database is CAplus.

The observed spectra of Ph₄X, where X = C, Si, Ge, Sn, or Pb, were studied. The Si-Ph vibration should occur near 515 cm.^-1 A strong band appears there for 22 compounds of the types Ph₄Si, Ph₃SiX, Ph₂SiX₂, Ph₂SiXY, and PhSiX₂Y.

Applied Spectroscopy published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Synthetic Route of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hoshi, Takashi published the artcileFirst C₂ Symmetrical Siloles: Synthetic, Structural, and Photophysical Studies of 7-Sila-7H-dibenzo[c,g]fluorenes, Category: catalysis-chemistry, the publication is Organometallics (2000), 19(22), 4483-4487, database is CAplus.

The syntheses of 7-sila-7H-dibenzo[c,g]fluorenes 1 were effected via dilithiation of 2,2′-dibromo-1,1′-binaphthyl (2) followed by cyclization of the resulting dianion with dihalosilanes: Me₂SiCl₂, Ph₂SiCl₂, and Ph₂SiF₂. The x-ray structural anal. of 7-sila-7,7-diphenyl-7H-dibenzo[c,g]fluorene (1b) provided the first geometrical parameters of the 7-sila-7H-dibenzo[c,g]fluorene derivative in which the silole skeleton was twisted in the C₂ sym. conformation due to the significant steric repulsion of the binaphthyl group fixed within the van der Waals radii. The photophys. study and semiempirical PM3 calculation suggested the presence of significant ¦Ò*-¦Ð* conjugation in the LUMO of the 7-sila-7H-dibenzo[c,g]fluorene 1 like a silole.

Organometallics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ohshita, Joji published the artcileSynthesis of Group 14 Dipyridinometalloles with Enhanced Electron-Deficient Properties and Solid-State Phosphorescence, Application of Difluorodiphenylsilane, the publication is Organometallics (2014), 33(2), 517-521, database is CAplus.

Si- and Ge-bridged bipyridyls were prepared, and their optical and electrochem. properties were studied. They exhibited enhanced electron deficiency and phosphorescence properties in comparison to parent bipyridyl. The single-crystal structure of a dipyridinosilole and results of DFT calculations on models are also described.

Organometallics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Application of Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kumar, Amit published the artcileSilicon Fluorides for Acid-Base Catalysis in Glycosidations, Application In Synthesis of 312-40-3, the publication is Advanced Synthesis & Catalysis (2012), 354(8), 1489-1499, database is CAplus.

Adduct formation between alcs. as glycosyl acceptors and phenylsilicon trifluoride (PhSiF₃) as catalyst permits acid-base-catalyzed glycosidations with O-glycosyl trichloroacetimidates as glycosyl donors. In this way, from various glycosyl donors and acceptors 1,2-trans- and some 1,2-cis-glycosides could be obtained with high anomeric selectivity. A preference for an intramol. bimol. nucleophilic substitution (S_N2-type) reaction course with concomitant donor and acceptor activation is supported by the results.

Advanced Synthesis & Catalysis published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Application In Synthesis of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hatanaka, Yasuo published the artcileSelective synthesis of unsymmetrical biaryls via palladium-catalyzed cross-coupling of arylfluorosilanes with aryl iodides, HPLC of Formula: 312-40-3, the publication is Chemistry Letters (1989), 1711-14, database is CAplus.

In the presence of KF, arylfluorosilanes readily participate in Pd-catalyzed cross-coupling reaction with aryl iodides to give unsym. biaryls in good yields. Thus the coupling of PhSiEtF₂ with 4-IC₆H₄OEt gave 81% 4-PhC₆H₄OEt.

Chemistry Letters published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, HPLC of Formula: 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wolfgramm, Regine published the artcileIrreversible Rearrangement of Silyl Groups between Oxygen and Nitrogen in Tris(silyl)hydroxylamines, Application of Difluorodiphenylsilane, the publication is Organometallics (1998), 17(15), 3222-3226, database is CAplus.

Diorganofluorosilylation of 1,2-bis(trimethylsilyl)hydroxylamines at low temperatures gives exclusively O-(diorganofluorosilyl)-N,N-bis(trimethylsilyl)hydroxylamines 1. The thermal rearrangement of 1 to the isomeric N-(diorganofluorosilyl)-N,O-bis(trimethylsilyl)hydroxylamines 2 is irreversible, and the exptl. data suggest an intramol. course of the isomerization. Ab initio and d. functional calculations for model compounds demonstrate the dyotropic course of the rearrangement. Anomeric stabilization of 2 by more favorable neg. F-Si-N and O-Si-C hyperconjugation is important for the irreversibility of the reaction.

Organometallics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C14H12O3, Application of Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Klanberg, Frank published the artcileNuclear magnetic resonance studies on pentacoordinate silicon fluorides, Product Details of C12H10F2Si, the publication is Inorganic Chemistry (1968), 7(1), 155-60, database is CAplus.

The 19F and 1H N.M.R. spectra of fluorosilicate anions SiF5, RSiF4- (R’ = alkyl, aryl), and (C6H5)2SiF3- have been examined as a function of temperature and solvent polarity. The spectra are consistent with the thesis that these anions exist as pentacoordinate entities in solvents of low polarity. The low-temperature spectra of SiF5- and RSiF4- show spectroscopic equivalence of all F atoms in these species, probably the result of rapid intramol. rearrangements. The spectrum of (C6H5)2SiF3- establishes two different F atom environments at low temperature which are ascribed to axial and equatorial positions in a trigonal-bipyramidal (C2)v configuration for the anion. Above -40¡ã, these two environments are averaged out into a single resonance. Spin coupling between Si and F nuclei (29Si-19F), as well as between F and H nuclei (19F-Si-C-H1), vanishes upon addition of excess fluoride ion or in protonic solvents such as water and alc. This in conjunction with the dramatic broadening of the 19F resonances observed under these conditions is rationalized in terms of rapid intermol. exchange RSiF4- + F*- ? RSiF3F*- + F-. 21 references.

Inorganic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Product Details of C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mueller, Richard published the artcileCarbonyl fluoride as a fluorination reagent in organosilicon chemistry, Product Details of C12H10F2Si, the publication is Zeitschrift fuer Chemie (1971), 11(10), 382-4, database is CAplus.

The title reaction was investigated on a series of silanols and siloxanes at 0-20¡ã. For example, Me3SiOH gave 79% Me3SiF; Ph2Si(OH)2 gave 59% Ph2SiF2; Me3SiOMe gave 97% Me3SiF and 73% FCO2Me; Me2Si(OEt)2 gave 77.5% Me2SiF2, 86% FCO2Et, and 1.8% (EtO)2CO2H. Other examples were given; Me3SiOSiMe3 and Me3SiOPh did not react.

Zeitschrift fuer Chemie published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Product Details of C12H10F2Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mueller, Richard published the artcileSilicones. LXIII. Thionyl fluoride as a fluorinating agent in organosilicon chemistry, Computed Properties of 312-40-3, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1963), 324(1-2), 86-9, database is CAplus.

In autoclaves at 20¡ã, SOF₂ with Me₂Si(OEt)₂, Me₃SiCl, Me₃SiOH, and Ph₂Si(OH)₂ gave 60-75% Me₂SiF₂ and SO(OEt)₂, 23% Me₃SiF, 90% Me₃SiF, and 80% Ph₂SiF, resp. SOF₂ did not fluorinate (Me₃Si)₂O.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Computed Properties of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia