Category: 31719-76-3

Rudinger-Adler, E. published the artcileSynthesis of several phenoxymethylphenyl derivatives with local anesthetic activity, Quality Control of 31719-76-3, the publication is Arzneimittel-Forschung (1979), 29(4), 591-4, database is CAplus and MEDLINE.

A series of 4-(phenoxymethyl)procaine derivatives, 4-PhOCH₂C₆H₄QCH₂CH₂NR₂ (I; NR₂ = NEt₂, NBu₂, 4-methyl-1-piperazinyl, Q = CO₂; NR₂ = NEt₂, Q = CO₂, CONH, COCH₂, OCH₂), were prepared and evaluated for local anesthetic activity. The local anesthetic activity decreased in the stated order of NR₂ in the 1st series of I and in the stated order of Q in the 2nd series.

Arzneimittel-Forschung published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Quality Control of 31719-76-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Takahashi, Eiki published the artcileThe discovery of potent glycine transporter type-2 inhibitors: Design and synthesis of phenoxymethylbenzamide derivatives, HPLC of Formula: 31719-76-3, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(18), 4603-4606, database is CAplus and MEDLINE.

The authors describe the discovery of phenoxymethylbenzamide derivatives as a novel class of glycine transporter type-2 (GlyT-2) inhibitors. The authors found a hit compound (human GlyT-2, IC₅₀ = 4040 nM) in their library and converted its 1-[[(2-naphthalenyl)methyl]-4-piperidinyl]-3-pyrrolidine group to an 1-(N,N-dimethylaminopropyl)piperidine group and its tert-Bu group to a trifluoromethyl group to obtain N-[1-[3-(dimethylamino)propyl]-4-piperidinyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamide. This compound showed good inhibitory activity against human GlyT-2 (IC₅₀ = 15.3 nM) and exhibited antiallodynia effects in a mouse neuropathic pain model. The title compounds thus formed included N-(1′-methyl[1,4′-bipiperidin]-4-yl)-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamide, N-[1-[3-(dimethylamino)propyl]-4-piperidinyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]benzamide. The synthesis of the target compounds was achieved by a reaction of 4-(phenoxymethyl)benzoic acid derivatives with amines, such as 1-[1-(phenylmethyl)-4-piperidinyl]-3-pyrrolidinamine, 1′-methyl-[1,4′-bipiperidin]-4-amine, 4-amino-N,N-dimethyl-1-piperidinepropanamine, 4-amino-1-piperidineethanol and similar compounds

Bioorganic & Medicinal Chemistry Letters published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H31NO2, HPLC of Formula: 31719-76-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia