Category: 6972-05-0

Eberl, H. Christian published the artcileChemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells, Formula: C3H8N2S, the publication is Scientific Reports (2019), 9(1), 1-14, database is CAplus and MEDLINE.

Kinobeads are a set of promiscuous kinase inhibitors immobilized on sepharose beads for the comprehensive enrichment of endogenously expressed protein kinases from cell lines and tissues. These beads enable chemoproteomics profiling of kinase inhibitors of interest in dose-dependent competition studies in combination with quant. mass spectrometry. We present improved bead matrixes that capture more than 350 protein kinases and 15 lipid kinases from human cell lysates, resp. A multiplexing strategy is suggested that enables determination of apparent dissociation constants in a single mass spectrometry experiment Miniaturization of the procedure enabled determining the target selectivity of the clin. BCR-ABL inhibitor dasatinib in peripheral blood mononuclear cell (PBMC) lysates from individual donors. Profiling of a set of Jak kinase inhibitors revealed kinase off-targets from nearly all kinase families underpinning the need to profile kinase inhibitors against the kinome. Potently bound off-targets of clin. inhibitors suggest polypharmacol., e.g. through MRCK alpha and beta, which bind to decernotinib with nanomolar affinity.

Scientific Reports published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reynolds, D. J. published the artcileCalculation of some nitrogen-15 and carbon-13 nuclear shielding parameters for some ureas and thioureas, Name: 1,1-Dimethylthiourea, the publication is Journal of Molecular Structure: THEOCHEM (1982), 7(3-4), 379-82, database is CAplus.

MO calculations using CNDO/S parameters are employed to determine bond-orders, charge-densities and the shielding of the ¹⁵N and ¹³C nuclei of a series of ureas and thioureas. For the sterically uncrowded mols. a linear relationship is noticed between the ¹⁵N chem. shifts and C-N bond-orders. When steric crowding occurs this simple relationship is no longer applicable.

Journal of Molecular Structure: THEOCHEM published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Name: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rau, Johannes H. published the artcileReactive fibers, Part III. Reactions of reactive fibers based on cyanuric cellulose with low-molecular-weight compounds, Computed Properties of 6972-05-0, the publication is Melliand Textilberichte (1979), 60(3), 258-63, database is CAplus.

Treatment of cotton fabrics with compounds containing various functional groups at 30-80¡ã in aqueous solutions at pH 3-9 showed that compounds containing primary and secondary amino groups, compounds containing phenolic OH groups, and thiourea and its derivatives were fixed on the fibers. Most compounds were sulfo acids or contained S in another form so bonding to the fiber could be measured by determination of S. The amount of compound bonded to the fibers fell between 0.3-9.7%; the yield, based on the amount of Cl contained in the reactive fiber, lay between 2.8 and 74%.

Melliand Textilberichte published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ikeda, Osamu published the artcileAdsorption effects of highly polarizable organic compounds on electrode kinetics, Name: 1,1-Dimethylthiourea, the publication is Bulletin of the Chemical Society of Japan (1984), 57(12), 3363-7, database is CAplus.

Adsorption effects of urea; 1,1-dimethylurea; tetramethylurea; thiourea; 1,1-dimethylthiourea; and tetramethylthiourea on electrode kinetics were studied by using the electrode reactions of Zn²⁺/Zn(Hg) and Eu³⁺/Eu²⁺. The standard rate constant for Zn²⁺/Zn(Hg) is controlled by the inner-layer permittivity. The effect of this permittivity is explained in terms of the solvent reorganization energy. The effect of the adsorbates on the electrode kinetics of Eu³⁺/Eu²⁺ cannot be explained in terms of the inner layer permittivity. These 2 results suggest different locations for the formation of the activated complex: inside the adsorption layer for Zn²⁺ and just outside the layer for Eu³⁺.

Bulletin of the Chemical Society of Japan published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Name: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jacquemin, Denis published the artcileAb initio investigation of the n ¡ú ¦Ð transitions in thiocarbonyl dyes, Quality Control of 6972-05-0, the publication is Journal of Physical Chemistry A (2006), 110(29), 9145-9152, database is CAplus and MEDLINE.

The n ¡ú ¦Ð* transitions in more than 100 thiocarbonyl dyes have been calculated with an ab initio procedure relying on the combination of time-dependent d. functional theory for evaluating excited states and the polarizable continuum model for modeling the bulk solvent effects on both the geometrical and electronic structures. Two hybrid functionals (B3LYP and PBE0) and several basis sets, some including f polarization functions, have been used. B3LYP provides the most accurate raw estimates, but once simple linear regression is performed, both functionals give similar results with a small advantage for PBE0. By use of the latter, the mean absolute deviation with respect to experiment is limited to 0.06 eV whereas less than 20% of the estimates differ from absorption data by more than 0.10 eV. To assess the validity limits of our model, compounds containing multiple C:S chromophores have also been considered.

Journal of Physical Chemistry A published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Quality Control of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Milosavljevic, Milutin M. published the artcileOptimization of the synthesis of N-alkyl and N,N-dialkyl thioureas from waste water containing ammonium thiocyanate, Computed Properties of 6972-05-0, the publication is Chemical Industry & Chemical Engineering Quarterly (2015), 21(4), 501-510, database is CAplus.

The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work. Thioureas synthesis was developed in two ways: Method I – reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II – reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, ¹H- and ¹³C-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatog. method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of byproducts and technol. applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacol. active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technol. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods.

Chemical Industry & Chemical Engineering Quarterly published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Utinan, M. F. published the artcileSynthesis and properties of 2-amino-5-(3,5,6-trichloro-1,4-benzoquinon-2-yl)thiazoles, Related Products of catalysis-chemistry, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1988), 692-8, database is CAplus.

Thiazoles (in the form of betaines) I (R² = Me, R³ = H, Me, Ph, allyl, Ac; R² = Et, R³ = Me) were prepared in 76-99% yields from benzoquinones II (R¹ = Et) via an intermediate coumaran III by treatment with appropriate thioureas in EtOH or from I (R¹ = Et) and thioureas in dioxane containing concentrated HCl.H₂O. Treating I with FeCl₃.6H₂O in aqueous DMF gave 75-95% benzoquinones IV.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C12H14O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sterk, G. J. published the artcileStudies on histaminergic compounds. Part II. Synthesis and histamine H₂-activity of dimaprit and some of its analogs, Synthetic Route of 6972-05-0, the publication is European Journal of Medicinal Chemistry (1984), 19(6), 545-50, database is CAplus.

By measuring the histamine H₂-activity of dimaprit??[65119-89-3] at the isolated right atrium of the guinea-pig at pH 7.0 and 7.5 it was found that a monocation of dimaprit is the active species. Taking into account the necessary proton transfer it was concluded this is probably the monocation protonated at the amino group. Addnl., some dimaprit analogs were prepared and it was found that although some substituents at the amidino part of dimaprit and quaternization of the amino group gave an increase in the desired protonated form, any change in the structure of dimaprit resulted in an undetectable level of the histamine H₂-activity.

European Journal of Medicinal Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C8H14O2, Synthetic Route of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shukuri, Miho published the artcileEx vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS, Application In Synthesis of 6972-05-0, the publication is Biochemical and Biophysical Research Communications (2021), 101-106, database is CAplus and MEDLINE.

Neuroinflammation and oxidative stress are hallmarks of neurodegenerative diseases. Microglia, the major important regulators of neuroinflammation, are activated in response to excessive generation of reactive oxygen species (ROS) from damaged cells and resulting in elevated and sustained damages. However, the relationship between microglia and ROS-regulatory system in the early stages of neuroinflammation prior to the appearance of neuronal damages have not been elucidated in detail. In this study, we analyzed the time-dependent changes in ROS generation during acute neuroinflammation in rats that were given an intrastriatal injection of lipopolysaccharide (LPS). We evaluated the effects of minocycline, an anti-inflammatory antibiotic, and N,N-dimethylthiourea (DMTU), a radical scavenger, to understand the correlation between activated microglia and ROS generation. Ex vivo fluorescence imaging using dihydroethidium (DHE) clearly demonstrated an increased ROS level in the infused side of striatum in the rats treated with LPS. The level of ROS was changed in time-dependent manner, and the highest level of ROS was observed on day 3 after the infusion of LPS. Immunohistochem. studies revealed that time-dependent changes in ROS generation were well correlated to the presence of activated microglia. The inhibition of microglial activation by minocycline remarkably reduced ROS levels in the LPS-injected striatum, which indicated that the increased ROS generation caused by LPS was induced by activated microglia. DMTU decreased ROS generation and resulted in remarkable inhibitory effect on microglial activation. This study demonstrated that ROS generation during acute neuroinflammation induced by LPS was considerably associated with microglial activation, in an intact rat brain. The results provides a basis for understanding the interaction of ROS-regulatory system and activated microglia during neuroinflammation underlying neurodegenerative diseases.

Biochemical and Biophysical Research Communications published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C7H16Cl2Si, Application In Synthesis of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Batenko, N. G. published the artcileSynthesis of 2,5-bis(2-aminothiazol-5-yl)-3,6-dichloro-1,4-benzoquinones, Application of 1,1-Dimethylthiourea, the publication is Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) (2000), 36(6), 733-737, database is CAplus.

A series of 2-(2-aminothiazol-5-yl)-3,6-dichloro-5-diethylaminoethenyl-1,4-benzoquinones was synthesized from 2-(2-aminothiazol-5-yl)-3,5,6-trichloro-1,4-benzoquinones using acetaldehyde and diethylamine in toluene solution Refluxing these compounds with substituted thioureas in acetonitrile in the presence of hydrochloric acid gives the corresponding 2,5-bis(2-aminothiazol-5-yl)-3,6-dichlorohydroquinones which can be oxidized to the target products with ferric chloride in aqueous DMF.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia