Category: 6972-05-0

Susnik, Marko P. published the artcileSynthesis of novel 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines as potential protein kinase inhibitors, Safety of 1,1-Dimethylthiourea, the publication is Monatshefte fuer Chemie (2009), 140(4), 423-430, database is CAplus.

A short and efficient sequence for the synthesis of a series of 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines I [R¹ = Ph, 4-MeOC₆H₄; R² = MeNH, Me₂N, H₂N; Ph, 3-MeOC₆H₄, 3-(MeCO)C₆H₄] was developed. 1-Phenyl-2-(4-pyrimidinyl)ethanones, obtained via Weinreb’s methodol., were used in a Hantzsch thiazole cyclization reaction, followed by introduction of the aniline moieties via nucleophilic substitution. Graphical abstract

Monatshefte fuer Chemie published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C15H24BN3O2, Safety of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yavari, Issa published the artcileA one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from thioamides or thioureas and 2-chloro-1,3-dicarbonyl compounds in an ionic liquid, Computed Properties of 6972-05-0, the publication is Monatshefte fuer Chemie (2009), 140(2), 209-211, database is CAplus.

A simple one-pot synthesis of functionalized Et 1,3-thiazole-5-carboxylates from the reaction of 2-chloro-1,3-dicarbonyl compounds with thioureas or thioamides in the presence of 1-butyl-3-methylimidazolium trifluoromethanesulfonate was described.

Monatshefte fuer Chemie published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C30H24BrCuN2P, Computed Properties of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kocabas, Erdal published the artcileA rapid and high-yielding synthesis of thiazoles and aminothiazoles using tetrabutylammonium salts, Category: catalysis-chemistry, the publication is Heterocycles (2010), 81(12), 2849-2854, database is CAplus.

A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of Bu₄NPF₆ at room temperature was developed. The products were formed rapidly within 15 min in high yields. The method is simple, rapid, and practical, generating thiazoles in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, ¹H NMR, ¹³C NMR, and elemental anal.

Heterocycles published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dwarakanath, K. published the artcileAssignments for the fundamental vibrations of N,N-dimethylthiourea and N,N-dimethylselenourea, Synthetic Route of 6972-05-0, the publication is Indian Journal of Pure and Applied Physics (1979), 17(3), 171-5, database is CAplus.

The IR spectra of Me₂NC(S)NH₂ (I) and Me₂NC(Se)NH₂ (II) and their N-deuterated and S-Me derivatives were measured between 4000 and 30 cm^-1. The fundamental frequencies of I and II were assigned and supported by normal coordinate calculations for the in-plane and out-of-plane modes of I–d₀ and –d₂. The coordinate treatment was extended to the in-plane vibrations of I–d₀ and –d₂ by introducing min. changes in transferring the force constants from I.

Indian Journal of Pure and Applied Physics published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Synthetic Route of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kar, Supratik published the artcileQSAR modeling of toxicity of diverse organic chemicals to Daphnia magna using 2D and 3D descriptors, SDS of cas: 6972-05-0, the publication is Journal of Hazardous Materials (2010), 177(1-3), 344-351, database is CAplus and MEDLINE.

One of the major economic alternatives to exptl. toxicity testing is the use of quant. structure-activity relationships (QSARs) which are used in formulating regulatory decisions of environmental protection agencies. In this background, we have modeled a large diverse group of 297 chems. for their toxicity to Daphnia magna using mechanistically interpretable descriptors. Three-dimensional (3D) (electronic and spatial) and two-dimensional (2D) (topol. and information content indexes) descriptors along with physicochem. parameter log K _o/w (n-octanol/water partition coefficient) and structural descriptors were used as predictor variables. The QSAR models were developed by stepwise multiple linear regression (MLR), partial least squares (PLS), genetic function approximation (GFA), and genetic PLS (G/PLS). All the models were validated internally and externally. Among several models developed using different chemometric tools, the best model based on both internal and external validation characteristics was a PLS equation with 7 descriptors and three latent variables explaining 67.8% leave-one-out predicted variance and 74.1% external predicted variance. The PLS model suggests that higher lipophilicity and electrophilicity, less neg. charge surface area and presence of ether linkage, hydrogen bond donor groups and acetylenic carbons are responsible for greater toxicity of chems. The developed model may be used for prediction of toxicity, safety and risk assessment of chems. to achieve better ecotoxicol. management and prevent adverse health consequences.

Journal of Hazardous Materials published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, SDS of cas: 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Govers, H. published the artcileExperimental determination and prediction of partition coefficients of thioureas and their toxicity to Photobacterium phosphoreum, Product Details of C3H8N2S, the publication is Chemosphere (1986), 15(4), 383-93, database is CAplus.

The partition coefficients between n-octanol and water of 11 thioureas (e.g., thiourea??[62-56-6] and N-methylthiourea??[598-52-7]) were determined via the shake-flask method. Moderately high to high correlation coefficients were calculated for the linear correlation between these partition coefficients and HPLC capacity factors, mol. connectivity indexes, Rekker partition coefficients, and mol. weight The combined ¹¦Ö^v plus ⁵¦Ö^vCH/⁶¦Ö^vCH (ring-) connectivity indexes were the best predictors. A crude Rekker fragmental value of 2.72 was derived for the thioureic fragment (NCSN). The toxicities of 10 thioureas to P. phosphoreum, determined via the microtox test, appeared to be correlated moderately high to partition coefficients as well as HPLC capacity factors, mol. connectivity, and mol. weight

Chemosphere published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Product Details of C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Zongchao published the artcileFTIR study of novel palladium trimethylphosphine carbonyl clusters encaged in zeolite Y, HPLC of Formula: 6972-05-0, the publication is Polyhedron (1991), 10(7), 673-81, database is CAplus.

Green Pd(Me₃P)(CO)₂ (TMPC) clusters in zeolite Y were prepared using a ship-in-a-bottle method. Me₃P (TMP) ligands stabilize Pd clusters of small nuclearity; they preferentially coordinate to the corner Pd atoms. Absorption bands of triply-bonded CO (1886 cm^-1) are observed only for samples with initially large Pd nuclearity (x > 4). Bands at 1960 and 1950 cm^-1, attributed to doubly-bonded CO in a butterfly configuration, dominate the IR spectra. The Pd core in Pd TMPC clusters is electron-rich, in comparison to Pd single crystals, due to electron donation from phosphorus to the Pd. The spectra of the zeolite encaged clusters differ from those reported for PdR₃P (R = alkyl) such as Et and Bu) clusters in solution with nuclearity varying 4-38. Zeolite encaged Pd TMPC clusters are stable at 200¡ã in a flow of H₂ + CO. At 300¡ã, the TMP ligands decompose and poison the Pd particles.

Polyhedron published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C10H10O2, HPLC of Formula: 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Schroth, Werner published the artcileSynthesis and chemical behavior of 6-sec-amino-1,3-thiazine-2-thiones, Application In Synthesis of 6972-05-0, the publication is Monatshefte fuer Chemie (1988), 119(4), 463-76, database is CAplus.

The title compounds I (R = H, Me, OMe, Cl, Br; NR¹R² = pyrrolidino, piperidino, morpholino) have been prepared by ring transformation reactions of the isomeric 2-sec-amino-1,3-thiazine-6-thiones II (NR³R⁴ = NMe₂, pyrrolidino, morpholino) via R²R¹NCSCH:C(C₆H₄R-4)NHCSNR³R⁴ (III) and via cyclocondensation reactions of thiocarboxamides R²R¹NCSCH:C(C₆H₄R-4)NH₂, and R²R¹N⁺:CClCH:C(C₆H₄R-4)OEt BF₄^– obtained from 4-RC₆H₄COCH:CCl₂. The pathways differ specifically in scope and limitations. On the other hand III also react with alkylating agents to give 2,6-di-sec-amino-1,3-thiazinium salts, which are also available via alkylation of I and aminolysis.

Monatshefte fuer Chemie published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application In Synthesis of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ariyo Olusegun, Moses published the artcileUnderstanding the role of flexible alkyl-¦Á,¦Ø-diamine linkers on the substitution behavior of dinuclear trans-platinum(II) complexes: A kinetic and mechanistic study, Formula: C3H8N2S, the publication is Inorganica Chimica Acta (2021), 120420, database is CAplus.

An investigation of the role of flexible alkyl-¦Á,¦Ø-diamine linkers on the substitution behavior of dinuclear trans-platinum(II) complexes. The substitution reactions of four dinuclear trans-platinum(II) complexes viz. [[PtNH₃Cl₂]₂-¦Ì-NH₂(CH₂)₂NH₂] (P12), [[PtNH₃Cl₂]₂-¦Ì-NH₂(CH₂)₃NH₂] (P13), [[PtNH₃Cl₂]₂-¦Ì-NH₂(CH₂)₄NH₂] (P14) and [[PtNH₃Cl₂]₂-¦Ì-NH₂(CH₂)₅NH₂] (P15) with three neutral thiourea-based nucleophiles specifically: thiourea (TU), N-methyl-2-thiourea (MTU) and N,N-dimethyl-2-thiourea (DMTU) were studied quant. under pseudo-first-order condition as function of concentration and temperature by conventional UV-Visible and stopped-flow spectrophotometers. The ligand substitution reaction of the complexes proceeds in veritably three consecutive steps. Each step follows first-order kinetics with the resp. complex and nucleophile. The pseudo first order rate constants, ko_bs(₁/₂/₃), for sequential substitution of the chlorido ligands, the ammine, and subsequent displacement of the linker obeyed the rate law: ko_bs(₁/₂/₃) = k(₁/₂/₃)[NU]. The ligand substitution reactions were driven by both electronic and steric factors. However, our findings revealed that upon the substitution of the chlorido ligands by the nucleophiles at the platinum centers, the ¦Ò-donor capacity via inductive effect of these electron-rich nucleophiles over compensate the steric strain imposed by the nucleophiles and by the alkanediamine linker at the substitution sites. Consequently, electronic factors governed the overall reaction pattern of these complexes. ¹⁹⁵Pt NMR results confirmed the simultaneous substitution of all the chlorido ligands by thiourea-based nucleophiles, followed by the subsequent but successive displacement of the ammine groups and the flexible alkanediamine linker from the metal centers. The order of reactivity of the nucleophiles with the complexes decreases with the increase in steric bulk in the nucleophiles: TU > MTU > DMTU. The small pos. enthalpy and the large but neg. entropy confirm the associative mode of activation for all the studied complexes. Computational modeling using d. functional theory (DFT) calculations was employed to rationalize the kinetic trends.

Inorganica Chimica Acta published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reddy, N. Koteeswara published the artcileElectrical properties of spray pyrolytic tin sulfide films, Application of 1,1-Dimethylthiourea, the publication is Solid-State Electronics (2005), 49(6), 902-906, database is CAplus.

Tin sulfide (Sn_xS_y) films were prepared using spray pyrolysis technique at different substrate temperatures (T_s), (100-450¡ãC) on Corning 7059 glass substrates. The phys. parameters such as elec. resistivity, Hall mobility and net carrier d. of the films were determined at room temperature The films grown in the substrate temperature range, 300-375¡ãC, were found to be p-type conducting. These SnS films showed average elec. resistivity of ?30 ¦¸ cm, Hall mobility of ?130 cm²/V s and carrier d., >10¹⁵ cm^-3. The temperature dependence of elec. conductivity of the films was also studied and the activation energies evaluated. The results obtained were discussed and reported.

Solid-State Electronics published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia