Category: 6972-05-0

Moosus, M. published the artcileQuantitative structure-activity relationship analysis of acute toxicity of diverse chemicals to Daphnia magna with whole molecule descriptors, COA of Formula: C3H8N2S, the publication is SAR and QSAR in Environmental Research (2011), 22(7-8), 757-774, database is CAplus and MEDLINE.

Quant. structure-activity relationship anal. and estimation of toxicol. effects at lower-mid trophic levels provide first aid means to understand the toxicity of chems. Daphnia magna serves as a good starting point for such toxicity studies and is also recognized for regulatory use in estimating the risk of chems. The ECOTOX database was queried and analyzed for available data and a homogeneous subset of 253 compounds for the endpoint LC50 48 h was established. A four-parameter quant. structure-activity relationship was derived (coefficient of determination, r² = 0.740) for half of the compounds and internally validated (leave-one-out cross-validated coefficient of determination, r²_cv = 0.714; leave-many-out coefficient of determination, r²_LMO = 0.738). External validation was carried out with the remaining half of the compounds (coefficient of determination for external validation, r²_ext = 0.634). Two of the descriptors in the model (log P, average bonding information content) capture the structural characteristics describing penetration through bio-membranes. Another two descriptors (energy of HOMO, weighted partial neg. surface area) capture the electronic structural characteristics describing the interaction between the chem. and its hypothetic target in the cell. The applicability domain was subsequently analyzed and discussed.

SAR and QSAR in Environmental Research published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, COA of Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Haglund, Aasa C. published the artcileHydrophobic and polar contributions to solute affinity for a highly crosslinked water-swollen (sephadex) gel, SDS of cas: 6972-05-0, the publication is Journal of Polymer Science, Polymer Letters Edition (1980), 18(4), 271-9, database is CAplus.

Adsorption affinity was studied on Sephadex gels, which are commonly used in gel chromatog. The studies support the hypothesis of a hydrophobic interaction in the adsorption of nonpolar and weakly polar aliphatic solutes, suggest that ¦Ð electrons in the solute promote affinity, suggest that a reduced affinity in hydroxyl derivatives of paraffins is caused by lowered hydrophobicity due to the polarity of the OH group, show that there are stringent demands on solute structure if mol. sieve behavior is to be manifest, and also show that, whereas the gel has an affinity for hydrocarbons, both aliphatic and aromatic, it does not prefer the latter; a higher aromatic affinity requires an addnl. condition. The studies included distribution coefficients, heat of adsorption, entropy of adsorption, and free energy of adsorption. The compounds studied included hydrocarbons, aldehydes, alcs., phenols, ketone, amides, urea derivatives, and thiourea derivatives

Journal of Polymer Science, Polymer Letters Edition published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, SDS of cas: 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Calixto-Rodriguez, M. published the artcileStructural, optical, and electrical properties of tin sulfide thin films grown by spray pyrolysis, Application In Synthesis of 6972-05-0, the publication is Thin Solid Films (2009), 517(7), 2497-2499, database is CAplus.

Sn sulfide (SnS) thin films have been prepared by spray pyrolysis (SP) technique using Sn chloride and N,N-dimethylthiourea as precursor compounds Thin films prepared at different temperatures have been characterized using several techniques. X-ray diffraction studies showed that substrate temperature (T _s) affects the crystalline structure of the deposited material as well as the optoelectronic properties. The calculated optical band gap (E_g) value for films deposited at T_s = 320-396¡ã was 1.70 eV (SnS). Addnl. phases of SnS₂ at 455¡ã and SnO₂ at 488¡ã were formed. The measured elec. resistivity value for SnS films was ?1 ¡Á 10⁴ ¦¸-cm.

Thin Solid Films published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application In Synthesis of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Barolli, Joao P. published the artcileHeteroleptic tris-chelate ruthenium(II) complexes of N,N-disubstituted-N’-acylthioureas: Synthesis, structural studies, cytotoxic activity and confocal microscopy studies, Product Details of C3H8N2S, the publication is Polyhedron (2017), 33-41, database is CAplus.

Ruthenium complexes were assessed as antitumor agents against cancer cells. In this project, new heteroleptic Ru(II) complexes [Ru(L)(bipy)(dppb)](PF₆) (L = N,N-disubstituted-N’-acylthiourea, bipy = 2,2′-bipyridine and dppb = 1,4-bis(diphenylphosphino)butane) were synthesized and characterized by elemental anal., IR and NMR (¹H and ³¹P{¹H}) spectroscopies, molar conductivity measurements and single crystal x-ray diffractometry. The IR and NMR data suggest the coordination of the ligands to the Ru(II) metal center through the thiocarbonyl and carbonyl groups. The structures of the new complexes were further studied by x-ray crystallog., which confirmed the coordination of the ligands with the metal through the S and O atoms, giving distorted octahedral complexes. The N,N-disubstituted-N’-acylthioureas and their complexes were screened with respect to their in vitro cytotoxicity. All compounds exhibited considerable antiproliferative activity against MCF-7 (human breast tumor cells ATCC HTB-26), DU-145 (human prostate tumor cells ATCC HTB-26), and relatively low toxicity against fibroblast L929 cells (health cell line from mouse ATCC CCL-1). A preliminary study regarding the mechanism of action of these compounds by confocal microscopy shows alterations of the actin filaments leading to modifications in cytoskeletal supporting the cell death and that the cell nucleus is not the main target of these complexes.

Polyhedron published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Product Details of C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Holte, Dane published the artcileEvaluation of PNU-159682 antibody drug conjugates (ADCs), Recommanded Product: 1,1-Dimethylthiourea, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(24), 127640, database is CAplus and MEDLINE.

PNU-159682 I is a highly potent secondary metabolite of nemorubicin belonging to the anthracycline class of natural products. Due to its extremely high potency and only partially understood mechanism of action, it was deemed an interesting starting point for the development of a new suite of linker drugs for antibody drug conjugates (ADCs). Structure-activity relationships were explored on the small mol. which led to six linker drugs being developed for conjugation to antibodies. Herein we describe the synthesis of novel PNU-159682 derivatives and the subsequent linker drugs as well as the corresponding biol. evaluations of the small mols. and ADCs.

Bioorganic & Medicinal Chemistry Letters published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Elenich, O. V. published the artcileSynthesis of nitrogen-containing heterocycles on the basis of 3-(4-acetylphenyl)-1-methylquinolin-2(1H)-one, Application In Synthesis of 6972-05-0, the publication is Russian Journal of Organic Chemistry (2016), 52(3), 373-378, database is CAplus.

The Meerwein reaction of 1-methylquinolin-2(1H)-one with 4-acetylbenzenediazonium chloride gave 3-(4-acetylphenyl)-1-methylquinolin-2(1H)-one which was brominated to 3-[4-(2-bromoacetyl)phenyl]-1-methylquinolin-2(1H)-one. The latter reacted with pyridine, 4-methylpyridine, quinoline, benzo[f]quinoline, and triphenylphosphine to afford the corresponding quaternary salts, and its reactions with thioacetamide, thiourea, 2-aminopyridine, and 2-aminopyrimidine led to the corresponding thiazole, imidazo[1,2-a]pyridine, and imidazo[1,2-a]pyrimidine derivatives containing a 2-oxoquinoline fragment. 3-(4-[2-[2-(arylmethylidene)-hydrazinyl]-1,3-thiazol-4-yl]phenyl)-1-methylquinolin-2(1H)-ones were obtained by condensation of 3-[4-(2-bromoacetyl)phenyl]-1-methylquinolin-2(1H)-one with thiosemicarbazide and aromatic aldehydes.

Russian Journal of Organic Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application In Synthesis of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Forlani, Luciano published the artcileMechanism of the formation of 1,2,4-thiadiazoles by condensation of aromatic thioamides and of N-substituted thioureas, Application of 1,1-Dimethylthiourea, the publication is Journal of Heterocyclic Chemistry (2000), 37(1), 63-69, database is CAplus.

The condensation reaction of thiobenzamide (as well as thionicotinamide and isothionicotinamide) in the presence of DMSO and of an acid affords 3,5-diphenyl-1,2,4-thiadiazole. Under the same exptl. conditions, N-substituted thioureas are also condensed to 1,2,4-thiadiazole derivatives; their structure is ascertained by spectroscopic properties and by X-ray diffraction. Some information on the mechanism of thiadiazole formation from both starting classes of compounds, thiobenzamides and N-substituted thiourea, is collected and discussed.

Journal of Heterocyclic Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ahmed, Shamshad published the artcilePurines, pyrimidines, and imidazoles. Part XLIV. Syntheses of some dihydro-1,3-oxazine derivatives and related substituted uracils, COA of Formula: C3H8N2S, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1976), 1969-75, database is CAplus and MEDLINE.

The oxazinedione I (R = Me, R1 = R2 = H, X = O) (II) was prepared from MeCOCH2CO2Et by reaction with CO(NHR3)2 (R3 = Me, Et) in AcOH-Ac2O, or by heating with H2NCO2Et in the presence or absence of solvent. II was also prepared by heating MeCOCH2CONHR3 (III; R3 = CO2Et), or by heating III (R3 = CONMe2) with AcOH-Ac2O or H2SO4; its structure was confirmed by 1H and 13C NMR spectroscopy. Similar treatment of various ¦Â-oxo esters, including C-methyl and C-benzyl derivatives, with H2NCO2Et and with CO(NHMe)2 gave 6-aryl- and 6-alkyloxazinediones and 5,6-dialkyloxazinediones. E.g. 4-FC6H4COCH2CO2Et with CO(NHMe)2 in AcOH-Ac2O at reflux for 4 hr gave I (R = 4-FC6H4, R1 = R2 = H, X = O) whereas similar treatment of H2NCO2Et with MeCOCHMeCO2Et gave I (R = R1 = Me, R2 = H, X = O). Treatment of the oxazinediones I (X = O) with ammonia and with primary amines gave substituted uracils, whereas with secondary amines, acylated ureas were obtained. E.g. II with NH3, MeNH2, and NH2OH gave the corresponding substituted uracils I (R = Me, R1 = R2 = H, X = NH, NMe, NOH, resp.) and with H2NCH2CO2H, the acylated urea I (R = Me, R1 = R2 = H, X = NCH2CO2H) was obtained. II dimerized on heating with NaOH to give (6-hydroxy-4-methyl-2-pyridyl)acetic acid.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, COA of Formula: C3H8N2S.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mao, Zhenkun published the artcileStrong hydrophilic monolithic column functionalized with amphiphilic benzyl quinine for capillary electrochromatography and application in pharmaceutical analysis, Safety of 1,1-Dimethylthiourea, the publication is Journal of Chromatography A (2020), 461031, database is CAplus and MEDLINE.

An innovative strong hydrophilic organic polymer monolithic column of poly(N-benzylquininium chloride-co-1, 3, 5-triacryloylhexahydro-1, 3, 5-triazine) (poly(NBQ-co-TAT)) has been successfully synthesized through in situ copolymerization for capillary electrochromatog. The amphiphilic monomer NBQ and the strong polar crosslinker TAT are firstly used in hydrophilic electrochromatog. by taking advantage of the exhibition of hydrophilicity at lower levels of organic solvent and ease formation of porous structure. The monolithic column poly(NBQ-co-TAT) shows powerful hydrophilic selectivity with mobile phase containing more than 60% organic solvent. The introduction of NBQ and TAT enlarges the sources of functional monomers and crosslinkers for HILIC. Due to the presence of the pos. charged group in NBQ, an anodic electroosmotic flow is generated with the change of pH values from 2.0 to 12.0. The monolithic column was used for the separations of thioureas, phenols, xanthines, nucleobases, acidic substances and pharmaceuticals. The highest column efficiency for N, N¡ä-dimethylthiourea is 1.15 ¡Á 10⁵ N m^-1. The application of the monolithic column for a real sample, cytochrome C digestion indicates its great potential in practical application.

Journal of Chromatography A published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Safety of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zou, Peihui published the artcileDirect current exerts electricidal and bioelectric effects on Porphyromonas gingivalis biofilms partially via promoting oxidative stress and antibiotic transport, Safety of 1,1-Dimethylthiourea, the publication is Journal of Microbiology (Seoul, Republic of Korea) (2022), 60(1), 70-78, database is CAplus and MEDLINE.

Low elec. current can inhibit certain microbial biofilms and enhance the efficacy of antimicrobials against them. This study investigated the electricidal and bioelec. effects of d.c. (DC) against Porphyromonas gingivalis biofilms as well as the underlying mechanisms. Here, we firstly showed that DC significantly suppressed biofilm formation of P. gingivalis in time- and intensity-dependent manners, and markedly inhibited preformed P. gingivalis biofilms. Moreover, DC enhanced the killing efficacy of metronidazole (MTZ) and amoxicillin with clavulanate potassium (AMC) against the biofilms. Notably, DC-treated biofilms displayed upregulated intracellular ROS and expression of ROS related genes (sod, feoB, and oxyR) as well as porin gene. Interestingly, DC-induced killing of biofilms was partially reversed by ROS scavenger N-dimethylthiourea (DMTU), and the synergistic effect of DC with MTZ/AMC was weakened by small interfering RNA of porin gene (si-Porin). In conclusion, DC can exert electricidal and bioelec. effects against P. gingivalis biofilms partially via promotion of oxidative stress and antibiotic transport, which offers a promising approach for effective management of periodontitis.

Journal of Microbiology (Seoul, Republic of Korea) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C4H10O2, Safety of 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia