Tag: M.W=200-250

Li, Nian published the artcileA highly selective decarboxylative deuteration of carboxylic acids, Related Products of catalysis-chemistry, the publication is Chemical Science (2021), 12(15), 5505-5510, database is CAplus and MEDLINE.

A mild and practical method for precise deuteration of aliphatic carboxylic acids by synergistic photoredox and HAT catalysis was reported. The reaction delivered excellent D-incorporation (up to 99%) at predicted sites even in substrates bearing reactive C-H bonds or versatile functional groups. The use of a recirculation reactor with a peristaltic pump supports a scalable preparative ability (up to 50 mmol) under very mild reaction conditions. The practical and precise deuteration of readily available complex carboxylic acids made this protocol promising for the preparation of deuterium-labeled compounds

Chemical Science published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nishimura, Takahiro published the artcilePalladium-Catalyzed Transformation of Cyclobutanone O-Benzoyloximes to Nitriles via C-C Bond Cleavage, Computed Properties of 4141-48-4, the publication is Journal of Organic Chemistry (2004), 69(16), 5342-5347, database is CAplus and MEDLINE.

Pd-catalyzed transformation of cyclobutanone O-benzoyloximes to a variety of nitriles is described. The reaction may proceed via two important steps, i.e., (i) oxidative addition of the N-O bond of oximes to Pd(0) to give a cyclobutylideneaminopalladium(II) species and (ii) ¦Â-C elimination of this species to afford a reactive alkylpalladium species. The kind of products is very dependent on the nature of substituents on the cyclobutane ring. The direction of the C-C bond cleavage is controlled by the kind of ligand employed. For example, (Z)-2-Allyl-3,3-dibenzylcyclobutanone O-benzoyloxime gave 19/81 and 78/22 2,2-Dibenzyl-4-methylenecyclopentanecarbonitrile and (E)-3,3-Dibenzylhepta-4,6-dienenitrile when two different chiral ligands were used. The sequential reaction composed of the C-C bond cleavage and the subsequent intra- and intermol. C-C bond formations via the corresponding alkylpalladium species is also demonstrated. For example, an oxime having an alkynyl moiety at a suitable position reacts with a variety of alkenes to afford nitriles bearing dienylcyclopentane moiety in moderate to good yields. For example, 50 % [3-[(E,E)-4-(diphenylphosphinyl)-1-phenylbut-2-enylidene]-1-methylcyclopentyl]acetonitrile (characterized by x-ray crystallog.) was obtained from 3-methyl-3-(4-phenylbut-3-ynyl)cyclobutanone O-benzoyloxime and Ph₂P(O)CH₂CH:CH2 in DMF in the presence of K₂CO₃, Pd(dba)₂ and (R)-BINAP.

Journal of Organic Chemistry published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C15H15OP, Computed Properties of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Toyota, Masahiro published the artcileSynthesis of a cancer growth-inhibiting diterpene – stereoselective formal synthesis of (+)-aphidicolin, Product Details of C15H15OP, the publication is Tetrahedron (1996), 52(31), 10347-10362, database is CAplus.

Stereoselective formal synthesis of the diterpene tetraol (+)-aphidicolin is described, employing as key steps the cycloisomerization of the enyne I to provide the bicyclo[3.2.1]octane derivative II and the intramol. Diels-Alder reaction of the triene III to form the aphidicolane-type ring system. This route is, in principal, highly stereocontrolled and extremely efficient.

Tetrahedron published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C9H12BNO4, Product Details of C15H15OP.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Toyota, Masahiro published the artcileEnantioselective total synthetic route to (+)-aphidicolin, Application In Synthesis of 4141-48-4, the publication is Tetrahedron Letters (1995), 36(30), 5379-82, database is CAplus.

Enantioselective total synthetic route to (+)-aphidicolin has been described. Cycloisomerization reaction of I to give II and intramol. Diels-Alder reaction of III to give IV were employed for the key steps of the sequence.

Tetrahedron Letters published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C4H12ClNO, Application In Synthesis of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Toyota, Masahiro published the artcileAn expeditious and efficient formal synthesis of (¡À)-aphidicolin, Application In Synthesis of 4141-48-4, the publication is Tetrahedron Letters (1994), 35(35), 6495-8, database is CAplus.

An expeditious and efficient formal total synthesis of antiviral and antitumor tetracyclic diterpene aphidicolin has been developed. An intramol. Heck reaction and an intramol. Diels-Alder reaction were utilized as key steps in the sequence.

Tetrahedron Letters published new progress about 4141-48-4. 4141-48-4 belongs to catalysis-chemistry, auxiliary class Aryl phosphine ligand,Mono-phosphine Ligands, name is Allyldiphenylphosphine oxide, and the molecular formula is C9H8BNO2, Application In Synthesis of 4141-48-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mutahi, Mwangi Wa published the artcileSilicon-Based Metalloprotease Inhibitors: Synthesis and Evaluation of Silanol and Silanediol Peptide Analogues as Inhibitors of Angiotensin-Converting Enzyme, Recommanded Product: Difluorodiphenylsilane, the publication is Journal of the American Chemical Society (2002), 124(25), 7363-7375, database is CAplus and MEDLINE.

Silanols are best known as unstable precursors of siloxane (silicone) polymers, substances generally considered stable and inert, but have the potential to mimic a hydrated carbonyl and inhibit protease enzymes. While previous testing of simple silanediol and silanetriol compounds as inhibitors of hydrolase enzymes found them ineffective, this study reports the synthesis of peptidomimetics containing a central methylsilanol, -Si(Me)(OH)-, or silanediol, -Si(OH)₂-, group and their assessment as effective transition state analog inhibitors of metalloprotease angiotensin-converting enzyme (ACE). Central to the synthesis strategy, phenylsilanes were employed as acid-hydrolyzable precursors of the silanol group. The N-benzoyl Leu-[SiMeOH]-Gly benzyl amides, PhCONHCH(iso-Bu)Si(Me)(OH)CH₂CH₂CONHBn, proved to be stable and readily characterized. In contrast, the Leu-[Si(OH)₂]-Gly, PhCONHCH(iso-Bu)Si(OH)₂CH₂CH₂CONHBn, structure was difficult to characterize, possibly because of self-association Capping the silanediol with chlorotrimethylsilane gave a well-defined trisiloxane, demonstrating that the silanediol was monomeric. The Leu-[Si]-Gly structures were converted to Leu-[Si]-Ala analogs by enolate alkylation. Coupling of the silanol precursors with L-proline tert-Bu ester, followed by treatment with TFA, gave N-benzoyl Leu-[Si]-Gly-Pro I (R = H; R¹ = Me, OH) and N-benzoyl Leu-[Si]-Ala-Pro I (R = Me; R¹ = Me, OH) tripeptide analogs. Silanediol peptides I (R = H, Me; R¹ = OH) inhibited ACE with IC₅₀ values ¡Ü 14 nM. Methylsilanol peptides I (R = H, Me; R¹ = Me), in contrast, were poor inhibitors, with IC₅₀ values > 3000 nM. These data, including comparisons with inhibition data from peptide carbon analogs II and III, are consistent with binding of the silanediols by chelation of the ACE active site zinc, whereas the methylsilanols ligate poorly.

Journal of the American Chemical Society published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Recommanded Product: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sieburth, Scott McN. published the artcileSilanediols: a new class of potent protease inhibitors, Synthetic Route of 312-40-3, the publication is Angewandte Chemie, International Edition (1998), 37(6), 812-814, database is CAplus and MEDLINE.

The preparation and ACE inhibitor activity of the silanediol-based dipeptide analogs PhC(O)NHCHⁱBuSi(OH)₂CH₂CHRC(O)R¹ (R¹ = (S)-2-carboxy-1-pyrrolidinyl; R = H, Me) are reported.

Angewandte Chemie, International Edition published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C11H21BF4N2O2, Synthetic Route of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Arasappan, Ashok published the artcileP2-P4 Macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease, Synthetic Route of 1860-58-8, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(15), 3960-3965, database is CAplus and MEDLINE.

Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor I bound to the protease is discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Synthetic Route of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shou, Hansen published the artcileFormation of multicolor polymeric objects by laser-initiated photopolymerization, Related Products of catalysis-chemistry, the publication is Journal of Imaging Science and Technology (1995), 39(1), 18-26, database is CAplus.

The formation of multicolor polymeric objects by laser-induced photopolymerization of photocurable compositions is reported. The formation of a colored plastic object results from: (1) a combination of photobleachable initiators that react at different rates as a function of differing wavelengths of irradiation; (2) an indicator and a photoacid-generating compound used in combination with a photocuring process or thereafter; or (3) a photochromic material used in combination with a photopolymerizable monomeric system. The influence of the factors affecting color formation and the photostability of the formed color polymeric film are evaluated.

Journal of Imaging Science and Technology published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C10H16O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Torres-Filho, a. published the artcileMechanical properties of acrylate networks formed by visible laser-induced polymerization. I. Dependence on photopolymerization parameters, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline, the publication is Journal of Applied Polymer Science (1994), 51(5), 931-7, database is CAplus.

The mech. properties of network mol. systems, prepared through visible (Ar⁺) laser-induced polymerization of multifunctional acrylates, were studied as a function of some of the photopolymerization parameters. Acrylate monomers used were 1,6-hexanediol diacrylate, trimethylolpropane triacrylate, dipentaerythritol pentaacrylate, and polyethylene glycol diacrylate. The properties investigated were the Young’s modulus of elasticity and the stress-at-break, both derived from the stress vs. strain test of dogbone-shaped photopolymerized samples. The parameters studied included the fluorone dye and co-initiator concentrations, and the laser power. The authors also compared the mech. properties of samples made using different types of fluorone dyes and using two different amines as co-initiator. Better polymers are formed by dyes with lower fluorescence quantum yield. The three photopolymerization parameters modify the mech. properties in a very similar way: they initially tend to increase both the Young’s modulus and the stress-at-break but have a deleterious effect on the material strength if used in excess. N-phenylglycine used as a co-initiator formed stronger polymers (higher Young’s modulus) than N,N-dimethyl-2,6-diisopropylaniline. The authors discussed possible mol. mechanisms for such observations.

Journal of Applied Polymer Science published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C15H24O2, Recommanded Product: 2,6-Diisopropyl-N,N-dimethylaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia