Tag: M.W=300-350

Zhou, Xinxing published the artcileAdsorption mechanism of polycyclic aromatic hydrocarbons using wood waste-derived biochar, Computed Properties of 191-07-1, the publication is Journal of Hazardous Materials (2022), 128003, database is CAplus and MEDLINE.

The polycyclic aromatic hydrocarbons (PAHs) have been attracted increasing attentions due to their carcinogenicity and teratogenicity. Adsorption is widely considered one of the most potential technologies for PAHs removal. In this study, we prepared two kinds of oxygen-rich biochar derived from waste wood to investigate the PAHs adsorption performance, and the mol. simulation was used to build the 16 priority PAHs, 23 nitrated PAHs, 9 oxygenated PAHs adsorption model. The surface adsorption performance of oxygen-rich biochar significantly depends on the pyrolysis conditions. The main out-comings demonstrated that the adsorption of naphthalene (C10H8) mols. first occurred, and the optimal adsorption positions of oxygen-rich biochar strongly adhered to functional groups of carboxyl and hydroxyl. Moreover, benzene ring, -COOH, and -CH₃ of biochar were the main adsorbed functional groups for PAHs adsorption. The oxygen-rich biochar had the targeted-adsorption effect on PAHs removal especially sym. PAHs, and the targeted-adsorption mechanism was finally proposed. The research is beneficial to guide the removal of PAHs from polluted water and mitigate the environmental pollution caused by biomass waste mismanagement, simultaneously.

Journal of Hazardous Materials published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C16H12O, Computed Properties of 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gong, Qiuyu published the artcileUltrasensitive Fluorescent Probes Reveal an Adverse Action of Dipeptide Peptidase IV and Fibroblast Activation Protein during Proliferation of Cancer Cells, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Analytical Chemistry (Washington, DC, United States) (2016), 88(16), 8309-8314, database is CAplus and MEDLINE.

Dipeptide peptidase IV (DPPIV) and fibroblast activation protein (FAP) are isoenzymes. Evidence shows that DPPIV is related to antitumor immunity, and FAP may be a drug target in cancer therapy, making it seem that the two enzymes might have a synergistic role during the proliferation of cancer cells. Surprisingly, herein, the authors find an adverse action of DPPIV and FAP in the proliferation process by analyzing their changes with two tailor-made ultrasensitive fluorescent probes. First, the up-regulation of DPPIV and down-regulation of FAP in cancer cells under the stimulation of genistein are detected. Then, the authors find that MGC803 cells with a higher FAP but lower DPPIV level than SGC7901 cells exhibit a faster proliferation rate. Importantly, inhibiting the DPPIV expression with siRNA increases the proliferation rate of MGC803 cells, whereas the FAP inhibition decreases the rate. These findings suggest that the two enzymes play an adverse role during the proliferation of cancer cells, which provides the authors a new viewpoint for cancer studies.

Analytical Chemistry (Washington, DC, United States) published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Lihong published the artcileSensitive Fluorescence Probe with Long Analytical Wavelengths for ¦Ã-Glutamyl Transpeptidase Detection in Human Serum and Living Cells, Application In Synthesis of 10510-54-0, the publication is Analytical Chemistry (Washington, DC, United States) (2015), 87(16), 8353-8359, database is CAplus and MEDLINE.

A new sensitive fluorescent probe (I) with long anal. wavelengths for ¦Ã-glutamyl transpeptidase (GGT) assay has been developed by incorporating the ¦Ã-glutamyl group as a recognition unit into the fluorophore of cresyl violet (CV). The detection mechanism of I is based on the GGT-catalyzed cleavage of the ¦Ã-glutamyl group, followed by the release of CV, which leads to a distinct color change from light yellow to pink and a large fluorescence enhancement at 615 nm (¦Ë_ex = 585 nm). Under the optimized conditions, the fluorescence intensity of I is directly proportional to the activity of GGT at 1-50 U/L with a detection limit of 5.6 mU/L. By virtue of its high sensitivity and long anal. wavelengths, I has been used to directly determine GGT in human serum samples from both healthy people and liver cancer patients, and the obtained results accord well with those acquired by com. GGT fluorometric assay kit. I has also been employed to image endogenous GGT in living cells. Notably, with the authors’ probe, the expression level of GGT in HepG2 cells under the action of sodium butyrate (an anticancer drug) was studied by fluorescence confocal microscopy, revealing that sodium butyrate can induce the upregulation of GGT in HepG2 cells in a dose- and time-dependent manner. This behavior of sodium butyrate has further been confirmed by lysate assay and inhibitor experiment I is rather simple and may find a wide use in the determination of GGT in clin. and biol. samples.

Analytical Chemistry (Washington, DC, United States) published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Application In Synthesis of 10510-54-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shyma Mary, Y. published the artcileComputational Study of Sorbic Acid Drug Adsorption onto Coronene/Fullerene/Fullerene-Like X12Y12 (X = Al, B and Y = N, P) Nanocages: DFT and Molecular Docking Investigations, Category: catalysis-chemistry, the publication is Journal of Cluster Science (2022), 33(4), 1809-1819, database is CAplus.

Adsorption of the sorbic acid drug onto the surface of coronene/fullerene/fullerene like nanocages was investigated by theor. calculations Our results showed that the sorbic acid drug connects the nanoclusters through oxygen and hydrogen atoms. Due to the adsorption of the sorbic acid drug, there are significant changes in chem. descriptors and nonlinear optical properties. Energy gap values of all nanocluster systems are reduced, resulting in enhance in the conductivity of systems except for fullerene. All complex¡äs UV visible wavenumber is blue-shifted and especially for coronene and fullerene complex, the values are very high. The enhancement for different functional group wavenumbers in the Raman spectrum indicates that it is possible to make a nanocage sensor for the detection of these compounds using surface-enhanced Raman scattering (SERS). Docking gives good values of at. contact energies and suitable for drug delivery.

Journal of Cluster Science published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C15H10O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hajjami, Maryam published the artcileSynthesis and Characterization of Magnetic Functionalized Ni and Cu Nano Catalysts and Their Application in Oxidation, Oxidative Coupling and Various Multi-Component Reactions, Computed Properties of 119-80-2, the publication is Catalysis Letters (2021), 151(8), 2420-2435, database is CAplus.

Two magnetic nano catalysts of nickel and copper, Fe₃O₄@SiO₂@DOP-BenPyr-M(II), (M=Ni and Cu) have been synthesized. These catalysts were applied as recoverable, efficient and new heterogeneous catalysts for the high yielding and room temperature one-pot procedure of selective oxidation of sulfides to sulfoxides and oxidative coupling of thiols to disulfides. In addition, the catalytic activity of Fe₃O₄@SiO₂@DOP-BenPyr-Ni(II) was investigated as heterogeneous nanocatalyst for synthesis of 2,3-dihydroquinazolin-4(1H)-ones, 5-substituted 1H-tetrazoles and polyhydroquinolines. The synthesized catalysts were characterized by FT-IR, TGA, XRD, VSM, EDX, ICP and SEM techniques. These catalysts were recovered by an external magnet and reused several times without significant loss of catalytic efficiency.

Catalysis Letters published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Computed Properties of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Lihua published the artcileInclusion of guest materials in aqueous coordination network shells spontaneously generated by reacting 2,5-dimercapto-1,3,4-thiadiazole with nanoscale metallic silver, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is RSC Advances (2014), 4(65), 34294-34302, database is CAplus.

Noble metal nanoparticles (NPs) are spontaneously enfolded by aqueous coordination networks generated by reacting 2,5-dimercapto-1,3,4-thiadiazole (DMcT) with Ag nanostructures in zero-oxidation state, and finally form novel hollow Au@Ag@infinite coordination polymers core-shell nanostructures (Au@Ag@void@ICPs). In this synthesis, DMcT mols. not only act as the bridging ligands but also directly oxidize Ag⁰ to Ag⁺ ions for the formation of amorphous DMcT-Ag ICPs. And, the sizes of the shell and void of Au@Ag@void@ICPs can be facilely tuned by modulating the amount of DMcT and the size ratio of Au@Ag NPs, resp. Due to the high structural tailorability of DMcT-Ag ICPs, multi-encapsulation of Au@Ag NPs with either small organic mols. or biol. macromols. (e.g., enzymes) can be achieved to fabricate multi-functional core-shell nanostructures. A case in point is that a highly sensitive biosensor of H₂O₂ with a wider detection window was constructed based on the prepared metal NPs-ICPs-enzyme composites and resonance Raman scattering. This study provides not only a new template for tailoring hollow core-shell nanomaterials but also a versatile platform for chem. (bio) sensing.

RSC Advances published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is 0, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kulkarni, Anand R. published the artcileDevelopment of a sensor for thiosalicylic acid at MWCNT modified gold, Name: 2,2′-Dithiodibenzoic acid, the publication is Materials Today: Proceedings (2019), 18(Part_3), 723-730, database is CAplus.

Development of nano level based sensor for the electrochem. performance of thiosalicylic acid by fabrication of multiwalled carbon nanotubes on glassy carbon electrode was made. Employing cyclic voltammetry and square wave voltammetry techniques in pH 4.2 phosphate buffer solution, parameters effect was estimated by varying pH, accumulation time, scan rate, excipients, and analyte concentration Number of electrons, protons involved in the reactions and also heterogeneous rate constant value was determined The proposed sensor was applied for the determination of analyte in pharmaceutical and human urine samples. The linear response was obtained in the concentration range studied with lower quantification limit value. Reaction mechanism for electrochem. oxidation of thiosalicylic acid was proposed. The modified sensor showed an excellent sensitivity, reproducibility, repeatability etc.

Materials Today: Proceedings published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Name: 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khan, Sadiq Noor published the artcilePeptide conjugates of 18¦Â-glycyrrhetinic acid as potent inhibitors of ¦Á-glucosidase and AGEs-induced oxidation, SDS of cas: 71989-31-6, the publication is European Journal of Pharmaceutical Sciences (2022), 106045, database is CAplus and MEDLINE.

18¦Â-Glycyrrhetinic acid (18¦Â-GA) is known for several biol. activities, and has been the focus of extensive research for the development of therapeutic agents. In the current study, 18¦Â-GA-peptide conjugates 2-11 were evaluated for their in vitro ¦Á-glucosidase inhibitory and antiglycation activities. Structure-activity relationship (SAR) established and mol. interactions of active bioconjugates with the enzyme¡äs binding sites were predicted through mol. modeling approach. In tripeptide moiety of conjugates 2-11, peptide residue at position 1 was found to have a significant role on ¦Á-glucosidase inhibition. The most active 18¦Â-GA-peptide conjugates 5 (18¦Â-GA-Cys¹-Tyr²-Gly³), and 8 (18¦Â-GA-Pro¹-Tyr²-Gly³) exhibited several-fold potent ¦Á-glucosidase inhibition (IC₅₀ values 20-28 ¦¬M), as compared to standard drug acarbose (IC₅₀ = 875.8 ¡À 2.10 ¦¬M). Kinetic studies of potent compounds, 4-8 revealed that conjugate 5 exhibits competitive-type of inhibition, while conjugates 6-8 showed a non-competitive type of inhibition. The simulation studies also supported the kinetic results that conjugate 5 (18¦Â-GA-Cys¹-Tyr²-Gly³) inhibits the ¦Á-glucosidase enzyme by blocking its substrate binding site. AGEs-induced NO? inhibitors play an important role in controlling the inflammation associated with diabetes mellitus. The peptide conjugates 2-11 were also evaluated in vitro for AGEs-induced NO? inhibition using RAW 264.7 macrophage cell line. Our data revealed that conjugates 7-10 were the more potent AGEs-induced NO? inhibitors, comparable to standards rutin, and PDTC. The peptide conjugate 5 (a competitive inhibitor of ¦Á-glucosidase) also exhibited a strong inhibitory activity against AGEs-induced NO? production Furthermore, peptide conjugates 2-11 were found non-cytotoxic to mouse fibroblast NIH-3T3, and murine macrophages RAW 264.7 cell lines. In conclusion, our data demonstrates that besides possessing strong ¦Á-glucosidase inhibition, the newly synthesized peptide conjugates also alleviated the AGEs-induced NO? production in RAW macrophages. Dual inhibition of ¦Á-glucosidase enzyme, and AGEs-induced NO? production by 18¦Â-GA-peptide conjugates qualify them for further research in anti-diabetic drug discovery.

European Journal of Pharmaceutical Sciences published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, SDS of cas: 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Goswami, Ravi Kumar published the artcileEffect of Lemna minor supplemented diets on growth, digestive physiology and expression of fatty acids biosynthesis genes of Cyprinus carpio, Name: Docosahexaenoic Acid, the publication is Scientific Reports (2022), 12(1), 3711, database is CAplus and MEDLINE.

The potential nutritional value of duckweed Lemna minor (Lemnaceae) was evaluated for common carp Cyprinus carpio fry. Fish were fed diets containing five graded levels of duckweed: 0% (LM0, control), 5% (LM5), 10% (LM10), 15% (LM15) and 20% (LM20). The final weight and specific growth rate were significantly higher in LM15 and LM20 diets fed fish compared to others. Amylase activity was significantly higher in LM0 treatment. Total protease, trypsin and chymotrypsin activities showed linear relationships with the increased level of duckweed in the diet. Protein and essential amino acids contents were significantly higher in carp fed diets LM15 and LM20 compared to others. Lipid content was significantly higher in fish fed duckweed-based diets compared to control. A direct relationship was found between the inclusion level of duckweed in the diet and n-3 long-chain polyunsaturated fatty acid (LC-PUFA) content of carp. Contents of desatd. and elongated products of dietary linolenic acid (18:3n-3) including 20:4n-3, 20:5n-3, 22:5n-3 and 22:6n-3 increased in a graded manner with increasing dietary duckweed. The monounsaturated fatty acids and n-6 PUFA contents reduced significantly in fish fed duckweed. Expression of fads2d6, elovl2, elovl5 and fas were higher in carp fed diets LM10, LM15 and LM20 compared to control fish. The inclusion of L. minor in diet enhanced the nutritional value of carp by increasing protein, lipid, amino acids and n-3 PUFA contents.

Scientific Reports published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Name: Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lopez-Vidal, Eva M. published the artcileDeep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers, Recommanded Product: Fmoc-Pro-OH, the publication is JACS Au (2021), 1(11), 2009-2020, database is CAplus and MEDLINE.

Therapeutic macromols. such as proteins and oligonucleotides can be highly efficacious but are often limited to extracellular targets due to the cell¡äs impermeable membrane. Cell-penetrating peptides (CPPs) are able to deliver such macromols. into cells, but limited structure-activity relationships and inconsistent literature reports make it difficult to design effective CPPs for a given cargo. For example, polyarginine motifs are common in CPPs, promoting cell uptake at the expense of systemic toxicity. Machine learning may be able to address this challenge by bridging gaps between exptl. data in order to discern sequence-activity relationships that evade our intuition. Our earlier data set and deep learning model led to the design of miniproteins (>40 amino acids) for antisense delivery. Here, we leveraged and expanded our model with data augmentation in the short CPP sequence space of the data set to extrapolate and discover short, low-arginine-content CPPs that would be easier to synthesize and amenable to rapid conjugation to desired cargo, and with minimal in vivo toxicity. The lead predicted peptide, termed P6, is as active as a polyarginine CPP for the delivery of an antisense oligomer, while having only one arginine side chain and 18 total residues. We determined the pentalysine motif and the C-terminal cysteine of P6 to be the main drivers of activity. The antisense conjugate was able to enhance corrective splicing in an animal model to produce functional eGFP in heart tissue in vivo while remaining nontoxic up to a dose of 60 mg/kg. In addition, P6 was able to deliver an enzyme to the cytosol of cells. Our findings suggest that, given a data set of long CPPs, we can discover by extrapolation short, active sequences that deliver antisense oligomers.

JACS Au published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia