Tag: M.W=300-350

Hu, Qi-Long published the artcileDemethylative alkylation of methionine residue by employing the sulfonium as the key intermediate, Application of Fmoc-Pro-OH, the publication is Organic Letters (2021), 23(21), 8543-8548, database is CAplus and MEDLINE.

Methionine (Met) offers a valuable handle to achieve peptide chem. modification owing to its unique thioether functional group. In contrast with cysteine, the site-selective functionalization of the hydrophobic and redox-sensitive thioether motif on peptides is still challenging, and strategies for diversification on the Met residue are rarely disclosed. Herein we report a transition-metal-free and redox-neutral approach for Met diversification with substrate diversity, which could be applied to synthesize cyclic peptides.

Organic Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Application of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Su, Jianpeng published the artcileEbsulfur as a potent scaffold for inhibition and labelling of New Delhi metallo-¦Â-lactamase-1 in vitro and in vivo, Synthetic Route of 119-80-2, the publication is Bioorganic Chemistry (2019), 192-201, database is CAplus and MEDLINE.

The superbug infection caused by New Delhi metallo-¦Â-lactamase (NDM-1) has grown into an emerging threat, labeling and inhibition of NDM-1 has proven challenging due to its shuttling between pathogenic bacteria. Here, we report a potent covalent scaffold, ebsulfur, for targeting the protein in vitro and in vivo. Enzymic kinetic study indicated that eighteen ebsulfurs gained except 1a-b and 1f inhibited NDM-1, exhibiting an IC₅₀ value ranging of 0.16-9 ¦ÌM, and 1g was found to be the best, dose- and time-dependent inhibitor with an IC₅₀ of 0.16 ¦ÌM. Also, these ebsulfurs effectively restored the antibacterial activity of cefazolin against E. coli expressing NDM-1, and the best effect was observed to be from 1g, 1i and 1n, resulting in an 256-fold reduction in MIC of the antibiotic at a dose of 16 ¦Ìg/mL. The equilibrium dialysis study implied that the ebsulfur disrupted the coordination of one Zn(II) ion at active site of NDM-1. Labeling of NDM-1 using a constructed fluorescent ebsulfur Ebs-R suggested that the inhibitor covalently bound to the target through SDS-PAGE anal. in vitro. Also, labeling NDM-1 in living E. coli cells with Ebs-R by confocal microscopic imaging showed the real-time distribution change process of intracellular recombinant protein NDM-1. Moreover, the cytotoxicity of these ebsulfurs against L929 mouse fibroblastic cells was tested, and their capability to restore antibacterial activity of antibiotic against clin. strains E. coli EC08 producing NDM-1 was determined The ebsulfur scaffold proposed here is valuable for development of the covalent irreversible inhibitors of NDM-1, and also for labeling the target in vitro and in vivo.

Bioorganic Chemistry published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C8H10N2O2, Synthetic Route of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhu, Liwei published the artcileA nanomedicine enables synergistic chemo/photodynamic therapy for pancreatic cancer treatment, Category: catalysis-chemistry, the publication is Biomaterials Science (2022), 10(13), 3624-3636, database is CAplus and MEDLINE.

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Gemcitabine (Gem) has been a key chemotherapy agent for pancreatic cancer treatment by suppressing cell proliferation and inducing apoptosis. However, the overexpression of inhibitors of apoptosis (IAP) family of proteins during the carcinogenesis of pancreatic cancer can develop resistance to chemotherapy treatment and result in poor efficacy. To achieve the synergistic combinations of multiple strategies for this dismal disease, we developed a robust nanomedicine system, consisting of a photodynamic therapeutic agent (chlorine e6, Ce6) and a pro-apoptotic peptide-Gem conjugate. To have spatiotemporally controlled drug release, the pro-apoptotic peptide-Gem conjugate was designed to have a vinyldithioether linker that was sensitive to reactive oxygen species (ROS). The nanomedicine was fabricated by the direct self-assembly of the pro-apoptotic peptide-Gem conjugate with Ce6. After being delivered into tumors, the nanomedicine disassembled and rapidly released Gem, Ce6, and the pro-apoptotic peptide upon light illumination (660 nm). Both in vitro and in vivo studies in pancreatic cancer models confirmed the tumor inhibition efficacy with low systemic toxicity to animals.

Biomaterials Science published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C17H16O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shan, Shijie published the artcileStretchable, robust and reprocessable poly(siloxane-urethanes) elastomers based on exchangeable aromatic disulfides, Category: catalysis-chemistry, the publication is Polymer (2021), 123588, database is CAplus.

The rapid expansion of dynamic covalent chem. world urges for materials not only possessing high mech. properties and stretchability, but also including high reprocessability and reforming. Herein, aromatic disulfide-containing polysiloxanes elastomers with modified urea as chain-extender and crosslinker were first designed and fabricated. Dynamic crosslinks, including hydrogen bonding formed between urea and amide bonds, and aromatic disulfide are connected with polysiloxanes backbones through isocyanate (DTSA-HDI) reacted with systematically controlled aminopropyl groups in the side chains. Consequently, a series of ATPx-SS elastomers with polysiloxanes of different mol. weight and APPx-SS elastomers with different crosslinking densities are developed. The molar amount of DTSA-HDI has been proved to play a crucial role in adjusting the mech. and thermal properties of the networks. Among all, ATP3-SS showed the best stretchability, of which the elongation at break was as high as 780%. APP1-SS achieved the highest tensile strength of 2.60 MPa. Besides, it has outstanding reprocessability and can be reprocessed and reformed without much decline of tensile strength after several cycles of hot-pressing. These remarkable properties demonstrate that the aromatic disulfide-containing elastomers are competitive to those un-filled polysiloxanes elastomers based on dynamic bonds ever reported.

Polymer published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C7H10O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Alvarez-Buylla, Arturo published the artcileCresyl violet: a red fluorescent Nissl stain, Formula: C18H15N3O3, the publication is Journal of Neuroscience Methods (1990), 33(2-3), 129-33, database is CAplus and MEDLINE.

A method is described for using cresyl violet as a red fluorescent Nissl stain. Unlike the bright-filed staining technique, fluorescent cresyl is compatible with other fluorescent dyes and tracers, such as fluorescein, Fluoro-Gold and Fast Blue. The procedure requires only minor modifications of routine bright-filed cresyl staining, the most significant being dilution of the stain. Thus, fluorescent red cresyl violet is simple to implement and may be of general use in fluorescence microscopy.

Journal of Neuroscience Methods published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Formula: C18H15N3O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cui, Wen published the artcileMitsunobu-reaction-based total solid-phase synthesis of Fanlizhicyclopeptide B, HPLC of Formula: 71989-31-6, the publication is Chemistry of Natural Compounds (2021), 57(6), 1086-1089, database is CAplus.

The first total synthesis of anti-inflammatory cyclic peptide fanlizhicyclopeptide B based on the Mitsunobu reaction is reported. The pre-made Fmoc-Tyr-OAllyl building block was coupled to the Wang resin via the Mitsunobu reaction catalyzed by triphenylphosphine and di-Et azodicarboxylate. After the remaining amino acids were assembled, macrocyclization was realized on solid support. Finally, the crude product was cleaved from resin and then purified by preparative reverse-phase high-performance liquid chromatog. (RP-HPLC) to provide the pure target fanlizhicyclopeptide B.

Chemistry of Natural Compounds published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, HPLC of Formula: 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tian, Mi published the artcileMeasurement of size-segregated airborne particulate bound polycyclic aromatic compounds and assessment of their human health impacts – A case study in a megacity of southwest China, HPLC of Formula: 191-07-1, the publication is Chemosphere (2021), 131339, database is CAplus and MEDLINE.

Particle size distribution of particulate polycyclic aromatic compounds (PACs) is one of the important factors controlling human exposure to PACs in air. In this study, size-segregated airborne particle samples were collected in a megacity in southwest China to analyze PACs concentrations and evaluate related health risks. Annual average concentrations of ¦²19PAHs (polycyclic aromatic hydrocarbons, 17.4 ng/m³) and ¦²10OPAHs (oxygenated PAHs, 15.3 ng/m³) were one order of magnitude higher than those of ¦²9MPAHs (Me PAHs, 0.97 ng/m³) and ¦²27NPAHs (nitrated PAHs, 1.54 ng/m³). More than 55% of PACs masses were associated with fine particles (aerodynamic diameter Dae < 2.1¦Ìm). Inhalation exposure assessment showed that less than 60% of particulate bound PACs could deposit in the respiratory tract, which implies that the traditional model using ambient concentration of PACs would overestimate the inhalation risk. On the other hand, incremental lifetime cancer risks from dermal absorption (ILCRderm) were comparable to those from inhalation (ILCRinh) exposure despite the much lower daily dermal absorption dose than the daily inhalation dose, which implies that the health impact might be underestimated if only considering inhalation exposure. Cancer risks from inhalation exposure were mainly attributed to fine particles while those from dermal exposure were mostly associated with coarse particles. Although neither ILCRderm nor ILCRinh exceeded the threshold value of 10^-6 set by USEPA, the total ILCR exceeded this criterion, manifesting potential health risks from exposure to airborne particulate PACs in this region.

Chemosphere published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C18H10, HPLC of Formula: 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Xue published the artcileEffects of cooking on the nutritional quality and volatile compounds in omega-3 fatty acids enriched eggs, Synthetic Route of 6217-54-5, the publication is Journal of the Science of Food and Agriculture (2022), 102(9), 3703-3711, database is CAplus and MEDLINE.

The extensive consumption of eggs and their utilization as an ingredient in food products globally offer excellent potential for increasing dietary omega-3 polyunsaturated fatty acid (PUFA) intake. Thus far, research involving dietary focused on changes in their phys. properties after boiling, protein denaturation, storage stability, and other characteristics. However, minimal reports are available regarding the evaluation of nutritional changes. Therefore, this study comprehensively investigated the impact of cooking on the nutritional quality and volatile compound profile of ordinary and omega-3 eggs. Compared with ordinary eggs, those enriched with omega-3 fatty acids contained higher proportions of total omega-3 PUFAs and ¦Á-tocopherol. However, no significant difference was evident between the amino acid compositions of the two types of eggs. Omega-3 eggs boiled for 20 min at 75¡ãC showed higher levels of omega-3 PUFAs, total tocopherol, and essential amino acids while increasing the heating time and temperature reduced these nutrients. Heat treatment significantly decreased the ketones and alc. content while increasing the hydrocarbons level. The overall variations in the metabolic response due to cooking temperature were evidenced by the multiple metabolic associations and clustering on the principal component anal. (PCA) plane and heat map. The findings provided useful information for ensuring quality retention in eggs, especially those enriched with omega-3. 2021 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Synthetic Route of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Daichun published the artcileSynthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents, Recommanded Product: Fmoc-Pro-OH, the publication is Marine Drugs (2022), 20(3), 158, database is CAplus and MEDLINE.

In this paper, eight new galaxamide analogs (Z-1?Z-8) were synthesized and evaluated for their cytotoxic activities against five cancer cell lines, MCF-7, MD-MBA-231, HepG2, Hela, and A549, using MTT assays. The modified analog Z-6 displayed broad spectrum cytotoxic activity toward each tested cell line with IC50 values of 1.65 ¡À 0.30 (MCF-7), 2.91 ¡À 0.17 (HepG2), 4.59 ¡À 0.27 (MD-MBA-231), 5.69 ¡À 0.37 (Hela), and 5.96 ¡À 0.41 (A549) ¦Ìg/mL, resp. The galaxamides Z-3 and Z-6 induced concentration-dependent apoptosis of the MCF-7 cells after 72 h as evaluated by the flow cytometry experiment The results showed that these compounds could induce MCF-7 cell apoptosis by arresting the G0/G1 phase of the cell cycle and finally achieving the effect of inhibiting the proliferation of MCF-7 cells.

Marine Drugs published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Guo-Cheng published the artcileMetal-induced various properties and structures of complexes based on methylene-derived diamide and S₂-bridged carboxylate, Product Details of C14H10O4S2, the publication is Polyhedron (2019), 294-302, database is CAplus.

By introducing different metal ions, six new coordination polymers (CPs) [Zn(L)_0.5(DTSA)]¡¤H₂O (CP1), [Cd(L)_0.5(DTSA)(H₂O)] (CP2), [Mn(L)_0.5(DTSA)(H₂O)] (CP3), [Co(L)_0.5(DTSA)(H₂O)] (CP4), [Ni(L)_0.5(DTSA)(H₂O)] (CP5), [Pb₂(L)_0.5(DTSA)₂] (CP6), [N,N’-bis(4-methylenepyridin-4-yl)-1,4-benzenedicarboxamide (L), 2,2′-dithiodibenzoic acid (H₂DTSA)] were synthesized under hydrothermal conditions. CP1 is a unified node (4,4)-connected network derived from Zn₂ nodes, pairs of DTSA anions and ¦Ì₂-L linkers. CP2-CP5 display similar binode (4,4)-connected layers based on single metal centers, ¦Ì₂-DTSA anions and ¦Ì₄-L linkers. CP6 show a novel 3-dimensional (3,4,4,5)-connected Pb-based framework, which is constructed form Pb-DTSA layers and ¦Ì₄-L linkers. The effect of metal ions on the architectures of the title complexes was studied. CP1, CP2 and CP6 are efficient luminescent sensors for the detection of Fe³⁺ ions (CP1 and CP2) and DMSO (CP1 and CP6). CP3-CP5 show different electrochem. response to nitrite and bromate in water solution

Polyhedron published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Product Details of C14H10O4S2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia