Tag: M.W=300-350

Fu, Hongxia published the artcileRatiometric Fluorescence Azide-Alkyne Cycloaddition for Live Mammalian Cell Imaging, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Analytical Chemistry (Washington, DC, United States) (2015), 87(22), 11332-11336, database is CAplus and MEDLINE.

Click chem. with metabolic labeling has been widely used for selectively imaging biomacromols. in cells. The first example of azide-alkyne cycloaddition for ratiometric fluorescent imaging of live cells is reported. The precursor of the azido fluorophore (cresyl violet) has a fluorescence emission peak at 620 nm. The electron-rich nitrogen of the azido group blue-shifts the emission peak to 566 nm. When the click reaction occurs, an emission peak appears at 620 nm due to the lower electronic d. of the newly formed triazole ring, which allows the authors to ratiometrically record fluorescence signals. This emission shift was applied to ratiometric imaging of propargylcholine- and dibenzocyclooctyne-labeled human breast cancer cells MCF-7 under laser confocal microscopy. Two typical triazole compounds were isolated for photophys. parameter measurements. The emission spectra presented a fluorescence emission peak around 620 nm for both click products. The results further confirmed the emission wavelength change was the result of azide-alkyne cycloaddition reaction. Since nearly all biomols. can be metabolically labeled by reported alkyne-functionalized derivatives of native metabolites, the authors’ method can be readily applied to image these biomacromols.

Analytical Chemistry (Washington, DC, United States) published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Han, Dong published the artcileAsymmetric Epoxidation of Unfunctionalized Olefins Catalyzed by Chiral (Pyrrolidine Salen) Mn (III) Complexes with Proline Sidearms, Computed Properties of 71989-31-6, the publication is Molecular Catalysis (2022), 112268, database is CAplus.

Four (R, R)-3, 4-diaminopyrrolidine-based chiral Salen ligands with L-Boc-N-proline, D-Boc-N-proline, L-proline, D-proline as resp. sidearms, as well as their manganese complexes were synthesized and characterized. These Salen-Mn(III) complexes were applied to the asym. epoxidations of unfunctionalized olefins with NaClO, and m-CPBA as resp. oxidants. The catalysis of the Salen-Mn (III) complexes varied with the change of sidearms. The one with D-Boc-N-proline as a sidearm showed the best asym. catalysis among the four chiral manganese complexes, and its catalysis was also better than that of the one with a benzyl sidearm, and comparable with that of Jacobsen’s catalyst. Moderate to excellent enantioselectivities and yields were achieved in the asym. of various olefins over this complex. The big enhancement of the D-Boc-N-proline sidearm on the enantioselectivity of the asym. epoxidation might be ascribed to its large steric hindrance and appropriate configuration, allowing the Boc moiety to be away from the side-on approach pathway of olefins to the active center but near the opposite side one in some degree, thus facilitating the approach of olefins to the active center from one direction.

Molecular Catalysis published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Computed Properties of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kou, Xinyue published the artcileConstruction of Multi-color fluorescent carbon dots by Aggregation-Induced emission, Application In Synthesis of 119-80-2, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2022), 121430, database is CAplus and MEDLINE.

Aggregation-induced emission luminogens (AIEgens) have garnered significant attention because of their outstanding photophys. characteristics. AIEgens are used in fluorescence imaging, sensors, tumor treatment, and other related fields. However, the synthese of these AIEgens are relatively complicated and requires expensive raw materials. These drawbacks limit their applications and development to a certain extent. In this study, using cheap and convenient materials, we developed a new type of carbon dots (O-CDs) using a one-step solvothermal method, which has the potential to become a new AIEgen. O-CDs exhibit different fluorescence colors in different solvents, and they exist as monomers in ethylic acid and, ethanol alc., etc., exhibiting blue fluorescence. After adding water, the fluorescence of O-CDs gradually turns orange red, because the internal rotation of the disulfide bond mols. is restricted and the AIE effect occurs. Using the unique AIE performance of O-CDs, we fabricated an anti-counterfeiting luminous ink, that can be used for encryption in the reversible double switch mode.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Application In Synthesis of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Gangwei published the artcileVisualization of Sulfane Sulfur in Plants with a Near-Infrared Fluorescent Probe, Quality Control of 119-80-2, the publication is ACS Sensors (2019), 4(2), 434-440, database is CAplus and MEDLINE.

Sulfane sulfur species are an important type of reactive sulfur species. These compounds have unique reactivity to attach reversibly to other sulfur atoms and exhibit regulatory effects in diverse biol. systems. Recent studies have suggested that sulfane sulfurs are involved in signal transduction processes of hydrogen sulfide (H₂S). The development of probes for selective, rapid, and sensitive detection of sulfane sulfur is of great significance for studying their physiol. and pathol. roles in biol. systems, especially in plant systems for which physiol. research has lagged behind. However, so far there is still a lack of sufficient chem. tools for directly tracking and measuring sulfane sulfur in biol. systems, and in particular, the detection of sulfane sulfur in living plant tissues is still challenging. Herein, the authors report a near-IR fluorescent probe, SSNIP, for the selective imaging of sulfane sulfur. SSNIP is capable of detecting sulfane sulfur at physiol. concentrations in both aqueous buffer and living human cells. Then, with SSNIP, the authors demonstrate the fluorescent monitoring of endogenous sulfane sulfur in plant tissues such as Arabidopsis thaliana roots for the first time. Furthermore, the application of SSNIP in evaluating the level of sulfane sulfur in Arabidopsis thaliana roots at different growth stages is performed. The results show that the level of sulfane sulfur in Arabidopsis thaliana roots correlates well with their growth stages, which suggests that sulfane sulfurs might act as actual signaling mols. to promote plant growth and root elongation. In addition, it reveals potential applications for the biol. and pathol. studies of sulfane sulfur, especially in plant physiol.

ACS Sensors published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Quality Control of 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Pengcheng published the artcileParticle volatility, size distribution and PAH/alkyl-PAH profiles during toluene pyrolysis in a flow reactor, COA of Formula: C24H12, the publication is Aerosol Science and Technology (2022), 56(9), 819-832, database is CAplus.

Particle volatility, size distribution, and parent and alkylated polycyclic aromatic hydrocarbon (PAH/alkyl-PAH) profiles during toluene pyrolysis in a flow reactor were studied. The experiments were conducted under three different gas residence times (0.2, 0.5 and 0.8 s) at temperatures from 950 to 1450¡ãC. Results showed that long residence times and high temperatures led to high particle mass concentrations, low particle volatility and a significant shift of particle size distribution to larger size. Total particle number concentrations exhibited a rise-then-fall trend (peaking at a critical temperature of 1050¡ãC) with increasing temperature, indicating that increasing temperature promoted a transition from nucleation to agglomeration and coagulation which dominated the particle size distributions. Among PAHs and alkyl-PAHs, those with 2-4 rings, presented the highest concentrations at 950¡ãC for 0.2 s. They appeared at 1050¡ãC for 0.5 and 0.8 s, consistent with the critical temperature of particle nucleation at long residence times (0.5 and 0.8 s). Particle peak number concentrations and total PAH mass concentrations exhibited consistent temperature dependence, indicating soot nucleation was highly related to PAH concentrations According to the comprehensive observations in this study, low mol. mass PAHs instead of larger PAHs appear to be the precursors of soot formation during high temperature pyrolysis processes. Copyright 2021 American Association for Aerosol Research.

Aerosol Science and Technology published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C10H10CoF6P, COA of Formula: C24H12.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Song, Lijuan published the artcileNatural gallic acid catalyzed aerobic oxidative coupling with the assistance of MnCO₃ for synthesis of disulfanes in water, SDS of cas: 119-80-2, the publication is Green Chemistry (2019), 21(6), 1432-1438, database is CAplus.

To pursue a sustainable approach for such a synthesis, an aerobic oxidative coupling method for the efficient preparation of organic disulfanes RSSR¹ [R = 4-MeC₆H₄, cyclohexyl, 2-thienyl, etc.; R¹ = t-Bu, 4-ClC₆H₄, 4-H₂NC₆H₄, etc.], using a low-toxic natural gallic acid as an organocatalyst, inexpensive MnCO₃ as a cocatalyst, O₂ as the terminal oxidant and water as the solvent, was successfully developed. Such metal-organic cooperative catalytic protocol provided an access to various sym. and unsym. disulfanes in up to 99% yield. Gram scale synthesis with practical convenience and low loading of catalysts further illustrated the practicability of our method.

Green Chemistry published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H31NO2, SDS of cas: 119-80-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wei, Wei published the artcilePhospholipid composition and fat globule structure II: Comparison of mammalian milk from five different species, Quality Control of 6217-54-5, the publication is Food Chemistry (2022), 132939, database is CAplus and MEDLINE.

We compared phospholipids (PLs) content, their mol. species, and milk fat globules size and microstructure in the milk of five mammalian species, including human, cow, goat, yak, and donkey. The absolute quantification of major PLs was determined using 31P NMR and their fatty acid composition with GC. The mol. species of PLs were analyzed using LC-MS where a total of 9 PL species, including one sphingomyelin (SM), six glycerophospholipid (GPL), and two lysoglycerophospholipids (lyso-GPLs), were identified. PLs profile shows an obvious difference among the species, with human milk showing higher SM content and more unsaturated fatty acyls than other mammalian milk. The mammalian milk show a similar core-membrane lipid structure but obvious different size distribution. These data provide a basis for better construction of infant formulas to provide PLs requirements and a similar milk fat globule structure for infants.

Food Chemistry published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C10H11NO4, Quality Control of 6217-54-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Shen published the artcileDetermination of tipping point in course of PM_2.5 organic extracts-induced malignant transformation by dynamic network biomarkers, Quality Control of 191-07-1, the publication is Journal of Hazardous Materials (2022), 128089, database is CAplus and MEDLINE.

The dynamic network biomarkers (DNBs) are designed to identify the tipping point and specific mols. in initiation of PM_2.5-induced lung cancers. To discover early-warning signals, we analyzed time-series gene expression datasets over a course of PM_2.5 organic extraction-induced human bronchial epithelial (HBE) cell transformation (0th?16th week). A composition index of DNB (CIDNB) was calculated to determine correlations and fluctuations in mol. clusters at each timepoint. We identified a group of genes with the highest CI_DNB at the 10th week, implicating a tipping point and corresponding DNBs. Functional experiments revealed that manipulating resp. DNB genes at the tipping point led to remarkable changes in malignant phenotypes, including four promoters (GAB2, NCF1, MMP25, LAPTM5) and three suppressors (BATF2, DOK3, DAP3). Notably, co-altered expression of seven core DNB genes resulted in an enhanced activity of malignant transformation compared to effects of single-gene manipulation. Perturbation of pathways (EMT, HMGB1, STAT3, NF-¦ÊB, PTEN) appeared in HBE cells at the tipping point. The core DNB genes were involved in regulating lung cancer cell growth and associated with poor survival, indicating their synergistic effects in initiation and development of lung cancers. These findings provided novel insights into the mechanism of dynamic networks attributable to PM_2.5-induced cell transformation.

Journal of Hazardous Materials published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Quality Control of 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Xue-Mei published the artcilePrediction of ^?OH-Initiated and ^?NO₃-Initiated Transformation Products of Polycyclic Aromatic Hydrocarbons by Electronic Structure Approaches, SDS of cas: 191-07-1, the publication is ACS Omega (2022), 7(29), 24942-24950, database is CAplus and MEDLINE.

The abiotic reaction products of polycyclic aromatic hydrocarbons (PAHs) with hydroxyl radicals (^?OH) and nitrate radicals (^?NO₃) are nitro-, oxygen-, and hydroxyl-containing PAHs (NPAHs, OPAHs, and OHPAHs). Four methods of the HOMO ), Fukui function (FF), dual descriptor (DD), and population of ¦Ð electrons (PP-¦Ð) are selected to predict the chem. reactivity of PAHs attacked by ^?OH and ^?NO₃ in this study. The predicted ^?OH-initiated and ^?NO₃-initiated transformation products are compared with the main PAH transformation products (PAH-TPs) observed in the laboratory The results indicate that PP-¦Ð and DD approaches fail to predict the transformation products of fused PAHs containing five-membered rings. By predicting the PAH-TPs of 13-14 out of the 15 parent PAHs accurately, HOMO and FF methods were shown to be suitable for predicting the transformation products formed from the abiotic reactions of fused PAHs with ^?OH and ^?NO₃.

ACS Omega published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, SDS of cas: 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Yiping published the artcileNDTP mediated direct rapid amide and peptide synthesis without epimerization, Recommanded Product: Fmoc-Pro-OH, the publication is Organic Letters (2022), 24(5), 1169-1174, database is CAplus and MEDLINE.

Herein, we explored an unprecedented mild, nonirritating, conveniently available, and recyclable coupling reagent NDTP, which could activate the carboxylic acids via acyl thiocyanide and enable the rapid amide and peptide synthesis at very mild conditions. In addition, the methodol. was compatible with Fmoc-SPPS (Fmoc = 9-flluorenylmethoxycarbonyl), which may provide an alternative to peptide manufacturing

Organic Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia