Tag: M.W=300-350

Berger, Or published the artcileMussel Adhesive-Inspired Proteomimetic Polymer, Name: Fmoc-Pro-OH, the publication is Journal of the American Chemical Society (2022), 144(10), 4383-4392, database is CAplus and MEDLINE.

Herein, a synthetic polymer proteomimetic is described that reconstitutes the key structural elements and function of mussel adhesive protein. The proteomimetic was prepared via graft-through ring-opening metathesis polymerization of a norbornenyl-peptide monomer. The peptide was derived from the natural underwater glue produced by marine mussels that is composed of a highly repetitive 10 amino acid tandem repeat sequence. The hypothesis was that recapitulation of the repeating unit in this manner would provide a facile route to a nature-inspired adhesive. To this end, the material, in which the arrangement of peptide units was as side chains on a brush polymer rather than in a linear fashion as in the natural protein, was examined and compared to the native protein. Mech. measurements of adhesion forces between solid surfaces revealed improved adhesion properties over the natural protein, making this strategy attractive for diverse applications. One such application is demonstrated, using the polymers as a surface adhesive for the immobilization of live cells.

Journal of the American Chemical Society published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Name: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wietzoreck, M. published the artcileNitro- and oxy-PAHs in grassland soils from decade-long sampling in central Europe, Recommanded Product: Coronene, the publication is Environmental Geochemistry and Health (2022), 44(8), 2743-2765, database is CAplus and MEDLINE.

Long-term exposure to polycyclic aromatic hydrocarbons (PAHs) and their nitrated (NPAHs) and oxygenated (OPAHs) derivatives can cause adverse health effects due to their carcinogenicity, mutagenicity and oxidative potential. The distribution of PAH derivatives in the terrestrial environment has hardly been studied, although several PAH derivatives are ubiquitous in air and long-lived in soil and water. We report the multi-annual variations in the concentrations of NPAHs, OPAHs and PAHs in soils sampled at a semi-urban (Mokra, Czech Republic) and a regional background site (Kosetice, Czech Republic) in central Europe. The concentrations of the Σ₁₈NPAHs and the Σ₁₁₊₂OPAHs and O-heterocycles were 0.31 ± 0.23 ng g^-1 and 4.03 ± 3.03 ng g^-1, resp., in Kosetice, while slightly higher concentrations of 0.54 ± 0.45 ng g^-1 and 5.91 ± 0.45 ng g^-1, resp., were found in soil from Mokra. Among the 5 NPAHs found in the soils, 1-nitropyrene and less so 6-nitrobenzo(a)pyrene were most abundant. The OPAHs were more evenly distributed. The ratios of the PAH derivatives to their parent PAHs in Kosetice indicate that they were long-range transported to the background site. Our results show that several NPAHs and OPAHs are abundant in soil and that gas-particle partitioning is a major factor influencing the concentration of several semi-volatile NPAHs and OPAHs in the soils. Complete understanding of the long-term variations of NPAH and OPAH concentrations in soil is limited by the lack of kinetic data describing their formation and degradation

Environmental Geochemistry and Health published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C12H10N2O5, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

So, Wing Ho published the artcileOn-resin Ugi reaction for C-terminally modified and head-to-tail cyclized antibacterial peptides, Category: catalysis-chemistry, the publication is Organic Letters (2021), 23(21), 8277-8281, database is CAplus and MEDLINE.

Here we report a method to synthesize C-terminally modified peptides on resin. A four-component Ugi reaction of isocyanide resin, an Fmoc-protected (Fmoc = 9-fluorenylmethoxycarbonyl) amino acid, an amine, and a 6-nitroveratrylaldehyde gives C-terminal photo-caged peptide amides, which can be photolyzed to generate C-terminal peptide amides. Changing the amine component in the Ugi reaction gives peptides with different C-terminal modifications including substituted anilides, alkyne, and azide. By installing an N-terminal azide and C-terminal alkyne, we synthesized a head-to-tail cyclized antibacterial peptide through copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The cyclized peptide exhibited higher proteolytic stability and antibacterial activity than the linear peptide.

Organic Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C26H45N5O7Si2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Yong published the artcileCombined Labelled and Label-free SERS Probes for Triplex Three-dimensional Cellular Imaging, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, the publication is Scientific Reports (2016), 19173, database is CAplus and MEDLINE.

Cells are complex chem. systems, where the mol. composition at different cellular locations and specific intracellular chem. interactions determine the biol. function. An in-situ nondestructive characterization of the complicated chem. processes (like e.g. apoptosis) is the goal of our study. Here, we present the results of simultaneous and three-dimensional imaging of double organelles (nucleus and membrane) in single HeLa cells by means of either labeled or label-free surface-enhanced Raman spectroscopy (SERS). This combination of imaging with and without labels is not possible when using fluorescence microscopy. The SERS technique is used for a stereoscopic description of the intrinsic chem. nature of nuclei and the precise localization of folate (FA) and LH-releasing hormone (LHRH) on the membrane under highly confocal conditions. We also report on the time-dependent changes of cell nuclei as well as membrane receptor proteins during apoptosis analyzed by statistical multivariate methods. The multiplex three-dimensional SERS imaging technique allows for both temporal (real time) and spatial (multiple organelles and mols. in three-dimensional space) live-cell imaging and therefore provides a new and attractive 2D/3D tracing method in biomedicine on subcellular level.

Scientific Reports published new progress about 10510-54-0. 10510-54-0 belongs to catalysis-chemistry, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Inhibitor,Inhibitor, name is 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate, and the molecular formula is C18H15N3O3, Recommanded Product: 5,9-Diaminobenzo[a]phenoxazin-7-ium acetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lo, Enlin published the artcilePhysiological insights into enhanced lipid accumulation and temperature tolerance by Tetraselmis suecica ultraviolet mutants, Name: Docosahexaenoic Acid, the publication is Science of the Total Environment (2022), 156361, database is CAplus and MEDLINE.

High outdoor temperatures significantly inhibit the growth and lipid production of the industrially promising marine microalga Tetraselmis suecica, which is viewed as a potential feedstock for high-value bioproducts and biofuels. To overcome this limitation, T. suecica was subjected to UV irradiation to generate mutants capable of being productive at higher temperatures The top two high-lipid mutants UV-25 and UV-31 isolated at 25°C and 31°C, resp., were compared to the wild type (WT) to delineate physiol. alterations and shed light on the mutants increased biomass and lipid productivity. At 25°C, UV-25 and UV-31 exhibited lipid productivity of 36.12 and 31.33 mg/L day, which were 1.4- and 1.2-fold higher than WT, resp. This increase in lipid biosynthesis correlated well with increased carotenoid content in UV-25 (2.2-fold) and UV-31 (3.6-fold), indicating an improved capacity to quench reactive oxygen species. At 31°C, the growth and lipid accumulation of UV-31 remained high, signifying adaptation to higher temperatures This is attributed to a well-coordinated modulation of the mutant’s cellular metabolism through an increase in galactose and phosphatidylglycerol levels, as well as in protein, all of which contributed to its performance at elevated temperatures The study successfully established a UV mutagenesis strategy for producing superior- performing microalgae strains with industrially desired traits, paving the way for future outdoor cultivation deployment.

Science of the Total Environment published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Name: Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Laps, Shay published the artcileInsight on the order of regioselective ultrafast formation of disulfide bonds in (antimicrobial) peptides and miniproteins, Formula: C20H19NO4, the publication is Angewandte Chemie, International Edition (2021), 60(45), 24137-24143, database is CAplus and MEDLINE.

Disulfide-rich peptides and proteins are among the most fascinating bioactive mols. The difficulties associated with the preparation of these targets have prompted the development of various chem. strategies. Nevertheless, the production of these targets remains very challenging or elusive. Recently, we introduced a strategy for one-pot disulfide bond formation, tackling most of the previous limitations. However, the effect of the order of oxidation remained an underexplored issue. Herein we report on the complete synthetic flexibility of the approach with respect to the order of oxidation of three disulfide bonds in targets that lack the knot motif. In contrast, our study reveals an essential order of disulfide bond formation in the EETI-II knotted miniprotein. This synthetic strategy was applied for the synthesis of novel analogs of the plectasin antimicrobial peptide with enhanced activities against methicillin-resistant Staphylococcus aureus (MRSA), a notorious human pathogen.

Angewandte Chemie, International Edition published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Formula: C20H19NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Shahne, Maryam Zare published the artcileParticulate emissions of real-world light-duty gasoline vehicle fleet in Iran, Name: Coronene, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 292(Part_A), 118303, database is CAplus and MEDLINE.

Fine particulate matter cause profound adverse health effects in Iran. Road traffic is one of the main sources of particulate matter (PM) in urban areas, and has a large contribution in PM_2.5 and organic carbon concentration, in Tehran, Iran. The composition of fine PM vehicle emission is poorly known, so this paper aims to determine the mixed fleet source profile by using the analyzed data from the two internal stations and the emission factor for PM light-duty vehicles emission. Tunnels are ideal media for extraction vehicle source profile and emission factor, due to vehicles are the only source of pollutant in the urban tunnels. In this study, PM samples were collected simultaneously in two road tunnel stations and at a background site in Niyayesh tunnel in Tehran, Iran. The tunnel samples show a large contribution for some elements and ions, such as Fe (0.23μg μg^-1 OC), Al (0.02μg μg^-1 OC), Ca (0.055μg μg^-1 OC), SO4 (0.047μg μg^-1 OC), Docosane (0.0017μg μg^-1 OC), Triacontane (0.016μg μg^-1 OC), Anthracenedione (0.0003μg μg^-1 OC) and Benzo-perylene (0.0002μg μg^-1 OC). In overall, on-road gasoline vehicle fleets source profile extracted in this study is similar to composite profiles derived from roadside tunnel measurment performed in other countries during the last decades. The PM_2.5 emission factor for Tehran’s light-duty vehicle fleet has been extracted 16.23 mg km^-1. vehicle^-1 and 0.09 g kg^-1. The profile would be used for Chem. Mass Balance Model studies for Iran and other countries with a similar road traffic fleet mix. Also, it would be very suitable for use in emission inventories improvement. The results of this study can be used for choosing the best management strategies and provide comperhensive insight to fine PM traffic emission in Tehran.

Environmental Pollution (Oxford, United Kingdom) published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C39H35N5O8, Name: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Allott, Louis published the artcileRadiolabelling an ¹⁸F biologic via facile IEDDA “click” chemistry on the GE FASTLab platform, Recommanded Product: (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid, the publication is Reaction Chemistry & Engineering (2021), 6(6), 1070-1078, database is CAplus and MEDLINE.

The use of biologics in positron emission tomog. (PET) imaging is an important area of radiopharmaceutical development and new automated methods are required to facilitate their production We report an automated radiosynthesis method to produce a radiolabeled biol. via facile inverse electron demand Diels-Alder (IEDDA) “click” chem. on a single GE FASTLab cassette. We exemplified the method by producing a fluorine-18 radiolabeled interleukin-2 (IL2) radioconjugate from a trans-cyclooctene (TCO) modified IL2 precursor. The radioconjugate was produced using a fully automated radiosynthesis on a single FASTLab cassette in a decay-corrected radiochem. yield (RCY, d.c.) of 19.8 ± 2.6% in 110 min (from start of synthesis); the molar activity was 132.3 ± 14.6 GBq μmol^-1. The in vitro uptake of [¹⁸F]TTCO-IL2 correlated with the differential receptor expression (CD25, CD122, CD132) in PC3, NK-92 and activated human PBMCs. The automated method may be adapted for the radiosynthesis of any TCO-modified protein via IEDDA chem.

Reaction Chemistry & Engineering published new progress about 1466420-02-9. 1466420-02-9 belongs to catalysis-chemistry, auxiliary class Copper-Free Click Chemistry,Tetrazine, name is (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid, and the molecular formula is C12H12F3N5O2, Recommanded Product: (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chakraborty, Amit published the artcileChemoselective disulfide formation by thiol-disulfide interchange in SIT-protected cysteinyl peptides, Quality Control of 71989-31-6, the publication is Journal of Organic Chemistry (2022), 87(1), 708-712, database is CAplus and MEDLINE.

Chemoselective disulfide formation is accomplished through a thiol-disulfide interchange approach using sec-isoamyl mercaptan (SIT) as an alkyl sulfenyl-protecting group of one of the Cys residues involved in the pairing. SIT has a dual and unique characteristic, acting as a masking group during the synthesis and directing disulfide formation in the presence of a free thiol. This novel approach is illustrated by the synthesis of several peptides of biol. interest.

Journal of Organic Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Quality Control of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Drayton, Matthew published the artcileEnzymatically releasable polyethylene glycol – host defense peptide conjugates with improved activity and biocompatibility, Formula: C20H19NO4, the publication is Journal of Controlled Release (2021), 220-231, database is CAplus and MEDLINE.

Host defense peptides (HDPs) have been the subject of great interest for the treatment of multidrug-resistant bacterial infections due to their multimodal activity and low induction of resistance. However, aggregation, toxicity, and short biol. half-life have limited their applicability for clin. treatment. Many methods have been explored to alleviate these issues, such as polymer (e.g., polyethylene glycol (PEG)) conjugation, but these are often accompanied by reductions in the activity of the HDP. Here, we detail the design of a novel PEG-HDP conjugate incorporating an enzymic cleavage sequence targeting matrix metalloproteinases (MMPs) that accumulate at sites of inflammation and infection. Addition of the cleavage sequence onto either the N- or the C-terminal region of the parent peptide (peptide 73, a derivative of the HDP aurein 2.2) was explored to determine the location for optimal antimicrobial activity following MMP cleavage; furthermore, the susceptibility of the peptide to MMP cleavage after conjugation to 2 kDa or 5 kDa PEG was examined The top candidate, L73, utilized an N-terminal cleavage site that was subsequently conjugated to a 2 kDa PEG polymer. Both L73 and the conjugate exhibited no antimicrobial activity in vitro until cleaved by purified MMP, which liberated a peptide fragment with 16- or 63-fold improved activity, resp., corresponding to a min. inhibitory concentration (MIC) of 8 μg/mL, comparable to that of peptide 73 (4 μg/mL). Furthermore, PEG conjugation improved the blood compatibility and reduced the aggregation tendency of the HDP in vitro, indicating enhanced biocompatibility. When administered as a single s.c. dose (âˆ?.6 mg, or a peptide concentration of 142 mg/kg) in a mouse abscess model of high-d. methicillin-resistant Staphylococcus aureus (MRSA) infection, the conjugate displayed strong activity, reducing abscess size and bacterial load by 73.3% and 58-fold, resp. This activity was completely lost when the cleavage site was rendered resistant to MMPs by the substitution of two D-amino acids, supporting the hypothesis that antimicrobial activity was dependent on cleavage by MMPs, which were shown here to increasingly accumulate at the abscess site up to 18 h post infection. Finally, the conjugate displayed biocompatibility in vivo, with no identifiable toxicity or aggregation.

Journal of Controlled Release published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Formula: C20H19NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia