Tag: M.W=300-350

Lv, Qiang published the artcileLattice-mismatch-free growth of organic heterostructure nanowires from cocrystals to alloys, Recommanded Product: Coronene, the publication is Nature Communications (2022), 13(1), 3099, database is CAplus and MEDLINE.

Organic heterostructure nanowires, such as multiblock, core/shell, branch-like and related compounds, have attracted chemists¡ä extensive attention because of their novel physicochem. properties. However, owing to the difficulty in solving the lattice mismatch of distinct mols., the construction of organic heterostructures at large scale remains challenging, which restricts its wide use in future applications. In this work, we define a concept of lattice-mismatch-free for hierarchical self-assembly of organic semiconductor mols., allowing for the large-scale synthesis of organic heterostructure nanowires composed of the organic alloys and cocrystals. Thus, various types of organic triblock nanowires are prepared in large scale, and the length ratio of different segments of the triblock nanowires can be precisely regulated by changing the stoichiometric ratio of different components. These results pave the way towards fine synthesis of heterostructures in a large scale and facilitate their applications in organic optoelectronics at micro/nanoscale.

Nature Communications published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Huang published the artcileA contorted nanographene shelter, HPLC of Formula: 191-07-1, the publication is Nature Communications (2021), 12(1), 5191, database is CAplus and MEDLINE.

Abstract: Nanographenes have kindled considerable interest in the fields of materials science and supramol. chem. as a result of their unique self-assembling and optoelectronic properties. Encapsulating the contorted nanographenes inside artificial receptors, however, remains challenging. Herein, we report the design and synthesis of a trigonal prismatic hexacationic cage, which has a large cavity and adopts a relatively flexible conformation. It serves as a receptor, not only for planar coronene, but also for contorted nanographene derivatives with diameters of approx. 15 ? and thicknesses of 7 ?. A comprehensive investigation of the host-guest interactions in the solid, solution and gaseous states by experimentation and theor. calculations reveals collectively an induced-fit binding mechanism with high binding affinities between the cage and the nanographenes. Notably, the photostability of the nanographenes is improved significantly by the ultrafast deactivation of their excited states within the cage. Encapsulating the contorted nanographenes inside the cage provides a noncovalent strategy for regulating their photoreactivity.

Nature Communications published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C18H26ClN3O, HPLC of Formula: 191-07-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lei, Yali published the artcileCharacteristics and health risks of parent, alkylated, and oxygenated PAHs and their contributions to reactive oxygen species from PM_2.5 vehicular emissions in the longest tunnel in downtown Xi¡äan, China, Related Products of catalysis-chemistry, the publication is Environmental Research (2022), 212(Part_C), 113357, database is CAplus and MEDLINE.

A vehicular emission study was conducted in the longest inner-city tunnel in Xi¡äan, northwestern China in four time periods (I: 07:30-10:30, II: 11:00-14:00, III: 16:30-19:30, and IV: 20:00-23:00 LST). A sum of 40 PAHs, including parent (p-PAHs), alkylated (a-PAHs), and oxygenated (o-PAHs) in fine particulate matter (PM_2.5) were quantified. The relationships between the PAHs and the formation of reactive oxygen species (ROS) were also studied. The average total quantified PAHs concentration was 236.3 ¡À 48.3 ng m^-3. The p-PAHs were found to be the most dominated group, accounting for an average of 88.1% of the total quantified PAHs, followed by a-PAHs (6.1%) and o-PAHs (5.8%). On the base of the number of aromatic rings, the groups of ¡Ü5 rings (92.5 ¡À 1.2%) had higher fractions than the high ones (¡Ý6 rings, 7.5 ¡À 1.2%) for pPAHs. Diurnal variations of PAHs subgroups exhibited the highest levels in Period III, consistent with the largest traffic counts in evening rush hours. However, less reduction of few PAHs in the night period demonstrates that the emissions of compressed natural gas (CNG) and methanol-fueled vehicles cannot be ignored while their contribution increased. High ROS activity levels were observed in the traffic-dominated samples, implying the potential oxidative damages to humans. Addnl., diurnal variation of the ROS activity was consistent with the total quantified PAHs and toxic equivalency of benzo[a]pyrene. Good correlations (R > 0.6, p < 0.05) were seen between individual groups of PAHs (especially for 3-5 rings p-PAHs, 4 rings a-PAHs, and 2-3 rings o-PAHs) and ROS activity, supporting that the vehicular emitted PAHs possibly initiate oxidative stress. The multiple linear regression anal. further illustrated that chrysene contributed the highest (25.0%) to ROS activity. In addition to highlighting the potential hazards to the PAHs from the vehicular emission, their roles to mitigate the health effects by formations of ROS were firstly reported in northwestern China.

Environmental Research published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Reja, Rahi M. published the artcileLysine-Targeting Reversible Covalent Inhibitors with Long Residence Time, Related Products of catalysis-chemistry, the publication is Journal of the American Chemical Society (2022), 144(3), 1152-1157, database is CAplus and MEDLINE.

We report a new reversible lysine conjugation that features a novel diazaborine product and much slowed dissociation kinetics in comparison to the previously known iminoboronate chem. Incorporating the diazaborine-forming warhead RMR1 to a peptide ligand gives potent and long-acting reversible covalent inhibitors of the staphylococcal sortase. The efficacy of sortase inhibition is demonstrated via biochem. and cell-based assays. A comparative study of RMR1 and an iminoboronate-forming warhead highlights the significance and potential of modulating bond dissociation kinetics in achieving long-acting reversible covalent inhibitors.

Journal of the American Chemical Society published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qiang, Ting published the artcileModulation of hyperglycemia by sodium alginate is associated with changes of serum metabolite and gut microbiota in mice, Category: catalysis-chemistry, the publication is Carbohydrate Polymers (2022), 119359, database is CAplus and MEDLINE.

Previous studies showed that sodium alginates of different mol. weights reduced postprandial glucose differently. We hypothesize that the differential modulation of hyperglycemia by sodium alginates with different mol. weights may be associated with their differential regulations of serum metabolites and gut microbiota. In this work, high-fat diet-fed mice were supplemented with high- and low-mol.-weight sodium alginate (H-SA, 3350 kDa; L-SA, 131 kDa). Blood glucose/lipid parameters, serum metabolites and gut microbiota were measured. Compared with L-SA, H-SA more significantly reduced fasting blood glucose, HOMA-IR, total cholesterol and body fat; H-SA more significantly enriched serum metabolites, including certain lipids, branched-chain amino acids, and vitamin D and E derivatives These changes were correlated with the differential modulation of gut microbiota by H-SA and L-SA. In conclusion, the differential effects of sodium alginates with different mol. weights in alleviating hyperglycemia were associated with their differential modulations of serum metabolites and gut microbiota.

Carbohydrate Polymers published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qi, Xin published the artcileSecond Natural Rubber with Self-Reinforcing Effect Based on Strain-Induced Crystallization, COA of Formula: C14H10O4S2, the publication is Macromolecules (Washington, DC, United States) (2022), 55(7), 2758-2767, database is CAplus.

Natural rubber (NR) has a strategic position in the rubber industry due to its excellent properties, but it faces the problem of insufficient output and difficulty in recycling. Here, a high-performance elastomer was prepared by the simple epoxidation modification of biobased Eucommia ulmoides gum (EUG). For the first time, it was found that epoxidized EUG (EEUG) with epoxy degree of 12.3%-17.4% no longer crystallized at room temperature but had the ability to strain-induced crystallization (SIC). As a result, its vulcanizates showed excellent tensile strength (17 MPa), toughness (37.8 MJ m^-3) and elasticity (strain recovery values >97%) without filler reinforcement, which is comparable with vulcanized NR. The SIC of EEUG was studied by synchrotron radiation wide-angle X-ray diffraction (SR-WAXD), and its performance was also compared with NR under the reinforcement of carbon black. In addition, through crosslinking by disulfide bonds, EEUG could be used to prepare high-performance (tensile strength of 10.5 MPa, toughness of 30.7 MJ m^-3), recyclable green elastomers. This new kind of elastomer can be used as the second natural rubber, which is of great significance to solve the problem of insufficient production and difficult recovery of NR.

Macromolecules (Washington, DC, United States) published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, COA of Formula: C14H10O4S2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rashidian, Mohammad published the artcileEnzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics, Application In Synthesis of 1466420-02-9, the publication is Angewandte Chemie, International Edition (2016), 55(2), 528-533, database is CAplus and MEDLINE.

Antibodies are currently the fastest-growing class of therapeutics. Although naked antibodies proved valuable as pharmaceutical agents, they have some limitations, such as low tissue penetration and a long circulatory half-life. They have been conjugated to toxic payloads, PEGs, or radioisotopes to increase and optimize their therapeutic efficacy. Although nonspecific conjugation is suitable for most in vitro applications, it has become evident that site specifically modified antibodies may have advantages for in vivo applications. Herein the authors describe a novel approach in which the antibody fragment is tagged with two handles: one for the introduction of a fluorophore or ¹⁸F isotope, and the second for further modification of the fragment with a PEG moiety or a second antibody fragment to tune its circulatory half-life or its avidity. Such constructs, which recognize Class II MHC products and CD11b, showed high avidity and specificity. They were used to image cancers and could detect small tumors.

Angewandte Chemie, International Edition published new progress about 1466420-02-9. 1466420-02-9 belongs to catalysis-chemistry, auxiliary class Copper-Free Click Chemistry,Tetrazine, name is (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid, and the molecular formula is C12H12F3N5O2, Application In Synthesis of 1466420-02-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Wencong published the artcilePreparation of room-temperature self-healing elastomers with high strength based on multiple dynamic bonds, Application of 2,2′-Dithiodibenzoic acid, the publication is European Polymer Journal (2021), 110614, database is CAplus.

As far as the self-healing elastomers are concerned, there is a contradiction between mech. strength and self-healing performance because it’s hard to acquire strong intermol. interaction and flexible segments motion concurrently. How to prepare room-temperature self-healing elastomers with high strength remains an enormous challenge. Herein, we synthesized room-temperature self-healing thermoplastic polyurethanes (TPUs) incorporated with multiple hydrogen bonds, reversible disulfide bonds and coordination bonds simultaneously. The prepared elastomers exhibit a tensile strength of over 16.1 MPa and a fracture strain of 771%, which are robust in comparison to most previous reports. The multiple dynamic bonds endow the elastomers with a high self-healing efficiency (94%) within 24 h at room temperature The self-healing mechanism was expounded from the perspective of the aggregate structure such as the degree of aggregation, the degree of microphase separation and mol. dynamics. It can be calculated by the dynamic mech. anal. that the activation energy of the target elastomer is lower than that of samples without dynamic interactions, which is of advantage to self-healing properties.

European Polymer Journal published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C19H14N2, Application of 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yuan, Gankun published the artcileA novel hierarchical targeting and controllable smart nanoparticles for enhanced in situ nuclear photodynamic therapy, Name: Fmoc-Pro-OH, the publication is Nano Research (2022), 15(5), 4212-4223, database is CAplus.

Photodynamic therapy (PDT) is a promising and non-invasive treatment for various cancers. Although nuclear PDT has considerable therapeutic prospects, it is still hindered by the non-specific recognition of tumor tissues or the degradation of nuclear targeting cationic groups by enzymes in the blood. Herein, a hierarchical targeted and controlled release strategy is proposed by using folate-modified poly-¦Â-cyclodextrin (poly-¦Â-CD) as a nano-carrier for loading nuclear localization signals (NLSs)-conjugated photosensitizer PAP (PAP = pyropheophorbide a-PAAKRVKLD). Excitingly, the obtained FA-CD@PAP (FA = folic acid) and nanoparticles (NPs) can specifically recognize tumor cells overexpressing folate receptors (FR) to remarkedly enhance the intracellular accumulation. Furthermore, the encapsulated PAP can be released under acidic conditions to realize precise nuclear localization. The reactive oxygen species (ROS) generated by the intranuclear-accumulated PAP upon irradiation can oxidize and destroy DNA chains or DNA repair enzymes instantaneously, which can directly induce cell death. As a result, FA-CD@PAP NPs exhibit excellent tumor regression and negligible side effects. This work provides an intelligent nuclear-targeted delivery strategy for in situ nuclear PDT with extremely prominent efficacy and high biol. safety.

Nano Research published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C10H18BNO4, Name: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gao, Min published the artcileImaging and evaluation of sulfane sulfur in acute brain ischemia using a mitochondria-targeted near-infrared fluorescent probe, Formula: C14H10O4S2, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2018), 6(17), 2608-2619, database is CAplus and MEDLINE.

Ischemia is a pathol. condition owing to the deficiency of blood supply to a limited area of tissue. Ischemia can induce burst production of reactive oxygen species and lead to oxidative damage. As a family member of reactive sulfur species, sulfane sulfur plays important physiol. roles in many biol. events including synthesis of cofactors, modulation of enzyme activities, sulfuration of tRNA, and especially regulation of the intracellular redox state. We hypothesize that the endogenous level of sulfane sulfur will be adjusted to deal with ischemia-induced oxidative damage. Therefore, the bioimaging of sulfane sulfur real-time changes during ischemia is important for better understanding its physiol. processes. Herein, we describe the development of a mitochondria-targeted fluorescent probe Mito-SH that allowed for selective and sensitive detection of sulfane sulfur. Mito-SH is designed on the basis of the tautomerization of sulfane sulfur to thiosulfoxide, which ensures its high selectivity and sensitivity. A lipophilic triphenylphosphonium cation is selected as the mitochondria-targeted moiety, which can precisely navigate Mito-SH into mitochondria. The emission profile of azo-BODIPY fluorophore locates at the near-IR region, which deeply penetrates tissue and effectively avoids the interference of biol. background. Mito-SH exhibits the desirable combination of selectivity, sensitivity and excellent fluorescence response upon reaction with sulfane sulfur in cells. By employing Mito-SH, we evaluate the real-time sulfane sulfur dynamic changes under oxygen-glucose deprivation. Finally, Mito-SH has been successfully used for imaging sulfane sulfur changes caused by acute ischemia in mice.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Formula: C14H10O4S2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia