Tag: M.W=400-450

Otsuki, Makoto published the artcileTherapeutic effects of camostat on caerulein-induced acute pancreatitis in rats, Application In Synthesis of 71079-09-9, the publication is Biomedical Research (1989), 10(Suppl. 1), 25-31, database is CAplus.

Acute pancreatitis was induced in rats by 4 s.c. injections of caerulein (20 ¦Ìg/kg) at hourly intervals. The animals were then given either 100 mg camostat/kg or 0.05M phosphate buffer via gastric tube 30 min after the last caerulein injection. The elevation of serum amylase activity in rats treated with caerulein was reduced by camostat treatment, and the peak value was seen 1 h earlier than that in the rats that did not receive camostat. This was accompanied by an alleviation of the histol. signs of acute pancreatitis, such as cellular infiltration and acinar cell vacuolization. After oral administration, camostat and its metabolite 4-(4-guanidinobenzoyloxy)phenylacetic acid were detectable in plasma for >6 h in concentrations high enough to have antiprotease activity. In addition, camostat stimulated endogenous secretin release. Oral administration of camostat may reduce the severity of caerulein-induced pancreatitis by releasing endogenous secretin and by its antiprotease activity.

Biomedical Research published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, Application In Synthesis of 71079-09-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Goeke, B. published the artcileStudies on the effect of FOY-305 on the pancreatic secretion of rats in vivo, HPLC of Formula: 71079-09-9, the publication is Verhandlungen der Deutschen Gesellschaft fuer Innere Medizin (1984), 1067-70, database is CAplus.

FOY-305??[59721-29-8] (0.1-5.0 mg/kg/h) administered i.v. to rats inhibited trypsin??[9002-07-7], but not amylase, activity in pancreatic juice was dependent on the dose. Pancreatic juice volume was not affected. FOY-251??[71079-09-9], a metabolite of FOY-305, was found in pancreatic juice and homogenates of rat pancreas after FOY-305 treatment and may be responsible for the antitryptic activity.

Verhandlungen der Deutschen Gesellschaft fuer Innere Medizin published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, HPLC of Formula: 71079-09-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Goeke, B. published the artcileEffect of a specific serine protease inhibitor on the rat pancreas: systemic administration of camostat and exocrine pancreatic secretion, HPLC of Formula: 71079-09-9, the publication is Digestion (1984), 30(3), 171-8, database is CAplus and MEDLINE.

Camostat??[59721-28-7], a synthetic serine?protease??[37259-58-8] inhibitor, specifically inhibits the trypsin??[9002-07-7] activity in vitro. Immediately after i.v. administration of camostat (5, 2.5, 0.5, and 0.1 mg/kg/h) the trypsin activity in the biliary-pancreatic juice was diminished dose-dependently in anesthetized rats. Amylase??[9000-92-4] release was not influenced. Camostat and its metabolites were detected by high-pressure liquid chromatog. in the pancreatic juice and tissue; in plasma, only the metabolites were found. Therefore, the inhibitory action of camostat on the trypsin activity in the biliary-pancreatic juice may be due to penetration of camostat into the juice.

Digestion published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, HPLC of Formula: 71079-09-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cal, Pedro M. S. D. published the artcileSite-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells, Application In Synthesis of 1395786-30-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(2), 368-371, database is CAplus and MEDLINE.

Fluorophores are indispensable for imaging biol. processes. The authors report the design and synthesis of azide-tagged boronic acid salicylidenehydrazone (BASHY) dyes and their use for site-selective labeling of Annexin V. The Annexin V-BASHY conjugate maintained function and fluorescence as demonstrated by the targeted detection of apoptotic cells.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C25H21N3O4, Application In Synthesis of 1395786-30-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mukhortava, Ann published the artcileEfficient Formation of Site-Specific Protein-DNA Hybrids Using Copper-Free Click Chemistry, SDS of cas: 1395786-30-7, the publication is Bioconjugate Chemistry (2016), 27(7), 1559-1563, database is CAplus and MEDLINE.

Protein-DNA hybrids have become increasingly popular mol. building blocks in bionanotechnol. and single-mol. studies to synergistically combine the programmability of DNA with the chem. diversity of proteins. The growing demand for protein-DNA hybrids requires powerful strategies for their conjugation. Here, we present an efficient two-step method for protein-DNA assembly based on copper-free click chem. The method allows site-specificity and high coupling efficiency, while maintaining the conservation of protein activity. We compare our method to a commonly used protocol of direct linkage of maleimide-modified oligos. We demonstrate the significantly higher yield with a protein-DNA conjugate, which is analyzed using single-mol. force spectroscopy.

Bioconjugate Chemistry published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C25H21N3O4, SDS of cas: 1395786-30-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nishihata, Toshiaki published the artcileIntestinal absorption of N,N’-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulfonate in rats, Synthetic Route of 71079-09-9, the publication is Chemical & Pharmaceutical Bulletin (1988), 36(7), 2544-50, database is CAplus and MEDLINE.

The intestinal absorption of N,N‘-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulfonate (FOY305) in rats was investigated using a rat intestinal loop method. Plasma drug concentrations and the disappearance of the drug from the intestinal lumen were measured. The absorption of FOY305 after administration into a rectal loop was greater than those after administration into variously positioned small intestinal loops. The low absorption of FOY305 after administration into the small intestine was due to the rapid degradation of FOY305 by esterase activity in the small intestinal lumen. The results are discussed with respect to the development of an oral or rectal dosage form of FOY305.

Chemical & Pharmaceutical Bulletin published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, Synthetic Route of 71079-09-9.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kohri, Naonori published the artcileDevelopment of camostat mesilate troche for the prevention of induced mucositis in the mouth at cancer chemotherapy, Recommanded Product: 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, the publication is Yakuzaigaku (2001), 61(1), 34-45, database is CAplus.

We prepared a troche containing camostat mesilate for the prevention of the mucositis in the mouth induced by cancer chemotherapy. The troche was formed by the direct compression of a powder mixture of camostat mesilate, a flavoring agent, hydroxypropyl cellulose, and magnesium stearate. A troche containing 10% or 20% hydroxypropyl cellulose and a flavoring agent of coffee or green apple diminished the bitterness of camostat mesilate. It was found that the metabolizing rate of camostat in saliva was much slower than that in blood, although metabolites in saliva were the same kinds as those in blood. The amounts of camostat retained in the mouth after administration of the troche to healthy subjects were much larger than those after applying a gargle which had a bitter taste. Moreover, the troche containing the flavoring agent of green apple showed smaller amounts of camostat and its metabolites retained in the mouth compared to the troche containing the flavoring agent of coffee. It is considered that the increase in the secreting volume of saliva after administration of the troche containing the flavoring agent of green apple would prevent the retaining of camostat and its metabolites in the mouth. Moreover, the administration of a troche is more convenient than that of a gargle for patients. The troche prepared in this study would be a substitute dosage form for the gargle and promote the quality of life in patients.

Yakuzaigaku published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, Recommanded Product: 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Stejskalova, Anna published the artcileBiologically Inspired, Cell-Selective Release of Aptamer-Trapped Growth Factors by Traction Forces, Computed Properties of 1395786-30-7, the publication is Advanced Materials (Weinheim, Germany) (2019), 31(7), n/a, database is CAplus and MEDLINE.

Biomaterial scaffolds that are designed to incorporate dynamic, spatiotemporal information have the potential to interface with cells and tissues to direct behavior. Here, a bioinspired, programmable nanotechnol.-based platform is described that harnesses cellular traction forces to activate growth factors, eliminating the need for exogenous triggers (e.g., light), spatially diffuse triggers (e.g., enzymes, pH changes), or passive activation (e.g., hydrolysis). Flexible aptamer technol. is used to create modular, synthetic mimics of the Large Latent Complex that restrains transforming growth factor-¦Â1 (TGF-¦Â1). This flexible nanotechnol.-based approach is shown here to work with both platelet-derived growth factor-BB (PDGF-BB) and vascular endothelial growth factor (VEGF-165), integrate with glass coverslips, polyacrylamide gels, and collagen scaffolds, enable activation by various cells (e.g., primary human dermal fibroblasts, HMEC-1 endothelial cells), and unlock fundamentally new capabilities such as selective activation of growth factors by differing cell types (e.g., activation by smooth muscle cells but not fibroblasts) within clin. relevant collagen sponges.

Advanced Materials (Weinheim, Germany) published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is 0, Computed Properties of 1395786-30-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yamamoto, Yukio published the artcilePulse radiolysis study of salt effects on reactions of aromatic radical cations with chloride: rate constants in the absence and presence of quaternary ammonium salts, Safety of N-hexadecyltrimethylammoniumhexafluorophosphate, the publication is Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases (1987), 83(6), 1795-804, database is CAplus.

The effect of quaternary ammonium salts on the decays of the radical cations of biphenyl, trans-stilbene, anthracene, and pyrene generated by pulse radiolysis in chlorohydrocarbons has been investigated. The decays, which are due to the neutralization reactions with Cl^–, are retarded by the addition of salts containing nonnucleophilic PF₆^–, BF₄^–, and ClO₄^–; the radical cations are rapidly quenched by salts containing I^– and BPh₄^–. The retarding effect of the salts is attributed to the formation of ion pairs between the reacting ions and the counter-ions from the salts. The rate constants for the neutralization reactions in 1,2-dichloroethane have been determined for the free-ion and ion-paired states; the latter state is attained by the addition of Bu₄NPF₆.

Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases published new progress about 101079-29-2. 101079-29-2 belongs to catalysis-chemistry, auxiliary class Surfactants, name is N-hexadecyltrimethylammoniumhexafluorophosphate, and the molecular formula is C17H20ClN3, Safety of N-hexadecyltrimethylammoniumhexafluorophosphate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yamamoto, Yukio published the artcilePulse radiolysis of trans-stilbene in tetrahydrofuran. Spectral shift and decay kinetics of the radical anions in the presence of quaternary ammonium salts, Synthetic Route of 101079-29-2, the publication is Journal of Physical Chemistry (1986), 90(9), 1921-4, database is CAplus.

Pulse radiolysis of trans-stilbene (St) in THF solution was carried out in the presence of quaternary ammonium salts, such as Bu₄NPF₆, Bu₄NI, Bu₄NBPh₄, CeMe₃NPF₆, PhMe₃NPF₆, and BzMe₃NPF₆ (Ce, cetyl). The absorption peak of the radical anions, St^–¡¤, was shifted to shorter wavelengths in the presence of the salts. The magnitude of the shift depended on the substituent groups of the quaternary ammonium cations. It is suggested that St^–¡¤ forms contact ion pairs with the quaternary ammonium cations. The decay rate of St^–¡¤ decreases with increasing salt concentration and becomes steady. The rate constants for the neutralization reaction of St^–¡¤ with the solvent counterions, THF(H⁺), were determined in the absence and presence of Bu₄NPF₆; in the latter case, the reaction occurs between the ion pairs St^–¡¤/Bu₄N⁺ and THF(H⁺)/PF₆^–. The results for other aromatic compounds such as biphenyl, anthracene, and pyrene are also presented. Comparison was made with the effect of NaBPh₄.

Journal of Physical Chemistry published new progress about 101079-29-2. 101079-29-2 belongs to catalysis-chemistry, auxiliary class Surfactants, name is N-hexadecyltrimethylammoniumhexafluorophosphate, and the molecular formula is C21H24O8, Synthetic Route of 101079-29-2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia