Month: November 2022

Wang, Tao published the artcileEngineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking, Quality Control of 1395786-30-7, the publication is Nature Communications (2022), 13(1), 160, database is CAplus and MEDLINE.

Immune response and new tissue formation are important aspects of tissue repair. However, only a single aspect is generally considered in previous biomedical interventions, and the synergistic effect is unclear. Here, a dual-effect coating with immobilized immunomodulatory metal ions (e.g., Zn²⁺) and osteoinductive growth factors (e.g., BMP-2 peptide) is designed via mussel adhesion-mediated ion coordination and mol. clicking strategy. Compared to the bare TiO₂ group, Zn²⁺ can increase M2 macrophage recruitment by up to 92.5% in vivo and upregulate the expression of M2 cytokine IL-10 by 84.5%; while the dual-effect of Zn²⁺ and BMP-2 peptide can increase M2 macrophages recruitment by up to 124.7% in vivo and upregulate the expression of M2 cytokine IL-10 by 171%. These benefits eventually significantly enhance bone-implant mech. fixation (203.3 N) and new bone ingrowth (82.1%) compared to the bare TiO2 (98.6 N and 45.1%, resp.). Taken together, the dual-effect coating can be utilized to synergistically modulate the osteoimmune microenvironment at the bone-implant interface, enhancing bone regeneration for successful implantation.

Nature Communications published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C8H6ClF, Quality Control of 1395786-30-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Eisapour, Mohammad published the artcileSynthesize and Characterize Branched Magnetic Nanoparticles for the Removal of Pb(II), Cu(II), and Co(II) from Aqueous Solution in Batch System, Safety of 3-(Trimethoxysilyl)propan-1-amine, the publication is International Journal of Environmental Research (2022), 16(3), 29, database is CAplus.

In this research, branched magnetic nanoparticles with dendritic amine groups were prepared and functionalized. These nanoparticles have a clear core-shell structure, uniform size, and high magnetization. The synthesized Fe₃O₄@SiO₂/Branched by Fourier transform IR spectroscopy (FTIR), thermogravimetric anal. (TGA), X-ray powder diffraction (XRD), scanning electron microscope (SEM), Transmission Electron Microscopy (TEM), zeta-potential measurement, and vibrating sample magnetometer (VSM) Characterization of nanoparticles. The effects of different factors were studied, including pH, equilibration time, metal concentration, Fe₃O₄@SiO₂/Branched dose, and temperature The kinetic anal. showed that the adsorption process was successfully adjusted using the pseudo-second kinetic model. The adsorption isotherm data are fitted using a Langmuir model. The adsorption of metal ions on Fe₃O₄@SiO₂/Branched is temperature-dependent and increases with the increase of system temperature, indicating the endothermic and spontaneous nature of adsorption. The maximum adsorption capacities of Pb(II), Cu(II), and Co(II) are 311, 204, and 146 mg/g, resp. The Fe₃O₄@SiO₂/Branched was regenerated and it was found that the adsorption capacity was not significantly reduced after repeated use for five times in the continuous adsorption and desorption cycle.

International Journal of Environmental Research published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Safety of 3-(Trimethoxysilyl)propan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sinha, Sujata published the artcileEffect of organic counter-ions on the surface activity, micellar formation and dye solubilization behaviour of cationic surfactants, Category: catalysis-chemistry, the publication is Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry (2002), 41A(5), 914-920, database is CAplus.

The effect of eight organic counterions (aliphatic, both mono and dicarboxylates) on the surface and micellar behavior of decyl and dodecyl ammonium carboxylates in aqueous solution has been examined by different physicochem. techniques such as surface tension, dye solubilization, conductance viscosity and NMR. The effect of these counter-ions as observed from surface activity, and critical micelle concentration (CMC) is explained in terms of their condensation /penetration onto/into the micelles. The decrease in CMC and increase in counter-ion binding of cationic surfactants is attributed to the increased hydrophobicity in alkyl chain of counter-ions. In the case of monocarboxylate counter-ions, CMC decreases significantly in the order: n-butyrate < propionate < acetate <formate, while for dicarboxylates decrease in CMC with increase in number of carbon atoms in the counter-ion is less substantial. Compared to monocarboxylates, dicarboxylate counter-ions condense strongly onto the micelle surface and thus are capable of being easily incorporated into the micelles and consequently show greater surface activity, and lower CMC of cationic surfactant. The effect of temperature on surface activity and micellar behavior of decyl ammonium succinate is also reported.

Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C7H13BrSi, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Mohammadi Ziarani, Ghodsi published the artcileSpiroindeno-pyridineindoles (SIPIs) as new visible colorimetric pH indicators, Quality Control of 13822-56-5, the publication is Chemosphere (2022), 135630, database is CAplus and MEDLINE.

Some new, highly selective, and sensitive colorimetric pH indicators, spiro[4H-indeno-[1,2-b]pyridine-4,3′-[3H]indoles] I (R¹ = H, Bn; R² = Me, Ph; R³ = Et; X = Br, I, F, etc.) (SIPIs) in aqueous solution were developed. SIPIs I were synthesized via a one-pot four-component condensation of isatin derivatives, II β-diketones R₂C(O)CH₂C(O)OEt, 1,3-indandione, and ammonium acetate using FSi-PrNH-BuSO₃H as a nanocatalyst in EtOH. According to the exptl. evaluations, it was found that SIPI derivatives are pH indicators for naked-eye detection of OH ion with intense color changes from orange to purple in the pH range of 10.3-12.

Chemosphere published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Quality Control of 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Musa, Musiliyu A. published the artcileIdentification of 7,8-dihydroxy-3-phenylcoumarin as a reversible monoamine oxidase enzyme inhibitor, HPLC of Formula: 104-03-0, the publication is Journal of Biochemical and Molecular Toxicology (2021), 35(2), e22651, database is CAplus and MEDLINE.

We herein report the biol. evaluation of 3-arylcoumarin derivatives (3a-l) as potential human monoamine oxidase-A and -B (hMAO-A and hMAO-B) inhibitors. The result indicated that 7,8-dihydroxy-3-(4-nitrophenyl)coumarin (3j) was most effective against MAO-A (inhibition concentration [IC₅₀] = 6.46 ± 0.02μM) and MAO-B (IC₅₀ = 3.8 ± 0.3μM) enzymes than other synthesized compounds and reference compounds (pargyline and moclobemide). Furthermore, compound (3j) showed (a) nonselectivity against hMAO enzymes, (b) reversible hMAO enzymes inhibition, and (c) neuroprotection against H₂O2-treated human neuroblastoma (N2a) cells. Finally, a mol. modeling study revealed that the hMAO enzymes inhibitory activity of the compound (3j) may be due to the orientation where the nitro (NO2) group lies deep into the receptor and the Ph ring directed toward flavin adenosine dinucleotide via hydrogen bond interaction, and possible π-π interaction with various important residues. Thus, the results of the present study demonstrate that compound (3j) can be considered as a promising scaffold for the development of hMAO-A and hMAO-B inhibitors.

Journal of Biochemical and Molecular Toxicology published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Courage-Maguire, Carol published the artcileCorrelation of in vitro anti-proliferative potential with in vivo teratogenicity in a series of valproate analogs, Product Details of C10H20O2, the publication is International Journal of Developmental Neuroscience (1997), 15(1), 37-43, database is CAplus and MEDLINE.

The prediction that an anti-proliferative effect coupled with a pro-differentiative action will detect a neural tube teratogen has been validated by comparison of these in vitro endpoints with in vivo teratogenicity in a series of closely allied valproate structural analogs. The majority of the compounds significantly inhibited C6 glioma proliferation, the most potent compounds being ranked as octanoic acid > 2-propylhexanoic acid â‰?2-ethylhexanoic acid â‰?valproic acid. The anti-proliferative potency of these compounds did not correlate strictly to their relative in vivo teratogenic potential. Valproic acid exhibited an anti-proliferative IC₅₀ of 1.45 mM, whereas 2-propyl-2-pentenoic acid and 2-propyl-4-pentenoic acid were virtually indistinguishable, exhibiting significantly lower IC₅₀ values of 2.5 and 2.55 mM, resp. The Con A lectin affinity assay was employed to establish whether an anti-proliferative action was coupled with an increased state of cell differentiation. In this lectin affinity assay, the most potent analogs to significantly attenuate the affinity of exposed C6 glioma cells for Con A lectin-coated plastic included 2-butylhexanoic acid, 2-propyl-4-pentenoic acid, 2-propylhexanoic acid, and 2-ethylhexanoic acid in a manner which can be related to their relative teratogenic potencies in vivo. All compounds screened pos. in both the anti-proliferative and pro-differentiative assays exhibited in vivo exencephalic rates of 5-44%. These included valproic acid, 2-ethylhexanoic acid, 2-propylhexanoic acid, and 2-butylhexanoic acid. It would appear that combined anti-proliferative and pro-differentiative screens provide a promising detection system for teratogenic status in a series of valproate analogs.

International Journal of Developmental Neuroscience published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Product Details of C10H20O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tanaka, Tetsuaki published the artcileA new sulfenylation reagent, 3-phenylsulfenyl-2-(N-cyanoimino)thiazolidine, and its optically active version, COA of Formula: C10H15NS, the publication is Synlett (2000), 33-36, database is CAplus.

A new sulfenylation reagent, 3-(phenylthio)-2-(N-cyanoimino)thiazolidine (I), was developed, which is readily available and stable upon storage. Compound I easily reacts with amines or thiols to give the corresponding sulfenamides or asym. disulfides in excellent yields. The α-sulfenylation of carbonyl compounds with I proceeds smoothly. Furthermore, the optically active 4-diphenylmethyl derivative of I was synthesized as an asym. sulfenylation reagent, which realized 96% ee upon α-sulfenylation of a cyclic β-keto ester.

Synlett published new progress about 19117-31-8. 19117-31-8 belongs to catalysis-chemistry, auxiliary class Oxidant, name is N-(tert-Butyl)-S-phenylthiohydroxylamine, and the molecular formula is C6H12O2, COA of Formula: C10H15NS.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Saadat, Mostafa published the artcileSulfonic acid-functionalized magnetic carbon nitride as highly efficient ionic composite for sustainable assembly of 1,2,3-triazoles, Product Details of C10H11NO4, the publication is Journal of the Iranian Chemical Society (2021), 18(8), 2057-2064, database is CAplus.

An efficient and straightforward method for constructing of biol. active 4-aryl-NH-1,2,3-triazoles I [Ar = Ph, 2-BrC₆H₄, 2-thienyl, etc.] by the 1,3-dipolar cycloaddition reaction of β-nitrostyrene and sodium azide in the presence of acidic graphitic carbon nitride (Fe₃O₄@g-C₃N₄-SO₃H) ionic nanocomposite had developed. Using a magnetically recoverable acidic ionic catalyst allows eco-friendly and facile conversion and simplifies exptl. setup and work-up procedure that enables the direct synthesis of triazole derivatives under mild conditions. The designed catalytic system provided a broader scope under short reaction times in good to excellent yields. Fe₃O₄@g-C₃N₄-SO₃H could be simply recovered by magnetic separation using an external magnet, maintaining stable activity up to five cycles without appreciable loss of activity.

Journal of the Iranian Chemical Society published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhang, Nan published the artcileSynthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents, Recommanded Product: 1,1,1-Trifluoropropan-2-amine, the publication is Bioorganic & Medicinal Chemistry (2009), 17(1), 111-118, database is CAplus and MEDLINE.

The synthesis and SAR of a series of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents are described. This series of 2-heteroarylpyrimidines was developed by modifying a series of anti-tumor [1,2,4]triazolo[1,5-a]pyrimidines and 2-cyanoaminopyrimidines we reported earlier. For the 2-heteroaryl group, the best activity is obtained when the heteroaryl group has a nitrogen atom at the ortho-position to the pyrimidyl core. The structure-activity relationship for the rest of the mol. in this 2-heteroarylpyrimidine series mimics that of the [1,2,4]triazolo[1,5-a]pyrimidine series. Like triazolopyrimidines and 2-cyanoaminopyrimidines, the 2-heteroarylpyrimidines retain the capability to overcome multidrug resistance due to Pgp. Mechanism of action studies showed that the lead compounds behaved in the same manner as triazolopyrimidines and 2-cyanoaminopyrimidines. The lead compounds in this series are more potent than the corresponding triazolopyrimidines in vitro and in vivo. Compound 21 (PTI-868) showed tumor growth inhibition in several nude mouse xenograft models, and was selected to advance to preclin. development.

Bioorganic & Medicinal Chemistry published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C6H12N2O, Recommanded Product: 1,1,1-Trifluoropropan-2-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Polster, Jake W. published the artcileRectified and Salt Concentration Dependent Wetting of Hydrophobic Nanopores, SDS of cas: 13822-56-5, the publication is Journal of the American Chemical Society (2022), 144(26), 11693-11705, database is CAplus and MEDLINE.

Nanopores lined with hydrophobic groups function as switches for water and all dissolved species, such that transport is allowed only when applying a sufficiently high transmembrane pressure difference or voltage. Here we show a hydrophobic nanopore system whose wetting and ability to transport water and ions is rectified and can be controlled with salt concentration The nanopore we study contains a junction between a hydrophobic zone and a pos. charged hydrophilic zone. The nanopore is closed for transport at low salt concentrations and exhibits finite current only when the concentration reaches a threshold value that is dependent on the pore opening diameter, voltage polarity and magnitude, and type of electrolyte. The smallest nanopore studied here had a 4 nm diameter and did not open for transport in any concentration of KCl or KI examined A 12 nm nanopore was closed for all KCl solutions but conducted current in KI at concentrations above 100 mM for neg. voltages and opened for both voltage polarities at 500 mM KI. Nanopores with a hydrophobic/hydrophilic junction can thus function as diodes, such that one can identify a range of salt concentrations where the pores transport water and ions for only one voltage polarity. Mol. dynamics simulations together with continuum models provided a multiscale explanation of the observed phenomena and linked the salt concentration dependence of wetting with an electrowetting model. Results presented are crucial for designing next-generation chem. and ionic separation devices, as well as understanding fundamental properties of hydrophobic interfaces under nanoconfinement. Pore opening probability for nanopores in a wide range of KCl and KI concentrations (a-d) TEM images of as prepared pores are shown on the left. The middle and right-hand side panels show data for KCl and KI, resp.

Journal of the American Chemical Society published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, SDS of cas: 13822-56-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia