Category: 4230-93-7

Kumar Yadav, Arvind published the artcile(NH₄)₂S₂O₈ mediated denitrative trifluoromethylation of ¦Â-nitrostyrenes: Synthesis of vinyltrifluoromethylated alkenes, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Results in Chemistry (2022), 100325, database is CAplus.

A metal-free denitrative trifluoromethylation of ¦Â-nitrostyrenes has been developed under mild reaction conditions using Langlois’ (CF₃SO₂Na) reagent to an easy access vinyltrifluoromethylated alkenes RCH:CHCF₃ (R = 3-MeOC₆H₄, 2-ClC₆H₄, 2-naphthyl, etc.). (NH₄)₂S₂O₈ used as a cheap radical initiator to produce CF₃ radical via desulfonylation at elevated temperature The product is predominantly trans (E)-selective and reaction is applicable to a wide range of the ¦Â-nitrostyrenes.

Results in Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kim, Sung-Gon published the artcileDiastereoselective organocatalytic Michael addition of 2-arylacetates having an electron-withdrawing group to nitro alkenes, Application In Synthesis of 4230-93-7, the publication is Letters in Organic Chemistry (2012), 9(8), 572-576, database is CAplus.

The first efficient organocatalytic conjugate addition reaction of 2-arylacetates and 2-arylacetonitriles having an electron-withdrawing group to nitro alkenes was achieved using a bifunctional amino thiourea catalyst. The reagents having NO₂-, CO₂Me-, and CN-functional groups on the aromatic ring can be used; the bifunctional catalyst, N-aminocyclohexyl-N’-bis(trifluoromethyl)phenylthiourea provided Michael adducts in the reaction of various nitro alkenes with broad generality in high yield and diastereoselectivity.

Letters in Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Application In Synthesis of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Barkov, Alexey Yu. published the artcileHighly regio- and stereoselective 1,3-dipolar cycloaddition of stabilised azomethine ylides to 3,3,3-trihalogeno-1-nitropropenes: synthesis of trihalomethylated spiro[indoline-3,2′-pyrrolidin]-2-ones and spiro[indoline-3,3′-pyrrolizin]-2-ones, COA of Formula: C10H11NO4, the publication is Tetrahedron (2016), 72(43), 6825-6836, database is CAplus.

Reactions of 3,3,3-trihalogen-1-nitropropenes with N-alkyl-¦Á-amino acids (sarcosine, proline) and isatins proceed regio- and diastereoselectively to give a wide range of trihalomethylated spiro[indoline-3,2′-pyrrolidin]-2-ones I (R¹ = H, 5,7-(Br)₂; R = H, CH₃, C₅H₁₁, Bn; X = F, Br, Cl) and spiro[indoline-3,3′-pyrrolizin]-2-ones II (R¹ = H, 5-NO₂, 5,7-(Br)₂; R = H, CH₃, C₅H₁₁, Bn; X = F, Br, Cl) in good yields as a result of a 1,3-dipolar cycloaddition of the intermediate stabilized azomethine ylide at the double bond of the nitroalkenes.

Tetrahedron published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, COA of Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sun, Haifeng published the artcileAsymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D₁, D₂ and serotonin 5-HT_1A multi-action profile, Category: catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry (2013), 21(4), 856-868, database is CAplus and MEDLINE.

An effective and rapid method for the microwave-assisted preparation of the key intermediate for the total synthesis of tetrahydroprotoberberines (THPBs) including l-stepholidine (l-SPD) was developed. Thirty-one THPB derivatives with diverse substituents on A and D ring were synthesized, and their binding affinity to dopamine D₁, D₂ and serotonin 5-HT_1A and 5-HT_2A receptors were determined Compounds (I) and (II) were identified as partial agonists at the D₁ receptor with K_i values of 50 and 6.3 nM, while both compounds act as D₂ receptor antagonists (K_i = 305 and 145 nM, resp.) and 5-HT_1A receptor full agonists (K_i = 149 and 908 nM, resp.). These two THPBs compounds exerted antipsychotic actions in animal models. Further electrophysiol. studies employing single-unit recording in intact animals demonstrated that I-excited dopaminergic (DA) neurons are associated with its 5-HT_1A receptor agonistic activity. These results suggest that these two compounds targeted to multiple neurotransmitter receptors may present novel lead drugs with new pharmacol. profiles for the treatment of schizophrenia.

Bioorganic & Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C19H21N3O3S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yu, Shuo-Wen published the artcileConstruction of Novel Kojic Acid Fused Furans by Domino Reactions of a Kojic Acid Derivative with (Z)-Bromonitroalkenes, Category: catalysis-chemistry, the publication is ChemistrySelect (2018), 3(17), 4827-4830, database is CAplus.

A series of novel kojic acid fused furans I (R = Ph, 1-naphthyl, 2-thienyl, etc.) have been synthesized by domino cyclization-elimination reactions of a kojic acid derivative with (Z)-bromonitroalkenes. In the presence of a bifunctional thiourea-tertiary amine organocatalyst and sodium bicarbonate, the reactions provided the products in up to quant. yields.

ChemistrySelect published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C5H11NO2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Chen-Ran published the artcileOrganocatalytic silyl transfer from silylborane to nitroalkenes for the synthesis of ¦Â-silyl nitroalkanes and ¦Â-silyl amines, SDS of cas: 4230-93-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(50), 7862-7865, database is CAplus and MEDLINE.

The silylation of a wide array of nitroalkenes is achieved by organocatalysts in yields up to 93%. The reaction is carried out in a toluene/water biphasic solvent under operationally simple conditions. Reduction of the nitro group provides efficient access to functionalized ¦Â-silyl amines.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, SDS of cas: 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Xue-Li published the artcileAsymmetric Synthesis of Functionalized Nitrophenols via a Copper(II)-Mediated Bromination/Debromination Aromatization Sequence, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Asian Journal of Organic Chemistry (2017), 6(8), 967-972, database is CAplus.

2″A stereospecific copper(II)-mediated bromination/debromination aromatization sequence leading to functionalized nitrophenols I (R¹ = H, 4-Me, 4-Et, 3-Me; R² = 3-methoxypheyl, 2-naphthyl, thiophen-2-yl, etc.) from corresponding ¦Ã-nitroketones II is described. This provides a simple methodol. for the construction of nitrophenols I in moderate to good yields and moderate to high enantioselectivities.

Asian Journal of Organic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gao, Jie published the artcileVisible-Light-Promoted Cross-Coupling of O-Aryl Oximes and Nitrostyrenes to Access Cyanoalkylated Alkenes, Synthetic Route of 4230-93-7, the publication is Organic Letters (2022), 24(25), 4640-4644, database is CAplus and MEDLINE.

A photoinduced, photocatalyst-free cyanoalkylation of nitrostyrenes was explored, affording a series of cyanoalkylated alkenes in moderate to good yields. Mechanistic studies reveal that an electron donor-acceptor complex formed between O-aryl oximes and DIPEA was presumably involved in this process. The excellent functional group compatibility of this newly designed synthetic protocol allows for cyanoalkylation of structurally varied substrates, which offered an eco-friendly pathway for the assembly of cyanoalkylated alkenes.

Organic Letters published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fan, Tian-Yun published the artcileStructure-activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Bioorganic Chemistry (2021), 104994, database is CAplus and MEDLINE.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency markedly enhances the survival rate of patients with cardiovascular diseases (CVDs). Forty berberine (BBR) derivatives I (R¹ = H, MeO, R² = MeO, OH, PhCH₂O, EtO, R³ = MeO, OH, EtO, R²R³ = OCH₂O, R⁴ = H, MeO, R⁵ = H, Cl, MeO, PhCH₂O, cyclobutylmethoxy, etc., R⁶ = MeO, OH, R⁷ = MeO, EtO, H) were synthesized and evaluated for their activity on down-regulating the transcription of PCSK9 in HepG2 cells, taking BBR as the lead. Structure-activity relationship (SAR) anal. revealed that the 2,3-dimethoxy moiety might be beneficial for activity. Among them, I (R¹ = R⁴ = R⁷ = H, R² = R³ = R⁶ = MeO, R⁵ = p-F₃CSC₆H₄CH₂O) (II) displayed the most potent activity with an IC₅₀ value of 9.5 ¡À 0.5¦ÌM, better than that of BBR. Also, it significantly decreased the PCSK9 protein level at the cellular level, as well as in the liver and serum of mice in vivo. Furthermore, II markedly increased LDLR expression and LDL-C clearance via down-regulating PCSK9 protein. The mechanism of action of II is targeting HNF1¦Á and/or Sp1 cluster modulation upstream of PCSK9, a different one from BBR. Therefore, II might have the potential to be a novel PCSK9 transcriptional inhibitor for the treatment of atherosclerosis, worthy for further investigation.

Bioorganic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Recommanded Product: 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhou, Binghua published the artcileGluconic acid aqueous solution as a sustainable and recyclable promoting medium for organic reactions, Product Details of C10H11NO4, the publication is Green Chemistry (2011), 13(8), 2204-2211, database is CAplus.

For the first time, gluconic acid aqueous solution (GAAS), a biobased weakly acidic liquid, was used as an effective promoting medium for organic reactions, such as the Michael addition of indoles to ¦Á,¦Â-unsaturated ketones, the electrophilic ring-opening reaction of 3,4-dihydropyran with indoles and Friedel-Crafts alkylation of electron-rich aromatics with benzyl alcs. The concept of using GAAS as a solvent for organic reactions not only offers a sustainable candidate for progress in solvent innovation, but also opens up a new avenue for the utilization of this biobased polyhydroxylated acid. Among the features that render GAAS as a solvent so interesting is the ability to act as both the reaction medium and catalyst. Moreover, this methodol. offers significant improvements with regard to the yield of products, simplicity in operation, cost efficiency and green aspects, in terms of avoiding toxic catalysts and minimizing the generation of waste.

Green Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C12H23N3S, Product Details of C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia