Month: November 2022

Drozdov, V. A. published the artcileAcid-base properties of alkyl(aryl)fluorosilanes in nonaqueous media, Computed Properties of 312-40-3, the publication is Zhurnal Obshchei Khimii (1970), 40(1), 104-9, database is CAplus.

Conventional syntheses gave the following: Me2EtSiF, b. 51¡ã, d20 -, n20D – (n15D 1.3570); Me2PrSiF, b. 77¡ã, -, 1.3708; Me2PhSiF, b. 155-7¡ã, -, 1.5471; (PhCH2)SiMe2F, b98 104¡ã, 0.9743, 1.4838; MeEt(PhCH2)SiF, b. 200-2¡ã, 0.9663, 1.4792; MePh(PhCH2)SiF, b. 117¡ã, 1.0610, 1.5481; MePh2SiF, b43 164.5¡ã, 1.077, 1.5482; Et3SiF, b. 109-10¡ã, 0.8392, 1.3906; Et2PhSiF, b8 77-8¡ã, 0.9837, 1.4880; Et2(PhCH2)SiF, b95 96¡ã, 0.9828, 1.4942; PhSiFCl2, b. 157-9¡ã, -, 1.5293; Ph2SiFCl, b10 131-2¡ã, -, 1.5471; MePhSiF2, b4 108-10¡ã, 1.2000, 1.5339; PhSiF2Cl, b. 129-30¡ã, -, 1.4575; PhSiF3, b. 102-3¡ã, 1.2270, 1.4106; and PhSiCl3, b100 225¡ã, 1.2220, 1.5821; also: MePh2SiCl, b45 191¡ã; MePhSiCl2, b100 223-5¡ã; MePh(PhCH2)SiCl, b. 149¡ã; Me2PhSiCl, b. 190-1¡ã; and Et2PhSiCl, b9 100-2¡ã. Ir spectral curves of 12 of these were shown and their thermodynamic acidity was determined by potentiometric titration in dry MeOH and EtOH relative to dry HCl in the same solvents. The relative values of such acidity expressed in units of pK (-SiR3) were, in MeOH and EtOH, resp.: Et3SiF, 10.9, 10.0; MeEt(PhCH2)-SiF 10.2, 9.56; Me2PhSiF 9.55, 9.14; MePh(PhCH2)SiF, 9.29, 8.80; and Me3SiF, 10.43, 9.69. Unlike chlorosilanes, the sub-stituent groups had considerable effect on the acidity of the fluorosilanes. This is ascribed to the low polarizability of these.

Zhurnal Obshchei Khimii published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Computed Properties of 312-40-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Borbala Horvath, Lilla published the artcileHost cell targeting of novel antimycobacterial 4-aminosalicylic acid derivatives with tuftsin carrier peptides, Name: Fmoc-Pro-OH, the publication is European Journal of Pharmaceutics and Biopharmaceutics (2022), 111-130, database is CAplus and MEDLINE.

Mycobacterium tuberculosis is an intracellular pathogen and the uptake of the antimycobacterial compounds by host cells is limited. Novel antimycobacterials effective against intracellular bacteria are needed. New N-substituted derivatives of 4-aminosalicylic acid have been designed and evaluated. To achieve intracellular efficacy and selectivity, these compounds were conjugated to tuftsin peptides via oxime or amide bonds. These delivery peptides can target tuftsin- and neuropilin receptor-bearing cells, such as macrophages and various other cells of lung origin. We have demonstrated that the in vitro antimycobacterial activity of the 4-aminosalicylic derivatives against M. tuberculosis H₃₇Rv was preserved in the peptide conjugates. The free drugs were ineffective on infected cells, but the conjugates were active against the intracellular bacteria and have the selectivity on various types of host cells. The intracellular distribution of the carrier peptides was assessed, and the peptides internalize and display mainly in the cytosol in a concentration-dependent manner. The penetration ability of the most promising carrier peptide OT5 was evaluated using Transwell-inserts and spheroids. The pentapeptide exhibited time- and concentration-dependent penetration across the non-contact monolayers. Also, the pentapeptide has a fair penetration rate towards the center of spheroids formed of EBC-1 cells.

European Journal of Pharmaceutics and Biopharmaceutics published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Name: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Csiba, I. published the artcileSolubilization properties of some water-soluble aryl alkyl ether derivatives. I. Preparation and solubilization properties of aryloxyacetic acids, SDS of cas: 1798-04-5, the publication is Cesko-Slovenska Farmacie (1968), 17(1), 28-33, database is CAplus and MEDLINE.

Aryloxyacetic acids of the general formula I were prepared by heating a mixture of the appropriate Na phenolate (II) and ClCH2CO2H on a boiling water bath, and extracting the reaction mixture with Et2O and saturated NaHCO3 solution In cases when II was not soluble, EtOH was added to the reaction mixture I prepared were (R1, R2, R3, R4, R5, % yield, and m.p. given): H, Me, H, H, H, 71.9, 101¡ã; H, H, Me, H, H, 72.3, 125¡ã; Et, H, H, H, H, 51.5, 138-40¡ã; NO2, H, H, H, H, 25, 152¡ã; H, H, NO2, H, H, (Ia), 50.1, 182¡ã; H, H, Cl, H, H, 61.5, 158-9¡ã; H, H, tert-Bu, H, H, (IIb), 54.2, 86¡ã; H, H, tert-C8H17, H, H (IIc), 48.3, 106-8¡ã; Ph, H, H, H, H, 28.8, 98-100¡ã; OMe, H, H, H, H, 68.3, 128¡ã; H, OMe, H, H, H, 54.5, 114-15¡ã; H, H, OMe, H, H, 35, 110-12¡ã; EtCO, H, H, H, H, 22.2, 127-9¡ã; H, H, EtCO, H, H, 61.5, 125-7¡ã; Me, Me, H, H, H, 60, 160; Me, H, Me, H, H, 48.6, 140¡ã; Me, H, H, Me, H, 34.5, 118¡ã; Cl, H, Cl, H, H, 56, 138-9¡ã; Me, H, H, iso-Pr, H, 53.8, 149¡ã; iso-Pr, H, H, Me, H, 62.4, 148¡ã; OMe, H, H, CHO, H, 57.5, 175-7¡ã; H, OMe, H, OMe, H, 32.6, 143-4¡ã; Me, H, Me, H, H, 76, 117¡ã; Cl, H, Cl, H, Cl, 49.3, 153-4¡ã; H, Me, Cl, Me, H, 54, 148-5¡ã. Ia (40 g.) and 394.86 g. FeSO4¡¤7H2O in 310 ml. 25% NH4OH was refluxed, and the mixture acidified with AcOH to give 66% I (R1 = R2 = R4 = R5 = H, R3 = NH2), m. 220-2¡ã. Na, K, or Li salts of I were prepared by treating an alc. solution of the appropriate I with alc. metallic hydroxide or alcoholate. Solubility of caffeine and (or) 8-methylcaffeine in solutions of I alkali salts was determined I with substituents having +I and +M effects had higher dissolution power than unsubstituted PhOCH2CO2H (III). IIb, and IIc, resp. acted as surfactants but their dissolution power was lower than that of III.

Cesko-Slovenska Farmacie published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, SDS of cas: 1798-04-5.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Raj, A. F. P. Allwin Mabes published the artcileRemoval of Pb²⁺, Cr³⁺ and Hg²⁺ ions from aqueous solutions using SiO₂ and amino-functionalized SiO₂ particles, Name: 3-(Trimethoxysilyl)propan-1-amine, the publication is Journal of Sol-Gel Science and Technology (2022), 103(1), 290-308, database is CAplus.

Herein we present silica (SiO₂) and amino-functionalized SiO₂ particles (NH₂@SiO₂) based on the Stober method involving the reaction of hydrolysis and condensation of alkoxide precursors tetraethoxysilane (TEOS), 3- (trimethoxysilylpropyl) diethylenetriamine (DETA) and (3-aminopropyl) trimethoxysilane (APTMS) for specific and selective removal of heavy metal ions such as Lead (Pb²⁺), Chromium (Cr³⁺) and Mercury (Hg²⁺). The prepared SiO₂ and NH₂@SiO₂ particles were characterized by Fourier IR Spectroscopy (FTIR) spectroscopy, thermogravimetric anal. (TGA), sp. surface area (BET), transmission electron microscopy (TEM), zeta potential (¦Æ) measurements and potential titration measurements. We studied the adsorption efficiency toward heavy metal ions (Pb²⁺, Cr³⁺ and Hg²⁺) in model salt solutions The adsorption process was evaluated in terms of adsorption efficiency, adsorption capacity, adsorption isotherms, kinetics and thermodn. parameters and desorption efficiency based on the result of the at. absorption spectroscopy (AAS) measurements for Pb²⁺ and Cr³⁺ ions and inductively coupled plasma optical emission spectrometer (ICP-OES) measurements for Hg²⁺. The results showed the highest adsorption efficiency and capacity for heavy metal ions (Pb²⁺, Cr³⁺ and Hg²⁺) by NH₂@SiO₂ using APTMS. Furthermore, the adsorption efficiency was 99.3% for Pb²⁺, 98.4% in the case of Cr³⁺ ions and 88% for Hg²⁺. The adsorption process for Pb²⁺, Cr³⁺ and Hg²⁺ ions using non-functionalized SiO₂ and NH₂@SiO₂ particles follows pseudo-second-order kinetics and is best described by the Langmuir adsorption model. The desorption results showed potential for reusing NH₂@SiO₂ particles with more than 91.8% desorbed Pb²⁺ ions using 0.1 M HCl and 100% desorbed Hg²⁺ ions using 1.5 M C6H8O7. Three alkoxide precursors (tetraethoxysilane (TEOS), 3-(trimethoxysilylpropyl), diethylenetriamine (DETA) and (3-aminopropyl) trimethoxysilane (APTMS)) were used in the one-pot synthesis of silica (SiO₂) and amino-functionalized SiO₂ (NH₂@SiO₂) particles. The prepared adsorbent materials were characterized and used for adsorption tests and desorption toward heavy metals ions (Pb²⁺, Cr³⁺ and Hg²⁺). Adsorption efficiency, adsorption capacity, adsorption isotherms, kinetics and thermodn. parameters were detected.

Journal of Sol-Gel Science and Technology published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Name: 3-(Trimethoxysilyl)propan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tolstikov, V. V. published the artcilePreparation of amides and esters of the antibiotic bruneomycin and study of their cytotoxic and antiretroviral activity, Product Details of C7H14N4, the publication is Khimiko-Farmatsevticheskii Zhurnal (1990), 24(2), 130-2, database is CAplus.

Amides of bruneomycin (I) with 7-amino-1,3,5-triazaadamantane, 5,7-dimethyl-6-amino-1,3-diazaadamantane, ¦Ã-aminobutyric acid or L– and D-isomers of S-methylthiomethylcysteine and an ester with bis(2-hydroxyethyl)amide of glycolic acid were prepared and their cytotoxic, antibacterial and antiviral activities were studied. The glycolic acid ester derivative and ¦Ã-aminobutyric acid amide showed cytotoxic and antiviral activity against Moloney’s sarcoma virus.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C11H24O3, Product Details of C7H14N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Levin, Vitalij V. published the artcileNucleophilic fluoroalkylation of iminium salts, Quality Control of 1206-46-8, the publication is Tetrahedron Letters (2008), 49(19), 3108-3111, database is CAplus.

Iminium cations generated by the coupling of aldehydes, N-trimethylsilylamines and TMSOTf or by the methylation of imines with MeOTf smoothly react with silanes of a general formula Me₃SiR_f (R _f = CF₃, CCl₂F, C₆F₅) to afford the corresponding tertiary amines having a fluorinated substituent. The key step, involving C-C bond formation, is promoted by NaOAc or KF in DMF as a solvent.

Tetrahedron Letters published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Quality Control of 1206-46-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Piela, Katarzyna published the artcileLow temperature emission spectra of optically nonlinear N-benzyl-2-methyl-4-nitroaniline crystal, Recommanded Product: N-Benzyl-2-methyl-4-nitroaniline, the publication is Chemical Physics (2012), 28-32, database is CAplus.

The fluorescence and phosphorescence spectra of N-benzyl-2-methyl-4-nitroaniline (BNA) orthorhombic crystal were measured between 5 and 200 K. The fluorescence spectrum of BNA in a Shpol’skii matrix of n-heptane was also recorded at 5 K. The electronic absorption spectra parameters such as singlet and triplet state energies, dipole moments and oscillator strengths were calculated by semi-empirical and TD DFT methods. The calculated energies of singlet and triplet states and electronic transitions in the BNA mol. were compared with the exptl. results. The phosphorescence decay time was estimated to be 270 ms at 5 K. It is presumed that the disappearance of vibronic structure above 30 K observed in the fluorescence spectra is caused by the nitro group vibrations while the structured phosphorescence originates from the trap states. The role of mol. shape towards emission processes in BNA crystal in terms of structure-property relationship is discussed.

Chemical Physics published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C14H14N2O2, Recommanded Product: N-Benzyl-2-methyl-4-nitroaniline.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Oka, Marina published the artcileGreen Aerobic Oxidation of Thiols to Disulfides by Flavin-Iodine Coupled Organocatalysis, Application of 2,2′-Dithiodibenzoic acid, the publication is Synlett (2021), 32(12), 1227-1230, database is CAplus.

Coupled catalysis using a riboflavin-derived organocatalyst and mol. iodine successfully promoted the aerobic oxidation of thiols to disulfides under metal-free mild conditions. The activation of mol. oxygen occurred smoothly at room temperature through the transfer of electrons from the iodine catalyst to the biomimetic flavin catalyst, forming the basis for a green oxidative synthesis of disulfides from thiols.

Synlett published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Application of 2,2′-Dithiodibenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qian, Xin published the artcileCatalytic double C-Cl bond activation in CH₂Cl₂ by iron(III) salts with Grignard reagents, Computed Properties of 457-68-1, the publication is Synlett (2011), 852-856, database is CAplus.

Cross-coupling of Grignard reagents with dichloromethane is achieved using iron(III) catalysts. Aryl- and benzyl-magnesium bromides show a range of activity toward double C-Cl bond activation resulting in the insertion of methylene fragments between two equivalent of the nucleophilic partner.

Synlett published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Computed Properties of 457-68-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Esmaili, Hamed published the artcileTiO2 nanoarrays modification by a novel Cobalt-heteroatom doped graphene complex for photoelectrochemical water splitting: An experimental and theoretical study, Category: catalysis-chemistry, the publication is Journal of Molecular Liquids (2022), 118960, database is CAplus.

Different graphene structures have received much attention due to their unique chem. and electron properties. In this report, we use heteroatom-doped graphene to coordinate Co2+ for use in photoelectrochem. cells. Flower-like TiO2 photoelectrode morphol. was used as a semiconductor. Its surface was covalently modified with Co2+ coordinated nitrogen and sulfur-doped graphene quantum dot (S, N-GQD). S, N-GQD was used to improve visible light absorption and electron transport properties. Also, cobalt ions were coordinated with pyridinic nitrogen in the GQD structure and, like the cobalt-bipyridine complexes, acted as a catalyst for the water oxidation reaction. The modified photoelectrode significantly improved cell performance and resulted in a photocurrent d. of 1.141 mA/cm². To study the electronic structure of the compounds in more detail, we also used d. functional theory (DFT) calculations The obtained results confirmed the effective interactions of cobalt and S, N-GQD, and showed the energy levels and band gaps in agreement with the exptl. results. This study led to the presentation of a new and robust strategy to improve the optical and catalytic performance of TiO2 nanoarrays in photoelectrochem. cells.

Journal of Molecular Liquids published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia