Month: December 2022

Kurnia, Dessy Yulyani published the artcileTotal synthesis of xylapeptide B [Cyclo-( L-Leu-L-Pro-N-Me-Phe-L-Val-D-Ala )], Product Details of C20H19NO4, the publication is Journal of Heterocyclic Chemistry (2022), 59(1), 131-136, database is CAplus.

Xylapeptide B is a cyclopentapeptide isolated from Xylaria sp. derived from the Chinese medicinal plant Sophora tonkinensis. Xylapeptide B was successfully synthesized by a combination of solid- and solution-phase, using the Fmoc (Fmoc = 9-fluorenylmethoxycarbonyl) strategy, and 2-chlorotrityl chloride resin. The coupling reagent used is a combination of HBTU/HOBt to assist in the formation of amide bonds. D-Ala was chosen as the C-terminal because it has a small residue and can facilitate the cyclization process. Linear peptide was cleaved from the resin using a dilute acid concentration of 20% TFA in DCM because the peptide has no protecting group at the side chain. Crude linear peptide was purified by semi-preparative RP-HPLC using 0%-100% ACN eluent for 35 min and obtained a pure mass of 22.4 mg (18.83%). Cyclization was carried out in solution phase using HBTU (3 equivalent) and DIPEA (1% volume/volume) in diluted concentration (1.25 mM) for 72 h at room temperature The cyclization stage was monitored by thin-layer chromatog. (TLC). Crude xylapeptide B was purified by semi-preparative RP-HPLC using 30%-80% ACN eluent for 40 min, to result in 6 mg (8.91%) of the desired xylapeptide B. All synthesized products were characterized by HR-TOFMS, ¹H-, and ¹³C-NMR.

Journal of Heterocyclic Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Product Details of C20H19NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dasgupta, G. published the artcileOxidation of diphenylamines by alkaline hexacyanoferrate(III). A kinetic study, SDS of cas: 1821-27-8, the publication is Oxidation Communications (2009), 32(2), 390-394, database is CAplus.

Oxidation of diphenylamines by alk. hexacyanoferrate(III) in aqueous methanol was dependent on the first powers of the concentrations of substrate and oxidant, but was independent of the concentration of alkali in the range studied. The Hammett plot gave a value of ¦Ñ = -1.0 The reaction proceeded via the formation of the diphenylamino radical, which was characterized by ESR spectroscopy.

Oxidation Communications published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, SDS of cas: 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Stoica, Ligia published the artcileKinetics of ionic and ion-molecular flotation. Part II. Flotation of copper(II) with amine collectors, Recommanded Product: Dodecylamineacetate, the publication is Revistade Chimie (Bucharest, Romania) (1991), 42(1-3), 63-6, database is CAplus.

The kinetics of the ion-mol. flotation of Cu(11) from a CuSi₄ solution by using laurylamine and stearylamine acetates as collector was studied. The graphical representation of the exptl. results show that flotation is a 1st order reaction with both collectors.

Revistade Chimie (Bucharest, Romania) published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C19H21N3O3S, Recommanded Product: Dodecylamineacetate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yanagisawa, Toshihiko published the artcileSubacute and chronic toxicity studies of triethylenetetramine dihydrochloride (TJA-250) by oral administration to F-344 rats, Safety of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Journal of Toxicological Sciences (1998), 23(Suppl. 4), 619-642, database is CAplus and MEDLINE.

Triethylenetetramine dihydrochloride (trientine-2HCl, TJA-250), a copper chelating agent used to treat Wilson’s disease, was administered orally to male and female F-344 rats for 4 or 8 wk at dosages of 0, 100, 350 or 1200 mg/kg/day or for 26 wk at dosages of 50, 175 or 600 mg/kg/day. Two males receiving 1200 mg/kg/day died during week 8 of treatment. In males receiving 1200 mg/kg/day during weeks 5 to 8 of treatment, body weight gain and food consumption were decreased and hunched posture and thin build were observed During week 4 or 8 of treatment urinalysis revealed, for males receiving 100 mg/kg/day or animals receiving 350 mg/kg/day or more, increased electrolyte outputs possibly due to the hydrochloride nature of trientine-2HCl, with low plasma alk. phosphatase activities evident in animals receiving 350 or 1200 mg/kg/day. After 4 and 8 wk, and during 8 wk of treatment, high lung weights and bronchiolar epithelium hypertrophy and broncho-alveolar pneumonia were recorded for animals receiving 1200 mg/kg/day, and submucosal acute inflammation within the glandular region of the stomach was recorded for males receiving 350 or 1200 mg/kg/day and in all treated female groups. One male receiving 175 mg/kg/day and three males receiving 600 mg/kg/day died, showing lung changes in the 26 wk study. The body weight gain of animals receiving 600 mg/kg/day was slightly decreased. Blood chem. and urinalysis examinations showed changes similar to those indicated in the 4- or 8-wk study. The low plasma copper concentrations seen in males receiving 600 mg/kg/day, the slightly low liver copper concentrations found in animals receiving 600 or 175 mg/kg/day and the high urinary copper concentrations found in all treated groups, are attributed to the pharmacol. action of trientine-2HCl. Histopathol. revealed a dosage-related incidence and severity of focal chronic interstitial pneumonitis accompanied by fibrosis of the alveolar walls in females receiving 175 mg/kg/day or more and all treated male groups, but no significant pathol. changes in the stomach. Apart from the histol. changes found in the lung, all the above changes were reversible. In conclusion, the NOAEL of trientine-2HCl in this 26-wk study was considered to be 50 mg/kg/day for females and less than 50 mg/kg/day for males.

Journal of Toxicological Sciences published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C4H3Cl2N3, Safety of N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bisht, Babita published the artcileQuick Access to High-Purity Peptide Drugs Bradykinin, Leuprolide Analogue, 2(PZ-128), and Rapastinel with Minimal Reagents, Application In Synthesis of 71989-31-6, the publication is Journal of Organic Chemistry (2021), 86(24), 17667-17672, database is CAplus and MEDLINE.

Peptide drugs bradykinin, a leuprolide analog, 2(PZ-128), and rapastinel are synthesized in 56-77% yield using heating-assisted liquid-phase peptide synthesis on a soluble polynorbornene support. These drugs of com. utility and complex structures are obtained in 2-5.5 h with no epimerization and >95% purity using only 1.2 equiv of amino acids and coupling reagents. The peptide yield and purity are comparable or superior to the reported methods.

Journal of Organic Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Application In Synthesis of 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Prathap, S. published the artcileGrowth, optical and thermal studies on N-benzyl-2 methyl-4-nitroaniline, Related Products of catalysis-chemistry, the publication is IOP Conference Series: Materials Science and Engineering (2015), 012033/1-012033/4, database is CAplus.

In this work we present the growth, optical and thermal studies of the nonlinear organic mol. crystal, N-benzyl-2-methyl-4-nitroaniline (BNA). BNA is also a good THz electromagnetic waves emitter in 0.1 – 15 THz range. Nonlinear optical property of the crystal has been confirmed using the Kurtz powder technique and a study of its second harmonic generation efficiency in comparison with KDP has been made. Knoop hardness test was carried out and its Young’s modulus was calculated Thermal behavior of the crystal was investigated by TG-DTG analyses.

IOP Conference Series: Materials Science and Engineering published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C14H14N2O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Chenxuan published the artcileInhibition of ¦¤-6 desaturase reduces fatty acid re-esterification in 3T3-L1 adipocytes independent of changes in n3-PUFA cellular content, Product Details of C22H32O2, the publication is Biochimica et Biophysica Acta, Molecular and Cell Biology of Lipids (2022), 1867(7), 159160, database is CAplus and MEDLINE.

¦¤-6 Desaturase (D6D) is a key enzyme in the synthesis of long-chain polyunsaturated fatty acids (LC-PUFA). Evidence suggests that reduced D6D activity not only disrupts LC-PUFA production, but also impacts whole body lipid handling and body weight; however, the mechanisms remain largely unexplored. Therefore, we investigated the effect of D6D inhibition on the regulation of lipid accumulation in 3T3-L1 adipocytes with and without changes in n-3 PUFA content. 3T3-L1 cells were treated with a D6D inhibitor (SC-26196) in the presence or absence of ¦Á-linolenic acid (ALA) throughout differentiation. We found that D6D inhibition blocked the conversion of ALA to eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPAn-3) when ALA was supplemented, while no changes in n-3 PUFA content were observed in cells treated with the D6D inhibitor alone. D6D inhibited cells had reduced triacylglycerol (TAG) accumulation despite an EPA/DPA deficiency. In addition, analyses of cellular protein markers, as well as non-esterified fatty acids and glycerol release in medium, suggested an increase in lipolysis and a decrease in fatty acid re-esterification in D6D-inhibited cells, independent of n-3 PUFA changes. To provide further evidence, we treated cells with the D6D inhibitor in the presence or absence of EPA and compared them with ALA-treated cells. Although EPA further reduced TAG content, the reduced markers of fatty acid re-esterification were not affected by ALA or EPA. Collectively, this study provides new insight showing that D6D inhibition reduces TAG accumulation and fatty acid re-esterification in adipocytes independent of changes in n-3 PUFA cellular content.

Biochimica et Biophysica Acta, Molecular and Cell Biology of Lipids published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C15H12O8, Product Details of C22H32O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

DeBenneville, Peter L. published the artcileBehavior of aliphatic aldehydes in the Leuckart-Wallach reaction, Application of 2-Ethyl-N,N-dimethylhexan-1-amine, the publication is Journal of the American Chemical Society (1950), 3073-5, database is CAplus.

The Leuckart-Wallach reaction with aliphatic aldehydes and secondary amines is initiated at a generally lower temperature than in the case of ketones and aromatic aldehydes and generally gives good yields of products. A possible explanation is the involvement of the H on the ¦Á-C atom of the aldehyde through an enamine intermediate. The following compounds were used: Aldehydes, EtCHO (I), PrCHO (II), iso-PrCHO (III), C₆H₁₃CHO (IV), BuEtCHCHO (V), Me₃CCH₂CHMeCH₂CHO (VI); ketones, cyclohexanone (VII), PhAc (VIII); amines, morpholine (IX), piperidine (X), Me₂NH (XI), (iso-Pr)₂NH (XII), (HOC₂H₄)₂NH (XIII), MeNHC₉H₁₉ (XIV), and PhNHMe (XV). The enamines were prepared by the method of Mannich and Davidsen (C.A. 30, 8217.2), with anhydrous K₂CO₃ or CaO as catalyst and temperatures of 5-50¡ã; the intermediate diimine was converted to the enamine by distillation One mol. of the enamine is treated dropwise with 1-1.1 mols. 98% HCO₂H, heated 1-2 h. at 50-70¡ã (occasionally at 90¡ã), poured into dilute HCl, extracted with ether, made basic with NaOH, and again extracted with ether. Enamines, Satd amine; Aldehyde, Amine, Yield, %, B.p., ¡ãC., Mm., Yield, %, B.p., ¡ãC., Mm.; II, IX, 95, 105-10, 20, 54, 94-9, 25; III, IX, 29, 89-93, 20, 73, 80-5, 20; IV, IX, 76, 91-4, 2, 32, 90-5, 2; IV, X, 60, 111-12, 3, 84, 78-82, 1; V, IX, 41, 95-115, 1, 60, 81, 0.7; VI, XI, 42, 46-50, 1, 80, 46, 1.5; VI, XII, 23, 79-81, 2, 62, 98-100, 4; VI, IX, 79, 107-10, 3, 85, 81-3, 2; VI, XIII, 52, 105-10, 0.7, 84, 147-50, 1.3; VI, XIV, 70, 117-21, 1, 57, 124-33, 1.5; In carrying out the Leuckart-Wallach alkylations, 1 mol. of the amine was added to 1 mol. HCO₂H, the temperature raised to 60¡ã, and the aldehyde added dropwise (1 h.); the mixture was then heated about 1 h. on. the steam bath; for I and II, the amine-HCO₂H ratio was 1:2. The following reactions are reported: Aldehyde, Amine, Yield, %, B.p., ¡ãC., Mm.; I, IX, 5, 78-82, 35; II, XI, 60, 94-6, 760; II, IX, 34, 95-8, 22; III, XI, 59, 70-6, 760; III, IX, 57, 80-4, 15; IV, IX, 46, 76-87, 1; V, XI, 60, 88-90, 20; VI, XI, 84, 52-5, 3; VI, XII, 47, 85-8, 2; VI, XIV, 54, 115-21, 1.5; VI, XV, 17, 117-40, 1.7; VII, X, 25, 113-15, 18; VIII, X, 0, -, -;

Journal of the American Chemical Society published new progress about 28056-87-3. 28056-87-3 belongs to catalysis-chemistry, auxiliary class Amine,Aliphatic hydrocarbon chain, name is 2-Ethyl-N,N-dimethylhexan-1-amine, and the molecular formula is C10H23N, Application of 2-Ethyl-N,N-dimethylhexan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tang, Mei published the artcileEngineering design of graphene tightly wrapped hollow structure for boosted lithium storage in conversion/alloying electrode: A case of SnO₂, Application of 3-(Trimethoxysilyl)propan-1-amine, the publication is Scripta Materialia (2022), 114649, database is CAplus.

Developing cost-effective and high-performance conversion/alloying anode materials in lithium-ion batteries (LIBs) depend on the exquisite design of nanostructure that can efficiently improve volume change and enhance lithium storage capability of active materials. Herein, taking the typical SnO₂ as an example, a universal strategy has been proposed to solve many difficulties faced by these electrode materials, i.e. in situ encapsulating hollow SnO₂ nanospheres into sack-like reduced oxide graphene nanosheets (SnO₂@RGO). This simple and ingenious design combines the flexibility of external graphene and the hollow characteristics of internal SnO₂, thus providing more insertion sites and greatly avoiding the occurrence of structural collapse caused by large volume changes upon cycling. As expected, the SnO₂@RGO electrode shows a larger initial discharge capacity, better capacity retention and more remarkable rate capability as compared to pristine SnO₂ nanospheres electrode when used as advanced anode for LIBs.

Scripta Materialia published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C9H7NO4, Application of 3-(Trimethoxysilyl)propan-1-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Lihong published the artcileNHC and visible light-mediated photoredox co-catalyzed 1,4-sulfonylacylation of 1,3-enynes for tetrasubstituted allenyl ketones, Recommanded Product: 4,4′-Dimethyldiphenyl, the publication is Chemical Science (2022), 13(11), 3169-3175, database is CAplus and MEDLINE.

Described NHC and visible light-mediated photoredox co-catalyzed radical 1,4-sulfonylacylation of 1,3-enynes, providing structurally diversified valuable tetrasubstituted allenyl ketones. Mechanistic studies indicated that ketyl radicals were formed from aroyl fluorides via the oxidative quenching of the photocatalyst excited state, allenyl radicals were generated from chemo-specific sulfonyl radical addition to the 1,3-enynes and finally, the key allenyl and ketyl radical cross-coupling provided tetrasubstituted allenyl ketones.

Chemical Science published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is 0, Recommanded Product: 4,4′-Dimethyldiphenyl.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia