Category: 38260-01-4

Uno, Taku published the artcileKidney dysfunction in Wilson disease, Quality Control of 38260-01-4, the publication is Biomedical Research on Trace Elements (1998), 9(2), 85-94, database is CAplus.

Forty-seven patients with Wilson disease were studied for their kidney dysfunction. Among them, 36 patients were not treated and 11 were treated. Over one-third of the patients revealed renal tubular abnormalities at first visit to our clinic. Such abnormalities could not explain the cause of hypouricemia in the fulminant and hemolytic anemia type of Wilson disease. Ten of 31 patients (32.3%) had nephrocalcinosis. These findings were almost completely improved following prolonged treatment with penicillamine or trientine hydrochloride. Significant microscopic hematuria was found in 21 of the 36 treated patients (58.3%) and proteinuria was found in 14 of these 36 patients (38.9%). Except for the fulminant and hemolytic anemia type of Wilson disease, dysmorphic urinary RBCs, granular and RBC casts were found on routine light microscopy in our study. These urinary findings suggest glomerular dysfunction. Besides the occurrence of local damage to the kidney or an irritant effect of copper on the glomeruli and renal tubules, we speculate that glomerular dysfunction due to liver cirrhosis should be considered, including for example, hepatic IgA glomerulonephritis.

Biomedical Research on Trace Elements published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C10H16Br3N, Quality Control of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Smith, G. published the artcileTriethylene tetramine. New potentiator of antibiotic activity, Synthetic Route of 38260-01-4, the publication is Experientia (1975), 31(1), 84-5, database is CAplus and MEDLINE.

Triethylenetetramine-2HCl (I) [38260-01-4] increased the efficacy of carbenicillin [4697-36-3] therapy against Pseudomonas aeruginosa in vitro and in mice. I apparently increased the permeability of the bacteria to the antibiotic, thereby enhancing the ability of the antibiotic to reach its site of action.

Experientia published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C9H12BClO3, Synthetic Route of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Purchase, Rupert published the artcileThe purification of triethylenetetramine and its dihydrochloride for the treatment of Wilson’s disease, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Journal of Chemical Research (2005), 233-235, database is CAplus.

A method for the purification of triethylenetetramine and its dihydrochloride for use in the treatment of Wilson’s disease is reported. Thus, tech. grade triethylenetetramine (I) 1.18 Kg was mixed with water 262 mL and seeded with a few crystals of I hydrate; the precipitated I hydrate was collected and washed with THF and di-Et ether; the I hydrate was slurried with water 500 mL, cooled and treated with HCl to pH 7.8; evaporation of the aqueous solution (below 60¡ãC, 12 mmHg) and treatment of the residue with cold 95% ethanol afforded the dihydrochloride of I (854 g) containing a trace of impurity.

Journal of Chemical Research published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Purchase, Rupert published the artcileThe link between copper and Wilson’s disease, Computed Properties of 38260-01-4, the publication is Science Progress (St. Albans, United Kingdom) (2013), 96(3), 213-223, database is CAplus and MEDLINE.

A review. Wilson’s disease (hepatolenticular degeneration) is a rare inherited autosomal recessive disorder of copper metabolism leading to copper accumulation in the liver and extrahepatic organs such as the brain and cornea. Patients may present with combinations of hepatic, neurol. and psychiatric symptoms. Copper is the therapeutic target for the treatment of Wilson’s disease. Discovering the linking of copper to Wilson’s disease encompasses a study of enzootic neonatal ataxia in lambs in the 1930s, the copper-chelating properties of British Anti-Lewisite, and the chem. anal. for copper of the organs of deceased Wilson’s disease patients in the mid-to-late 1940s. Wilson’s disease is one of a number of copper-related disorders where loss of copper homeostasis as a result of genetic, nutritional or environmental factors affects human health.

Science Progress (St. Albans, United Kingdom) published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Computed Properties of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Casy, A. F. published the artcileCarbon-13 NMR as a convenient aid to the differentiation of triethylenetetraamine (TETA) dihydrochloride from related impurities, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Journal of Pharmacy and Pharmacology (1981), 33(5), 333-4, database is CAplus and MEDLINE.

Proton-noise and off-resonance decoupled ¹³C spectra were obtained on an NMR spectrometer for recrystallized TETA-2HCl [38260-01-4] in D₂O. The correct number of lines required by the 3 nonequivalent C atoms in this structure were displayed, whereas that of the impurity, tris(2-aminoethyl)amine-3HCl [4097-89-6] showed one less signal, consistent with 2 nonequivalent C atoms. A com. sample of diethylenetriamine [111-40-0] had a spectrum with 2 major lines only. Piperazine and other impurities were observable in spectrums of TETA base samples. Levels of impurities of 5% and probably lower could be detected.

Journal of Pharmacy and Pharmacology published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Brewer, George J. published the artcileNovel therapeutic approaches to the treatment of Wilson’s disease, Category: catalysis-chemistry, the publication is Expert Opinion on Pharmacotherapy (2006), 7(3), 317-324, database is CAplus and MEDLINE.

A review. The treatment of Wilson’s disease has changed considerably in recent times, from the use of penicillamine (Cuprimine^, Merck) for all stages and types of disease, to the use of three other anticopper drugs at appropriate times for appropriate patients. Each type and stage of the disease can be considered as a therapeutic target, for which specialised therapy is appropriate. This paper systematically reviews the various types and stages of Wilson’s disease presentation, and provides opinion on the appropriate therapy for each. For patients presenting with neurol. disease, the use of tetrathiomolybdate is optimum; for patients presenting with mild-to-moderate hepatic failure, a combination of trientine (Syprine, Merck) and zinc is recommended, whereas liver transplantation is necessary for those with severe failure; zinc therapy alone or trientine alone as second choice is recommended for patients presenting with hepatitis or cirrhosis without liver failure, for maintenance therapy, for treatment of presymptomatic patients and for treatment of pediatric and pregnant patients.

Expert Opinion on Pharmacotherapy published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Anonymous published the artcileTriethylenetetramine hydrochloride morph, COA of Formula: C6H20Cl2N4, the publication is IP.com Journal (2017), 17(3A), 1-8, database is CAplus.

A process for preparation of dihydrochloride salt of triethylenetetramine or N,N’-bis(2-aminoethyl)-1,2-ethanediamine (Form T) has been disclosed. Form T is characterized by X-ray diffraction spectra, Infra-red spectra, differential scanning calorimetry (DSC) and m.p.

IP.com Journal published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, COA of Formula: C6H20Cl2N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yoshiji, Hitoshi published the artcileCombination of copper-chelating agent, trientine, and methotrexate attenuates colorectal carcinoma developmental and angiogenesis in mice, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Oncology Reports (2005), 14(1), 213-218, database is CAplus.

Recent studies have suggested that an antiangiogenic agent could improve the inhibitory effects of standard chemotherapeutic drugs against tumor development. We previously reported that the clin. used copper-chelating agent, trientine dihydrochloride (trientine), exerted strong anti-angiogenic activity and inhibited tumor growth. The aim of the current study was to examine the combined effect of trientine and methotrexate on the development and angiogenesis of xenograft human colorectal carcinoma (CRC) cells at clin. comparable low doses. When used individually, both trientine and methotrexate significantly suppressed CRC development along with inhibition of neovascularization in the tumor. A combination regimen of trientine and methotrexate exerted the most potent tumoricidal effect and led to ‘tumor dormancy.’. The combination of these agents also resulted in a marked suppression of the angiogenic factors, in particular the vascular endothelial growth factor and interleukin-8, and an increase of apoptosis in the tumor. In vitro studies revealed that neither trientine nor methotrexate was cytotoxic for tumor cells. On the other hand, the endothelial cell proliferation and tubular formation were significantly suppressed by these agents. The combined treatment of trientine and methotrexate at clin. comparable low doses could inhibit CRC development and angiogenesis, as well as suppress the angiogenic factors. Because both agents are widely used in clin. practice, the combination regimen may represent a potential new strategy for CRC therapy in the future.

Oncology Reports published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C3H5BN2O2, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hyvonen, Mervi T. published the artcileMetabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N¹-acetyltransferase and thialysine acetyltransferase, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Drug Metabolism & Disposition (2013), 41(1), 30-32, database is CAplus and MEDLINE.

Triethylenetetramine (TETA; Syprine; Merck Rahway, NJ), a drug for Wilson’s disease, is a copper chelator and a charge-deficient analog of polyamine spermidine. We recently showed that TETA is metabolized in vitro by polyamine catabolic enzyme spermidine/spermine-N¹-acetyltransferase (SSAT1) and by thialysine acetyltransferase (SSAT2) to its monoacetylated derivative (MAT). The acetylation of TETA is increased in SSAT1-overexpressing mice compared with wild-type mice. However, SSAT1-deficient mice metabolize TETA at the same rate as the wild-type mice, indicating the existence of another N-acetylase respons 2ible for its metabolism in mice. Here, we show that siRNA-mediated knockdown of SSAT2 in HEPG2 cells and in primary hepatocytes from the SSAT1-deficient or wild-type mice reduced the metabolism of TETA to MAT. By contrast, 1,12-diamino-3,6,9-triazadodecane(SpmTrien), a charge-deficient spermine analog, was an extremely poor substrate of human recombinant SSAT2 and was metabolized by SSAT1 in HEPG2 cells and in wild-type primary hepatocytes. Thus, despite the similar structures of TETA and SpmTrien, SSAT2 is the main acetylator of TETA, whereas SpmTrien is primarily acetylated by SSAT1.

Drug Metabolism & Disposition published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jones, Mark M. published the artcileCharacteristics of chelate antidotes for acute copper(II) intoxication, Application In Synthesis of 38260-01-4, the publication is Journal of Inorganic and Nuclear Chemistry (1981), 43(9), 2175-81, database is CAplus.

Twenty-five chelating agents were exptl. screened to determination the structural features characteristic of antidotes for acute Cu(II) intoxication in mice. Four structural classes of antidote were identified: vicinal dithiols, polyaminocarboxylates, polyethyleneamines and their derivatives, and compounds derived from the ¦Â-mercaptoethylamine structure. The most effective antidote of the compounds examined was HSCH₂CH(SH)CH₂SO₂Na [4076-02-2], with a survival ratio in mice of 37:45 when given at a 10:1 mol ratio with CuSO₄ at a dosage of 10 mg/kg i.p.

Journal of Inorganic and Nuclear Chemistry published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Application In Synthesis of 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia