Month: December 2022

Li, Yuanming published the artcileAmide Bond Formation through Iron-Catalyzed Oxidative Amidation of Tertiary Amines with Anhydrides, Category: catalysis-chemistry, the publication is Journal of Organic Chemistry (2013), 78(11), 5638-5646, database is CAplus and MEDLINE.

A general and efficient method for amide bond synthesis has been developed. The method allows for synthesis of tertiary amides from readily available tertiary amines and anhydrides in the presence of FeCl₂ as catalyst and tert-Bu hydroperoxide in water (T-Hydro) as oxidant. Mechanistic studies indicated that the in situ-generated ¦Á-amino peroxide of tertiary amine and iminium ion act as key intermediates in this oxidative transformation.

Journal of Organic Chemistry published new progress about 2909-77-5. 2909-77-5 belongs to catalysis-chemistry, auxiliary class Amine,Benzene, name is 2,6-Diisopropyl-N,N-dimethylaniline, and the molecular formula is C14H23N, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Narayanam, Maruthi Kumar published the artcileNucleophilic 18F-fluorination of anilines via N-arylsydnone intermediates, Recommanded Product: Tetraethylammonium hydrogencarbonate, the publication is Synlett (2018), 29(9), 1131-1135, database is CAplus.

Preparation of [ ¹⁸F]fluoroarenes with nucleophilic [ ¹⁸F]fluoride for positron emission tomog. (PET) mol. imaging research is a challenging chem. endeavor. Advances in radiofluorination have soared in the last decade, broadening the availability of potential ¹⁸F-fluoroarenes. In this Synpacts article, we highlight the recent development from our laboratory of a practical radiofluorination of anilines via N-arylsydnone intermediates to afford [ ¹⁸F]fluoroarenes. Further, we emphasize the utility of this methodol. towards peptide labeling applications by preparing an ¹⁸F-labeled neuropeptide.

Synlett published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, Recommanded Product: Tetraethylammonium hydrogencarbonate.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiao, Ke-Jin published the artcileNickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids, Quality Control of 1860-58-8, the publication is Organic Chemistry Frontiers (2021), 8(23), 6603-6608, database is CAplus.

A highly regioselective Ni-catalyzed electrochem. (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides was developed. This strategy allowed the direct acylation of benzylic C(sp³)-H bonds in good yields from com. available alkyl carboxylic acids, thus provided an alternative strategy for the synthesis of dialkyl ketones. Various functional groups were tolerated under mild reaction conditions.

Organic Chemistry Frontiers published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Quality Control of 1860-58-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ma, Lin published the artcileRegulation of the Assembled Structure of a Flexible Porphyrin Derivative Containing Tetra Isophthalic Acids by Coronene or Different Pyridines, Recommanded Product: Coronene, the publication is Langmuir (2022), 38(14), 4434-4441, database is CAplus and MEDLINE.

Based on previous research, a new coassembly formed by a porphyrin derivative (IPETPP), which contains a flexible substituent of m-phthalic acid, is observed with coronene (COR) mols. at a higher concentration Besides, a fresh IPETPP self-assembly formed at a lower concentration and another new coassembly with COR mols. are obtained. Moreover, the addition of a series of bipyridines alters the diamond arrangement of IPETPP, which enhances the stability of the two-component structures. It is unprecedented that bipyridine derivatives break intermol. hydrogen bonds containing m-phthalic acid substituents. All the coassemblies are investigated by scanning tunneling microscopy on a highly oriented pyrolytic graphite. Combined with d. functional theory, the formation mechanism of the assembled structures is revealed. These results would contribute to understanding the interfacial crystal behaviors and probably provide an efficient pathway to regulate the binary structures.

Langmuir published new progress about 191-07-1. 191-07-1 belongs to catalysis-chemistry, auxiliary class Electronic Materials, name is Coronene, and the molecular formula is C24H12, Recommanded Product: Coronene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Hui published the artcileLigand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products, COA of Formula: C9H5F3O, the publication is ACS Catalysis (2021), 11(3), 1758-1764, database is CAplus.

A palladium-catalyzed ligand-promoted alkynation of unstrained aryl ketones RC(O)R¹ (R = naphthalen-2-yl, 1-benzothiophen-5-yl, 4-(2H-1,2,3-triazol-2-yl)benzen-1-yl, etc.; R¹ = Me, n-Pr, Ph, etc.) have been reported. The protocol allows the alkynation to be carried out in a one-pot procedure with broad functional-group tolerance and substrate scope for the synthesis of aryl-/terminal alkynes RCCR² (R² = 2-fluorophenyl, naphthalen-2-yl, thiophen-2-yl, etc.) and RCCH. The potential applications of this protocol in drug discovery and chem. biol. are further demonstrated by late-stage diversification of a number of pharmaceuticals and natural products e.g., I. More importantly, two different biol. important fragments R³CCR⁴ (R = 3-methoxy-4-([(2S,3R,4S,5R,6R)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy)benzen-1-yl, 6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalen-2-yl; R⁴ = 4-(dipropylsulfamoyl)phenyl) derived from a pharmaceutical and natural product could be connected by the consecutive alkynation of ketones CH₃(CH₂)₂C(O)R⁴. Distinct from aryl halides in conventional Sonogashira reactions, the protocol provides a practical tool for the 1,2-bifunctionalization of aryl ketone (1-[(17¦Â)-17-(acetyloxy)estra-1,3,5(10)-trien-2-yl]ethanone) by merging ketone-directed ortho-C-H activation with ligand-promoted ipso-Ar-C(O) alkynation.

ACS Catalysis published new progress about 866683-57-0. 866683-57-0 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Alkynyl,Benzene,Ether, name is 1-Ethynyl-3-(trifluoromethoxy)benzene, and the molecular formula is C4H6O3, COA of Formula: C9H5F3O.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

M, Vinothkumar published the artcileSilane Grafted Cellulose and Biosilica Toughened Glass-Epoxy Composite: Mechanical, Hydrophobicity and Low Velocity Impact Behavior, Product Details of C6H17NO3Si, the publication is Silicon (2022), 14(7), 3601-3613, database is CAplus.

High toughness, impact damage resistance biocompatible glass-epoxy composites were prepared using 3-Aminopropyltrimethoxysilane (APTMS) treated cellulose and biosilica nanoparticle and evaluated for their tensile, flexural, impact, wear and water absorption behavior. The main aim of this present investigation was to improve the strength characteristics and load-bearing effect of glass-epoxy composite using biocompatible fillers and how the surface modification process helps in the improvement of the properties. The cellulose and biosilica particle was surface-treated using (APTMS) via wet solution method. Similarly, the glass-epoxy composites were prepared via the hand layup method followed by room temperature curing. The results revealed that the addition of cellulose particle into the glass-epoxy composite improved the toughness and energy absorption. However, the subsequent addition of biosilica particle improved the mech., wear and drop load impact toughness by about 200-300%. It is noted that in all composites the silane treated reinforcements gives improved results of a min. of 20-50%. The hydrophobicity of composites retained with higher contact angle for silane treated reinforcements in epoxy resin composite. The scanning electron microscopic images revealed uniform dispersion and improved adhesion with matrix for silane treated reinforcements.

Silicon published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, Product Details of C6H17NO3Si.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Elenich, O. V. published the artcileSynthesis of nitrogen-containing heterocycles on the basis of 3-(4-acetylphenyl)-1-methylquinolin-2(1H)-one, Application In Synthesis of 6972-05-0, the publication is Russian Journal of Organic Chemistry (2016), 52(3), 373-378, database is CAplus.

The Meerwein reaction of 1-methylquinolin-2(1H)-one with 4-acetylbenzenediazonium chloride gave 3-(4-acetylphenyl)-1-methylquinolin-2(1H)-one which was brominated to 3-[4-(2-bromoacetyl)phenyl]-1-methylquinolin-2(1H)-one. The latter reacted with pyridine, 4-methylpyridine, quinoline, benzo[f]quinoline, and triphenylphosphine to afford the corresponding quaternary salts, and its reactions with thioacetamide, thiourea, 2-aminopyridine, and 2-aminopyrimidine led to the corresponding thiazole, imidazo[1,2-a]pyridine, and imidazo[1,2-a]pyrimidine derivatives containing a 2-oxoquinoline fragment. 3-(4-[2-[2-(arylmethylidene)-hydrazinyl]-1,3-thiazol-4-yl]phenyl)-1-methylquinolin-2(1H)-ones were obtained by condensation of 3-[4-(2-bromoacetyl)phenyl]-1-methylquinolin-2(1H)-one with thiosemicarbazide and aromatic aldehydes.

Russian Journal of Organic Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application In Synthesis of 6972-05-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Holte, Dane published the artcileEvaluation of PNU-159682 antibody drug conjugates (ADCs), Recommanded Product: 1,1-Dimethylthiourea, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(24), 127640, database is CAplus and MEDLINE.

PNU-159682 I is a highly potent secondary metabolite of nemorubicin belonging to the anthracycline class of natural products. Due to its extremely high potency and only partially understood mechanism of action, it was deemed an interesting starting point for the development of a new suite of linker drugs for antibody drug conjugates (ADCs). Structure-activity relationships were explored on the small mol. which led to six linker drugs being developed for conjugation to antibodies. Herein we describe the synthesis of novel PNU-159682 derivatives and the subsequent linker drugs as well as the corresponding biol. evaluations of the small mols. and ADCs.

Bioorganic & Medicinal Chemistry Letters published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Korlyukov, Alexander A. published the artcileSi-Fluoro substituted quasisilatranes (N¡úSi) FYSi(OCH₂CH₂)₂NR, Category: catalysis-chemistry, the publication is Journal of Organometallic Chemistry (2009), 694(5), 607-615, database is CAplus.

The reaction of fluorosilanes XYSiF₂ (X = Y = F; X = F, Y = Ph; X = Ph, Y = Me) with diethanolamines and their O-trimethylsilyl derivatives affords novel Si-fluoro substituted quasisilatranes 3, 5 and 9. These compounds were characterized by the multinuclear NMR spectroscopy and x-ray diffraction anal. Exptl. and theor. calculated electron d. distribution functions in crystal structure of 9 have shown that the N ¡ú Si coordination bond corresponds to polar bond with pronounced ionic contribution. Calculated N ¡ú Si bond order in the compound 9 does not exceed 1/3 of the normal Si-N bond. A strong N ¡ú Si coordination bond exists in compounds 3, 5 and 9 the length of which varies in the range 1.98-2.175 ?.

Journal of Organometallic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kovtun, G. A. published the artcileMechanism of the inhibition of oxidation reactions by metal complexes. 2. Effect of substituents in the imino component of a Schiff base on the antioxidant properties of copper salicylaldiminates, Synthetic Route of 1821-27-8, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1979), 293-7, database is CAplus.

I (R = H, OH, Me, MeO, NO₂) and II participated repeatedly in chain terminations (in the oxidation of cyclohexylamine) via reaction with ¦Á-amino peroxy radicals (III). The rate constants of single-electron oxidation and reduction of III decreased with increasing donor character of R. The rates of chain termination by (4-RC₆H₄)₂NH increased with increasing donor character of R.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 1821-27-8. 1821-27-8 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is Bis(4-nitrophenyl)amine, and the molecular formula is C12H9N3O4, Synthetic Route of 1821-27-8.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia