Category: 866683-57-0

Yuan, Shuo published the artcilePalladium-Catalyzed Ligand-Free Double Cyclization Reactions for the Synthesis of 3-(1′-Indolyl)-phthalides, Safety of 1-Ethynyl-3-(trifluoromethoxy)benzene, the publication is Organic Letters (2020), 22(3), 814-817, database is CAplus and MEDLINE.

Indole and phthalide are privileged heterocyclic scaffolds in numerous natural products and bioactive mols. The synthesis and biol. evaluation of the compounds combining these two scaffolds have rarely been reported. The first palladium-catalyzed ligand-free double cyclization reactions that enable efficient synthesis of 3-(1′-indolyl)-phthalides, e.g., I, under mild conditions is reported. Notably, only 1.0 mol % of catalyst loading is used, suggesting high efficiency. Late-stage elaborations give highly functionalized analogs.

Organic Letters published new progress about 866683-57-0. 866683-57-0 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Alkynyl,Benzene,Ether, name is 1-Ethynyl-3-(trifluoromethoxy)benzene, and the molecular formula is C9H9NO, Safety of 1-Ethynyl-3-(trifluoromethoxy)benzene.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Teo, Wei Jie published the artcileCobalt-Catalyzed Z-Selective Hydrosilylation of Terminal Alkynes, Formula: C9H5F3O, the publication is Angewandte Chemie, International Edition (2017), 56(15), 4328-4332, database is CAplus and MEDLINE.

A cobalt-catalyzed Z-selective hydrosilylation of alkynes has been developed relying on catalysts generated from bench-stable Co(OAc)₂ and pyridine-2,6-diimine (PDI) ligands. A variety of functionalized aromatic and aliphatic alkynes undergo this transformation, yielding Z-vinylsilanes in high yields with excellent selectivities (Z/E ratio ranges from 90:10 to >99:1). The addition of a catalytic amount of phenol effectively suppressed the Z/E-isomerization of the Z-vinylsilanes that formed under catalytic conditions.

Angewandte Chemie, International Edition published new progress about 866683-57-0. 866683-57-0 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Alkynyl,Benzene,Ether, name is 1-Ethynyl-3-(trifluoromethoxy)benzene, and the molecular formula is C8H11NO, Formula: C9H5F3O.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Hui published the artcileLigand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products, COA of Formula: C9H5F3O, the publication is ACS Catalysis (2021), 11(3), 1758-1764, database is CAplus.

A palladium-catalyzed ligand-promoted alkynation of unstrained aryl ketones RC(O)R¹ (R = naphthalen-2-yl, 1-benzothiophen-5-yl, 4-(2H-1,2,3-triazol-2-yl)benzen-1-yl, etc.; R¹ = Me, n-Pr, Ph, etc.) have been reported. The protocol allows the alkynation to be carried out in a one-pot procedure with broad functional-group tolerance and substrate scope for the synthesis of aryl-/terminal alkynes RCCR² (R² = 2-fluorophenyl, naphthalen-2-yl, thiophen-2-yl, etc.) and RCCH. The potential applications of this protocol in drug discovery and chem. biol. are further demonstrated by late-stage diversification of a number of pharmaceuticals and natural products e.g., I. More importantly, two different biol. important fragments R³CCR⁴ (R = 3-methoxy-4-([(2S,3R,4S,5R,6R)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy)benzen-1-yl, 6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalen-2-yl; R⁴ = 4-(dipropylsulfamoyl)phenyl) derived from a pharmaceutical and natural product could be connected by the consecutive alkynation of ketones CH₃(CH₂)₂C(O)R⁴. Distinct from aryl halides in conventional Sonogashira reactions, the protocol provides a practical tool for the 1,2-bifunctionalization of aryl ketone (1-[(17¦Â)-17-(acetyloxy)estra-1,3,5(10)-trien-2-yl]ethanone) by merging ketone-directed ortho-C-H activation with ligand-promoted ipso-Ar-C(O) alkynation.

ACS Catalysis published new progress about 866683-57-0. 866683-57-0 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Alkynyl,Benzene,Ether, name is 1-Ethynyl-3-(trifluoromethoxy)benzene, and the molecular formula is C4H6O3, COA of Formula: C9H5F3O.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Junker, Anna published the artcileStructure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y₁₄ Receptor Antagonists, HPLC of Formula: 866683-57-0, the publication is Journal of Medicinal Chemistry (2016), 59(13), 6149-6168, database is CAplus and MEDLINE.

UDP and UDP-glucose activate the P2Y₁₄ receptor (P2Y₁₄R) to modulate processes related to inflammation, diabetes, and asthma. A computational pipeline suggested alternatives to naphthalene of a previously reported P2Y₁₄R antagonist (3, PPTN) using docking and mol. dynamics simulations on a hP2Y₁₄R homol. model based on P2Y₁₂R structures. By reevaluating the binding of 3 to P2Y₁₄R computationally, two alternatives, i.e., alkynyl and triazolyl derivatives, were identified. Improved synthesis of fluorescent antagonist 4 enabled affinity quantification (IC₅₀s, nM) using flow cytometry of P2Y₁₄R-expressing CHO cells. p-F₃C-phenyl-triazole 65 (32) was more potent than a corresponding alkyne 11. Thus, addnl. triazolyl derivatives were prepared, as guided by docking simulations, with nonpolar aryl substituents favored. Although triazoles were less potent than 3 (6), simpler synthesis facilitated further structural optimization. Addnl., relative P2Y₁₄R affinities agreed with predicted binding of alkynyl and triazole analogs. These triazoles, designed through a structure-based approach, can be assessed in disease models.

Journal of Medicinal Chemistry published new progress about 866683-57-0. 866683-57-0 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Alkynyl,Benzene,Ether, name is 1-Ethynyl-3-(trifluoromethoxy)benzene, and the molecular formula is C9H5F3O, HPLC of Formula: 866683-57-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia