Month: December 2022

Dewangan, Rikeshwer Prasad published the artcileCell-penetrating peptide conjugates of indole-3-acetic acid-based DNA primase/Gyrase inhibitors as potent anti-tubercular agents against planktonic and biofilm culture of Mycobacterium smegmatis, Safety of Fmoc-Pro-OH, the publication is Chemical Biology & Drug Design (2021), 98(5), 722-732, database is CAplus and MEDLINE.

Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium that caused 1.5 million fatalities globally in 2018. New strains of Mtb resistant to all known classes of antibiotics pose a global healthcare problem. In this work, we have conjugated novel indole-3-acetic acid-based DNA primase/gyrase inhibitor with cell-penetrating peptide via cleavable and non-cleavable bonds. For non-cleavable linkage, inhibitor was conjugated with peptide via an amide bond to the N-terminus, whereas a cleavable linkage was obtained by conjugating the inhibitor through a disulfide bond. We performed the conjugation of the inhibitor either directly on a solid surface or by using solution-phase chem. M. smegmatis (non-pathogenic model of Mtb) was used to determine the minimal inhibitory concentration (MIC) of the synthetic conjugates. Conjugates were found more active as compared to free inhibitor mols. Strikingly, the conjugate also impairs the development of biofilm, showing a therapeutic potential against infections caused by both planktonic and sessile forms of mycobacterium species.

Chemical Biology & Drug Design published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Safety of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hsu, Che Ju published the artcileSuperior improvement in dynamic response of liquid crystal lens using organic and inorganic nanocomposite, Application In Synthesis of 201157-13-3, the publication is Scientific Reports (2021), 11(1), 17349, database is CAplus and MEDLINE.

In this study, the response time of a 4 mm-aperture hole-patterned liquid crystal (HLC) lens has been significantly improved with doping of N-benzyl-2-methyl-4-nitroaniline (BNA) and rutile titanium dioxide nanoparticle (TiO₂ NP) nanocomposite. The proposed HLC lens provides the focus and defocus times that are 8.5x and 14x faster than the pristine HLC lens, resp. Meanwhile, the focus and defocus times of the proposed HLC lens reach the order of millisecond. Result shows that the synergistic effect of BNA and TiO₂ NP induces a 78% decrement in the viscosity of pristine LC mixture that significantly shortens the focus and defocus times of HLC lens. The remarkable decrement in viscosity is mainly attributed to spontaneous polarization elec. fields from the permanent dipole moments of the additives. Besides, the strengthened elec. field surrounding TiO2 NP assists in decreasing the focus time of HLC lens. The focus and defocus times of HLC lens are related to the wavefront (or phase profile) bending speed. The time-dependent phase profiles of the HLC lenses with various viscosities are calculated This result shows the decrease in wavefront bending time is not simply proportional to viscosity decrement. Furthermore, the proposed HLC lens emerges a larger tunable focus capability within smaller voltage interval than the pristine HLC lens.

Scientific Reports published new progress about 201157-13-3. 201157-13-3 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Amine,Benzene, name is N-Benzyl-2-methyl-4-nitroaniline, and the molecular formula is C14H14N2O2, Application In Synthesis of 201157-13-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pandeya, S. N. published the artcileSynthesis, anticonvulsant and analgesic activity of 1,2,4-dithiazoline derivatives, Recommanded Product: 1,1-Dimethylthiourea, the publication is Indian Journal of Pharmaceutical Sciences (1982), 44(2), 31-3, database is CAplus.

Iminodithiazolines I (R = 4-EtOC₆H₄NH, Me₂N; R¹ = Ph, 4-MeC₆H₄, PhCH₂, Me) were prepared by S-benzylating RCSNH₂, treating RC(:NH)SCH₂Ph with R¹NCS, and oxidative cyclization of R¹NHCSN:CRSCH₂Ph with Br₂. I (R = 4-MeC₆H₄, R¹ = CH₂Ph) was obtained as a by-product. At 10 mg/kg i.p. I (R = 4-EtOC₆H₄NH, R¹ = Ph, 4-MeC₆H₄; R = NMe₂, R¹ = 4-MeC₆H₄; R = 4-MeC₆H₄, R¹ = CH₂Ph) had 40-80% anticonvulsant activity in maximum electroshock test. I (R = 4-EtOC₆H₄NH, R¹ = 4-MeC₆H₄, PhCH₂; R = 4-MeC₆H₄, R¹ = CH₂Ph) had analgesic activity at 10 mg/kg i.p. in rats.

Indian Journal of Pharmaceutical Sciences published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Temdee, Wattana published the artcileEffect of vacuum packaging on shelf-life extension of cooked and peeled harpiosquillid mantis shrimp (Harpiosquilla raphidea) during refrigerated storage, Recommanded Product: Docosahexaenoic Acid, the publication is International Journal of Food Science and Technology (2022), 57(7), 4451-4462, database is CAplus.

Effects of vacuum packaging (VP) on quality changes of cooked and peeled harpiosquillid mantis shrimp (HMS) during storage at 4¡ãC of 15 days were investigated. VP inhibited bacterial growth as ascertained by the lower rate of increases in total viable and psychrotrophic bacteria counts as well as other pathogenic and spoilage bacteria counts. VP samples had lower total volatile base and trimethylamine contents as compared to the sample packed in air (AP). Clostridium perfringens was undetectable in both samples. During storage, VP samples possessed lower pH than AP counterpart. Exudate and TCA-soluble peptide (TSP) contents of sample increased during the storage, regardless of packaging atmospheres. Fatty acid (FA) content, especially PUFA and MUFA, was decreased after 9 and 15 days of storage for AP and VP samples, resp. The cooked and peeled HMS contained 32 volatile organic compounds, consisting of several aldehydes and alcs. Carnobacterium and Pseudomonas were mainly involved in spoilage in samples as confirmed by next generation sequencing.

International Journal of Food Science and Technology published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C8H14O4, Recommanded Product: Docosahexaenoic Acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kumar, Jogendra published the artcileEnhancing the Extent of Enolization for ¦Á-C-H Bonds of Aliphatic Carboxylic Acid Equivalents via Ion Pair Catalysis: Application toward ¦Á-Chalcogenation, HPLC of Formula: 104-03-0, the publication is Journal of Organic Chemistry (2022), 87(9), 6330-6335, database is CAplus and MEDLINE.

In general, the ¦Á-functionalization of carboxylic acid derivatives RCH₂C(O)NHR¹ [R = Me, n-Bu, Ph, 3-thienyl, etc.; R¹ = pyridin-2-yl, 4-Methylpyridin-2-yl, pyrimidin-2-yl, etc.] requires either a transition metal catalyst or a stoichiometric activating agent/strong base/external additive. A transition metal free ¦Á-chalcogenation of aliphatic carboxylic acid equivalent was reported via ion pair formation using K₃PO₄ as a catalyst. Mild conditions, broad scope, scalability of the process, attaining bioactive glucokinase activators, and some synthetic intermediates establish merits of the strategy.

Journal of Organic Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 104-03-0.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rani, Anjeeta published the artcileProfiling the impact of choline chloride on the self-assembly of collagen mimetic peptide (Pro-Hyp-Gly)₁₀, SDS of cas: 71989-31-6, the publication is Process Biochemistry (Oxford, United Kingdom) (2022), 26-34, database is CAplus.

The promising applications of collagen in tissue engineering, regenerative medicine and biomaterials have intrigued great interest in development of collagen mimetic peptides (CMPs). In past decades, the large-scale collagen structures via the self-assembly of small CMPs have been extensively explored. Moreover, CMPs entail novel strategies in order to play a critical role in the discovery of new generation biomaterials. In this regard, we herein have synthesized a CMP, (Pro-Hyp-Gly)₁₀ i.e.POG10. CMP has been examined in the presence of varying concentration of choline chloride (ChCl) by using various biophys. techniques such as CD (CD), UV-vis spectroscopy, fluorescence spectroscopy, Fourier transform IR spectroscopy (FTIR) spectroscopy, differential scanning calorimetry (DSC), transmission electron microscopy (TEM) and dynamic light scattering (DLS). For the first time, we have demonstrated the use of choline chloride (ChCl) to manipulate stability and aggregation of CMP triple helixes in order to delineate the factors responsible for the stability of triple helixes.

Process Biochemistry (Oxford, United Kingdom) published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, SDS of cas: 71989-31-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Allouche, Emmanuelle M. D. published the artcileN-Terminal selective C-H azidation of proline-containing peptides: A platform for late-stage diversification, Recommanded Product: Fmoc-Pro-OH, the publication is Chemistry – A European Journal (2022), 28(17), e202200368, database is CAplus and MEDLINE.

A methodol. for the C-H azidation of N-terminal proline-containing peptides was developed employing only com. available reagents. Peptides bearing a broad range of functionalities and containing up to 6 amino acids were selectively azidated at the carbamate-protected N-terminal residue in presence of the numerous other functional groups present on the mols. Post-functionalizations of the obtained aminal compounds were achieved: cycloaddition reactions or C-C bond formations via a sequence of imine formation/nucleophilic addition were performed, offering an easy access to diversified peptides.

Chemistry – A European Journal published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Damrauer, Robert published the artcileSynthesis of fluorosilanes from chlorosilanes: the use of hexafluorosilicates, Name: Difluorodiphenylsilane, the publication is Organometallics (1988), 7(5), 1161-4, database is CAplus.

The conversion of chlorosilanes to fluorosilanes has been studied by using sodium and ammonium hexafluorosilicate. Of particular interest has been their efficiency in the conversion of highly hindered chlorosilanes like dimesityldichlorosilane and (Me₃C)₂SiCl₂. (NH₄)₂SiF₆ was superior reagent for these conversions, since its reactions are more easily worked up and give higher yields. In addition, (NH₄)₂SiF₆ does not affect the Si-H, Si-Si, or Si-O-Si linkages as do many reagents which bring about chlorosilane to fluorosilane conversions.

Organometallics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Name: Difluorodiphenylsilane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Spearin, E. Y. published the artcileSurface and flotation properties of silver chloride as a function of induced point defects, Formula: C14H31NO2, the publication is Colloids and Surfaces (1987), 257-71, database is CAplus.

AgCl has a Frenkel-type disorder which consists of cation interstitials and an equivalent number of cation vacancies. Zeta potential, critical surface tension of wetting, contact angle, and flotation studies over a broad range of pAg and in the presence and absence of cationic and anionic surfactants were made. Cd-doping has a profound effect on all of these properties. Such doping makes the surface less hydrophobic for both the bare solid and the solid with either cationic or anionic adsorbed surfactants.

Colloids and Surfaces published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C11H21BF4N2O2, Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Balachandran, S. B. published the artcileThe influence of point defects on the floatability of cassiterite, II. Electrostatic collector interactions, COA of Formula: C14H31NO2, the publication is International Journal of Mineral Processing (1987), 21(3-4), 173-84, database is CAplus.

Cassiterite flotation, irresp. of trace element dopants, follows the electrostatic theory of flotation with Na dodecyl sulfate and dodecyl ammonium acetate collectors. This behavior is the underlying mechanism for cassiterite flotation with a broad variety of collectors, though other attachment mechanisms are frequently superimposed on this basic mechanism. Flotation of cassiterite with these collectors is strongly influenced by the dopant present. The ease of flotation follows the pattern Fe³⁺-doped > undoped > Sb⁵⁺-doped cassiterite. The Fe³⁺-doped cassiterite floats at ?10% of the collector concentration required to float Sb⁵⁺-doped cassiterite.

International Journal of Mineral Processing published new progress about 2016-56-0. 2016-56-0 belongs to catalysis-chemistry, auxiliary class Active Esterification, name is Dodecylamineacetate, and the molecular formula is C14H31NO2, COA of Formula: C14H31NO2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia