Month: December 2022

Okajima, Masayuki published the artcileGeneration of diarylcarbenium ion pools via electrochemical C-H bond dissociation, Recommanded Product: Bis(4-fluorophenyl)methane, the publication is Bulletin of the Chemical Society of Japan (2009), 82(5), 594-599, database is CAplus.

The “cation pools” of diarylcarbenium ions have been generated by the low-temperature electrochem. oxidation of diphenylmethane derivatives In addition to diphenylmethanes having various substituents, 9,10-dihydroanthracene, dibenzosuberane, and xanthenes, which are annulated derivatives of diphenylmethane were also found to serve as a precursor of cation pools. The generation of the diarylcarbenium ion was confirmed by low-temperature NMR anal. and cold-spray mass anal. Reactivity was also investigated by reactions with various carbon nucleophiles such as allyltrimethylsilane, 1,3,5-trimethylbenzene, and anisole.

Bulletin of the Chemical Society of Japan published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Recommanded Product: Bis(4-fluorophenyl)methane.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Srivastava, Santosh K. published the artcileThe effect of some oligoamines and -guanidines on membrane permeability in higher plants, Product Details of C3H12Cl2N2, the publication is Phytochemistry (Elsevier) (1982), 21(5), 997-1008, database is CAplus.

Diamines [NH₂(CH₂)_xNH₂] (x = ¡Ü10) decreased betacyanin efflux from beetroot disks, especially at x = 7. Triamines [NH₂(CH₂)_xNH(CH₂)₃NH₂] (x ¡Ü 8) had a similar effect, but increased total ion loss (x = 4-10). Tetraamines [NH₂(CH₂)₃NH(CH₂)_xNH(CH₂)₃NH₂] (x = 2-4) also reduced betacyanin efflux. Spermine potentiated the toxic effects of guazatine and dodine in beetroot disks, but with Ca reduced the induced ion efflux in swede disks, spinach leaves, and apple cells; putrescine, cadaverine, and spermidine did not have such an effect. Monoguanidines [NH₂C(=NH)NH(CH₂)_x-1Me], esp x = 10-12 and diguanidines [NH₂C(=NH)NH(CH₂)_xNHC(=NH)NH₂), especially x = 12, caused efflux of betacyanin and ions.

Phytochemistry (Elsevier) published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C7H8BNO4, Product Details of C3H12Cl2N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gamage, Swarna A. published the artcileIntramolecular aromatic substitution with bisthiocarbocations. Variations of Lewis acid, solvent and orthothio substituents, Related Products of catalysis-chemistry, the publication is Australian Journal of Chemistry (1990), 43(5), 815-24, database is CAplus.

The effects of Lewis acid, solvent and orthothio substituent have been examined with regard to intramol. electrophilic aromatic substitution with bisthiocarbocations. A suspension of silver trifluoromethanesulfonate in dichloromethane, creating bis(arylthio)carbocations, was found to be the most effective for annulation of six-membered rings. E.g., o-phenylene trithiocarbonate was condensed with 3-MeOC₆H₄(CH₂)₃I to give 2-[3-(3-methoxyphenyl)propyl]-2-methylthio-1,3-benzodithiole which was subject to intramol. aromatic substitution to give 6-methoxy-1-tetralone.

Australian Journal of Chemistry published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Aksenov, Alexander V. published the artcileMetal-free transannulation reaction of indoles with nitrostyrenes: a simple practical synthesis of 3-substituted 2-quinolones, COA of Formula: C10H11NO4, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(81), 9305-9307, database is CAplus and MEDLINE.

3-Substituted 2-quinolones are obtained via a novel, metal-free transannulation reaction of 2-substituted indoles with 2-nitroalkenes in polyphosphoric acid. The reaction can be used in conjunction with the Fisher indole synthesis offering a practical three-component heteroannulation methodol. to produce 2-quinolones from arylhydrazines, 2-nitroalkenes and acetophenone.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, COA of Formula: C10H11NO4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Aksenov, Alexander V. published the artcileActivity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells, Computed Properties of 4230-93-7, the publication is Journal of Medicinal Chemistry (2015), 58(5), 2206-2220, database is CAplus and MEDLINE.

Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. The authors describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis- and multidrug-resistant cancer cells as well as glioblastoma neurosphere stem-like cell cultures derived from patients. Thus, the described compounds serve as a novel chem. scaffold for the development of potentially highly effective clin. cancer drugs.

Journal of Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Computed Properties of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nguyen, Dat P. published the artcileScope and limitations of reductive amination catalyzed by half-sandwich iridium complexes under mild reaction conditions, Formula: C10H10O3, the publication is Tetrahedron Letters (2020), 61(32), 152196, database is CAplus and MEDLINE.

The conversion of aldehydes and ketones RC(O)R¹ (R = Ph, thiophen-2-yl, 4-bromophenyl, etc.; R¹ = H, Me, CF₃, Ph), 9H-fluoren-9-one to 1¡ã amines RCH(NH₂)R¹ could be promoted by half-sandwich iridium complexes using ammonium formate as both the nitrogen and hydride source. To optimize this method for green chem. synthesis, various carbonyl substrates in common polar solvents at physiol. temperature (37¡ãC) and ambient pressure were tested. The excellent selectivity for the amine over alc./amide RCH(OH)R¹/RCH(R¹)NHCHO products could be achieved for a broad assortment of carbonyl-containing compounds in methanol. In aqueous media, selective reduction of carbonyls to 1¡ã amines was achieved in the absence of acids. Unfortunately, at Ir catalyst concentrations of <1 mM in water, reductive amination efficiency dropped significantly, which suggest that this catalytic methodol. might be not suitable for aqueous applications where very low catalyst concentration is required (e.g., inside living cells).

Tetrahedron Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Formula: C10H10O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kuzhalmozhi Madarasi, Packirisamy published the artcileGrignard reagent dictated copper(I) phosphines catalyzed reductive coupling of diazo compounds: The chemistry beyond carbene generation, Category: catalysis-chemistry, the publication is Applied Organometallic Chemistry (2022), 36(2), e6522, database is CAplus.

Copper-dppf catalyzed reductive coupling of diazo compounds through a terminal nitrogen is reported. However, copper catalysts are known to produce carbene from diazo compounds Reaction conditions play an important role in formation of diazine over carbene generation. Several control experiments were conducted to understand the reaction mechanism and the authors found that formation of a copper-Mg heterobimetallic complex is responsible for the observed reactivity pattern. The reaction produced diazine as a reductive coupling product along with biphenyl as a byproduct. All synthesized diazines were characterized fully by using anal. and spectroscopic techniques.

Applied Organometallic Chemistry published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rasajna, G. published the artcileGCMS analysis and evaluation of thrombolytic activity of essential oil obtain from the flowers of nyctanthes arbor tristislinn, Computed Properties of 140-28-3, the publication is Indian Research Journal of Pharmacy and Science (2020), 7(2), 2121-2131, database is CAplus.

Objective: The objectives of this study were to identify the chem. composition of the essential obtained from the flowers of Nyctanthes arbor tristis and to carry out in vitro thrombolytic activity studies. Methods: the essential oil was obtained from the flowers of Nyctanthes arbor tristis by hydrodistillation and the chem. composition was determined by gas chromatog.-mass spectrometry anal. Thrombolytic activity was conducted using %clot lysis assay using streptokinase as standard drug. Results: 11 compounds were identified in the essential oil in which betulin (26.58), (23.29%) Undec-10-ynoic acid, undec-2-en-1 -yl ester(23.29%), were predominant followed 1-propoxy propene (19.23%), 9,17-Octadecadienal (12.02%), in clot lysis assay the essential oil showed % clot lysis of 82.60, 86.36, 94.44, for 50mg/mL, 100mg/mL, 150mg/mL resp. Conclusion: The chem. composition of essential oil reveals the presence of betulin in higher concentration which is known for its thrombolytic activity in the clot lysis assay and all the 11 compounds are being reported for the first time in Nyctanthes arbor tristis flowers which fiend their use in cosmetic industry. Therefore the flowers of Nyctanthes arbor tristis grown in yanam region can be a good source of fragrance for cosmetic industry.

Indian Research Journal of Pharmacy and Science published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Computed Properties of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Aziz, I. published the artcileSynthesis, Characterization, DNA Interaction Study, Antibacterial and Anticancer Activities of New Palladium(II) Phosphine Complexes, Category: catalysis-chemistry, the publication is Russian Journal of General Chemistry (2018), 88(3), 551-559, database is CAplus.

Palladium(II) complexes with N,N-dimethylthiourea and phosphines [tri-p-tolylphosphine (Tptp), benzyl(diphenyl)phosphine (Bdp), cyclohexyl(diphenyl)phosphine (Cdp)] were synthesized by the direct reaction of K₂[(PdCl₄)] with the corresponding phosphines and then with N,N-dimethylthiourea at a molar ratio of 1:2:2, resp. The general formula of these complexes is [Pd(L1)₂(L₂)₂]Cl₂, where L1 = N,N-dimethylthiourea (Dmtu), L2 = Tptp, Bdp, Cdp. The complexes were characterized by elemental analyses, multinuclear NMR (¹H, ¹³C, ³¹P), and FTIR. The complex with cyclohexyl(diphenyl)phosphine was also characterized by single crystal x-ray anal. The spectral and crystallog. data suggest monodentate coordination of dimethylthiourea through the S atom and of the phosphine ligand through the P atom and distorted square planar environment of Pd(II). The synthesized complexes were screened for DNA binding, antibacterial, cytotoxic, and antitumor activities. The complexes show interaction with DNA via intercalative mode. The complexes show good activity against both gram pos. and gram neg. bacteria as compared to that of a standard drug, Imipenem. Their antitumor activity against MCF7 tumor cell line is comparable with doxorubicin. MTT assay was used to study the cytotoxicity of the studied compounds

Russian Journal of General Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bansal, Shobha published the artcileAn efficient solvent free microwave assisted MgFe₂O₄ magnetic nanoparticles catalyzed green protocol towards Michael addition, Related Products of catalysis-chemistry, the publication is Chemistry & Chemical Technology (2019), 13(1), 18-22, database is CAplus.

MgFe₂O₄ magnetic nanoparticles were used as an efficient catalyst for the synthesis of Michael products by treating substituted chalcones and ¦Â-nitro styrenes with malononitrile and Et cyanoacetate in solvent-free microwave conditions. At 10 mol% catalyst loading, MgFe₂O₄ magnetic nanoparticles were a better heterogeneous catalyst tried for Michael addition than several reported catalysts. MgFe₂O₄ nanoparticles were used five times without appreciable loss of catalytic activity.

Chemistry & Chemical Technology published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia