Category: 118-90-1

Pei, Chunzhe published the artcileNi-Catalyzed Direct Carboxylation of Aryl C-H Bonds in Benzamides with CO₂, Name: 2-Methylbenzoic acid, the publication is Advanced Synthesis & Catalysis (2022), 364(3), 493-499, database is CAplus.

The direct carboxylation of inert aryl C-H bond catalyzed by abundant and cheap nickel is still facing challenge. Herein, authors report the Ni-catalyzed direct carboxylation of aryl C-H bonds in benzamides under 1 atm of CO₂ to afford various Me carboxylates or phthalimides, dealing with different post-processing. The reaction displays excellent functional group tolerance and affords moderate to high carboxylation yields under mild conditions. Detail mechanistic studies suggest that a Ni(0)-Ni(II)-Ni(I) catalytic cycle may be involved in this reaction.

Advanced Synthesis & Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Name: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Lei published the artcileLigand-Controlled NiH-Catalyzed Regiodivergent Chain-Walking Hydroalkylation of Alkenes, Computed Properties of 118-90-1, the publication is Angewandte Chemie, International Edition (2022), 61(30), e202204716, database is CAplus and MEDLINE.

A NiH-catalyzed migratory hydroalkylation of alkenyl amines with predictable and switchable regioselectivity is reported. By utilizing a ligand-controlled, directing group-assisted strategy, various alkyl units are site-selectively installed at inert sp³ C-H sites far away from the original C=C bonds. A range of structurally diverse ¦Á- and ¦Â-branched protected amines are conveniently synthesized via stabilization of 5- and 6-membered nickelacycles resp. This method exhibits broad scope and high functional group tolerance, and can be applied to late-stage modification of medicinally relevant mols.

Angewandte Chemie, International Edition published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C9H4F6O, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Yiming published the artcileDirect sulfhydryl ligand derived UiO-66 for removal of aqueous mercury and its subsequent application as catalyst for transfer vinylation, COA of Formula: C8H8O2, the publication is Dalton Transactions (2022), 51(10), 4043-4051, database is CAplus and MEDLINE.

The treatment of mercury pollutants in water has been wide concern. Adsorption is a promising method for mercury removal that has been extensively studied. Nevertheless, the secondary application of the immobilized Hg is seldom investigated. In this paper, the Hg adsorption behavior of UiO-66 bearing sulfhydryl groups is studied. The research shows that the porous structure and sulfhydryl groups of UiO-66-SH can effectively promote the removal of mercury from water. In addition, this work also pushes forward the sequential application of the recovered adsorbent, which contains the adsorbed mercury that may cause secondary pollution. The recovered waste adsorbent, UiO-66-S-Hg, was successfully used as an efficient catalyst for transfer vinylation, which produces value-added products, vinyl benzoates. Eight vinyl esters have been successfully synthesized with a yield of up to 89%. This methodol. provides a promising way for not only the treatment of mercury contamination, but also secondary pollution protection and the resource utilization of immobilized Hg.

Dalton Transactions published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C17H18N3NaO3S, COA of Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Xiaochen published the artcileCombined Photoredox and Carbene Catalysis for the Synthesis of ¦Á-Amino Ketones from Carboxylic Acids, Application In Synthesis of 118-90-1, the publication is ACS Catalysis (2022), 12(4), 2522-2531, database is CAplus.

Herein, a mild, operationally simple method for direct acylation of ¦Á-amino C(sp³)-H bonds from carboxylic acids RC(O)OH (R = cyclopropyl, Ph, 2-chlorophenyl, etc.) via the merger of carbene and photoredox catalysis was reported. Specifically, cross-coupling reactions between a wide range of carboxylic acids, a class of feedstock chems., and readily available N-alkyl anilines R¹CH₂N(R²)R³ (R¹ = H; R² = Me; R¹R² = -(CH₂)₃-, -(CH₂OCH₂CH₂)-; R³ = Ph, 4-bromophenyl, pyridin-2-yl, etc.) and 1-phenyl-2,3-dihydro-1H-indole by means of single-electron N-heterocyclic carbene catalysis combined with photocatalysis provided access to structurally diverse ¦Á-amino ketones RC(O)CH(R¹)N(R²)R³ and (1-phenylindolin-2-yl)(p-tolyl)methanone. The method features a broad substrate scope and is compatible with a wide array of functional groups. To demonstrate the potential applications of the method, one of the ¦Á-amino ketone products was subjected to further transformations.

ACS Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C13H10O2, Application In Synthesis of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Tianhao published the artcileNickel-Catalyzed Decarbonylative Thioetherification of Carboxylic Acids with Thiols, Recommanded Product: 2-Methylbenzoic acid, the publication is Journal of Organic Chemistry (2022), 87(13), 8672-8684, database is CAplus and MEDLINE.

A nickel-catalyzed decarbonylative thioetherification of carboxylic acids RC(O)OH (R = naphthalen-2-yl, 1-benzofuran-2-yl, 1-benzothiophen-2-yl, etc.) with thiols R¹HS (R¹ = 4-methylphenyl, naphthalen-2-yl, 2-methylfuran-3-yl, etc.) was developed. Under the reaction conditions, benzoic acids, cinnamic acids, and benzyl carboxylic acids coupled with various thiols including both aromatic and aliphatic ones produce the corresponding thioethers RSR¹ in up to 99% yields. Moreover, this reaction was applicable to the modification of bioactive mols. such as 3-methylflavone-8-carboxylic acid, probenecid, and flufenamic acid, and the synthesis of acaricide chlorbenside. These results well demonstrated the potential synthetic value of this new reaction in organic synthesis.

Journal of Organic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H14O2, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zheng, Wei-Xiang published the artcileSynthesis of Aryl Ketones from Carboxylic Acids and Arylboronic Acids Using 2-Chloroimidazolium Chloride as a Coupling Reagent, Recommanded Product: 2-Methylbenzoic acid, the publication is Synthesis, database is CAplus.

Carboxylic acids are an abundant and structurally diverse class of com. available materials, which are commonly used as stable reagents in organic synthesis. The Suzuki-Miyaura coupling reaction directly using carboxylic acid as a substrate has been rarely reported. Here, authors report an efficient coupling reaction of carboxylic acids with arylboronic acids in toluene in the presence of IPrCl-Cl, Pd(OAc)₂, PPh₃, and K₃PO₄¡¤7H₂O at 90 ¡ãC to give the corresponding aryl ketones.

Synthesis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C7H6O3, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Long, Yang published the artcileNickel-Catalyzed Synthesis of an Aryl Nitrile via Aryl Exchange between an Aromatic Amide and a Simple Nitrile, Recommanded Product: 2-Methylbenzoic acid, the publication is ACS Catalysis (2022), 12(8), 4688-4695, database is CAplus.

A nickel-catalyzed synthesis of an aryl nitrile via aryl exchange between an aromatic amide and a simple nitrile was developed. By using cheap, easy-to-handle, and low-toxic 4-cyanopyridine as the cyanating source, cyanation of various aromatic amides afforded an assortment of aryl nitriles including bioactive drugs and organic luminescent mols. in good yields. The reaction exhibited wide substrate scope, good functional group tolerance, and unique selectivity that were complementary to traditional methods. Moreover, two key nickel complexes formed by oxidative addition to each substrate are obtained and determined by X-ray crystallog., which gave strong support for the mechanism elucidations.

ACS Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yin, Shenxiang published the artcileAcceptorless dehydrogenation of primary alcohols to carboxylic acids by self-supported NHC-Ru single-site catalysts, Recommanded Product: 2-Methylbenzoic acid, the publication is Journal of Catalysis (2022), 165-172, database is CAplus.

The acceptorless dehydrogenation of diverse aromatic and aliphatic primary alcs. to corresponding carboxylic acids was accomplished by self-supported NHC-Ru single-site catalysts under mild reaction conditions. Besides broad substrates with excellent activity, selectivity and good tolerance to sensitive functional groups, the solid single-site catalyst could be recovered and reused for more than 20 runs without deactivation. Remarkably, up to 1.8 x 10⁴ turnover numbers could be achieved by this newly developed sustainable protocol in gram scale at low catalyst loading, highlighting its potential in industry.

Journal of Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wen, Si published the artcileRuthenium(II)-catalyzed synthesis of CF₃-isoquinolinones via C-H activation/annulation of benzoic acids and CF₃-imidoyl sulfoxonium ylides, Safety of 2-Methylbenzoic acid, the publication is Organic Chemistry Frontiers (2022), 9(16), 4388-4393, database is CAplus.

A ruthenium(II)-catalyzed C-H activation/annulation reaction of benzoic acids and CF₃-imidoyl sulfoxonium ylides enabled by weak O-coordination was achieved. A series of 3-trifluoromethyl-isoquinolinones I [R = Ph, 2-MeC₆H₄, CH₂CH₂Ph, etc.; R¹ = 8-Me, 7-F, 6-I, etc.; R² = F, CF₂CF₃, CF₂CF₂CF₃] were synthesized in 37-75% yields under redox-neutral reaction conditions.

Organic Chemistry Frontiers published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C4H6BrFO2, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Fang, Ze-Yu published the artcileDesign, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors, HPLC of Formula: 118-90-1, the publication is Chemistry & Biodiversity (2022), 19(6), e202200189, database is CAplus and MEDLINE.

A series of novel quinazolinone hydrazide derivatives were designed and synthesized as EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti-tumor cell proliferation and EGFR inhibitory activities. In the comprehensive anal. of all the tested compounds, the target compound 9c showed the best anti-tumor cell proliferation activity, (IC50=1.31 ¦ÌM for MCF-7, IC50=1.89 ¦ÌM for HepG2, IC50=2.10 ¦ÌM for SGC), and IC50=0.59 ¦ÌM for the EGFR inhibitory activity. Docking results showed that compound 9c could ideally insert the active site and interact with the critical amino acid residues (Val702, Lys721, Met769, Asp831) in the active site.

Chemistry & Biodiversity published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia