Category: 118-90-1

Huang, Yuanjing published the artcilePotassium tert-Butoxide Facilitated Amination of Carboxylic Acids with N,N-Dimethylformamide, SDS of cas: 118-90-1, the publication is Synthesis (2022), 54(16), 3595-3604, database is CAplus.

A practical and efficient potassium tert-butoxide (KO^tBu)-facilitated amination of carboxylic acids with N,N-dimethylamine was described. In the presence of catalytic amount of KO^tBu, a variety of aliphatic and aromatic carboxylic acids were transformed to N,N-dimethylamides using DMF as the dimethylamine reagent with the assistance of trimethylacetic anhydride. The applicability of this protocol was demonstrated by late-stage dimethylamidation of complex drug mols. A plausible reaction mechanism involving KO^tBu-facilitated in-situ amine generation from formamide decomposition and anhydride-mediated condensation was proposed on the basis of mechanistic investigations.

Synthesis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, SDS of cas: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ruan, Xiao-Yun published the artcilePhotoinduced and palladium-catalyzed hydrogen atom transfer triggered 1,2-difunctionalization of 1,3-dienes with hydroxamides, Computed Properties of 118-90-1, the publication is Science China: Chemistry (2022), 65(5), 863-869, database is CAplus.

The discovery of novel catalysis modes to generate a significant increase in structural complexity from readily available reactants is a fundamental goal in modern organic synthesis. Here, Authors report a photoinduced palladium-catalyzed hydrogen atom transfer triggered 1,2-difunctionalization of conjugated dienes. Without the employment of exogeneous photosensitizers and external oxidants, the cascade reaction realized the integration of remote functionalization of various C(sp³)-H bonds and selective difunctionalization of 1,3-dienes with 100% atom efficiency, allowing for the synthesis of structurally diverse amides with up to 90% yields. Given the prevalence of amides in pharmaceuticals and natural products, the current protocol has provided an efficient means to access highly functionalized amides from readily available carboxylic acid derivatives and 1,3-dienes.

Science China: Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zeng, Xiang published the artcileAlterations of the gut microbiota and metabolomics in children with e-waste lead exposure, Safety of 2-Methylbenzoic acid, the publication is Journal of Hazardous Materials (2022), 128842, database is CAplus and MEDLINE.

A lead (Pb) exposure can alter the composition and metabolites of gut microbiota. However, few studies investigated this association in the children. A total of 551 children aged 3-7 years were recruited from Guiyu (the e-waste dismantling area) and Haojiang (the reference area). There were finally 70 subjects met the inclusive criteria. Blood and urinary Pb concentrations were detected by GFAAS and ICP-MS techniques. The microbiota and metabolites were measured in stool samples using 16 S rRNA MiSeq sequencing technol. and gas chromatog.-mass spectrometry (GC-MS), resp. Average Pb concentrations in the blood and urine of children were higher in Guiyu than in Haojiang. There were 58 kinds of differential genera and 19 types of discrepant metabolites between the two groups, and wide and significant correlations were found between them. Exposure to Pb caused the most significant differences in microbiota, metabolites, and phys. development parameters between the two groups in terms of microbiota, metabolites, and phys. development indicators. Sphingolipid metabolism and ion transport may also be altered by Pb exposure. Exposure to Pb is associated with significant alterations in the gut microbiota and metabolome in children. More research is needed to confirm the findings of this study.

Journal of Hazardous Materials published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C5H5NO3S, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gudun, Kristina A. published the artcileCobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides, Product Details of C8H8O2, the publication is Advanced Synthesis & Catalysis (2022), 364(3), 601-611, database is CAplus.

The com. available and bench-stable Co(acac)₂ ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h^-1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds

Advanced Synthesis & Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Product Details of C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zahra, Urage published the artcileNew acetylphenol-based acyl thioureas broaden the scope of drug candidates for urease inhibition: synthesis, in vitro screening and in silico analysis, HPLC of Formula: 118-90-1, the publication is International Journal of Biological Macromolecules (2022), 157-167, database is CAplus and MEDLINE.

In the present research, developed a new series of acetylphenol-based acyl thioureas I [R = t-Bu, 2-MeC₆H₄, 4-ClC₆H₄, etc.] that could potentially provide a new template for drug candidates to inhibit urease enzyme. Newly synthesized compounds I were evaluated for urease inhibitory strength using thiourea as a pos. control. In vitro inhibitory results revealed that all the tested compounds were significantly potent than the standard drug. The most active lead compound I [R =3-ClC₆H₄] competitively inhibited the enzyme and displayed an IC₅₀ value of 0.054 ¡À 0.002¦ÌM, a ?413-fold strong inhibitory potential than thiourea (IC₅₀ = 22.3 ¡À 0.031¦ÌM). Various insightful structure-activity relationships were developed showing the key structural requirements for potent inhibitory effects. Mol. docking anal. of compound I [R =3-ClC₆H₄] inside the active pocket of urease suggested several important interactions with amino acid residues such as ILE411, MET637, ARG439, GLN635, ALA636 and ALA440. Finally, pharmacokinetic properties suggested that the tested derivatives were safe to develop as low-mol.-weight drugs to treat ureolytic bacterial infections.

International Journal of Biological Macromolecules published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C9H12O, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hong, Chao published the artcileRh-Catalyzed Coupling of Acrylic/Benzoic Acids with ¦Á-Diazocarbonyl Compounds: An Alternative Route for ¦Á-Pyrones and Isocoumarins, Formula: C8H8O2, the publication is Organic Letters (2022), 24(3), 815-820, database is CAplus and MEDLINE.

A coupling of acrylic acids/benzoic acids with ¦Á-diazocarbonyl compounds had been realized by a combined catalytic system of rhodium catalyst and Zn(OAc)₂ additive. The presence of Zn(OAc)₂ obviously accelerates the C(sp²)-H activation and destructed the formation of carboxylic ester that was formed via a nucleophilic O-H insertion to metal carbenoid. The procedure featured mild reaction conditions and broad substrate scope, providing a straightforward approach to the synthesis of ¦Á-pyrones I [R¹ = Me, Ph, Bn, etc.; R² = H, Me, Ph; R¹R² = (CH₂)₄; R³ = Me, Et, allyl, t-Bu, R⁴ = Me, Et, Ph, etc.] and isocoumarins II [R = H, 8-Me, 8-Me-6-MeO, etc.] without the transformation of carboxylic acids to the corresponding amides.

Organic Letters published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gao, Yang published the artcilePractical synthesis of 3-aryl anthranils via an electrophilic aromatic substitution strategy, Computed Properties of 118-90-1, the publication is Chemical Science (2022), 13(7), 2105-2114, database is CAplus and MEDLINE.

A practical route for the synthesis of valuable 3-aryl anthranils from readily available anthranils and simple arenes by using the classical electrophilic aromatic substitution (EAS) strategy was reported. This transformation goes through an electrophilic substitution and rearomatisation sequence by employing Tf₂O as an effective activator. A wide range of arenes were compatible in this transformation, delivering various structurally diversified 3-aryl anthranils in good yields and high regioselectivity. In addition, a variety of readily available feedstocks such as olefins, alkenyl triflates, silyl enolethers, carbonyl compounds, thiophenols and thiols could also participate in the reaction to achieve the C3 alkenylation, alkylation and thioetherification of anthranils. Of note, the synthesized 3-aryl anthranils proved to be a highly robust platform to access a series of biol. active compounds, drug derivatives and organic optoelectronic materials.

Chemical Science published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Computed Properties of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

He, Min published the artcile7,10-Dibromo-2,3-dicyanopyrazinophenanthrene Aggregates as a Photosensitizer for Nickel-Catalyzed Aryl Esterification, Quality Control of 118-90-1, the publication is Synlett (2022), 33(12), 1189-1193, database is CAplus.

Self-assembled aggregates of 7,10-dibromo-2,3-dicyanopyrazinophenanthrene which act as a new organophotocatalyst in combination with Ni catalyst for the C_aryl-O_acyl cross-coupling reactions of carboxylic acids with aryl halides are described. This visible-light-induced C_aryl-O_acyl bond-formation reaction proceeded smoothly to afford aryl esters with satisfactory to excellent yields.

Synlett published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhao, Long published the artcileOne-Pot Synthesis of 3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by DEAD-Promoted Oxidative Ugi-Wittig Reaction Starting from Phosphonium Salt Precursors, COA of Formula: C8H8O2, the publication is Synlett (2022), 33(1), 66-69, database is CAplus.

A new one-pot synthesis of 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2 H)-ones I (R¹ = H, Cl, Br; R² = TsCH₂, C₆H₅CH₂, CH₂CO₂OMe; R³ = Ph, 4-MeC₆H₄, etc.) by DEAD-promoted oxidative Ugi-Wittig reaction was developed. The sequential reactions of (2-carboxybenzyl)triphenylphosphonium salts II?Br^– (R¹ = H, Cl, Br), isocyanides R²NC, and N-aryl-1,2,3,4-tetrahydroisoquinolines III produced 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2 H)-ones I in moderate to good overall yields in the presence of DEAD and Et₃N.

Synlett published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C13H11NO, COA of Formula: C8H8O2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Xiaofei published the artcileReinforced catalytic oxidation of polyoxometalate@charge transfer complex by on-site heating from photothermal conversion, Safety of 2-Methylbenzoic acid, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 446(Part_2), 137134, database is CAplus.

Near IR (NIR) absorption at low energy region has been demonstrated to devoted to photothermal conversion efficiently. This process provides a possibility for valuable extension in emerging photothermal catalysis following a specific approach of mol. composition To exploit novel photothermal materials in increasing the catalytic activity of comment catalysts, a typical yet unnoticed charge transfer (CT) complex of 3,3¡ä,5,5¡ä-tetramethylbenzidine (TMB_CT) is used here as an on-site heater. Through the electrostatic complexation of cationic CT complex bearing strong NIR absorption with series polyanionic clusters, composite catalysts are prepared These nano-assembled catalysts in size of 5-10 nm display integrated NIR photothermal effect and highly enhanced catalysis for the mild oxidation of toluene and its derivatives into corresponding alcs. with high conversion and selection. While NIR photothermal stability of TMB_CT is maintained, the catalytic activity of inorganic clusters is largely improved. The increments in conversion unattainable under external heating condition are realized and the extension to the mild oxidation of thioethers and olefins into sulfoxides and epoxides with acceptable catalytic recyclability and structural stability are demonstrated. All results from the detailed characterizations figure out the applicability of the NIR photothermal conversion to the catalytic reactions with similar catalytic centers.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Safety of 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia