Category: 118-90-1

Dai, Rongke published the artcileSynthesis of panaxadiol thiadiazole derivatives and study on its potential cell cycle arrest, Related Products of catalysis-chemistry, the publication is Journal of Molecular Structure (2022), 133208, database is CAplus.

In this study, panaxadiol (PD) derivs, I [R¹ = 2-Me, 3-O₂N, 3,4,5-trimethoxy, etc.] and II [R² = H, AcO] were designed and synthesized by the reaction of thiadiazoles with PD. The identity of all final products I and II was elucidated by ¹H, ¹³C NMR, HR-MS. The cytotoxicity activities of the derivatives I and II were evaluated against four cancer cell lines using the MTT assay which revealed they indicated excellent anticancer activity. Among these compounds, II [R² = H] had the most significant cytotoxicity and distinctly inhibited the growth of a variety of tumor cells. Further studies showed that compound II [R² = H] could decrease the expression levels of CDKs protein family and Cyclin D1 in A549, suggesting that compound II [R² = H] could block the cell cycle. To prove the above conclusions, the binding sites of the two proteins were simulated by mol. docking method. The results demonstrated that the docking scores of II [R² = H] and the two cyclins are higher than that of PD. Based on the complex of the target protein and ligand, it was speculated that the enhanced antiproliferative activity may be related to the increased hydrogen bonding interactions. Therefore, these data provide a reference that compound II [R² = H] could be a promising lead drug for cancer treatment.

Journal of Molecular Structure published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Bing published the artcileSelective Oxidative Cleavage of the C-C Bond in ¦Á,¦Â-Epoxy Ketone into Carbonyl Compounds, Name: 2-Methylbenzoic acid, the publication is ACS Omega (2022), 7(25), 21608-21614, database is CAplus and MEDLINE.

This method afforded aromatic carbonyl compounds under TBHP via selective oxidative cleavage of the C-C bond in ¦Á,¦Â-epoxy ketones. Aromatic acid came from the aroyl section, and aromatic aldehyde came from the other aromatic group. TBHP acted as a free radical initiator and oxidant. The reaction within the solvent went through a ring-opening addition, cleavage of the C-C bond in the ethylene oxide section, and oxidation, affording the target compounds in moderate to good yields. The HPLC yield of aromatic aldehyde was up to 91%. The HPLC yield of aromatic acid was up to 99%. The reaction under solvent-free conditions gave two kinds of aromatic acids coming from different moieties of ¦Á,¦Â-epoxy ketone via the further oxidation of aromatic aldehyde. The substituent effect was discussed, and the reaction mechanism was proposed. This method allowed the reaction to occur in a simple system metal-free.

ACS Omega published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Name: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Song, Li-Rui published the artcileMetal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)-C(Alkyl) bond cleavage for quinolone scaffold synthesis, HPLC of Formula: 118-90-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(60), 8340-8343, database is CAplus and MEDLINE.

An unexpected iodine(III)-mediated C(sp³)-C(sp²) bond cleavage of 3-(methylamino)-2-(2-substitutedbenzoyl)acrylates 2-R-3-R¹-4- R²-5-R³C₆HC(O)C(C(O)OEt)=CHNHR⁴ (R = H, Me, Ph, 2-(naphthalen-2-yl)ethyl, etc.; R¹ = H, Me, OMe, NO₂, etc.; R² = H, Me, Br, NO₂, etc.; R³ = H, Me; R⁴ = Et, Bn, Me, i-pr) for efficient synthesis of privileged scaffold 4-quinolones I was described. Notably, a wide range of alkyl groups (e.g. Me, tert-Bu or alkyl chain) can be conveniently cleaved in this system. The detailed mechanism studies revealed that the transformation proceeded through cascade ipso-cyclization and 1,2-carbonyl migration, and the smaller bond energy determined ortho C-C bond cleavage rather than C-H bond cleavage, via an enamine radical intermediate.

Chemical Communications (Cambridge, United Kingdom) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C12H15BBrFO2, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Xu, Dan published the artcileSelective oxidation of alcohols to high value-added carbonyl compounds using air over Co-Co₃O₄@NC catalysts, HPLC of Formula: 118-90-1, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 134545, database is CAplus.

The sustainable catalytic transformation of alcs. to high value-added fine chems. is a significant and challenging research topic. Herein, a set of nitrogen-doped carbon encapsulated Co-based catalysts (Co-Co₃O₄@NC-T) were prepared by using low-cost dicyandiamide, glyoxal and cobalt nitrate as precursors. The obtained catalysts were utilized for the selective oxidation of alcs. to high value-added esters and carboxylic acids with air as the oxygen source and displayed wide applicability for the oxidation of both aromatic and aliphatic alcs. Based on the controlled experiments, the protective effect of N-doped carbon structure and the synergistic effect between Co core and Co₃O₄ species guaranteed the high reaction conversion and selectivity. Benefitting from heterogeneity and magnetism of the catalyst, it can be easily recycled and reused for long-term stability. Reasonable mechanisms of selective oxidation reaction were proposed through EPR anal. and controlled experiments The present work provides a facile strategy for potential large-scale preparation of heterogeneous catalyst for sustainable and green catalytic transformations.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C19H21N, HPLC of Formula: 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wu, Xiaopeng published the artcileNickel-catalyzed Thioester Transfer Reaction with sp²-Hybridized Electrophiles, Quality Control of 118-90-1, the publication is Journal of Organic Chemistry (2022), 87(15), 10003-10017, database is CAplus and MEDLINE.

Authors report a thioacylation transfer reaction based on nickel-catalyzed C-C bond cleavage of thioesters with sp²-hybridized electrophiles. Aryl bromides, iodides, and alkenyl triflates can participate in thioester transfer reaction of aryl thioesters, affording a wide range of structurally diverse new thioesters in yields of up to 98% under mild reaction conditions. With this protocol, it is possible to construct alkenyl thioesters from the corresponding ketones through the generation of alkenyl triflates.

Journal of Organic Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C9H12O, Quality Control of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Nguyen, Hai Truong published the artcileIntermolecular and Intramolecular Friedel-Crafts Acylation of Carboxylic Acids using Binary Ionic Liquids: An Experimental and Computational Study, Recommanded Product: 2-Methylbenzoic acid, the publication is ChemistrySelect (2022), 7(2), e202103708, database is CAplus.

In this study, the desired products 2-RC₆H₄C(O)R¹ (R = H, Br, Cl, F, Me; R¹ = 4-methoxyphenyl, naphthalen-2-yl, 1H-indol-3-yl, etc.) were obtained at moderate to good yields under microwave irradiation for a short reaction time. The Friedel-Crafts cyclization of 4-phenylbutyric acid is more effective than 3-phenylpropionoic acid under the present method. The reaction mechanism is proposed by combining experiments with d. functional theory calculations, highlighting the critical role of ZnCl₂, triflate anion (CF3COO-) in binary ionic liquids, and acidic conditions in accommodating a kinetic accessible pathway making the C-C bond.

ChemistrySelect published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Recommanded Product: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Singh, Vikramjeet published the artcileRedox noninnocence of the formazanate ligand applied to catalytic formation of ¦Á-ketoamides, Application In Synthesis of 118-90-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(46), 6630-6633, database is CAplus and MEDLINE.

An iron-formazanate mol. I (X = pyridine-1-yl) for efficiently preparing ¦Á-keto amides R(R¹)NC(O)R² [R = Me, Et, 2-(4-chlorophenyl)ethyl; R¹ = Et, Ph, 4-bromophenyl, etc.; RR¹ = -(CH₂)₄-, -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-; R² = benzoyl, (thiophen-2-yl)carbonyl, cyclohexyl, etc.] is crucial reductive cleavage of the substrate mol. and tightly regulated by the electron donation from the formazanate, in a reversible manner.

Chemical Communications (Cambridge, United Kingdom) published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C36H45ClN3O8P, Application In Synthesis of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Thakral, Sumit published the artcile2′-Aryl-2,5′-bibenzoxazoles: Synthesis, crystal structure and evaluation of cytotoxicity against cervical (HeLa) and liver (HepG2) cancer cell lines, Related Products of catalysis-chemistry, the publication is Journal of Molecular Structure (2022), 133386, database is CAplus.

A library of twenty-four 2′-aryl-2,5′-bibenzoxazoles I [R¹ = H, Me, OH; R² = H, Me; R³ = H, Me, F, Cl, Br; R⁴ = H, Me; R⁵ = H, Cl] had been synthesized from 2-arylbenzoxazole-5-carboxylic acids which in turn were obtained by hydrolysis of Me 2-arylbenzoxazole-5-carboxylates in excellent yields. These carboxylates were prepared form Me 3-amino-4-hydroxybenzoate and readily available various benzoic acids. The bibenzoxazoles were characterized using NMR, FT-IR and HRMS techniques and the structure of compound I [R¹ = OH; R² = R³ = R⁴ = R⁵ = H] was established by X-ray crystallog. All the synthesized compounds were screened for cytotoxicity (in vitro) against cervical cancer (HeLa) and hepato-carcinoma (HepG2) cell lines and non-cancerous (HEK293) cell line. Compounds, I [R¹ = H, Me, OH; R² = H, Me; R³ = H, F, Br; R⁴ = R⁵ = H] showed good activity against HeLa cancer lines having the IC₅₀ values 4.787, 9.611 and 10.68¦ÌM, resp.

Journal of Molecular Structure published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C11H22N2O4, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zubkov, Mikhail O. published the artcilePhotocatalyzed Decarboxylative Thiolation of Carboxylic Acids Enabled by Fluorinated Disulfide, Application In Synthesis of 118-90-1, the publication is Organic Letters (2022), 24(12), 2354-2358, database is CAplus and MEDLINE.

Thiolation of carboxylic acids using a disulfide reagent having tetrafluoropyridinyl groups was described. The light-mediated process was performed using an acridine-type photocatalyst. Primary, secondary, tertiary and heteroatom-substituted carboxylic acids could be thiolated, and the method could be applied to the late-stage modification of a range of naturally occurring compounds and drugs. The fluorinated pyridine fragment was believed to enable the C-S bond formation. The resulting sulfides were used as redox-active radical precursors.

Organic Letters published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H6ClF3, Application In Synthesis of 118-90-1.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wen, Ya-Ting published the artcileNi-Catalyzed Remote Radical/Cross-Electrophile Coupling Cascade for Selective C(sp³)-H Arylation, Name: 2-Methylbenzoic acid, the publication is Organic Letters (2022), 24(12), 2399-2403, database is CAplus and MEDLINE.

An innovative 1,5-HAT cascade strategy was advanced for the nickel-catalyzed distal arylation via cross-electrophile coupling. Through specific migration, the remote C(sp³)-H bond was regioselectively activated, and Ar-I as the available electrophile is used for the construction of the C(sp³)-C(sp²) bond. This method also has broad applicability for benzylic and aliphatic N-fluorocarboxamides with yields up to 80%. Furthermore, a series of control experiments demonstrated that this reaction was probably initiated by a radical process.

Organic Letters published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C15H14O, Name: 2-Methylbenzoic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia