Category: 140-28-3

Abassian, Maryam published the artcileA new class of organoplatinum-based DFNS for the production of cyclic carbonates from olefins and CO₂, SDS of cas: 140-28-3, the publication is RSC Advances (2020), 10(26), 15044-15051, database is CAplus and MEDLINE.

We studied the potential application of an efficient, reusable, and easily recoverable catalyst of dendritic fibrous nanosilica (DFNS)-supported platinum(II) complexes (DFNS/Pt(II) NPs) to form cyclic carbonates in the presence of epoxides by converting carbon dioxide. Cyclic carbonates from epoxides and carbon dioxide is proposed as the most appropriate way to synthesis this C1 building block. We performed FE-SEM, TEM, TGA, BET, VSM, and ICP-MS to thoroughly characterize DFNS/Pt(II) NPs.

RSC Advances published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, SDS of cas: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Yong-Qing published the artcileOne-pot synthesis of imidazolinium salts via the ring opening of tetrahydrofuran, SDS of cas: 140-28-3, the publication is Dalton Transactions (2017), 46(37), 12430-12433, database is CAplus and MEDLINE.

A new one-pot synthesis of C2-hydroxypropyl-substituted imidazolinium salts I (R = Me, benzyl, 4-hydroxybenzyl, etc.; n = 1, 2) via the ring opening of THF with N,N’-disubstituted diamines such as N,N’-dibenzylideneethane-1,2-diamine, N,N’-bis(4-dimethylaminobenzylidene)ethane-1,2-diamine, N,N’-bis(4-hydroxybenzylidene)ethane-1,2-diamine, etc. has been developed. Preliminary studies of the reaction mechanism suggest the CO₂-promoted oxidative ring opening of THF followed by Hg(II)-mediated oxidation of an imidazolidine intermediate. These novel C2-substituted imidazolinium salts I have shown to be active catalysts for the aza-Diels-Alder reactions.

Dalton Transactions published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, SDS of cas: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sena, Arlene C. published the artcileA systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is BMC Infectious Diseases (2015), 479/1-479/15, database is CAplus and MEDLINE.

Syphilis remains a global public health threat and can lead to severe complications. In addition to resolution of clin. manifestations, a reduction in nontreponemal antibody titers after treatment is regarded as “proof of cure.” However, some patients manifest < 4-fold decline (“serol. non-response”) or persistently pos. nontreponemal titers despite an appropriate decline (“serofast”) that may represent treatment failure, reinfection, or a benign immune response. To delineate these treatment phenomena, we conducted a systematic review of the literature regarding serol. outcomes and associated factors among HIV-infected and -uninfected subjects. Six databases (PubMed, Embase, CINAHL, Web of Science, Scopus, and BIOSIS) were searched with no date restrictions. Relevant articles that evaluated serol. treatment responses and correlates of serol. cure (¡Ý fourfold decline in nontreponemal titers) were included. We identified 1693 reports in the literature, of which 20 studies met selection criteria. The median proportion of patients who had serol. non-response was 12.1 % overall (interquartile range, 4.9-25.6), but varied depending on the time points after therapy. The serofast proportion could only be estimated from 2 studies, which ranged from 35.2-44.4 %. Serol. cure was primarily associated with younger age, higher baseline nontreponemal titers, and earlier syphilis stage. The relationship between serol. cure and HIV status was inconsistent; among HIV-infected patients, CD4 count and HIV viral load was not associated with serol. cure. Serol. non-response and the serofast state are common syphilis treatment outcomes, highlighting the importance of determining the immunol. and clin. significance of persistent nontreponemal antibody titers after therapy.

BMC Infectious Diseases published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C9H7NO3, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Chao published the artcileSynthesis, crystal structure and catalytic properties of novel Zn-N metal complexes based on ethylenediamine derivatives, Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Rengong Jingti Xuebao (2015), 44(1), 287-293, database is CAplus.

Two novel Zn-N metal complexes [Zn(OAc)₂L] (L = N,N-dimethylethylenediamine (1), N,N’-dibenzylethylenediamine (2)) were synthesized with N,N-dimethylethylenediamine and N,N’-dibenzylethylenediamine as ligand, and the structures were characterized and analyzed by ¹H NMR, IR, elemental anal. and x-ray single crystal diffraction. The catalytic properties of the complexes in Henry reaction of aromatic aldehydes with nitromethane and the influences of the reaction conditions were studied, and the applicable scope of aromatic aldehydes in Henry reaction with complex as catalyst is discussed. The complexes can efficiently catalyze the Henry reaction of different aromatic aldehydes with nitromethane under the conditions as follows: methanol as solvent, complex 1 as catalyst mediated by equimolar triethylamine, and catalyst amount for 25 mol%.

Rengong Jingti Xuebao published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Meizi published the artcileExploring the N-terminus region: Synthesis, bioactivity and 3D-QSAR of allatostatin analogs as novel insect growth regulators, Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Chinese Chemical Letters (2018), 29(9), 1375-1378, database is CAplus.

Allatostatins (ASTs), a family of insect neuropeptide, can inhibit juvenile hormone (JH) biosynthesis by the corpora allata (CA) in Diploptera punctata, and therefore be regarded as potential leads for the discovery of new insect growth regulators (IGRs). But several shortcomings, such as their sensitivity to peptidases and high cost, impeded their practical application in pest management. In order to discover new IGRs, one AST analog B1 (I) possessing non-peptide group was discovered with high ability to inhibit JH biosynthesis in vitro (IC₅₀: 0.09 ¦Ìmol/L) in our previous studies. In the present work, two series of I analogs with different substituents on the N-terminus region were designed and synthesized. The result suggested that benzene showed better activity than other heterocycles, and the para-substitution on the benzene was beneficial for activity. Moreover, analogs with logP value over 2.0 exhibited good activity, which indicated the hydrophobicity is important to the bioactivity. Three dimension quant. structure-activity relationship (3D-QSAR) studies were performed to highlight the structural requirements of AST analogs, which demonstrated introduction of bulkier substituents on the N-terminus would increase the activity. Analog (II) (IC₅₀: 0.08 ¦Ìmol/L) exhibited similar inhibitory activity to the lead B1, but its synthetic route was simpler than B1. Therefore, II could be used as a new lead compound for the discovery ecofriendly IGRs.

Chinese Chemical Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C2H4ClNO, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yan, Gang published the artcileDivergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process, Synthetic Route of 140-28-3, the publication is Chemistry – A European Journal (2020), 26(11), 2486-2492, database is CAplus and MEDLINE.

A highly efficient 2-chloroquinazolin-4(3H)-one rearrangement was developed that predictably generated either twisted-cyclic or ring-fused guanidines in a single operation, depending on the presence of a primary vs. secondary amine in the accompanying diamine reagent. Exclusive formation of twisted-cyclic guanidines results from pairing 2-chloroquinazolinones with secondary diamines. Use of primary amine-containing diamines permited a domino quinazolinone rearrangement/intramol. cyclization gated through (E)-twisted-cyclic guanidines to afford ring-fused N-acylguanidines. This scalable, structurally tolerant transformation generated 55 guanidines and delivered twisted-cyclic guanidines with robust plasma stability and an abbreviated total synthesis of an antitumor ring-fused guanidine (4 steps, 55% yield).

Chemistry – A European Journal published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C11H22N2O4, Synthetic Route of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ouyang, Hao published the artcileSynthesis and Characterization of Dinuclear Salan Rare-Earth Metal Complexes and Their Application in the Homo- and Copolymerization of Cyclic Esters, Name: N1,N2-Dibenzylethane-1,2-diamine, the publication is Inorganic Chemistry (2018), 57(15), 9028-9038, database is CAplus and MEDLINE.

Four rare-earth-metal aryloxo complexes stabilized by a tetradentate Salan ligand were prepared, and their catalytic properties for the (co)polymerization of lactides and ¦Å-caprolactone were elucidated. The proton-exchange reactions of (C₅H₅)₃Ln(THF) with the Salan ligand N,N’-(CH₂Ph)₂-N,N’-[CH₂(2-OH-C₆H₂-Me₂-3,5)]₂ (LH₂) in a 1:1 molar ratio, and subsequently with 1 equiv of p-methylphenol, gave the rare-earth-metal aryloxides [LLn(OC₆H₄-4-CH₃)(THF)_n]₂ [n = 0 and Ln = Y (1), Sm (2), and Nd (3); n = 1 and Ln = La (4)] in good isolated yields. These complexes were fully characterized by elemental anal., IR, and NMR spectroscopy (for complexes 1 and 4). Solid-state structures of complexes 1-4 were confirmed by single-crystal X-ray diffraction anal. Complexes 1-4 have dinuclear solid-state structures, with a Ln₂O₂ core bridging the Salan ligands. The coordination geometry around each of the metals is a slightly distorted octahedron in complexes 1-3, whereas it is a capped trigonal prism in complex 4. It was found that complexes 1-4 can initiate efficiently the homopolymerization of L-lactide (L-LA) and rac-lactide (rac-LA) at 30 ¡ãC in THF. The increasing activity of these complexes is in agreement with increasing ionic radii. A kinetic study revealed that seven-coordinated lanthanum complex 4 is more active for rac-LA polymerization compared with L-LA. A further study revealed that complex 4 was also an efficient initiator for the random copolymerization of L-LA and ¦Å-caprolactone with the simultaneous addition of these two monomers, and the T_g values of the copolymers obtained increase linearly from -30.2 to +38.3 ¡ãC with an increase of the percentage of LA units. A mechanism study revealed that transesterification plays a crucial role in the formation of a random copolymer.

Inorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Name: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cui, De-Yun published the artcileSystematic research of H₂dedpa derivatives as potent inhibitors of New Delhi Metallo-¦Â-lactamase-1, Quality Control of 140-28-3, the publication is Bioorganic Chemistry (2020), 103965, database is CAplus and MEDLINE.

New Delhi Metallo-¦Â-lactamase-1 (NDM-1), a Zn (II)-dependent enzyme, can catalyze the hydrolysis of almost all ¦Â-lactam antibiotics including carbapenems, resulting in bacterial antibiotic resistance, which threatens public health globally. Based on our finding that H2dedpa is as an efficient NDM-1 inhibitor, a series of H2dedpa derivatives was systematically prepared These compounds exhibited significant activity against NDM-1, with IC50 values 0.06-0.94 ¦ÌM. In vitro, compounds 6k and 6n could restore the activity of meropenem against Klebsiella pneumoniae, Escherichia coli and Proteus mirabilis possessing either NDM or IMP. In particular, the activity of meropenem against E. coli producing NDM-4 could be improved up to 5333 times when these two compounds were used. Time-kill cell-based assays showed that 99.9% of P. mirabilis were killed when treated with meropenem in combination with compound 6k or 6n. Furthermore, compounds 6k and 6n were nonhemolytic (HC50 > 1280 ¦Ìg/mL) and showed low toxicity toward mammalian (HeLa) cells. Mechanistic studies indicated that compounds 6k and 6n inhibit NDM-1 by chelating the Zn2+ ion of the enzyme.

Bioorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liaw, Joshua Y published the artcileLessons to be learned: Using National Immunisation strategies to improve adherence to acute rheumatic fever secondary prophylaxis., Formula: C16H20N2, the publication is Journal of paediatrics and child health (2019), 55(10), 1170-1176, database is MEDLINE.

Rheumatic heart disease, as a result of a single or recurrent episode of acute rheumatic fever (ARF), remains a significant cause of morbidity and mortality in northern and remote Australia; ARF has a peak incidence among 5-14-year-old Aboriginal and Torres Strait Islander children. Long-term regular benzathine penicillin G injections are the only currently successful secondary prevention strategy; however, rates of adherence remain critically low. In contrast, rates of adherence to immunisations on the National Immunisation Program (NIP) Schedule are high, even among this target population. This article compares strategies used to implement and improve ARF secondary prophylaxis with those used in the NIP. Some successful NIP strategies, such as Service Incentive Payment for health providers, home-visiting delivery models and integration into the National Immunisation Register, if applied to ARF secondary prophylaxis have the potential to improve benzathine penicillin G adherence.

Journal of paediatrics and child health published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Montagnat, Oliver D. published the artcileLessons learned in development of sustained release penicillin drug delivery systems for prophylactic treatment of rheumatic heart disease (RHD), Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Drug Delivery and Translational Research (2018), 8(3), 729-739, database is CAplus and MEDLINE.

The current prophylactic treatment to prevent rheumatic heart disease requires four-weekly i.m. injection of a suspension of the poorly soluble benzathine salt form of penicillin G (BPG) often for more than 10 years. In seeking to reduce the frequency of administration to improve adherence, biodegradable polymer matrixes have been investigated. Poly(lactide-co-glycolide) (PLGA)-based in situ forming precursor systems containing N-methyl-2-pyrrolidone as solvent and PLGA-based monolithic implants for surgical implantation containing BPG were developed. Long-term release studies indicated low and plateaued release of penicillin G, but continual favorable release profiles for the benzathine counterion, indicating degradation of the polymer and generation of acidic microenvironment being detrimental to penicillin stability. In order to avoid the issue of the acidic product, poly(caprolactone)(PCL) implants were also investigated, with favorable penicillin G release behavior being achieved, and slow release over 180 days. However, when taking into account the mass of polymer, and the total dose of drug calculated from literature pharmacokinetic parameters for penicillin G, we concluded that an implant size of over 7 g would still be required. This may preclude clin. deployment of a polymer matrix type delivery system for this indication in children and adolescents. Therefore, we have learned that biodegradable PLGA-type systems are not suitable for development of sustained release BPG treatments and that although the PCL system provides favorable release behavior, the total size of the implant may still present a hurdle for future development.

Drug Delivery and Translational Research published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia