Category: 140-28-3

Ding, Peipei published the artcileSynthesis of heterobinuclear Cu(II)-Ni(II) complex: Structure, CT-DNA interaction, hydrolytic function and antibacterial studies, HPLC of Formula: 140-28-3, the publication is Journal of Molecular Structure (2019), 836-843, database is CAplus.

A new benzyls pendant-armed macrobicyclic heterbinuclear Cu(II)-Ni(II) complex has been obtained by template-directed synthesis and characterized by elemental anal., IR spectra, electrospray mass spectra, and single crystal x-ray diffraction. The complex was bridged by two phenolic oxygens and an acetate radical, with the Cu(II)-Ni(II) distance of 2.9292(8) ?. The hydrolytic function, CT-DNA binding and antibacterial properties were also studied. The initial rate values for the hydrolysis of 4-nitrophenylphosphate to 4-nitrophenolate by the Cu(II)-Ni(II) complex was 1.33 ¡Á 10^-5 s^-1, and 10⁴ times faster than that the spontaneous hydrolysis of the phosphate monoester. The complex shows a better binding property to CT-DNA and the intrinsic binding constant is 1.29 ¡Á 10⁵ M^-1. The Stern-Volmer constant is 1.25 ¡Á 10⁵ M^-1. The viscosity increased obviously with the increase of complex concentration, the results showed that the complex bind to DNA through intercalation mode, which was in accordance with the absorption and emission spectral studies. The antibacterial activities against E.coli was also investigated using the Gentamycinas reference system.

Journal of Molecular Structure published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, HPLC of Formula: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kou, Huizhi published the artcileA new macrocyclic heterobinuclear Cu(II)-Zn(II) complex: synthesis, crystal structure, phosphate hydrolysis, and DNA binding studies, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Journal of Coordination Chemistry (2019), 72(10), 1683-1696, database is CAplus.

A new macrocyclic heterobinuclear Cu(II)-Zn(II) complex was synthesized and characterized by elemental anal., FTIR, ES-MS, and single-crystal x-ray diffraction. Five-coordinate geometry for the new complex is proposed. The Cu…Zn distance bridged by two phenolic oxygens and a acetate ligand is 2.9508 ?. The phosphate ester hydrolysis activity and the DNA binding ability of the complex were studied. The present complex has an efficient catalytic activity of phosphoester bond cleavage. The catalytic rate constant k_cat for the hydrolysis of 4-nitrophenyl phosphate disodium salt hexahydrate (pNPP) by the synthesized complex is 2.69 ¡Á 10^-4 s^-1 and 10⁵ times faster than the spontaneous hydrolysis of the phosphate monoester. The complex shows a good binding ability to calf thymus (CT-DNA) and the corresponding binding constant is 1.9 ¡Á 10⁵ M^-1. The linear Stern-Volmer quenching constant obtained by the fluorescent spectroscopic is 6.3 ¡Á 10⁴ M^-1.

Journal of Coordination Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kostelnik, Thomas I. published the artcileRapid Thermodynamically Stable Complex Formation of [^nat/111In]In³⁺, [^nat/90Y]Y³⁺, and [^nat/177Lu]Lu³⁺ with H₆dappa, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Inorganic Chemistry (2020), 59(10), 7238-7251, database is CAplus and MEDLINE.

A phosphinate-bearing picolinic acid-based chelating ligand (H₆dappa) was synthesized and characterized to assess its potential as a bifunctional chelator (BFC) for inorganic radiopharmaceuticals. NMR spectroscopy was employed to investigate the chelator coordination chem. with a variety of nonradioactive trivalent metal ions (In³⁺, Lu³⁺, Y³⁺, Sc³⁺, La³⁺, Bi³⁺). D. functional theory (DFT) calculations explored the coordination environments of aforementioned metal complexes. The thermodn. stability of H₆dappa with four metal ions (In³⁺, Lu³⁺, Y³⁺, Sc³⁺) was deeply investigated via potentiometric and spectrophotometric (UV-vis) titrations, employing a combination of acidic in-batch, joint potentiometric/spectrophotometric, and ligand-ligand competition titrations; high stability constants and pM values were calculated for all four metal complexes. Radiolabeling conditions for three clin. relevant radiometal ions were optimized ([¹¹¹In]In³⁺, [¹⁷⁷Lu]Lu³⁺, [⁹⁰Y]Y³⁺), and the serum stability of [¹¹¹In][In(dappa)]^3- was studied. Through concentration-, time-, temperature-, and pH-dependent labeling experiments, it was determined that H₆dappa radiolabels most effectively at near-physiol. pH for all radiometal ions. Furthermore, very rapid radiolabeling at ambient temperature was observed, as maximal radiolabeling was achieved in less than 1 min. Molar activities of 29.8 GBq/¦Ìmol and 28.2 GBq/¦Ìmol were achieved for [¹¹¹In]In³⁺ and [¹⁷⁷Lu]Lu³⁺, resp. For H₆dappa, high thermodn. stability did not correlate with kinetic inertness-lability was observed in serum stability studies, suggesting that its metal complexes might not be suitable as a BFC in radiopharmaceuticals. Thermodn. stability of H₆dappa metal complexes is very high, most notably In³⁺-dappa (left); radiolabeling of H₆dappa is rapidly occurring in just 1 min at room temperature with a host of radionuclides-shown here is labeling data with [¹⁷⁷Lu]Lu³⁺ (right).

Inorganic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Morris, David T. J. published the artcileA molecular communication channel consisting of a single reversible chain of hydrogen bonds in a conformationally flexible oligomer, Category: catalysis-chemistry, the publication is Chem (2021), 7(9), 2460-2472, database is CAplus and MEDLINE.

Communication of information through the global switching of conformation in synthetic mols. has hitherto entailed the inversion of chirality. Here, we report a class of oligomer through which information may be communicated through a global reversal of polarity. Ethylene-bridged oligoureas are constitutionally sym., conformationally flexible mols. organized by a single chain of hydrogen bonds running the full length of the oligomer. NMR reveals that this hydrogen-bonded chain may undergo a coherent reversal of directionality. The directional uniformity of the hydrogen-bond chain allows it to act as a channel for the spatial communication of information on a mol. scale. A binding site at the terminus of an oligomer detects local information about changes in pH or anion concentration and transmits that information-in the form of a directionality switch in the hydrogen-bond chain-to a remote polarity-sensitive fluorophore. This propagation of polarity-encoded information provides a new mechanism for mol. communication.

Chem published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Meninno, Sara published the artcileAsymmetric Epoxidation of Alkylidenemalononitriles: Key Step for One-Pot Approach to Enantioenriched 3-Substituted Piperazin-2-ones, COA of Formula: C16H20N2, the publication is Organic Letters (2015), 17(17), 4348-4351, database is CAplus and MEDLINE.

The first enantioselective epoxidation of readily available alkylidenemalononitriles has been developed by using a multifunctional cinchona derived thiourea as the organocatalyst and cumyl hydroperoxide as the oxidant. A new simple one-pot asym. epoxidation/S_N2 ring-opening reaction with 1,2-diamines leading to important enantioenriched heterocycles, i.e. 3-substituted piperazin-2-ones, e. g., I, has been established.

Organic Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tie, Yaxin published the artcileDevelopment and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market, Formula: C16H20N2, the publication is Talanta (2019), 876-887, database is CAplus and MEDLINE.

Estimations, made by the World Health Organization (WHO), state that 10% of the medical products in low- and middle-income countries are substandard or falsified (SF). Among them, antibiotics and antimalarials are the most commonly reported since 2013. Besides the fact that falsification is a crime, the worldwide use of poor quality antimicrobials could result in treatment failures, stronger antimicrobial resistance and even the promotion of the emergence of superbugs. Therefore, simple and accurate anal. methods are necessary, which are capable to detect and quantify a wide range of antimicrobials in suspected illegal products. In this work, a screening and a quantification method using ultra-high performance liquid chromatog. with tandem mass spectrometry (UHPLC-MS²) and diode array detection (UHPLC-DAD), resp. were developed and validated. These methods could be used for routine anal. and enable a more in-depth characterization of SF-antimicrobials. According to their popularity as SF-antimicrobials, 31 antibiotics, 3 antibacterial agents, 1 antifungal agent and 1 ¦Â-lactamase inhibitor, covering eleven different antibacterial classes, were selected. The UHPLC-MS² screening method with gradient elution is able to selectively detect these 36 compounds within 18 min (including wash and equilibration step). It was validated for sensitivity, selectivity and matrix effects. Within an anal. time of 32 min, the UHPLC-DAD method could quantify 32 compounds (4 showed insufficient UV absorbance) and resulted in sufficient selectivity, necessary since some SF-antimicrobials may include more than one antimicrobial component. This quantification method was validated for the pos. hits found during screening tests of suspected illegal samples. This resulted in a validation set of 11 antimicrobials and 1 ¦Â-lactamase inhibitor. The ”total error” approach in accordance with the validation requirements of ISO-17025 was employed for the validation. 57 real-life illegal samples, seized by inspectors from the Belgium Federal Agency for Medicinal and Health Products (FAMHP), were analyzed using the two described methods. About half of them were not compliant and some samples that contained clavulanic acid showed a serious reduction in the amount of this mol. (in one sample only 14% of the claimed dosage was found). These quality issues might be attributed to either poor manufacturing, storage or transportation conditions.

Talanta published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H16OSi, Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Moon, Euy Sung published the artcileIn vitro evaluation of the squaramide-conjugated fibroblast activation protein inhibitor-based agents AAZTA⁵.SA.FAPi and DOTA.SA.FAPi, Application In Synthesis of 140-28-3, the publication is Molecules (2021), 26(12), 3482, database is CAplus and MEDLINE.

Recently, the first squaramide-(SA) containing FAP inhibitor-derived radiotracers were introduced. DATA^5m.SA.FAPi and DOTA.SA.FAPi with their non-radioactive complexes showed high affinity and selectivity for FAP. After a successful preclin. study with [⁶⁸Ga]Ga-DOTA.SA.FAPi, the first patient studies were realized for both compounds Here, we present a new squaramide-containing compound targeting FAP, based on the AAZTA⁵ chelator 1,4-bis-(carboxylmethyl)-6-[bis-(carboxymethyl)-amino-6-pentanoic-acid]-perhydro-1,4-diazepine. For this mol. (AAZTA⁵.SA.FAPi), complexation with radionuclides such as gallium-68, scandium-44, and lutetium-177 was investigated, and the in vitro properties of the complexes were characterized and compared with those of DOTA.SA.FAPi. AAZTA⁵.SA.FAPi and its derivatives labeled with non-radioactive isotopes demonstrated similar excellent inhibitory potencies compared to the previously published SA.FAPi ligands, i.e., sub-nanomolar IC₅₀ values for FAP and high selectivity indexes over the serine proteases PREP and DPPs. Labeling with all three radiometals was easier and faster with AAZTA⁵.SA.FAPi compared to the corresponding DOTA analog at ambient temperature Especially, scandium-44 labeling with the AAZTA derivative resulted in higher specific activities. Both DOTA.SA.FAPi and AAZTA⁵.SA.FAPi showed sufficiently high stability in different media. Therefore, these FAP inhibitor agents could be promising for theranostic approaches targeting FAP.

Molecules published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kibardina, L. K. published the artcilePyridoxal reactions with amines and aliphatic diamines, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Russian Journal of General Chemistry (2016), 86(3), 607-612, database is CAplus.

Interaction of pyridoxal with amines such as pyridin-2-amine, N-(2-aminoethyl)aniline, methyl[2-(methylamino)ethyl]amine, etc. led to the formation of compounds having imine, imidazolidine and pyrimidine moieties in their structure, e.g., I. Structure of the obtained compounds was proved by X-ray diffraction anal.

Russian Journal of General Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kibardina, L. K. published the artcileAzomethines Based on Pyridoxal-Derived Aromatic Aldehydes, Application In Synthesis of 140-28-3, the publication is Russian Journal of General Chemistry (2018), 88(1), 41-47, database is CAplus.

The reaction of pyridoxal with 2,4-dihydroxybenzaldehyde in a hydrochloric acid solution gave 1-(5-formyl-2,4-dihydroxyphenyl)-7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-5-ium chloride. Treatment of the latter with sodium hydride in ethanol afforded a free aldehyde, 2,4-dihydroxy-5-(7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-1-yl)benzaldehyde in 85% yield. A series of azomethines I [R = (CH₂)₃NMe, Ph, 4-H₂NC₆H₄, etc.] and imidazolidines II [R¹ = Me, Bn] was obtained by reacting the obtained aldehyde with various amines and diamines.

Russian Journal of General Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Cheekatla, Subba Rao published the artcileAza-Oxa-Triazole Based Macrocycles with Tunable Properties: Design, Synthesis, and Bioactivity, Application of N1,N2-Dibenzylethane-1,2-diamine, the publication is Molecules (2022), 27(11), 3409, database is CAplus and MEDLINE.

A modular platform for the synthesis of tunable aza-oxa-based macrocycles was established. Modulations in the backbone and the side-chain functional groups have been rendered to achieve the tunable property. These aza-oxa-based macrocycles can also differ in the number of heteroatoms in the backbone and the ring size of the macrocycles. For the proof of concept, a library of macrocycles was synthesized with various hanging functional groups, different combinations of heteroatoms, and ring sizes in the range of 17-27 atoms and was characterized by NMR and mass spectrometry. In light of the importance of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction and the significance of triazole groups for various applications, we employed the click-reaction-based macrocyclization. The competence of the synthesized macrocycles in various biomedical applications was proven by studying the interactions with the serum albumin proteins; bovine serum albumin and human serum albumin. It was observed that some candidates, based on their hanging functional groups and specific backbone atoms, could interact well with the protein, thus improving the bioactive properties. On the whole, this work is a proof-of-concept to explore the backbone- and side-chain-tunable macrocycle for different properties and applications.

Molecules published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia