Category: 140-28-3

Pudovik, M. A. published the artcile2-(2-Hydroxyphenyl)imidazolidines and their O-phosphorylated derivatives, Name: N1,N2-Dibenzylethane-1,2-diamine, the publication is Russian Journal of General Chemistry (2017), 87(1), 60-65, database is CAplus.

2-(2-Hydroxyaryl)imidazolidines were synthesized by reaction of aromatic carbonyl compounds with N,N’-dialkylethylenediamines. The title compounds were also prepared using the corresponding Schiff bases instead of carbonyl compounds Phosphorylation of 2-(2-hydroxyphenyl)imidazolidines with phosphoryl and phosphorothioyl chlorides and phosphorochloridites was accomplished. The reaction of O-phosphorylsalicylaldehyde with N,N’-dialkylethylenediamines also afforded 2-(2-hydroxyphenyl)imidazolidines.

Russian Journal of General Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Name: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Jiaxing published the artcileIn vitro and in vivo evaluation of benzathine foscarnet microcrystals as a potential intravitreal drug depot, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is RSC Advances (2019), 9(37), 21318-21322, database is CAplus and MEDLINE.

Sodium foscarnet is an antiviral drug against cytomegalovirus retinitis, and clin. it is used via frequent intravitreal injection which causes various ocular complications. Here we propose to use benzathine foscarnet in a new salt form with much lower aqueous solubility, and as a potential long-acting intravitreally injectable solid form for foscarnet. Benzathine foscarnet (1 : 1) microcrystals were synthesized and evaluated both in vitro and in vivo. The aqueous solubility of benzathine foscarnet was 14.2 mM, which is in between those of the currently-used sodium foscarnet and our previously-reported calcium foscarnet salt. In a rabbit model, the injected microcrystals last for about 3 wk in the vitreous, suggesting its solubility and dissolution profile is appropriate for its intended use. However, the injected benzathine foscarnet microcrystals also caused adverse effects in vivo.

RSC Advances published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C25H47NO8, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yao, Wei published the artcilePhoto-induced C-H bond activation of N,N’-dialkylethylenediamine upon aza-Michael addition to 1,8-pyrenedione: facile synthesis of fluorescent pyrene derivatives, Application In Synthesis of 140-28-3, the publication is Organic Chemistry Frontiers (2018), 5(10), 1679-1683, database is CAplus.

Reaction between 1,8-pyrenedione and N,N’-dialkylethylenediamine to form highly fluorescent products, via aza-Michael addition followed by double C-H activation facilitated by visible light is discovered. Remarkably, the reaction intermediates and mono C-H bond activation product could only be formed when the reaction was carried out in the presence of a base and UV-light (254 nm). Dehydrogenation of the intermediate under room lighting converts it to the final products. The reaction is a general one as it works with a number of ethylenediamines with different substituents. The reaction mechanisms suggested that nucleophilic addition of the amine followed by dehydrogenation occurs to restore aromaticity and give an amine substituted 1,8-pyrenedione intermediate. The C-H activation requires photoexcitation via a radical mechanism. This work opens a new avenue for the construction of novel mols. with a pyrene core as a fluorophore with good quantum yields.

Organic Chemistry Frontiers published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H13NO2, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kaplaneris, Nikolaos published the artcileEnantioselective Organocatalytic Synthesis of 2-Oxopiperazines from Aldehydes: Identification of the Elusive Epoxy Lactone Intermediate, Computed Properties of 140-28-3, the publication is Organic Letters (2016), 18(22), 5800-5803, database is CAplus and MEDLINE.

An organocatalytic linchpin catalysis approach was envisaged to convert simple aldehydes into enantioenriched 2-oxopiperazines. A four-step reaction sequence (chlorination, oxidation, substitution, and cyclization) was developed and led to different substitution patterns in high yields and selectivities. The reaction mechanism was studied, and the previously elusive epoxy lactone intermediate was identified by HRMS.

Organic Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Computed Properties of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Uyank, Sultan published the artcileMono 1,4-diaza-2,3-diborinane and bicyclic species: Synthesis and structures, HPLC of Formula: 140-28-3, the publication is Polyhedron (2017), 145-151, database is CAplus.

The derivatives of diazadiborinane containing a ring with two nitrogen atoms and two boron atoms are a class of 6-membered heterocyclic compounds Previous studies conducted on the synthesis of diazadiborinane showed that their structures are highly unstable and that some prepared isomer mixtures have no defined mono structure. New monocyclic 1,4-diaza-2,3-diborinane derivatives B₂{1,4-(NAr)₂C₂H₄} and the new bicyclic (B₂{1,2-(NAr)₂C₂H₄}₂) isomer were prepared The structures of these new derivatives were characterized using NMR (NMR) spectroscopy. The mol. and crystal structures of monocyclic and bicyclic species were determined using the single crystal X-ray diffraction technique.

Polyhedron published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C10H10O2, HPLC of Formula: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Rasajna, G. published the artcileGCMS analysis and evaluation of thrombolytic activity of essential oil obtain from the flowers of nyctanthes arbor tristislinn, Computed Properties of 140-28-3, the publication is Indian Research Journal of Pharmacy and Science (2020), 7(2), 2121-2131, database is CAplus.

Objective: The objectives of this study were to identify the chem. composition of the essential obtained from the flowers of Nyctanthes arbor tristis and to carry out in vitro thrombolytic activity studies. Methods: the essential oil was obtained from the flowers of Nyctanthes arbor tristis by hydrodistillation and the chem. composition was determined by gas chromatog.-mass spectrometry anal. Thrombolytic activity was conducted using %clot lysis assay using streptokinase as standard drug. Results: 11 compounds were identified in the essential oil in which betulin (26.58), (23.29%) Undec-10-ynoic acid, undec-2-en-1 -yl ester(23.29%), were predominant followed 1-propoxy propene (19.23%), 9,17-Octadecadienal (12.02%), in clot lysis assay the essential oil showed % clot lysis of 82.60, 86.36, 94.44, for 50mg/mL, 100mg/mL, 150mg/mL resp. Conclusion: The chem. composition of essential oil reveals the presence of betulin in higher concentration which is known for its thrombolytic activity in the clot lysis assay and all the 11 compounds are being reported for the first time in Nyctanthes arbor tristis flowers which fiend their use in cosmetic industry. Therefore the flowers of Nyctanthes arbor tristis grown in yanam region can be a good source of fragrance for cosmetic industry.

Indian Research Journal of Pharmacy and Science published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Computed Properties of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hu, Maowei published the artcileEfficient and Stable Dye-Sensitized Solar Cells Based on a Tetradentate Copper(II/I) Redox Mediator, Category: catalysis-chemistry, the publication is ACS Applied Materials & Interfaces (2018), 10(36), 30409-30416, database is CAplus and MEDLINE.

The identification of an efficient and stable redox mediator is of paramount importance for commercialization of dye-sensitized solar cells (DSCs). Herein, a new class is reported of copper complexes containing diamine-dipyridine tetradentate ligands (L1 = N,N’-dibenzyl-N,N’-bis(pyridin-2-ylmethyl)ethylenediamine; L2 = N,N’-dibenzyl-N,N’-bis(6-methylpyridin-2-ylmethyl)ethylenediamine) as redox mediators in DSCs. Devices constructed with [Cu(L2)]^2+/+ redox couple afford an impressive power conversion efficiency (PCE) of 9.2% measured under simulated one sun irradiation (100 mW cm^-2, AM 1.5G), which is among the top efficiencies reported thus far for DSCs with copper complex-based redox mediators. Remarkably, the excellent air, photo, and electrochem. stability of the [Cu(L2)]^2+/+ complexes renders an outstanding long-term stability of the whole DSC device, maintaining ?90% of the initial efficiency over 500 h under continuous full sun irradiation This work unfolds a new platform for developing highly efficient and stable redox mediators for large-scale application of DSCs.

ACS Applied Materials & Interfaces published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Pegoli, Andrea published the artcileRadiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M₂ Muscarinic Acetylcholine Receptor, Application In Synthesis of 140-28-3, the publication is Journal of Medicinal Chemistry (2017), 60(8), 3314-3334, database is CAplus and MEDLINE.

The dualsteric ligand approach, aiming at ligands with improved subtype selectivity, has been increasingly applied to muscarinic receptors (MRs). In this article we present the synthesis and characterization of a M₂R subtype-preferring radiolabeled dibenzodiazepinone-type antagonist [³H]UNSW-MK259, (I) and its homodimeric analog [³H]UR-AP060, (II). Saturation binding studies at the M₂R, using the orthosteric antagonist atropine to determine unspecific binding, proved that the monomeric and the dimeric compound bind to the orthosteric binding site (apparent K_d: 0.87 and 0.24 nM, resp.). Various binding studies with I and II at the M₂R, for instance, saturation binding experiments in the presence of the allosteric MR modulators W84 or LY2119620 (Schild-like anal.) suggested a competitive mechanism between the allosteric modulator and the dibenzodiazepinone derivatives, and thus a dualsteric binding mode of both I and II. This was consistent with the results of M₂R MD simulations (¡Ý2 ¦Ìs) performed with I and II.

Journal of Medicinal Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Menz, J. published the artcileUsage pattern-based exposure screening as a simple tool for the regional priority-setting in environmental risk assessment of veterinary antibiotics: A case study of north-western Germany, Application In Synthesis of 140-28-3, the publication is Chemosphere (2015), 42-48, database is CAplus and MEDLINE.

Veterinary antibiotics (VAs) are widely recognized as important environmental contaminants. Despite the extensive use of antibiotic agents in meat and poultry production and the known resistance problems in human and veterinary medicine, detailed knowledge about usage patterns of VAs in Germany is still scarce. This lack of knowledge severely impacts current research on the environmental risk of VAs, but it is expected that recently established surveillance programs for antimicrobial drug usage will close this knowledge gap. Therefore, a spatially more precise environmental risk assessment and management might become possible in the near future. In this study, a new usage pattern-based exposure screening (UPES) approach for the comprehensive environmental exposure assessment of veterinary antibiotics was preliminarily assessed using approximated scenarios of antimicrobial substance usage in German meat and poultry production Resulting predicted manure concentrations covered seven orders of magnitude ranging from ng kg^-1 to g kg^-1 dry weight (dw). Beyond that 14 antibiotic substances of 10 different antimicrobial classes were predicted to have the potential to occur in soil concentrations higher than 100 ¦Ìg kg^-1 dw. These findings raise further questions regarding the environmental exposure and risks of frequently used VAs, especially in regions with higher-than-average livestock d. With this case study we demonstrate that UPES simplifies to account for differing local agricultural factors and therefore facilitates priority-setting on a regional level. In this context a simple prioritization scheme for environmental assessment of VAs, considering both the expected environmental concentration and the frequency of application, is proposed in this paper.

Chemosphere published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Isiklan, Muhammet published the artcileSynthesis, structural characterization, and cytotoxic activity of new spirocyclic octachlorocyclotetraphosphazenes, Quality Control of 140-28-3, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2016), 191(9), 1216-1222, database is CAplus.

Octachlorocyclotetraphosphazene, N₄P₄Cl₈, (1) was reacted with N,N’-dibenzylethylenediamine to synthesize partially substituted monospiro- (2), dispiro- (5) and tetraspirocyclotetraphosphazene (8) derivatives The reactions of and with excess pyrrolidine and morpholine produced fully substituted pyrrolidino (3 and 6) morpholino (4 and 7) spirocyclotetraphosphazenes. The structures of the compounds were determined with 1D (¹H, ¹³C, ³¹P, and DEPT) NMR, 2D (HSQC) NMR, ESI-MS, FTIR, and elemental anal. The solid-state structures of and were examined by x-ray crystallog. In 7, intramol. C-H¡¤¡¤¡¤O hydrogen bonds link the mols. into centrosym. dimmers. The cytotoxic activity of all the compounds against human cervix carcinoma cell lines (HeLa) was investigated. The study showed that these compounds exert limited cytotoxic, apoptotic and necrotic effects on HeLa cancer cell lines.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia