Category: 140-28-3

Jash, Apratim published the artcileActivated release of bioactive aldehydes from their precursors embedded in electrospun poly(lactic acid) nonwovens, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is RSC Advances (2018), 8(36), 19930-19938, database is CAplus and MEDLINE.

Hexanal and benzaldehyde are naturally-occurring aroma compounds from plants with enzyme-inhibition and antimicrobial properties. Although useful for food preservation applications, the end-use of these compounds can be challenging due to their volatility and susceptibility to oxidative degradation In this study, stable precursors for benzaldehyde and hexanal were synthesized via reversible condensation reactions with N,N¡ä-dibenzylethane-1,2-diamine. The mol. structures of the resulting 1,3-dibenzylethane-2-Ph and 1,3-dibenzylethane-2-pentyl imidazolidines were confirmed by NMR analyses. The precursors were encapsulated in poly(lactic acid) fibers via electrospinning, using a 90 : 10 Et formate : DMSO blend as a solvent. Triggered release of benzaldehyde and/or hexanal from the resulting active nonwovens was achieved by the addition of 1 N citric acid, which can be described using a pseudo first order kinetic equation involving rapid and slow release steps.

RSC Advances published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dowlati, Bahram published the artcileA combination risk assessment of paracetamol: electrochemical oxidation behavior and cytotoxic effect evaluation of paracetamol in the presence of N¹,N²-dibenzylethane-1,2-diamine, Related Products of catalysis-chemistry, the publication is New Journal of Chemistry (2016), 40(6), 5121-5127, database is CAplus.

The cytotoxic effect of paracetamol in the presence of a diamine derivative was evaluated in liver cells. In this study, hydropyrazinoquinoxalinylidene-acetamide (HPQA), as an agent that is toxic to the liver, was synthesized in an electrochem. cell as a simulated body environment by an electrooxidation reaction. A direct electron transfer (DET) mechanism occurred during the process on the surface of the carbon anode. The electrochem. oxidation of paracetamol was studied using cyclic voltammetry and controlled-potential coulometry (CPC) techniques. The product was characterized by FT-IR, ¹H NMR, ¹³C NMR and ESI-MS² after purification The cytotoxicity of the final compound was evaluated using an MTT assay on the CCL-13 liver cell line. The results indicate that the presence of amine derivatives leads to an increase in the toxic effects of paracetamol in the human body. The cell viability at a concentration of 500 ¦Ìg mL^-1 was 78% for paracetamol, whereas the viability of liver cells in the presence of the product was 18% at 168 ¦Ìg mL^-1. A cycloaddition mechanism was suggested according to the overall results that were obtained.

New Journal of Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Gajewska, Agnieszka published the artcileSynthesis of sulfur containing macrocycles with sucrose scaffold, Product Details of C16H20N2, the publication is Carbohydrate Research (2019), 107825, database is CAplus and MEDLINE.

The first synthesis of sucrose-based macrocycles containing two sulfur atoms in the ring was presented. The synthesis was initiated from known 6,6′-dideoxy-6,6′-di-chloro-1′,2,3,3′,4,4′-hexa-O-benzyl-sucrose in which both terminal positions (C6 and C6′) were elongated by the -S-CH₂-CH₂-OH unit. The resulting diol was converted into dichloride and reacted further with a series of diamines which afforded the corresponding macrocyclic derivatives in high yields.

Carbohydrate Research published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Product Details of C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Marques Borges, Gabriel Silva published the artcileNovel self-nanoemulsifying drug-delivery system enhances antileukemic properties of all-trans retinoic acid, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Nanomedicine (London, United Kingdom) (2020), 15(15), 1471-1486, database is CAplus and MEDLINE.

All-trans retinoic acid (ATRA) shows erratic oral bioavailability when administered orally against leukemia, which can be solved through its incorporation in self-nanoemulsifying drug-delivery systems (SEDDS). The SEDDS developed contained a hydrophobic ion pair between benzathine (BZT) and ATRA and was enriched with tocotrienols by the input of a palm oil tocotrienol rich fraction (TRF) in its composition SEDDS-TRF-ATRA-BZT allowed the formation of emulsions with nanometric size that retained ATRA within their core after dispersion. Pharmacokinetic parameters after oral administration of SEDDS-TRF-ATRA-BZT in mice were improved compared with what was seen for an ATRA solution Moreover, SEDDS-TRF-ATRA-BZT had improved activity against HL-60 cells compared with SEDDS without TRF. SEDDS-TRF-ATRA-BZT is a promising therapeutic choice over ATRA conventional medicine. SEDDS-TRF-ATRA-BZT after dispersion in ultrapure water produces nanoemulsions that have improved ATRA oral pharmacokinetics in Swiss male mice and improved its differentiation and cytotoxic properties against HL-60 cells.

Nanomedicine (London, United Kingdom) published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sigfridsson, Kalle published the artcilePreformulation investigation and challenges; salt formation, salt disproportionation and hepatic recirculation, Name: N1,N2-Dibenzylethane-1,2-diamine, the publication is European Journal of Pharmaceutical Sciences (2017), 262-272, database is CAplus and MEDLINE.

A compound, which is a selective peroxisome proliferator activated receptor (PPAR) agonist, was investigated. The aim of the presented studies was to evaluate the potential of the further development of the compound Fundamental physicochem. properties and stability of the compound were characterized in solution by liquid chromatog. and NMR and in solid-state by various techniques. The drug itself is a lipophilic acid with tendency to form aggregates in solution The neutral form was only obtained in amorphous form with a glass-transition temperature of approx. 0¡ãC. The intrinsic solubility at room temperature was determined to 0.03 mg/mL. Chem. stability studies of the compound in aqueous solutions showed good stability for at least two weeks at room temperature, except at pH 1, where a slight degradation was already observed after one day. The chem. stability in the amorphous solid-state was investigated during a period of three months. At 25¡ãC/60% relative humidity (RH) and 40¡ãC/75% RH no significant degradation was observed At 80¡ãC, however, some degradation was observed after four weeks and approx. 3% after three months. In an accelerated photostability study, degradation of approx. 4% was observed Attempts to identify a crystalline form of the neutral compound were unsuccessful, however, salt formation with tert-butylamine, resulted in crystalline material. Results from stability tests of the presented crystalline salt form indicated improved chem. stability at conditions whereas the amorphous neutral form degraded.

European Journal of Pharmaceutical Sciences published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C17H29BO2, Name: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Abbas, H. A. published the artcileDecolourization of crystal violet using nano-sized novel fluorite structure Ga₂Zr_2-xW_xO₇ photocatalyst under visible light irradiation, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Royal Society Open Science (2020), 7(3), 191632, database is CAplus and MEDLINE.

Fluorite-type Zr-based oxides with the composition Ga₂Zr_2-xW_xO₇ (x = 0, 0.05, 0.1, 0.15 and 0.2) were prepared using the citrate technique. Appropriate characterizations of all prepared materials were carried out. X-ray diffraction clarified that the undoped and W-doped Ga₂Zr₂O₇ samples were crystallized in the cubic fluorite phase structure. The average particle size of the samples was in the range of 3-8 nm. The lowest band gap (1.7 eV) and the highest surface area (124.3 m² g^-1) were recorded for Ga₂Zr_0.85W_0.15O₇. The photocatalytic impacts of the prepared systems were studied by removal of crystal violet (CV) dye employing visible light illumination and taking into consideration the initial dye concentrations, duration of visible irradiation treatment, catalysts dose and the dopant concentration The obtained results showed higher dye removal with the boost of the catalyst dosage. W doping shifted the absorption to the visible light range by decreasing the band gap from 4.95 eV for parent Ga₂Zr₂O₇ to 1.7 eV for 15 mol% tungsten-doped Ga₂Zr₂O₇ enhancing the photocatalytic decolorization of CV from 4.2% to 83.6% for undoped and 15 mol% W-doped Ga₂Zr₂O₇, resp., at optimum operating conditions (pH 9, 1gl^-1 catalyst dose and 300 min) while heavily doped W sample containing 20 mol% W showed lower removal than 15 mol% W-doped Ga₂Zr₂O₇. Complete CV degradation using 15 mol% W-doped Ga₂Zr₂O₇ was attained with the assistance of 25 mmol l^-1 hydrogen peroxide. The reaction is aligned to pseudo-first-order kinetics. Different scavengers were introduced to decide the significance of the reactive species in CV degradation O-?2 and h+ had the major role in the degradation of CV by Ga₂Zr_2-xW_xO₇ system compared with HO?.

Royal Society Open Science published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Thurakkal, Liya published the artcileDesign, synthesis and bioactive properties of a class of macrocycles with tunable functional groups and ring size, Name: N1,N2-Dibenzylethane-1,2-diamine, the publication is Scientific Reports (2022), 12(1), 4815, database is CAplus and MEDLINE.

Abstract: The design and synthesis of a versatile class of macrocycles with tunable functional groups and ring size are unfolded. Herein, a synthetic strategy is reported to furnish a new class of macrocycles in multi-gram scale in a two-step reaction. The total time taken for synthesizing a macrocycle is 1.5 h. Dithiocarbamates, an important functional group in biomedical and material sciences, is strategically incorporated in the macrocyclic backbone without metal for the first time. It is noteworthy that when state-of-the-art macrocycle synthesis is in millimolar concentration, this work employs the reaction in molar concentration (0.2-0.4 M). As proof-of-principle, a library of macrocycles was synthesized, varying the functional groups and ring size. The physicochem. properties of macrocycles revealed their druggable nature and are affirmed by protein (serum albumin) interaction study theor. and exptl. Diverse functional groups and ring sizes of macrocycles brought about twenty-five-fold difference in binding constant with the model protein.

Scientific Reports published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C9H6BrNO, Name: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Yamazaki, Shoko published the artcileSynthesis of Piperidines via Intramolecular Hydride Transfer from ¦Á-Amino sp³ Carbon Atoms to Ethenetricarboxylate-Derived Fragments and Further Cyclization, Application In Synthesis of 140-28-3, the publication is ChemistrySelect (2018), 3(16), 4505-4511, database is CAplus.

The cyclization of amides derived from ethenetricarboxylic acid bearing tert-amino groups wsa examined The amides were efficiently converted to piperidine derivatives (2-piperidones) upon heating in a polar solvent (e. g., DMSO or DMF) via intramol. hydride transfer and subsequent ring closure. The reaction was less efficient in the presence of a Lewis acid. The reactivity varies depending on the alkyl substituents of tert-amino groups, probably due to steric effects. The hydride transfer/cyclization mechanism was investigated by DFT calculations The reaction of the carboxylic acid and relatively bulky diamines such as diisopropyl-substituted diamine in the presence of amide condensation reagents at 60 ¡ã gave the piperidine derivatives in a one-pot reaction. The reaction of the diisopropylamine substituted piperidine product with primary amines gave secondary amine-substituted piperidines.

ChemistrySelect published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H4ClN3S, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Farkas, Edit published the artcileEquilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATA^m and DATA^5m Ligands, Related Products of catalysis-chemistry, the publication is Chemistry – A European Journal (2017), 23(43), 10358-10371, database is CAplus and MEDLINE.

The development of ⁶⁸Ge/⁶⁸Ga generators has made the positron-emitting ⁶⁸Ga isotope widely accessible and raised interest in new chelate complexes of Ga³⁺. The hexadentate 1,4-di(acetate)-6-methyl[amino(methyl)acetate]perhydro-1,4-diazepane (DATA^m) ligand and its bifunctional analog, 1,4-di(acetate)-6-pentanoic acid-6-[amino(methyl)acetate]perhydro-1,4-diazepane (DATA^5m), rapidly form complexes with ⁶⁸Ga in high radiochem. yield. The stability constants of DATA^m and DATA^5m complexes formed with Ga³⁺, Zn²⁺, Cu²⁺, Mn²⁺ and Ca²⁺ were determined by using pH potentiometry, spectrophotometry (Cu²⁺) and ¹H and ⁷¹Ga NMR spectroscopy (Ga³⁺). The stability constants of Ga(DATA^m) and Ga(DATA^5m) complexes are slightly higher than those of Ga(AAZTA). The species distribution calculations indicated the predominance of Ga(L)OH mixed-hydroxo complexes at physiol. pH. The ¹H and ⁷¹Ga NMR spectroscopy studies provided information about the coordinated functional groups of ligands and on the kinetics of exchange between the Ga(L) and Ga(L)OH complexes. The transmetalation reactions between the Ga(L) complexes and Cu²⁺ citrate (6 < pH < 8.5) occur through both spontaneous and OH^–-assisted dissociation of the Ga(L)OH species. At pH 7.4 and 25¡ã, the half-lives of the dissociation of Ga(DATA^m), Ga(DATA^5m) and Ga(AAZTA) were 11, 44 and 24 h, resp. Similar half-lives were obtained for the ligand-exchange reactions between the Ga(L)OH complexes and transferrin. The equilibrium and kinetic data indicate that the Ga(DATA^5m) complex is a good ⁶⁸Ga-based radiodiagnostic candidate.

Chemistry – A European Journal published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lahnif, Hanane published the artcileHybrid Chelator-Based PSMA Radiopharmaceuticals: Translational Approach, Related Products of catalysis-chemistry, the publication is Molecules (2021), 26(21), 6332, database is CAplus and MEDLINE.

Prostate-specific membrane antigen (PSMA) has been extensively studied in the last decade. It became a promising biol. target in the diagnosis and therapy of PSMA-expressing cancer diseases. Although there are several radiolabeled PSMA inhibitors available, the search for new compounds with improved pharmacokinetic properties and simplified synthesis is still ongoing. In this study, we developed PSMA ligands with two different hybrid chelators and a modified linker. Both compounds have displayed a promising pharmacokinetic profile. DATA5m.SA.KuE and AAZTA5.SA.KuE were synthesized. DATA5m.SA.KuE was labeled with gallium-68 and radiochem. yields of various amounts of precursor at different temperatures were determined Complex stability in phosphate-buffered saline (PBS) and human serum (HS) was examined at 37 ¡ãC. Binding affinity and internalization ratio were determined in in vitro assays using PSMA-pos. LNCaP cells. Tumor accumulation and biodistribution were evaluated in vivo and ex vivo using an LNCaP Balb/c nude mouse model. All experiments were conducted with PSMA-11 as reference DATA5m.SA.KuE was synthesized successfully. AAZTA5.SA.KuE was synthesized and labeled according to the literature. Radiolabeling of DATA5m.SA.KuE with gallium-68 was performed in ammonium acetate buffer (1 M, pH 5.5). High radiochem. yields (>98%) were obtained with 5 nmol at 70 ¡ãC, 15 nmol at 50 ¡ãC, and 60 nmol (50 ¦Ìg) at room temperature [68Ga]Ga-DATA5m.SA.KuE was stable in human serum as well as in PBS after 120 min. PSMA binding affinities of AAZTA5.SA.KuE and DATA5m.SA.KuE were in the nanomolar range. PSMA-specific internalization ratio was comparable to PSMA-11. In vivo and ex vivo studies of [177Lu]Lu-AAZTA5.SA.KuE, [44Sc]Sc-AAZTA5.SA.KuE and [68Ga]Ga-DATA5m.SA.KuE displayed specific accumulation in the tumor along with fast clearance and reduced off-target uptake. Both KuE-conjugates showed promising properties especially in vivo allowing for translational theranostic use.

Molecules published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia