Category: 140-28-3

Jakobsson, Jimmy E. published the artcile[¹¹C]Carbonyl Difluoride-a New and Highly Efficient [¹¹C]Carbonyl Group Transfer Agent, Name: N1,N2-Dibenzylethane-1,2-diamine, the publication is Angewandte Chemie, International Edition (2020), 59(18), 7256-7260, database is CAplus and MEDLINE.

Herein, the synthesis and use of [¹¹C]carbonyl difluoride for labeling heterocycles with [¹¹C]carbonyl groups in high molar activity is described. A very mild single-pass gas-phase conversion of [¹¹C]carbon monoxide into [¹¹C]carbonyl difluoride over silver(II) fluoride provides easy access to this new synthon in robust quant. yield for labeling a broad range of cyclic substrates, for example, imidazolidin-2-ones, thiazolidin-2-ones, and oxazolidin-2-ones. Labeling reactions may utilize close-to-stoichiometric precursor quantities and short reaction times at room temperature in a wide range of solvents while also showing high water tolerability. The overall radiosynthesis protocol is both simple and reproducible. The required apparatus can be constructed from widely available parts and is therefore well suited to be automated for PET radiotracer production We foresee that this straightforward method will gain wide acceptance for PET radiotracer syntheses across the radiochem. community.

Angewandte Chemie, International Edition published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Name: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Mei published the artcileBiomimetic synthesis and anti-inflammatory effects of horsfiequinone A, Related Products of catalysis-chemistry, the publication is Tetrahedron Letters (2021), 152756, database is CAplus.

Inspired by the oxy-tyrosinase type II copper enzyme, a biomimetic synthesis of the natural product horsfiequinone A (I) has been achieved using CuOTf/DBED/O₂ catalyzed oxidation as a key step. The synthetic route furnished 1 in 33% overall yield (64% brsm) from com. available para-hydroxybenzaldehyde. Moreover, revisiting the biol. activity of 1 resulted in the discovery of its in vitro inhibitory activity towards nitric oxide (NO) production in LPS-induced RAW264.7 cells with an IC₅₀ value of 4.42 ¡À 0.81¦ÌM. The anti-inflammatory effect of 1 was further supported by an iNOS expression inhibition assay and mol. docking simulation.

Tetrahedron Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C6H9N3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Huang, Yong published the artcileAn Efficient Synthesis of N,N,N-Substituted 1,4,7-Triazacyclononane, HPLC of Formula: 140-28-3, the publication is European Journal of Organic Chemistry (2018), 2018(13), 1546-1551, database is CAplus.

A new and efficient synthetic approach is reported for various N,N,N-substituted 1,4,7-triazacyclononanes (TACN) in moderate to excellent yields, with optimization of the reaction sequences and conditions of the intermediate 1,4,7-tribenzyl-1,4,7-triazonane-2,6-dione reduction with LiAlH₄, removal of benzyl with Pd/C, and alkylation reactions. This reaction scheme provides a convenient and flexible method to prepare various N,N,N-substituted TACN derivatives

European Journal of Organic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, HPLC of Formula: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Yajun published the artcileIdentification and structure-activity studies of 1,3-Dibenzyl-2-aryl imidazolidines as novel Hsp90 inhibitors, Product Details of C16H20N2, the publication is Molecules (2019), 24(11), 2105, database is CAplus and MEDLINE.

Hsp90 (Heat shock protein 90) is involved in various processes in cancer occurrence and development, and therefore represents a promising drug target for cancer therapy. In this work, a virtual screening strategy was employed, leading to the identification of a series of compounds bearing a scaffold of 1,3-dibenzyl-2-aryl imidazolidine as novel Hsp90 inhibitors. Compound 4a showed the highest binding affinity to Hsp90a (IC₅₀ = 12 nM) in fluorescence polarization (FP) competition assay and the strongest anti-proliferative activity against human breast adenocarcinoma cell line (MCF-7) and human lung epithelial cell line (A549) with IC₅₀ values of 21.58 M and 31.22 M, resp. Western blotting assays revealed that these novel Hsp90 inhibitors significantly down-regulated the expression level of Her2, a client protein of Hsp90, resulting in the cytotoxicity of these novel Hsp90 inhibitors. The mol. docking study showed that these novel Hsp90 inhibitors bound to the ATP (ATP) binding site at the N-terminus of Hsp90. Furthermore, structure-activity relationship studies indicated that the N-benzyl group is important for the anti-cancer activity of 1,3-dibenzyl-2-aryl imidazolidines.

Molecules published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Product Details of C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jash, Apratim published the artcileTriggered release of hexanal from an imidazolidine precursor encapsulated in poly(lactic acid) and ethylcellulose carriers, Product Details of C16H20N2, the publication is Journal of Materials Science (2018), 53(3), 2221-2235, database is CAplus.

Hexanal is a naturally occurring aliphatic aldehyde with antimicrobial and phospholipase D inhibition properties, useful for post-harvest preservation of fresh fruits and produce. However, hexanal is highly volatile and susceptible to oxidative degradation To overcome these issues, a precursor was synthesized and entrapped in poly(lactic acid) (PLA) fiber or ethylcellulose (EC) particulate carriers. The precursor was synthesized through nucleophilic addition of hexanal to N,N’-dibenzylethane-1,2-diamine to form 1,3-dibenzylethane-2-pentyl imidazolidine-a stable hexanal precursor compound ¹H and ¹³C NMR analyses confirmed the formation of heterocyclic ring structure in the precursor. SEM anal. revealed that the precursor was dispersed homogeneously within the PLA and EC carriers by electrospinning or electrospraying processes, resp. The release of hexanal was triggered by the hydrolysis of the imidazolidine compound at 5, 25, and 45 ¡ãC, via the addition of 0.1 N citric acid to the precursor-loaded carriers. The citric acid solution resulted in significantly (p < 0.05) higher amounts and rates of hexanal released in PLA than EC, but both carriers had similar activation energies of hexanal release. FTIR anal. did not detect specific interactions between the precursor and the polymers. The hexanal precursor developed here potentially can be used as a component of active packaging to deliver hexanal and other aldehydes to enhance storage stability of fresh produce.

Journal of Materials Science published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Product Details of C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lu, Haikong published the artcileHigh frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilis, Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Emerging Microbes & Infections (2015), 4(2), e10, database is CAplus and MEDLINE.

The preferred drugs for the treatment of syphilis, benzathine and procaine penicillin, have not been available in Shanghai for many years, and currently, the incidence of syphilis is increasing. Alternative antibiotics for patients with syphilis during the benzathine and procaine penicillin shortage include macrolides. The failure of macrolide treatment in syphilis patients has been reported in Shanghai, but the reason for this treatment failure remains unclear. The authors used polymerase chain reaction technol. to detect a 23S rRNA A2058G mutation in Treponema pallidum in 109 specimens from syphilis patients. The use of azithromycin/erythromycin in the syphilis patients and the physicians’ prescription habits were also assessed based on two questionnaires regarding the use of macrolides. A total of 104 specimens (95.4%) were pos. for the A2058G mutation in both copies of the 23S rRNA gene, indicating macrolide resistance. A questionnaire provided to 122 dermatologists showed that during the penicillin shortage, they prescribed erythromycin and azithromycin for 8.24 ¡À 13.95% and 3.21 ¡À 6.37% of their patients, resp., and in the case of penicillin allergy, erythromycin and azithromycin were prescribed 15.24 ¡À 22.89% and 7.23 ¡À 16.60% of the time, resp. A second questionnaire provided to the syphilis patients showed that 150 (33.7%), 106 (23.8%) and 34 (7.6%) individuals had used azithromycin, erythromycin or both, resp., although the majority did not use the drugs for syphilis treatment. The authors’ findings suggest that macrolide resistance in Treponema pallidum is widespread in Shanghai. More than half of the syphilis patients had a history of macrolide use for other treatment purposes, which may led to the high prevalence of macrolide resistance. Physicians in China are advised to not use azithromycin for early syphilis.

Emerging Microbes & Infections published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Zheng-Tang published the artcileTitanium, aluminum and zinc complexes containing diamine-bis(benzotriazole phenolate) ligands: Synthesis, structural characterization and catalytic studies for ring-opening polymerization of ¦Å-caprolactone, Synthetic Route of 140-28-3, the publication is Journal of Molecular Structure (2017), 395-403, database is CAplus.

Structurally diverse metal complexes bearing diamine-bis(benzotriazole phenolate) (DiBTP) ligands were synthesized and fully characterized by single crystal x-ray crystallog. The reaction of Ti(OⁱPr)₄ with ^C8MEADiBTP-H₂ or ^C8BEADiBTP-H₂ (1.0 mol equivalent) generated the monomeric Ti alkoxy complexes [(^C8MEADiBTP)Ti(OⁱPr)₂] (1) and [(^C8BEADiBTP)Ti(OⁱPr)₂] (2), resp. Also, ^C8BEADiBTP-H₂ reacted with 2.0 molar equivalent of AlMe₃ to give the tetracoordinated di-Al complex [(^C8BEADiBTP)Al₂Me₄] (3). Zn complex [(^C8BEADiBTP)Zn₂Et₂] (4) could be obtained by the alkane elimination of ZnEt₂ (2.0 equiv) with ^C8BEADiBTP-H₂ as the pro-ligand under similar synthetic methods in good yield. Single-crystal x-ray diffraction indicates that 3 is a bimetallic Al di-Me complex with a tetradentate ^C8BEADiBTP moiety chelating two metal atoms, whereas complex 4 displays the dinuclear feature containing both tetra- and pentacoordinated Zn atoms bonded by one ONNON-pentadentate ^C8BEADiBTP ligand. Catalytic studies for ring-opening polymerization of ¦Å-caprolactone of complex 1–4 were systematic explored; the comparative studies of such polymerization are also discussed.

Journal of Molecular Structure published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Synthetic Route of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Coward, Daniel L. published the artcileRadically Initiated Group Transfer Polymerization of Methacrylates by Titanium Amino-Phenolate Complexes, COA of Formula: C16H20N2, the publication is Macromolecules (Washington, DC, United States) (2019), 52(9), 3252-3256, database is CAplus.

Radical initiation of Me methacrylate polymerizations mediated by titanium amino-phenolate complexes gave exceptional control without the need for any cocatalyst or activator. The polymerization proceeds not by a classical controlled radical or coordination insertion mechanism but via a unique bimetallic group transfer process. Detailed exptl. and computational studies support a polymerization mechanism with a titanium(IV)-enolate complex and a second titanium(III) complex that delivers an activated monomer and provides new insight into both titanium-mediated radical reactions and polymerizations

Macromolecules (Washington, DC, United States) published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tamaki, Airi published the artcileExamination of Pyridazine as a Possible Scaffold for Nucleophilic Catalysis, Safety of N1,N2-Dibenzylethane-1,2-diamine, the publication is Journal of Organic Chemistry (2016), 81(19), 8710-8721, database is CAplus and MEDLINE.

Pyridazines with amino groups positioned para to each aromatic ring nitrogen and fixed in six-membered rings were prepared The representative sym. amino N-Et derivative was found to slightly exceed DMAP in catalytic activity in the acetylation reaction of a tertiary alc. in C₆D₆. Nucleophilicity eclipsing that of DMAP was established in competitive reactions using phenacyl bromide as the electrophile, and the unsym. N-Et derivative was revealed to have even higher nucleophilicity.

Journal of Organic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C13H10F2, Safety of N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ryan, Michael C. published the artcilePiperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones, Related Products of catalysis-chemistry, the publication is ACS Medicinal Chemistry Letters (2022), 13(4), 546-553, database is CAplus and MEDLINE.

While expanding the pharmacophoric model of antialphaviral amidines prepared via a quinazolinone rearrangement, we discovered that diamine-treated, 2-dihalomethylquinolinones unexpectedly afforded ring-expanded piperazine-fused benzodiazepinones I [R¹ = NO₂, F, CN; R² = H, NO₂; R³ = H, Br, 2-morpholinyl, etc.; R⁴ = Me, Bn; R⁵ = Me, cyclohexyl, Bn; Ar = Ph, 4-MeOC₆H₄, 4-FC₆H₄, etc.]. Notably, this new chemotype showed potent, submicromolar inhibition of virus-induced cell death, >7-log reduction of viral yield, and tractable structure-activity relationships across both viruses. Antiviral activity was confirmed in primary human neuronal cells. A mechanistic rationale for product formation is proposed, and key structural elements were comparatively modeled between a similarly substituted antiviral amidine and piperazinobenzodiazepinone prototypes to guide future antiviral development.

ACS Medicinal Chemistry Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia