Category: 140-28-3

Kristoffersen, Tone published the artcileMicrowave-Assisted Synthesis of Heterocycles from Aryldiazoacetates, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is European Journal of Organic Chemistry (2020), 2020(45), 7069-7078, database is CAplus.

Herein, we describe a rapid microwave-assisted, metal-free synthesis of substituted quinoxalinones and quinoxalines using the carbene-mediated reaction between aryldiazo esters and 1,2-diamines. The reaction can encompass a range of substituents and structural variations to afford quinoxalin-2-ones in 14-80% yield and corresponding quinoxalines in good to excellent yields upon oxidation (67-96%). The approach can be employed to generate sym. and unsym. 2,3-diarylquinoxalines, bis-quinoxalines as well as novel quinoxaline-substituted diazo esters and should be a valuable addition to the heterocycle synthesis toolbox.

European Journal of Organic Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Larde, H. published the artcileAn observational cohort study on antimicrobial usage on dairy farms in Quebec, Canada, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine, the publication is Journal of Dairy Science (2021), 104(2), 1864-1880, database is CAplus and MEDLINE.

Quantification of antimicrobial usage (AMU) is crucial to measure the effect of intervention programs, to determine associations between usage and resistance, to compare populations, and for benchmarking purposes. The primary objective of the study was to describe quant. the AMU on Quebec dairy farms over 1 yr: (1) the total AMU, (2) the AMU per administration route (intramammary, injectable, oral, intrauterine), and (3) the AMU per antimicrobial class and according to the categorizations of Health Canada and the World Health Organization. The secondary objective was to assess the effect of several characteristics (herd size, level of milk production, and incidence rate of common infectious diseases) on AMU rate. The AMU data were obtained for 101 dairy farms randomly selected in 3 important Quebec dairy regions by collecting and recording all empty drug packaging and invoices for medicated feed (spring 2017 to spring 2018). The AMU rate was reported in number of Canadian defined course doses for cattle per 100 cow-years. The average herd size was 67 cows per farm, and 2/101 farms were certified organic Overall, an estimated mean of 537 Canadian defined course doses for cattle/100 cow-years was observed The intramammary route during lactation was the most frequently observed, followed, in decreasing order of usage, by oral route in the feed, intramammary route at drying-off, and injectable route. Oral (other than in animal feed) and intrauterine formulations were infrequently collected from the garbage cans. The 5 most frequently observed antimicrobial classes were, by decreasing order of usage, ionophores, penicillins, aminocoumarins, aminoglycosides, and polymyxins. Highest priority critically important antimicrobials as defined by the World Health Organization were mainly collected from intramammary formulations during lactation followed by injectable and drying-off intramammary formulations. The herd size was pos. associated with the total AMU rate but not with the usage rate of highest priority critically important antimicrobials. Incidence of diseases along with preventive use of antimicrobials (drying-off and medicated feed with antimicrobials) explained 48% of the variance in total AMU rate.

Journal of Dairy Science published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Recommanded Product: N1,N2-Dibenzylethane-1,2-diamine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bellini, Clement published the artcileAlkaline-Earth-Catalyzed Cross-Dehydrocoupling of Amines and Hydrosilanes: Reactivity Trends, Scope and Mechanism, COA of Formula: C16H20N2, the publication is Chemistry – A European Journal (2016), 22(13), 4564-4583, database is CAplus and MEDLINE.

Alk.-earth (Ae = Ca, Sr, Ba) complexes catalyze the chemoselective cross-dehydrocoupling (CDC) of amines and hydrosilanes. Key trends were delineated in the benchmark couplings of Ph₃SiH with pyrrolidine or tBuNH₂. Ae{E(SiMe₃)₂}₂¡¤(THF)_x (E = N, CH; x = 2-3) are more efficient than [N?]Ae[E(SiMe₃)₂]¡¤(THF)_n (E = N, CH; n = 1-2) complexes ([N?]^– = [ArN(o-C₆H₄)C(H):NAr]^– with Ar = 2,6-iPr₂C₆H₃) bearing an iminoanilide ligand, and alkyl pre-catalysts are better than amido analogs. Turnover frequencies (TOFs) increase in the order Ca<Sr<Ba. Ba[CH(SiMe₃)₂]₂¡¤(THF)₃ displays the best performance (TOF up to 3600 h^-1). The substrate scope (>30 products) includes diamines and di(hydrosilane)s. Kinetic anal. of the Ba-promoted CDC of pyrrolidine and Ph₃SiH shows that 1: the kinetic law is rate = k[Ba]¹[amine]⁰[hydrosilane]¹, 2: electron-withdrawing p-substituents on the arylhydrosilane improve the reaction rate and 3: a maximal kinetic isotopic effect (k_SiH/k_SiD=4.7) is seen for Ph₃SiX (X = H, D). DFT calculations identified the prevailing mechanism; instead of an inaccessible ¦Ò-bond-breaking metathesis pathway, the CDC appears to follow a stepwise reaction path with N-Si bond-forming nucleophilic attack of the catalytically competent Ba pyrrolide onto the incoming silane, followed by rate limiting H-atom transfer to Ba. The participation of a Ba silyl species is prevented energetically. The reactivity trend Ca<Sr<Ba results from greater accessibility of the metal center and decreasing Ae-N_amide bond strength upon descending Group 2.

Chemistry – A European Journal published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, COA of Formula: C16H20N2.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Vagner, Adrienn published the artcileA rigidified AAZTA-like ligand as efficient chelator for ⁶⁸Ga radiopharmaceuticals, Quality Control of 140-28-3, the publication is ChemistrySelect (2016), 1(2), 163-171, database is CAplus.

The new cyclohexane-fused CyAAZTA ligand was synthesized to increase the structural rigidity of the heptadentate chelator AAZTA with the aim of improving the overall stability of its Ga^III complex. The stability constant of Ga(CyAAZTA)^–, determined both by pH-potentiometry (logK_GaL=21.39) and by ⁷¹Ga NMR (logK_GaL=21.92), was found similar to that of GaAAZTA (logK_GaL=22.18). The kinetic inertness of Ga(CyAAZTA)^– was investigated by following its transmetallation and ligand exchange reactions with Cu²⁺ and human serum transferrin, resp. The formation of a hydroxido-complex near pH 7 decreases the half-life (t_1/2) of the dissociation reactions for Ga(CyAAZTA)^– compared to Ga(AAZTA)^– (8.5 h vs 21 h, pH 7.4). However, at pH < 7 the t_1/2 of Ga(CyAAZTA)^– is much longer (234 h at pH 6). Finally, CyAAZTA was successfully radiolabeled with ⁶⁸Ga in acetate buffer at pH 3.8, in 15 min at room temperature at [CyAAZTA]=10 ¦ÌM, with a labeling yield higher than 80 %. A 1 ¦ÌM solution of CyAAZTA was successfully labeled (L.Y.: 97.4 %) in 5 min at 90 ¡ãC. Stability tests in human serum and in the presence of 50 mM DTPA showed no significant decomposition of ⁶⁸GaCyAAZTA over 90 min.

ChemistrySelect published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C5H10N2OS, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lin, Pei-Min published the artcileBimetallic Nickel Complexes that Bear Diamine-Bis(Benzotriazole Phenolate) Derivatives as Efficient Catalysts for the Copolymerization of Carbon Dioxide with Epoxides, Related Products of catalysis-chemistry, the publication is ChemCatChem (2016), 8(5), 984-991, database is CAplus.

We report the facile synthesis and structural characterization of efficient bimetallic nickel catalysts that bear diamine-bis(benzotriazole phenolate) derivatives for the copolymerization of CO₂ and epoxides. Thermally robust di-nickel 2 is an effective catalyst for the alternating copolymerization of cyclohexene oxide (CHO) with CO₂ to give turnover numbers of up to >4000 and turnover frequencies of up to >400 h^-1. Ni catalyst 2 leads to not only controlled CO₂/CHO coupling, but it has also been applied to catalyze the copolymerization of 4-vinyl-1,2-cyclohexene oxide (VCHO) and CO₂ to obtain the corresponding polycarbonate with the vinyl functionality on the side chains. This is the first example of a dinuclear Ni complex that is efficient for both CO₂/VCHO copolymerization and the formation of a high-mol.-weight copolymer with a large amount of carbonate linkages.

ChemCatChem published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bruno, Claudio published the artcileThe chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca²⁺/calmodulin-dependent kinase II, SDS of cas: 140-28-3, the publication is European Journal of Medicinal Chemistry (2016), 36-45, database is CAplus and MEDLINE.

An affinity capillary electrophoresis (ACE) method to estimate apparent dissociation constants between bovine brain calmodulin (CaM) and nonpeptidic ligands was developed. The method was validated reproducing the dissociation constants of a number of well-known CaM ligands. In particular, the potent antagonist 125-C9 was ad hoc synthesized through an improved synthetic procedure. The ACE method was successfully applied to verify CaM affinity for lubeluzole, a well-known neuroprotective agent recently proved useful to potentiate the activity of anticancer drugs. Lubeluzole was slightly less potent than 125-C9 (K_d = 2.9¡À0.7 and 0.47¡À0.06 ¦ÌM, resp.) and displayed Ca²⁺/calmodulin-dependent kinase II (CaMKII) inhibition (IC₅₀ = 40¡À1 ¦ÌM). Possible binding modes of lubeluzole to CaM were explored by docking studies based on the x-ray crystal structures of several trifluoperazine-CaM complexes. An estimated dissociation constant in good agreement with the exptl. one was found and the main aminoacidic residues and interactions contributing to complex formation were highlighted. The possibility that interference with Ca²⁺ pathways may contribute to the previously observed chemosensitizing effects of lubeluzole on human ovarian adenocarcinoma and lung carcinoma cells are discussed.

European Journal of Medicinal Chemistry published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, SDS of cas: 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bellini, Clement published the artcileBarium-Mediated Cross-Dehydrocoupling of Hydrosilanes with Amines: A Theoretical and Experimental Approach, Application In Synthesis of 140-28-3, the publication is Angewandte Chemie, International Edition (2015), 54(26), 7679-7683, database is CAplus and MEDLINE.

Alk.-earth (most prominently barium) complexes of the type [Ae{N(SiMe₃)₂}₂¡¤(THF)_x] and [{NN?}Ae{N(SiMe₃)₂}¡¤(THF)_x] are very active and productive precatalysts (TON = 396, TOF up to 3600 h^-1; Ca < Sr < Ba) for N-H/H-Si cross-dehydrocoupling, with excellent chemoselectivity in the reaction of (di)amines with (di)hydrosilanes. Exptl. and DFT investigations revealed that the reactions proceed by nucleophilic attack of a metal amide at the incoming silane and subsequent turnover-limiting hydrogen transfer to the metal center.

Angewandte Chemie, International Edition published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Application In Synthesis of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wei, Duo published the artcileManganese-Catalyzed Transfer Hydrogenation of Aldimines, Synthetic Route of 140-28-3, the publication is ChemCatChem (2019), 11(21), 5256-5259, database is CAplus.

The reduction of imines to amines R¹CH₂NHR² [R¹ = Ph, 2-pyridyl, CH=CHPh, etc.; R² = Ph, cyclohexyl, Bn, etc.] via transfer hydrogenation was achieved by using a phosphine-free manganese(I) catalyst. Using isopropanol as reductant, in the presence of t-BuOK (4 mol %) and manganese complex [Mn(CO)₃Br(¦Ê²N,N-PyCH₂NH₂)] (2 mol %), a large variety of aldimines (30 examples) were typically reduced in 3 h at 80 ¡ãC with good to excellent yield.

ChemCatChem published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C12H12F3N5O2, Synthetic Route of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wei, Duo published the artcileManganese catalyzed reductive amination of aldehydes using hydrogen as a reductant, Quality Control of 140-28-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(34), 4302-4305, database is CAplus and MEDLINE.

A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using mol. dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in-situ was performed under mild conditions (50-100¡ã) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (> 90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcs.

Chemical Communications (Cambridge, United Kingdom) published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C9H17NO, Quality Control of 140-28-3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Dekkers, Bart G. J. published the artcileRelevance of the drug-drug interactions between lidocaine and the pharmacokinetic enhancers ritonavir and cobicistat, Related Products of catalysis-chemistry, the publication is AIDS (London, United Kingdom) (2019), 33(6), 1100-1102, database is CAplus and MEDLINE.

Reporting on the serol. response to syphilis treatment with penicillin benzathine or doxycycline in patients with HIV following a manufacturing shortfall of penicillin benzathine. Discomfort of these injections can be reduced by replacing part of the solvent by a lidocaine (lignocaine) solution To enhance exposure to antiretroviral drugs, such as atazanavir, darunavir and elvitegravir, ritonavir and cobicistat are used as boosters in combined antiretroviral therapy. Ritonavir and cobicistat inhibit CYP3A4, resulting in an increased exposure (increased area under the curve) , increased maximum concentration (Cmax) and increased half-life 1/2 of antiretroviral drugs that are substrates of CYP3A4. Drug-drug interactions between ritonavir or cobicistat and lidocaine have been suggested to increase lidocaine exposure by more than three-fold complicating treatment with benzylpenicillin benzathine as this interaction may lead to higher plasma lidocaine levels and adverse effects, including neurol. and cardiac side effects.

AIDS (London, United Kingdom) published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia