Category: 14707-75-6

Kafka, Zdenek published the artcileNitrogen compounds of adamontane. IX. Preparation and reactions of nitrogen analogs of adamantane, Recommanded Product: 1,3,5-Triazaadamantan-7-amine, the publication is Sbornik Vysoke Skoly Chemicko-Technologicke v Praze, D: Technologie Paliv (1976), 127-57, database is CAplus.

Substituted 1-aza-, 1,3-diaza-, 1,3,5-triazaadamantanes (I), and 1,3-diazaadamantan-6-ols (II) and their derivatives were prepared and characterized by ir, gas chromatog., and paper chromatog. Reaction of Me2CO, AcONH4, and aromatic aldehydes gave tetrasubstituted 3,7-diazabicyclo[3.3.1]nonan-9-ones, which gave 1,3-diazaadamantan-6-ones on boiling with paraformaldehyde. These compounds were hydrogenated to tetracyclohexyl derivatives of II over Raney Ni. The 7-nitro derivative of I was prepared and reduced to the 7-amino derivative with Zn or Al in alk. medium. The latter compound gave 7-halo compounds and other derivatives Aromatic aldehydes and the 7-amino derivative of I gave aldimines, which were hydrogenated to secondary amines. I was stable in mineral acids but not in a reducing acid medium. Reductive methylation of the 7-amino derivative of I gave 7-alkylamino derivative The nitrile of N-(1,3,5-triaza-1-adamantyl)aminoacetic acid, prepared by cyanomethylation, was reduced to the 7-(aminomethyl)amino derivative with LiAlH4. Partial hydrogenation of the 7-nitro derivative of I gave the 7-hydroxylamino derivative, which with hexamethyldisilazane gave the trimethylsilyl derivative Oxidation with H2O2 or ozonization of the 7-nitro derivative of I gave the N-oxide.

Sbornik Vysoke Skoly Chemicko-Technologicke v Praze, D: Technologie Paliv published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Recommanded Product: 1,3,5-Triazaadamantan-7-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Agadzhanyan, Ts. E. published the artcileSynthesis and transformations of polyhedric compounds. IV. Synthesis of 1,3,5-triazaadamantyl-7-amides of amino acids, Application of 1,3,5-Triazaadamantan-7-amine, the publication is Armyanskii Khimicheskii Zhurnal (1982), 35(6), 398-402, database is CAplus.

Title amides (e.g., I) of benzoic acid and acylglycines (phthalyl, benzoyl, methoxycarbonyl, ethoxycarbonyl) were prepared by the carbodiimide or mixed anhydride method. Reaction of I with N₂H₄ gave the free glycinamide. Reaction of 7-nitro-1,3,5-triazaadamantane with BzO₂COEt gave II.

Armyanskii Khimicheskii Zhurnal published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Application of 1,3,5-Triazaadamantan-7-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Burmistrov, Vladimir published the artcileEffects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability, Computed Properties of 14707-75-6, the publication is Bioorganic Chemistry (2018), 510-527, database is CAplus and MEDLINE.

Adamantyl groups are widely used in medicinal chem. However, metabolism limits their usage. Herein, the authors report the first systematic study of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers between urea groups and adamantane group, and tested their effects on soluble epoxide hydrolase inhibitor potency and metabolic stability. Interestingly, the effect on activity against human and murine sEH varied in opposite ways with each new Me group introduced into the mol. Compounds with three Me substituents in adamantane were very poor inhibitors of murine sEH while still very potent against human sEH. In addition, diureas with terminal groups bigger than sEH catalytic tunnel diameter were still good inhibitors suggesting that the active site of sEH opens to capture the substrate or inhibitor mol. The introduction of one Me group leads to 4-fold increase in potency without noticeable loss of metabolic stability compared to the unsubstituted adamantane. However, introduction of two or three Me groups leads to 8-fold and 98-fold decrease in stability in human liver microsomes for the corresponding compounds

Bioorganic Chemistry published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Computed Properties of 14707-75-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Zhurba, Yu. I. published the artcileThe study of photographic activity of azaadamantane. I. Antifogging properties of 1,3,5-triazaadamandane derivatives, Quality Control of 14707-75-6, the publication is Zhurnal Nauchnoi i Prikladnoi Fotografii i Kinematografii (1990), 35(2), 102-6, database is CAplus.

Antifogging properties were studied of I (R = NO₂, NHOH, Br, Cl, NHCSNHPh). The best antifogging properties were observed for I (NHCSNHPh) in combination with KBr. The optimal concentrations were 0.01-0.5 g/L of I (NHCSNHPh) and 1.5-3 g/L of KBr. Thus, fog d. was 3-4 times reduced using a developer solution containing 3 g/L KBr and 0.01 g/L I (NHCSNHPh).

Zhurnal Nauchnoi i Prikladnoi Fotografii i Kinematografii published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C8H6ClN, Quality Control of 14707-75-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Tolstikov, V. V. published the artcilePreparation of amides and esters of the antibiotic bruneomycin and study of their cytotoxic and antiretroviral activity, Product Details of C7H14N4, the publication is Khimiko-Farmatsevticheskii Zhurnal (1990), 24(2), 130-2, database is CAplus.

Amides of bruneomycin (I) with 7-amino-1,3,5-triazaadamantane, 5,7-dimethyl-6-amino-1,3-diazaadamantane, ¦Ã-aminobutyric acid or L– and D-isomers of S-methylthiomethylcysteine and an ester with bis(2-hydroxyethyl)amide of glycolic acid were prepared and their cytotoxic, antibacterial and antiviral activities were studied. The glycolic acid ester derivative and ¦Ã-aminobutyric acid amide showed cytotoxic and antiviral activity against Moloney’s sarcoma virus.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C11H24O3, Product Details of C7H14N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kuznetsov, A. I. published the artcileHeteroadamantanes and their derivatives. 4. Synthesis of 1,3,5-triazaadamantane, Recommanded Product: 1,3,5-Triazaadamantan-7-amine, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1985), 837-40, database is CAplus.

7-Hydroxyamino- and 7-amino-1,3,5-triazaadamantane I [R = NHOH, NH₂ (II)] were obtained in 67 and 90.3%, resp., by reduction of the 7-nitro derivative by N₂H₄.H₂O in the presence of Raney Ni. Treating II with concentrated HBr and aqueous NaNO₂ gave 52.9% I (R = Br) which was debrominated by N₂H₄.H₂O in the presence of Raney Ni to give 95% title compound I (R = H). The latter was also obtained from I (R = SCN) in 60.3% yield by treatment with Raney Ni in Me₂CHOH.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Recommanded Product: 1,3,5-Triazaadamantan-7-amine.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Malik, Sameena N. published the artcileNano catalytic ozonation of biomethanated distillery wastewater for biodegradability enhancement, color and toxicity reduction with biofuel production, Computed Properties of 14707-75-6, the publication is Chemosphere (2019), 449-461, database is CAplus and MEDLINE.

The effectiveness of O₃, O₃/Fe²⁺, and O₃/nZVI processes on biomethanated distillery wastewater (BMDWW) was evaluated in terms of biodegradability index (BI) enhancement, biofuel production, COD, color, and toxicity reduction A significant increase in biodegradability, COD, color, and toxicity reduction was observed in O₃/nZVI compared with O₃ and O₃/Fe²⁺ due to more hydroxyl radical production The O₃/nZVI pretreated wastewater with enhanced BI (up to 0.71) showed 60% COD removal with addnl. biogas generation (64% methane content). From gas chromatog.-mass spectrometric (GC-MS) anal., 18 foremost organic compounds were predominantly detected in the raw distillery wastewater. The disappearance of the corresponding FTIR (Fourier transform IR spectroscopy) and GC-MS spectra during pretreatment processes signified the degradation or transformation of the recalcitrant present in the distillery wastewater. Subsequent (AnO + AO, AO) of pretreated BMDWW resulted in biodegradation rate enhancement by (1.83, 1.67), (3.5, 2.4) and (4.7, 2.9) times for O₃, O₃/Fe²⁺, and O₃/nZVI processes, resp.

Chemosphere published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Computed Properties of 14707-75-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Galik, Vlastimil published the artcileNitrogenous compounds of adamantane. X. Preparation and some reactions of derivatives of 1,3,5-triazaadamantane, Category: catalysis-chemistry, the publication is Sbornik Vysoke Skoly Chemicko-Technologicke v Praze, D: Technologie Paliv (1977), 109-18, database is CAplus.

7-Nitro-1,3,5-triazaadamantane (I), prepared (60%) by condensation of hexamethylenetetramine with MeNO2 in the presence of HCO2H, was cleaved with Ac2O to give 3,7-diacetyl-5-nitro-1,3,7-triazabicyclo[3.3.1]nonane (II). Similar treatment of I 3-oxide gave 51% II 1-oxide. Reduction of I with Fe in aqueous HCl gave 81% 7-amino-1,3,5-triazaadamantane (III), which was converted on heating with urea at 150¡ã to N,N’-bis(1,3,5-triaza-7-adamantyl)urea (70%). The condensation of III with furfural gave the corresponding Schiff base in 87% yield. The HCl salt of I 3-oxide, the nicotinate, isonicotinate, glutarate, and adipate salts of III, and the quaternary salts IV (R = NO2, R1 = Me, Et; R = NH2, R1 = Me, Et) and V were also prepared

Sbornik Vysoke Skoly Chemicko-Technologicke v Praze, D: Technologie Paliv published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Henry, Ronald A. published the artcileAnomalous reaction of pentafluorophenacyl bromide with hexamethylenetetramine. Structure of the product, Application In Synthesis of 14707-75-6, the publication is Journal of Organic Chemistry (1990), 55(6), 1796-801, database is CAplus.

The title compounds condense in CHCl₃ to yield tetrafluorobenzotetraazatetracyclotetradecanone I (X = N), a reaction proposed to involve both an ortho-fluorine elimination and two Stevens type rearrangements. Structural assignment of the fluorescent product I (X = N) was based upon ¹H, ¹³C, ¹⁹F, and ¹⁵N NMR spectra and a complete x-ray crystallog. determination Addnl. studies supported the proposed mechanism and allowed improvements and modifications of the Delepine reaction as applied to phenacyl halides and for the preparation of I (X = CBr, CNH₂, CNO₂).

Journal of Organic Chemistry published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Application In Synthesis of 14707-75-6.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Harutyunyan, G. L. published the artcileSynthesis of Dihydrochlorides of Azaadamantanes Containing 8-Hydroxyquinoline Fragments and their Antibacterial Activity in Mice with Dysentery and Staphylococcal Infections, Product Details of C7H14N4, the publication is Pharmaceutical Chemistry Journal (2021), 54(12), 1205-1208, database is CAplus.

New azaadamantane derivatives containing 8-hydroxyquinoline fragments were synthesized. Their antibacterial activity was studied. The synthesized compounds exhibited high antibacterial activity in vitro. The 6-oxo-5,7-diethyl- and 5,7-dimethyl-2-(8′-hydroxyquinolyl-5′)-1,3-diazaadamantane dihydrochlorides showed therapeutic effects in mice with dysentery and staphylococcal infections.

Pharmaceutical Chemistry Journal published new progress about 14707-75-6. 14707-75-6 belongs to catalysis-chemistry, auxiliary class Triazinanes, name is 1,3,5-Triazaadamantan-7-amine, and the molecular formula is C7H14N4, Product Details of C7H14N4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia