Category: 163839-73-4

Wang, Xiaobin published the artcileSynthesis and antibacterial activity of oxime ester derivatives containing 1,2,4-triazole or 1,3,4-oxadiazole moiety, Formula: C9H7F3O3, the publication is Chemical Papers (2017), 71(10), 1953-1960, database is CAplus.

A series of 1,3,4-oxadiazolyl oxime ester derivatives I [R¹ = Me, Et; R² = 3,4-dimethoxyphenyl, (4-methoxyphenoxy)methyl, [4-(trifluoromethyl)phenoxy]methyl, etc.] and 1,2,4-triazolyl oxime esters II [R¹ = Me, Et; R² = H, F, MeO, etc.] were designed and synthesized and their antibacterial activities in-vitro against Xanthomonas axonopodis pv. citri (Xac) and Xanthomonas oryzae pv. oryzae (Xoo) were evaluated. The bioassays showed that all the title compounds I and II exhibited potent antibacterial activity against Xac and Xoo. In particular, compound I [R¹ = Me, R² = 3,4-dimethoxyphenyl] and compounds II [R¹ = Me, R² = H, F, CF₃; R¹ = Et, R² = H, F, CF₃] exhibited remarkable antibacterial activity against Xoo, with the EC₅₀ values ranging from 15.15 to 49.34 ¦Ìg/mL, which were superior to that of bismerthiazol (92.61 ¦Ìg/mL). This study indicated that oxime ester derivatives containing 1,2,4-triazole I or 1,3,4-oxadiazole II moiety were used as potential alternative templates in the search for novel antibacterial agents.

Chemical Papers published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C4H11NO, Formula: C9H7F3O3.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Tao published the artcileSynthesis and Biological Activity of 1-(Substituted phenoxyacetoxy)-1-(pyridin-2-yl or thien-2-yl)methylphosphonates, Recommanded Product: 2-(4-(Trifluoromethyl)phenoxy)acetic acid, the publication is Journal of Heterocyclic Chemistry (2015), 52(1), 173-179, database is CAplus.

A series of novel O,O-di-Me 1-(substituted phenoxyacetoxy)-1-(pyridin-2-yl/thien-2-yl)methylphosphonates were synthesized. Structures were confirmed by IR, ¹H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. Some possess 90-100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas others possess 92-100% inhibition against Fusarium oxysporum, Phyricularia grisea, Botrytis cinereapers, Gibberella zeae, Sclerotinia sclerotiorum, and Cercospora beticola at the concentration of 50 mg/L.

Journal of Heterocyclic Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C14H20BClO2, Recommanded Product: 2-(4-(Trifluoromethyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Di-Zao published the artcileSynthesis and cytotoxicity of novel 20-O-linked homocamptothecin ester derivatives as potent topoisomerase I inhibitors, Related Products of catalysis-chemistry, the publication is Journal of Asian Natural Products Research (2013), 15(11), 1179-1188, database is CAplus and MEDLINE.

In an attempt to improve the antitumor activity of homocamptothecins (hCPTs), a series of novel 20-O-linked hCPT ester derivatives were first designed and synthesized based on a synthetic route, by which hCPTs are acylated with different substituted phenoxyacetic acid ester derivatives Most of the derivatives were assayed for in vitro cytotoxicity against six human cancer cell lines KB, KB/VCR, A549, HCT-8, Bel7402, and A2780, and most of the assayed compounds exhibited good antiproliferative activity on these tumor cell lines especially on KB.

Journal of Asian Natural Products Research published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Related Products of catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Ting published the artcileThe synthesis and herbicidal evaluation of fluorine-containing phenoxyacetoxyalkylphosphonate derivatives, SDS of cas: 163839-73-4, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2006), 181(9), 2135-2145, database is CAplus.

To investigate the influence of a fluorine moiety on the biol. activity of phenoxyacetoxyalkylphosphonates, e.g., 2-Cl,4-FC₆H₃OCH₂CO₂CHMeP(O)(OMe)₂ (I), a series of fluorine-containing phenoxyacetoxyalkylphosphonates were synthesized and screened for herbicidal activity in a greenhouse. The majority of the title compounds showed better preemergence activity than postemergence activity against the test plants, especially on monocotyledon. Compound I exhibited notable activity. Results showed that by introducing a fluorine moiety to the parent structure of phenoxyacetoxyalkylphosphonates, a series of new compounds with satisfactory herbicidal activity could be synthesized. A reasonable combination of a fluorine moiety and other substituents on the benzene ring had a great influence on the herbicidal activity.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, SDS of cas: 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Dawei published the artcileProbing strigolactone perception mechanisms with rationally designed small-molecule agonists stimulating germination of root parasitic weeds, Synthetic Route of 163839-73-4, the publication is Nature Communications (2022), 13(1), 3987, database is CAplus and MEDLINE.

The development of potent strigolactone (SL) agonists as suicidal germination inducers could be a useful strategy for controlling root parasitic weeds, but uncertainty about the SL perception mechanism impedes real progress. Here we describe small-mol. agonists that efficiently stimulate Phelipanchce aegyptiaca, and Striga hermonthica, germination in concentrations as low as 10-8 to 10-17 M. We show that full efficiency of synthetic SL agonists in triggering signaling through the Striga SL receptor, ShHTL7, depends on the receptor-catalyzed hydrolytic reaction of the agonists. Addnl., we reveal that the stereochem. of synthetic SL analogs affects the hydrolytic ability of ShHTL7 by influencing the probability of the privileged conformations of ShHTL7. Importantly, an alternative ShHTL7-mediated hydrolysis mechanism, proceeding via nucleophilic attack of the NE2 atom of H246 to the 2¡äC of the D-ring, is reported. Together, our findings provide insight into SL hydrolysis and structure-perception mechanisms, and potent suicide germination stimulants, which would contribute to the elimination of the noxious parasitic weeds.

Nature Communications published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C10H11N3O3S, Synthetic Route of 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ragle, Lauren E. published the artcileDiscovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition, HPLC of Formula: 163839-73-4, the publication is Bioorganic & Medicinal Chemistry (2016), 24(19), 4660-4674, database is CAplus and MEDLINE.

Autotaxin (ATX) is a ubiquitous ectoenzyme that hydrolyzes lysophosphatidylcholine (LPC) to form the bioactive lipid mediator lysophosphatidic acid (LPA). LPA activates specific G-protein coupled receptors to elicit downstream effects leading to cellular motility, survival, and invasion. Through these pathways, upregulation of ATX is linked to diseases such as cancer and cardiovascular disease. Recent crystal structures confirm that the catalytic domain of ATX contains multiple binding regions including a polar active site, hydrophobic tunnel, and a hydrophobic pocket. This finding is consistent with the promiscuous nature of ATX hydrolysis of multiple and diverse substrates and prior investigations of inhibitor impacts on ATX enzyme kinetics. The current study used virtual screening methods to guide exptl. identification and characterization of inhibitors targeting the hydrophobic region of ATX. An initially discovered inhibitor, GRI392104 (IC₅₀ 4 ¦ÌM) was used as a lead for synthetic optimization. In total twelve newly synthesized inhibitors of ATX were more potent than GRI392104 and were selective for ATX as they had no effect on other LPC-specific NPP family members or on LPA_1-5 GPCR.

Bioorganic & Medicinal Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, HPLC of Formula: 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Manley, David W. published the artcileTitania-Promoted Carboxylic Acid Alkylations of Alkenes and Cascade Addition-Cyclizations, Quality Control of 163839-73-4, the publication is Journal of Organic Chemistry (2014), 79(3), 1386-1398, database is CAplus and MEDLINE.

Photochem. reactions employing TiO₂ and carboxylic acids under dry anaerobic conditions led to several types of C-C bond-forming processes with electron-deficient alkenes. The efficiency of alkylation varied appreciably with substituents in the carboxylic acids. The reactions of aryloxyacetic acids with maleimides resulted in a cascade process in which a pyrrolochromene derivative accompanied the alkylated succinimide. The selectivity for one or other of these products could be tuned to some extent by employing the photoredox catalyst under different conditions. Aryloxyacetic acids adapted for intramol. ring closures by inclusion of 2-alkenyl, 2-aryl, or 2-oximinyl functionality reacted rather poorly. Profiles of reactant consumption and product formation for these systems were obtained by an in situ NMR monitoring technique. An array of different catalyst forms were tested for efficiency and ease of use. The proposed mechanism, involving hole capture at the TiO₂ surface by the carboxylates followed by CO₂ loss, was supported by EPR spectroscopic evidence of the intermediates. Deuterium labeling indicated that the titania likely donates protons from surface hydroxyl groups as well as supplying electrons and holes, thus acting as both a catalyst and a reaction partner.

Journal of Organic Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Quality Control of 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Da-Wei published the artcileAn Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors, Computed Properties of 163839-73-4, the publication is Journal of Agricultural and Food Chemistry (2016), 64(47), 8986-8993, database is CAplus and MEDLINE.

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. To search for novel HPPD inhibitors, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using of N,N’-Carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH₂Cl₂. A total of 58 triketone compounds were prepared in good to excellent yields. Some of the synthesized compounds displayed potent Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one (I) displayed high, broad-spectrum and post-emergent herbicidal activity at the rate of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, I showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that I might have the potential as herbicide for the weed control in maize and canola fields. I is the first HPPD inhibitor showing good crop safety towards canola.

Journal of Agricultural and Food Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C15H12O8, Computed Properties of 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ozcan, Sevil published the artcileOxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors, Synthetic Route of 163839-73-4, the publication is Journal of Medicinal Chemistry (2013), 56(10), 3783-3805, database is CAplus and MEDLINE.

Screening of the 50 000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide I (PI-1833) which inhibited chymotrypsin-like (CT-L) activity (IC₅₀ = 0.60 ¦ÌM) with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). LC-MS/MS and dialysis show that I is a noncovalent and rapidly reversible CT-L inhibitor. Focused library synthesis provided II (PI-1840) with CT-L activity (IC₅₀ = 27 nM). Detailed SAR studies indicate that the amide moiety and the two Ph rings are sensitive toward modifications. Hydrophobic residues, such as Pr or Bu in the para position (not ortho or meta) of the A-ring and a m-pyridyl group as B-ring, significantly improve activity. Compound II (IC₅₀ = 0.37 ¦ÌM) is more potent than I (IC₅₀ = 3.5 ¦ÌM) at inhibiting CT-L activity in intact MDA-MB-468 human breast cancer cells and inhibiting their survival. The activity of II warrants further preclin. investigation of this class as noncovalent proteasome inhibitors.

Journal of Medicinal Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Synthetic Route of 163839-73-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hearn, Brian R. published the artcileStructure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response, Application of 2-(4-(Trifluoromethyl)phenoxy)acetic acid, the publication is ChemMedChem (2016), 11(8), 870-880, database is CAplus and MEDLINE.

The integrated stress response (ISR) comprises multiple signaling pathways for detecting and responding to cellular stress that converge at a single event – the phosphorylation of Ser51 on the ¦Á-subunit of eukaryotic translation initiation factor 2 (eIF2¦Á). Phosphorylation of eIF2¦Á (eIF2¦Á-P) results in attenuation of global protein synthesis via the inhibitory effects of eIF2¦Á-P on eIF2B, the guanine exchange factor (GEF) for eIF2. Herein we describe structure-activity relationship (SAR) studies of bis-O-arylglycolamides, first-in-class integrated stress response inhibitors (ISRIB). ISRIB analogs make cells insensitive to the effects of eIF2¦Á-P by activating the GEF activity of eIF2B and allowing global protein synthesis to proceed with residual unphosphorylated eIF2¦Á. The SAR studies described herein support the proposed pharmacol. of ISRIB analogs as binding across a sym. protein-protein interface formed between protein subunits of the dimeric eIF2B heteropentamer.

ChemMedChem published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C9H7F3O3, Application of 2-(4-(Trifluoromethyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia