Category: 16909-09-4

Jutz, Christian published the artcileUnsaturated aldehydes and ketones. I. Preparation of unsaturated aldehydes by a method involving the Vilsmeier reaction, SDS of cas: 16909-09-4, the publication is Chemische Berichte (1958), 850-61, database is CAplus.

cf. Vilsmeier, Chemiker-Ztg. 75, 133(1951). MeNPh(CH:CH)_nCHO (I) (n = 1), b_0.8 144-5¡ã, m. 48-9¡ã (Et₂O), was prepared from PhNHMe and CHú·CCHO (prepared from CHú·CCH₂OH by oxidation with CrO₃ in H₂O; cf. Huber, Dissertation, Munich, 1953). I (n = 2), properties not given [cf. Zincke and W¨¹rker, Ann. 338, 109(1905)] was formed by treating pyridine in the presence of PhNHMe with BrCN, and treating the resulting 1-methylanilino-1,3-pentadien-5-al methylanil bromide [cf. K?nig, J. Prakt Chem. 69, 134(1904)] (details not given). To I (n = 1) (0.1 mole) and 0.115 mole PhNMe₂ in 50 cc. absolute CHCl₃ or tetrahydrofuran below 0¡ã were added gradually 16 g. POCl₃, giving a mixture of salts of p-dimethylaminocinnamaldehyde methylanil, dark green, partially crystalline sirup, the separation of which was increased by adding petr. ether, and keeping at 20¡ã overnight. The upper phase was decanted and the sirup (II) extracted several times with petr. ether, taken up in 100 cc. MeOH and treated dropwise with 10% aqueous Na₂CO₃ until alk. The separated oil was steam distilled briefly to remove PhNHMe without loss of the partially volatile product. The cooled still residue was extracted with four 50-cc. portions of CHCl₃ giving 12-14 g. p-Me₂NC₆H₄CH:CHCHO (III), yellow leaflets, m. 141¡ã (K?nig, et al., C.A. 23, 381). An aliquot of II in MeOH with aqueous NaClO₄ gave p-dimethylaminocinnamaldehyde methylanil perchlorate (IV), C₁₈H₂₁N₂ClO₄, dark violet crystals, or bluish-green crystals with metallic luster, m. 158-9¡ã (Me₂CO-Et₂O, or MeOH-Et₂O). IV was also formed by warming III and PhNHMe at 50¡ã with the min. amount 2N HCl and adding NaClO₄. Formed similarly to III, from 8 g. each of I (n = 1), PhNEt₂, and POCl₃ was 8.6 g. p-Et₂NC₆H₄CH:CHCHO, yellow, m. 73-4¡ã (MeOH). Equimolar amounts of PhNMeCHO, POCl₃, and PhNMe₂ caused a separation of intermediate salts, from which was formed p-dimethylaminobenzaldehyde methylanil perchlorate, C₁₆H₁₉N₂ClO₄, pale yellow, m. 179-80¡ã(Me₂CO or MeOH-Et₂O), also formed from PhNMe₂ and Me₂NC₆H₄CHO in acid with HClO₄. Similarly, primary aromatic amines reacted with p-Me₂NC₆H₄CHO in aqueous acid solutions and then with NaClO₄ to form the corresponding anil perchlorates of the following: p-dimethylaminobenzaldehyde, C₁₅H₁₇N₂ClO₄, orange, m. 230-1¡ã (decomposition) (Me₂CO-Et₂O); p-dimethylaminocinnamaldehyde, C₁₇H₁₉N₂ClO₄, violet, m. 190¡ã (decomposition) (MeOH-Et₂O). I (n = 2) (9.4 g.) and 7 g. PhNMe₂ in tetrahydrofuran at -20¡ã with 9 g. POCl₃ and 5 g. PhNMe₂ treated as in the case of III gave, after a fully-described purification, 2 g. p-Me₂NC₆H₄(CH:CH)₂CHO, golden yellow, m. 156-7¡ã (sublimation in high vacuum followed by ligroine), whose methylanil perchlorate, blue violet with metallic luster, m. 205¡ã (decomposition) (Me₂CO-Et₂O). To 4 g. I (n = 1) and 5.6 g. 1-phenyl-1-(p-dimethylaminophenyl)ethylene in 25 cc. absolute C₆H₆, cooled, was added 10 cc. Ac₂O, shaken, and then treated dropwise with 2.5 g. anhydrous ZnCl₂ in 10 cc. AcOH, giving a violet-blue Zn complex salt. After removing the excess Ac₂O, AcOH, and C₆H₆ in vacuo, the residue dissolved in 200 cc. 25% MeOH was treated with 1 g. PhNHMe in 2N HCl, warmed to 50¡ã, filtered, and saturated NaClO₄ added to the filtrate, giving 9.3 g. 1-phenyl-1-(p-dimethylaminophenyl)-1,3-pentadien-5-al methylanil perchlorate (V), moss-green leaflets, m. 214-15¡ã (decomposition). V in CHCl₃ shaken with 20% aqueous Na₂CO₃ and filtered, the CHCl₃ separated, and the aqueous phase re?xtd. with CHCl₃; the combined extracts gave about 94% (crude) 1-phenyl-1-(p-dimethylaminophenyl)-1,3-pentadien-5-al, orange, m. 119.5-20.5¡ã (ligroine). I (n = 1) (0.1 mole) and 0.115 mole m-C₆H₄(OMe)₂ in CHCl₃, stirred and cooled below 0¡ã were treated with 16 g. POCl₃ in 20 cc. CHCl₃, warmed gradually to 35¡ã, stirred and treated with 200 cc. ligroine which caused the separation of 2 phases; the lower one was washed repeatedly with petr. ether, dissolved in 150 cc. CHCl₃, and washed successively with H₂O, 2N HCl, H₂O, 10% Na₂CO₃, and H₂O, dried and evaporated giving 17-17.5 g. 2,4-dimethoxycinnamaldehyde (VI), m. 99.5-100¡ã (C₆H₁₄ or aqueous MeOH); semicarbazone, m. 198-201¡ã (decomposition) (EtOH). VI oxidized in alc. NaOH with Ag₂O gave 2,4-(MeO)₂C₆H₃CH:CHCO₂H, m. 186-7¡ã. 1-Tetrahydroquinolinyl-1-propen-3-al (9.4 g.) and 10 g. CH₂(CO₂H)₂ in 60 cc. glacial AcOH, treated with 15 cc. Ac₂O and 2 g. ZnCl₂ in 5 cc. AcOH turned from brown to blue and evolved CO₂ slowly; after 24 hrs. 50 cc. MeOH was added, the mixture warmed to 50¡ã and poured into 1 l. 2% NaClO₄ solution, giving, on cooling a mixture of perchlorates, which was dried and extracted in a Soxhlet with 200 cc. Me₂CO. The extract treated with 70 cc. C₆H₆ gave 6 g. 1,7-bis(1-tetrahydroquinolinyl)heptamethine monoperchlorate, C₂₅H₂₇N₂ClO₄, long needles with blue metallic surface luster, m. 168¡ã (decomposition) (Me₂CO). The thimble residue, insoluble in Me₂CO, yielded 3 g. 1,3-bis(1-tetrahydroquinolinyl)trimethine monoperchlorate (properties not given). VII in CHCl₃ shaken with aqueous K₂CO₃ gave 1-tetrahydroquinolinyl-1,3,5-heptatrien-7-al, m. 149-50¡ã (C₆H₁₄) (cf. Dieterle and Riester, C.A. 31, 4911⁷). 1-Methylanilino-1-propen-3-al (8 g.) treated as in the preparation of VII gave an incompletely separated mixture (IX) of the methylanil perchlorates of 1-methylanilino-1,3,5-heptatrien-7-al and 1-methylanilino-1-propen-3-al (IXa). IX sintered 155¡ã, m. 163-4¡ã, and contained about 65-70% IXa (gaged from anal. data). Pure IXa, m. 166¡ã (decomposition), was prepared from I, PhNHMe and NaClO₄, in acid solution IX (4 g.) in 50 cc. CHCl₃, shaken with aqueous K₂CO₃, the aqueous phase extracted with CHCl₃, and the combined organic extracts washed with H₂O and Na₂CO₃, dried and evaporated gave 0.7-0.9 g. 1-methylanilino-1,3,5-heptatrien-7-al, orange-brown, m. 120-1¡ã (decomposition) (after extraction with ligroine, b. 60-80¡ã, discarding these extracts and then extracting with ligroine b. 80-120¡ã). p-Me₂NC₆H₄CHO (3 g.) and 3 g. PhNMe₂ in 20 cc. CHCl₃ was added dropwise to 3.5 g. POCl₃ in 10 cc. CHCl₃ at 0¡ã; after standing at 20¡ã and warming to 35¡ã, 100 cc. petr. ether were added and the resulting sirup (X) washed repeatedly with petr. ether. X, in little cold EtOH with aqueous NaClO₄ yielded 5.5-6.5 g. 4,4′-bis(dimethylamino)benzhydrol perchlorate, metallic blue leaflets, m. 161-3¡ã (decomposition) (varying with rate of heating) (Me₂CO-Et₂O).

Chemische Berichte published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, SDS of cas: 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chen, Gaozhi published the artcileDiscovery of a New Inhibitor of Myeloid Differentiation 2 from Cinnamamide Derivatives with Anti-Inflammatory Activity in Sepsis and Acute Lung Injury, Name: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Journal of Medicinal Chemistry (2016), 59(6), 2436-2451, database is CAplus and MEDLINE.

Acute inflammatory diseases, including acute lung injury and sepsis, remain the most common life-threatening illness in intensive care units worldwide. Cinnamamide has been incorporated in several synthetic compounds with therapeutic potentials including anti-inflammatory properties. However, the possible mechanism and direct mol. target of cinnamamides for their anti-inflammatory effects were rarely investigated. In this study, we synthesized a series of cinnamamides and evaluated their anti-inflammatory activities. The most active compound, 2i, was found to block LPS-induced MD2/TLR4 pro-inflammatory signaling activation in vitro and to attenuate LPS-caused sepsis and acute lung injury in vivo. Mechanistically, we demonstrated that 2i exerts its anti-inflammatory effects by directly targeting and binding MD2 in Arg90 and Tyr102 residues and inhibiting MD2/TLR4 complex formation. Taken together, this work presents a novel MD2 inhibitor, 2i, which has the potential to be developed as a candidate for the treatment of sepsis, and provides a new lead structure for the development of anti-inflammatory agents targeting MD2.

Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Name: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Jiang, Yongwei published the artcileSynthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(15), 4471-4475, database is CAplus and MEDLINE.

On the basis of the active site of lanosterol 14¦Á-demethylase from Candida albicans (CACYP51), a series of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one derivatives I (R = 4-F, 2-F, 4-Cl, 3-Cl, 2,4-Cl₂, 3-Br, 2-Br, 4-MeO, 3-MeO, 4-OCF₃, 4-Me, 3-Me, 2-Me, 3,4-Me₂, 2,4-Me₂, 4-nPr, 4-Bu, 4-pentyl, 4-hexyl, 4-tBu, 4-iPr) and II (R = 4-F, 3-F, 2-F, 4-Cl, 3,4-Cl₂, 4-Br, 3-Br, 4-Me, 2,3-Me₂, 4-MeO, 3,4-(MeO)₂,2,4-(MeO)₂, 4-NO₂, 3-NO₂, 2-NO₂, 3-CN) were synthesized as fluconazole analogs. Results of the preliminary antifungal tests against eight human pathogenic fungi in vitro showed that these compounds exhibited activities to some extent, and some displayed excellent antifungal activities against C. albicans than reference drug fluconazole. Flexible mol. docking was used to analyze the structure-activity relationships (SARs) of the target compounds The designed compounds interact with CACYP51 through hydrophobic, van der Waals and hydrogen-bonding interactions.

Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Chang, Sheng published the artcileDesign and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Molecules (2009), 14(10), 4166-4179, database is CAplus and MEDLINE.

A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl]acrylamide(12d) was the most effective cell growth inhibitor and was 3-fold more potent than STI-571.

Molecules published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Zhaojing published the artcileAsymmetric Catalytic Synthesis of Hexahydropyrrolo-isoquinolines via Three-Component 1,3-Dipolar-Cycloaddition, Category: catalysis-chemistry, the publication is Chemistry – A European Journal (2021), 27(60), 14841-14845, database is CAplus and MEDLINE.

An asym. three-component 1,3-dipolar cycloaddition of 3,4-dihydroisoquinolines, bromoacetates and ¦Á,¦Â-unsaturated pyrazole amides was realized by using a chiral N,N’-dioxide-Y(OTf)₃ complex as the catalyst. The process included a base-promoted formation of dihydroisoquinolium ylides in situ, and a chiral Lewis acid-catalyzed asym. [3+2] cycloaddition with ¦Á,¦Â-unsaturated pyrazole amides. A series of hexahydropyrrolo-isoquinolines I [R = Pr, Ph, 4-BrC₆H₄, etc.; R¹ = Et, OMe, O-tBu, OBn; R² = H, 5-Br, 6-OMe, etc.] were obtained in moderate to good yields with excellent diastereo- and enantioselectivities.

Chemistry – A European Journal published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Li, Yueqing published the artcileSynthesis and anti-platelet aggregation assay of cinnamoyl-tyramine amide analogues, Application In Synthesis of 16909-09-4, the publication is Yingyong Huaxue (2018), 35(10), 1174-1183, database is CAplus.

In order to explore the influence of methoxy substitution in benzene ring, methylation of tyramine hydroxyl and cinnamoyl-tyramine amines, on anti-platelet aggregation activities analogs, cinnamoyl-tyramine amide analogs were synthesized via condensation and methylation with eight benzaldehyde derivatives as raw materials. The structures of synthesized compounds were characterized by NMR spectroscopy(NMR), mass spectrometry(MS) and single crystal diffraction. Based on variable-temperature NMR, rotational isomerization based on amide bond was studied for compounds 4a?4h. Their anti-platelet aggregation activities were tested in vitro and assayed by Born test. The results show that nine analogs are more active than podocarpamide. Specifically, compounds 2c, 4c and 4f show inhibition rates of 50.03%, 60.87% and 53.33%, resp., at 200 ¦Ìmol/L. The preliminary structure-activity relationship studies on these compounds indicate that 4-methoxy substituent is the most favorable for anti-ADP(adenosine-diphosphate) induced platelet aggregation, and methylated hydroxyl group on ring B and the amide nitrogen also increase the activities to some extent.

Yingyong Huaxue published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Liu, Xingui published the artcileSenolytic activity of piperlongumine analogues: Synthesis and biological evaluation, COA of Formula: C11H12O4, the publication is Bioorganic & Medicinal Chemistry (2018), 26(14), 3925-3938, database is CAplus and MEDLINE.

Selective clearance of senescent cells (SCs) has emerged as a potential therapeutic approach for age-related diseases, as well as chemotherapy- and radiotherapy-induced adverse effects. Through a cell-based phenotypic screening approach, we recently identified piperlongumine (PL), a dietary natural product, as a novel senolytic agent, referring to small mols. that can selectively kill SCs over normal or non-senescent cells. In an effort to establish the structure-senolytic activity relationships of PL analogs, we performed a series of structural modifications on the trimethoxyphenyl and the ¦Á,¦Â-unsaturated ¦Ä-valerolactam rings of PL. We show that modifications on the trimethoxyphenyl ring are well tolerated, while the Michael acceptor on the lactam ring is critical for the senolytic activity. Replacing the endocyclic C2-C3 olefin with an exocyclic methylene at C2 render PL analogs 47-49 with increased senolytic activity. These ¦Á-methylene containing analogs are also more potent than PL in inducing ROS production in WI-38 SCs. Similar to PL, 47-49 reduce the protein levels of oxidation resistance 1 (OXR1), an important oxidative stress response protein that regulates the expression of a variety of antioxidant enzymes, in cells. This study represents a useful starting point toward the discovery of senolytic agents for therapeutic uses.

Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, COA of Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Santavy, Frantisek published the artcileUltraviolet spectra of the methoxy and methylenedioxy groups of some aromatic compounds and alkaloids. IV. Effect of hydroxyl, methoxyl, and methylenedioxy groups on ultraviolet spectra of aromatic compounds conjugated with an oxo group or with an ¦Á,¦Â-double bond in the side chain, Category: catalysis-chemistry, the publication is Collection of Czechoslovak Chemical Communications (1972), 37(6), 1825-50, database is CAplus.

Uv spectra of hydroxy, methoxy, and methylenedioxy derivatives of C6H6, PhCHO, BzOH, MeBz, EtBz, 1-indanone, 1,2-indanedione, MeCH:CHPh, cis- and trans-cinnamic acids, PhCH:NOH, PhCMe:NOH, and 1-indanone oxime were measured in dioxane or EtOH or EtOH-NaOH and discussed.

Collection of Czechoslovak Chemical Communications published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bomon, Jeroen published the artcileBronsted Acid Catalyzed Tandem Defunctionalization of Biorenewable Ferulic acid and Derivates into Bio-Catechol, COA of Formula: C11H12O4, the publication is Angewandte Chemie, International Edition (2020), 59(8), 3063-3068, database is CAplus and MEDLINE.

An efficient conversion of biorenewable ferulic acid into bio-catechol was developed. The transformation comprises two consecutive defunctionalizations of the substrate, i.e., C-O (demethylation) and C-C (de-2-carboxyvinylation) bond cleavage, occurring in one step. The process only requires heating of ferulic acid with HCl (or H₂SO₄) as catalyst in pressurized hot water (250¡ã, 50 bar N₂). The versatility is shown on a variety of other (biorenewable) substrates yielding up to 84% di- (catechol, resorcinol, hydroquinone) and trihydroxybenzenes (pyrogallol, hydroxyquinol), in most cases just requiring simple extraction as work-up.

Angewandte Chemie, International Edition published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, COA of Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Luadthong, C. published the artcileSynthesis and characterization of micro/nanoparticles of poly(vinylalcohol-co-vinylcinnamate) derivatives, Synthetic Route of 16909-09-4, the publication is European Polymer Journal (2008), 44(5), 1285-1295, database is CAplus.

Various poly(vinylalc.-co-vinylcinnamate) derivatives including poly(vinylalc.-co-vinylcinnamate), poly(vinylalc.-co-vinyl-4-methoxycinnamate), poly(vinylalc.-co-vinyl-2,4-dimethoxycinnamate) and poly(vinylalc.-co-vinyl-2,4,5-trimethoxycinnamate) were synthesized by grafting poly(vinylalc.) with appropriate cinnamoyl groups. The self-assembly of grafted products into spherical micellar nanoparticles was performed, and particles were analyzed using dynamic light scattering, SEM, and transmission electron microscopy. ¹H NMR analyses of the well-dispersed micellar particle suspensions and polymer solutions indicated that the hydroxyl groups of the polymer were on the outer surface of the spheres, while the cinnamoyl moieties were buried inside the spheres forming crystalline structure. Polymer with a higher degree of cinnamoyl substitution gave smaller particles upon self-assembly. Variations in particle sizes obtained from PV(OH) grafted with cinnamoyl derivatives of different methoxy substitution on the benzene ring were observed Mol. weight of the polymers did not significantly affect nanoparticle size and morphol. In addition, self-assembly of the poly(vinylalc.-co-vinylcinnamate) derivatives into hollow reverse micellar microparticles of uniform size was also demonstrated. ¹H NMR spectrum of the reverse micellar micro-particle suspension indicated that the cinnamoyl moieties were not in a crystalline state.

European Polymer Journal published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Synthetic Route of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia