Category: 16909-09-4

Nawrocka, Wanda P. published the artcileSynthesis of New 4(3H)-Quinazolinone Derivatives by Reaction of 3-Amino-2(1H)-thioxo-4(3H)-quinazolinone with Selected Substituted Cinnamic Acids and Halogenoketones, Application In Synthesis of 16909-09-4, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2008), 183(6), 1379-1387, database is CAplus.

Two series of N-acylated and S-alkylated 4(3H)-quinazolinone derivatives, e.g., I (R = H, Me, MeO, F, Cl, Br, NO₂), have been synthesized by reaction of 3-amino-2(1H)-thioxo-4(3H)-quinazolinone with substituted cinnamic acids or halogenoketones (phenacyl bromides), resp.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Bohme, Horst published the artcileOptical studies on coumarins. II. Ultraviolet absorption of monohydroxycoumarins and derivatives, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft (1957), 405-12, database is CAplus.

cf. C.A. 51, 15270h. In comparative studies of 4 monohydroxycoumarins, the longwave absorption bands were found to be moved bathochromically by introduction of a hydroxy group in the 6 or 7 position, while the corresponding maximum of 5-and 8-hydroxycoumarins lies at shorter wave lengths. As with coumarin itself 3 bands appear with 5-, 6-, and 8-hydroxycoumarin. 7-Hydroxycoumarin does not produce the medial bands with an inflection at 240 m¦Ì. Dihydroxy-trans-cinnamic acids are optically very similar to their methylated derivatives, but big differences were noted between hydroxycoumarins and dimethoxy-cis-cinnamic acids.

Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Giessel, Josephine M. published the artcileSubstituted cinnamic anhydrides act as selective inhibitors of acetylcholinesterase, Category: catalysis-chemistry, the publication is Bioorganic Chemistry (2019), 103058, database is CAplus and MEDLINE.

Cinnamic anhydrides have been shown to be more than reactive reagents, but they also act as inhibitors of the enzyme acetylcholinesterease (AChE). Thus, out of a set of 33 synthesized derivatives, several of them were mixed type inhibitors for AChE (from elec. eel). Thus, (E)-3-(2,4-dimethoxyphenyl)acrylic anhydride (2c) showed K_i = 8.30 ¡À 0.94 ¦ÌM and K_i‘ = 9.54 ¡À 0.38 ¦ÌM, and for (E)-3-(3-chlorophenyl)acrylic anhydride (2u) K_i = 8.23 ¡À 0.93 ¦ÌM and K_i‘ = 13.07 ¡À 0.46 ¦ÌM were measured. While being not cytotoxic to many human cell lines, these compounds showed an unprecedented and noteworthy inhibitory effect for AChE but not for butyrylcholinesterase (BChE).

Bioorganic Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Uemura, Takahito published the artcileA Concise Enantiodivergent Synthesis of Equol, SDS of cas: 16909-09-4, the publication is Synlett (2021), 32(7), 693-696, database is CAplus.

Equol, a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein, has been synthesized as both enantioenriched forms based on MacMillan’s ¦Á-arylation of carbonyl compound mediated by amino acid derived indazolidinones and copper precatalysts. The natural form of (S)-equol and its enantiomer (R)-equol have been synthesized in 8 steps from 2,4-dimethoxybenzaldehyde with good enantiomeric purity (90% ee and 90% ee, resp.).

Synlett published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C12H23N3S, SDS of cas: 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

De Simone, Filippo published the artcileFormal Homo-Nazarov and Other Cyclization Reactions of Activated Cyclopropanes, Formula: C11H12O4, the publication is Chemistry – A European Journal (2011), 17(51), 14527-14538, S14527/1-S14527/124, database is CAplus and MEDLINE.

The Nazarov cyclization of divinyl ketones gives access to cyclopentenones. Replacing one of the vinyl groups by a cyclopropane leads to a formal homo-Nazarov process for the synthesis of cyclohexenones. In contrast to the Nazarov reaction, the cyclization of vinyl-cyclopropyl ketones is a stepwise process, often requiring harsh conditions. Herein are described two different approaches for further polarization of the three-membered ring of vinyl-cyclopropyl ketones to allow the formal homo-Nazarov reaction under mild catalytic conditions. In the first approach, the introduction of an ester group ¦Á to the carbonyl on the cyclopropane gave a more than tenfold increase in reaction rate, allowing us to extend the scope of the reaction to non-electron-rich aryl donor substituents in the ¦Â position to the carbonyl on the cyclopropane. In this case, a proof of principle for asym. induction could be achieved using chiral Lewis acid catalysts. In the second approach, heteroatoms, especially nitrogen, were introduced ¦Â to the carbonyl on the cyclopropane. In this case, the reaction was especially successful when the vinyl group was replaced by an indole heterocycle. With a free indole, the formal homo-Nazarov cyclization on the C3 position of indole was observed using a copper catalyst. In contrast, a new cyclization reaction on the N1 position was observed with Bronsted acid catalysts. Both reactions were applied to the synthesis of natural alkaloids. Preliminary investigations on the rationalization of the observed regioselectivity are also reported.

Chemistry – A European Journal published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Peterson, John R. published the artcileSynthesis and experimental ionization energies of certain (E)-3-arylpropenoic acids and their methyl esters, Formula: C11H12O4, the publication is Journal of Chemical and Engineering Data (1988), 33(4), 534-7, database is CAplus.

Ionization energies for methoxy-substituted (E)-3-arylpropenoic acids and Me (E)-3-arylpropenoates were exptl. determined by mass spectroscopy. The title compounds were prepared in excellent yield by Knoevenagel condensation of an aromatic aldehyde with malonic acid and by Fischer esterification of the acid with methanol.

Journal of Chemical and Engineering Data published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Otero, Elver published the artcileSynthesis and leishmanicidal activity of cinnamic acid esters: structure-activity relationship, Computed Properties of 16909-09-4, the publication is Medicinal Chemistry Research (2014), 23(3), 1378-1386, database is CAplus.

Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids derivatives with aliphatic alcs. Structures of the products were elucidated by spectroscopic anal. The synthesized compounds were evaluated for antileishmanial activity against L. (V) panamensis amastigotes and cytotoxic activity was evaluated against mammalian U-937 cells. The compounds 11, 15-17, and 23, were active against Leishmania parasite and although toxic for mammalian cells, they still are potential candidates for antileishmanial drug development. A SAR anal. indicates that first, while smaller alkyl chains lead to higher selectivity indexes (10, 11 vs. 12-17); second, the degree of oxygenation is essential for activity, primarily in positions 3 and 4 (17 vs. 18-20 and 22); and third, hydroxyl groups increase both activity and cytotoxicity (14 vs. 23). On the other hand, the presence of a double bond in the side chain is crucial for cytotoxicity and leishmanicidal activity (12 vs. 21). However, further studies are required to optimize the structure of the promising mols. and to validate the in vitro activity against Leishmania demonstrated here with in vivo studies.

Medicinal Chemistry Research published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Computed Properties of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Navarrete, Andres published the artcileSynthesis and nematocidal activities of N-(2-methylpropyl)-3-(X-phenyl)-2E-propenamides, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Proceedings of the Western Pharmacology Society (2002), 114-117, database is CAplus and MEDLINE.

Various N-(2-methylpropyl)-3-(X-phenyl)-2E-propenamides were synthesized and evaluated for their nematocidal activities. N-(2-methylpropyl)-3-(X-phenyl)-2E propenamides, in which x was equal to -Cl, -F or -NO₂ at position 3 or di-OCH₃ at position 3,4 in the aromatic ring, showed nematocidal activity in vitro against Ascaris suum inducing morphol. changes in the cephalic region.

Proceedings of the Western Pharmacology Society published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Angapelly, Srinivas published the artcileDevelopment of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors, Formula: C11H12O4, the publication is Bioorganic & Medicinal Chemistry (2017), 25(20), 5726-5732, database is CAplus and MEDLINE.

A series of novel sulfonamides incorporating phenylacrylamido functionalities were synthesized and investigated for the inhibition of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). The physiol. and pharmacol. relevant human (h) isoforms hCA I and II (cytosolic isoenzymes), as well as the transmembrane tumor-associated hCA IX and XII were included in the study. These compounds showed low nanomolar or sub-nanomolar inhibition constants against hCA II (K_Is in the range of 0.50-50.5 nM), hCA IX (K_Is of 1.8-228.5 nM), and hCA XII (K_Is of 3.5-96.2 nM) being less effective as inhibitors of the off target isoform hCA I. A detailed structure-activity relationship study demonstrates that the nature and position of substituents present on the aromatic part of the scaffold strongly influence the inhibition of CA isoforms. As hCA II, IX and XII are involved in pathologies such as glaucoma and hypoxic, and metastatic tumors, compounds of the type reported may be useful preclin. candidates.

Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Namera, Dipti L. published the artcileMicrowave assisted synthesis of 2,5-distyryl-1,3,4-oxadiazole derivatives as antimicrobial agents, Application In Synthesis of 16909-09-4, the publication is International Letters of Chemistry, Physics and Astronomy (2014), 46-54, 9 pp., database is CAplus.

A new series of 2,5-distyryl-1,3,4-oxadiazoles derivatives have been synthesized from cinnamic hydrazide on reaction with various cinnamic acid derivatives The structures of synthesized compounds have been elucidated by spectral studies like IR, 1HNMR, Mass and also Elemental Anal. Furthermore, all synthesized compounds were screened for in vitro anti microbial activity against the gram pos. (Staphylococcus aureus, Pseudomonas aeruginosa) and gram neg. (Escherichia coli) bacterial strain. In which some the compounds show potential inhibition against the test organisms.

International Letters of Chemistry, Physics and Astronomy published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia