Category: 16909-09-4

Giessel, Josephine M. published the artcileCaffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2019), 259-268, database is CAplus and MEDLINE.

Unexpected inhibitory effects against eeAChE could be found for a newly synthesized class of caffeic acid phenethyl ester (CAPE) derivatives Thus, phenethyl-(E)-3-(3,5-dimethoxy-4-phenethoxyphenyl)-acrylate (K_i = 1.97 ¡À 0.38 ¦ÌM, K_i’ = 2.44 ¡À 0.07 ¦ÌM) and 4-(2-(((E)-3-(3,4-bis(benzyloxy)phenyl)acryloyl)oxy)ethyl)-1,2-phenylene (2E,2’E)-bis(3-(3,4-bis(benzyloxy)phenyl)acrylate) (K_i = 0.72 ¡À 0.31 ¦ÌM, K_i’ = 1.80 ¡À 0.21 ¦ÌM) showed very good inhibition of eeAChE, while being non cytotoxic for malignant human cancer cells and non-malignant mouse fibroblasts. Also, they are weak inhibitors for BChE (from equine serum).

European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Wang, Bo published the artcileSyntheses and structure-activity relationship studies of N-substituted-¦Â-D-glucosaminides as selective cytotoxic agents, Application In Synthesis of 16909-09-4, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(23), 7110-7113, database is CAplus and MEDLINE.

Twenty-four diosgenyl saponins bearing cinnamoyl, carbamido and thiosemicarbazone groups, e.g. I (R = H, R¹ = Me, OMe; R = OMe, R¹ = H), were synthesized concisely. The cytotoxicities of the synthetic compounds on six human caner cell lines were evaluated employing MTT method. Structure-activity relationship could be observed, and two of the synthesized compounds I (R = H, R¹ = Me, OMe) exhibited selective inhibition on HeLa and MCF-7 cells, while three of them, e.g. I (R = OMe, R¹ = H), showed strong inhibition against HT1080.

Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C7H10O4, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Ji, Jing published the artcilePeroxide promoted tunable decarboxylative alkylation of cinnamic acids to form alkenes or ketones under metal-free conditions, Formula: C11H12O4, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(35), 7546-7549, database is CAplus and MEDLINE.

A tunable decarboxylative alkylation of cinnamic acids with alkanes was developed to form alkenes or ketones under transition metal-free conditions. In the presence of DTBP or DTBP/TBHP, the reaction gave alkenes and ketones resp. via a radical mechanism in moderate to good yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Formula: C11H12O4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Qiao, Jingxin published the artcileSARS-CoV-2 M^pro inhibitors with antiviral activity in a transgenic mouse model, Name: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Science (Washington, DC, United States) (2021), 371(6536), 1374-1378, database is CAplus and MEDLINE.

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continually poses serious threats to global public health. The main protease (M^pro) of SARS-CoV-2 plays a central role in viral replication. We designed and synthesized 32 new bicycloproline-containing M^pro inhibitors derived from either boceprevir or telaprevir, both of which are approved antivirals. All compounds inhibited SARS-CoV-2 M^pro activity in vitro, with 50% inhibitory concentration values ranging from 7.6 to 748.5 nM. The cocrystal structure of M^pro in complex with MI-23, one of the most potent compounds, revealed its interaction mode. Two compounds (MI-09 and MI-30) showed excellent antiviral activity in cell-based assays. In a transgenic mouse model of SARS-CoV-2 infection, oral or i.p. treatment with MI-09 or MI-30 significantly reduced lung viral loads and lung lesions. Both also displayed good pharmacokinetic properties and safety in rats.

Science (Washington, DC, United States) published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Name: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Sharma, Abhishek published the artcileUnique versatility of ionic liquids as clean decarboxylation catalyst cum solvent: a metal- and quinoline-free paradigm towards synthesis of indoles, styrenes, stilbenes and arene derivatives under microwave irradiation in aqueous conditions, Application In Synthesis of 16909-09-4, the publication is Advanced Synthesis & Catalysis (2008), 350(18), 2910-2920, database is CAplus.

Ionic liquids have been found to provide a new platform for metal- and quinoline-free decarboxylation of various N-heteroaryl and aryl carboxylic acids under microwave irradiation in aqueous condition. The method was found to possess a wide substrate scope towards the synthesis of various pharmacol. and industrially important aromatic compounds including indoles, styrenes, stilbenes, and nitro- or hydroxyarene derivatives The decarboxylation of indole and ¦Á-phenylcinnamic acids proceeded well without addition of any catalyst in neat 1-hexyl-3-methylimidazolium bromide ([hmim]Br) and 1-methylimidazolium p-toluenesulfonic acid ([Hmim]PTSA), resp., while addition of a mild base like aqueous sodium hydrogen carbonate to [hmim]Br further improved the decarboxylation of hydroxylated cinnamic and aromatic acid substrates. The developed methodol. not only precludes the usage of toxic metal/quinoline and harsh organic bases but also offers several inherent benefits like recyclability of reagent system, reduction in waste and hazards, short reaction time besides ease of product recovery.

Advanced Synthesis & Catalysis published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C5H5F3O2, Application In Synthesis of 16909-09-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Hsu, I-Nan published the artcileDissociation constants of four disubstituted cinnamic acids, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Journal of the Indian Chemical Society (1967), 44(6), 540-1, database is CAplus.

The apparent pK values of trans-2,3-dimethoxycinnamic acid, trans-2,4-dimethoxycinnamic acid, trans-3,4-dimethoxycinnamic acid, and trans-3,5-dimethoxycinnamic acid were calculated at various concentrations, and extrapolation to a bulk concentration of 0 gives pK 4.37 ¡À 0.03, 4.80 ¡À 0.03, 4.53 ¡À 0.03, and 4.36 ¡À 0.003, resp. It is assumed that the activity coefficient of the undissociated acid is unity. Inductive and mesomeric effects are discussed.

Journal of the Indian Chemical Society published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Safety of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Lee, Jee-Hyun published the artcileSynthesis and evaluation of (+)-decursin derivatives as inhibitors of the Wnt/¦Â-catenin pathway, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(15), 3529-3532, database is CAplus and MEDLINE.

We synthesized (+)-decursin derivatives substituted with cinnamoyl- and Ph propionyl groups originating from (+)-CGK062 and screened them using a cell-based assay to detect relative luciferase reporter activity. Of this series, compound I, in which a 3-acetoxy cinnamoyl group was introduced, most potently inhibited (97.0%) the Wnt/¦Â-catenin pathway. Specifically, compound I dose-dependently inhibited Wnt3a-induced expression of the ¦Â-catenin response transcription (CRT) and increased ¦Â-catenin degradation in HEK293 reporter cells. Furthermore, compound I suppressed expression of the downstream ¦Â-catenin target genes cyclin D1 and c-myc and suppressed PC3 cell growth in a concentration-dependent manner.

Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Khosropour, Ahmad Reza published the artcileSynthesis of trans-cinnamic acids from aryl aldehydes and aryl aldehyde bisulfite adducts with malonic acid using piperazine, Category: catalysis-chemistry, the publication is Journal of Chemical Research (2005), 364-365, database is CAplus.

Piperazine as a new reagent for the condensation of aryl aldehydes and their bisulfite adducts with malonic acid are described which afford the corresponding cinnamic acids in excellent yields and short reaction times in the absence of solvents under microwave irradiation

Journal of Chemical Research published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Category: catalysis-chemistry.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Kumar, Abhishek published the artcileCopper(II)-catalyzed decarboxylative cyclization for accessing biologically relevant 3-(2-furanyl)indoles from 3-cyanoacetyl indoles and cinnamic acids, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Tetrahedron (2020), 76(36), 131433, database is CAplus.

A novel and efficient route for the synthesis of 3-(2-furanyl)indoles I (R¹ = H, Me, Et; R² = H, Me; R³ = 6-Cl, 5-OMe, 5-F, etc.; R⁴ = Ph, 2-BrC₆H₄, 1-naphthyl, etc.) from readily available 3-cyanoacetyl indoles and ¦Á,¦Â-unsaturated carboxylic acids via Cu(II)-catalyzed decarboxylative, intermol. annulation is reported. In this transformation, di-tert-Bu peroxide was used as an external oxidant. This reaction underwent radical addition, decarboxylative processes, and provides a facile regioselective 3-(2-furanyl)indole derivatives in good to excellent yields.

Tetrahedron published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia

Maeta, Naoya published the artcileRadical-Cation Vinylcyclopropane Rearrangements by TiO₂ Photocatalysis, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Journal of Organic Chemistry (2020), 85(10), 6551-6566, database is CAplus and MEDLINE.

Radical cation vinylcyclopropane rearrangements by TiO₂ photocatalysis in lithium perchlorate/nitromethane solution are described. The reactions are triggered by oxidative single electron transfer, which is followed by immediate ring-opening of the cyclopropanes to generate distonic radical cations as unique reactive intermediates. This approach can also be applied to vinylcyclobutane, leading to the construction of six-membered rings. A stepwise mechanism via distonic radical cations is proposed based on preliminary mechanistic studies, which is supported by d. functional theory calculations

Journal of Organic Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia